Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol

Analytical Biochemistry

Volumn 381, Issue 1, 2008, Pages 151-153

  DeBarber, Andrea E ^a   Lütjohann, Dieter ^b   Merkens, Louise ^a   Steiner, Robert D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; SEPARATION;

CHOLESTEROL EFFLUX; CHROMATOGRAPHIC SEPARATIONS; GAS CHROMATOGRAPHY-MASS SPECTROMETRIES (GC-MS); LC-MS METHODS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; PRACTICAL MEASURES; TANDEM MASS SPECTROMETRY;

GAS CHROMATOGRAPHY;

24S HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; OXYSTEROL;

ACCURACY; ARTICLE; CHROMATOGRAPHY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 49049121010     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.05.037     Document Type: Article

References (15)

1. Björkhem I., and Meaney S. Brain cholesterol: Long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 806-815
2. Lütjohann D. Cholesterol metabolism in the brain: Importance of 24S-hydroxylation. Acta Neurol. Scand. Suppl. 185 (2006) 33-42
3. Lütjohann D., Breuer O., Ahlborg G., Nennesmo I., Siden A., Diczfalusy U., and Björkhem I. Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93 (1996) 9799-9804
4. Björkhem I., Lütjohann D., Diczfalusy U., Stahle L., Ahlborg G., and Wahren J. Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res. 39 (1998) 1594-1600
5. Björkhem I. Rediscovery of cerebrosterol. Lipids 42 (2007) 5-14
6. Dzeletovic S., Breuer O., Lund E., and Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225 (1995) 73-80
7. Griffiths W.J., Wang Y., Alvelius G., Liu S., Bodin K., and Sjövall J. Analysis of oxysterols by electrospray tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 17 (2006) 341-362
8. Burkard I., Rentsch K.M., and von Eckardstein E. Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J. Lipid Res. 45 (2004) 776-781
9. McDonald J.G., Thompson B.M., McCrum E.C., and Russell D.W. Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry. Methods Enzymol. 432 (2007) 145-170
10. Pulfer M.K., Taube C., Gelfand E., and Murphy R.C. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. J. Pharmacol. Exp. Ther. 312 (2005) 256-264
11. Raith K., Brenner C., Farwanah H., Muller G., Eder K., and Neubert R.H. A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. J. Chromatogr. A 1067 (2005) 207-211
12. Verge K.M., and Agnes G.R. Plasticizer contamination from vacuum system O-rings in a quadrupole ion trap mass spectrometer. J. Am. Soc. Mass Spectrom. 13 (2002) 901-905
13. Thelen K.M., Lütjohann D., Vesalainen R., Janatuinen T., Knuuti J., von Bergmann K., Lehtimaki T., and Laaksonen R. Effect of pravastatin on plasma sterols and oxysterols in men. Eur. J. Clin. Pharmacol. 62 (2006) 9-14
14. Bland J.M., and Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1 (1986) 307-310
15. Passing H., and Bablock W. A new biometrical procedure for testing the equality of measurements from two different analytical methods: Application of linear regression procedures for method comparison in clinical chemistry (part 1). J. Clin. Chem. Biochem. 21 (1983) 709-720