Fingolimod protects cultured cortical neurons against excitotoxic death

Pharmacological Research

Volumn 67, Issue 1, 2013, Pages 1-9

  Di Menna, Luisa ^a   Molinaro, Gemma ^a   Di Nuzzo, Luigi ^b   Riozzi, Barbara ^a   Zappulla, Cristina ^a   Pozzilli, Carlo ^b   Turrini, Renato ^c   Caraci, Filippo ^d   Copani, Agata ^d   Battaglia, Giuseppe ^a   Nicoletti, Ferdinando ^a,e   Bruno, Valeria ^a,e  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Italy   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cortical cultures; Excitotoxicity; FTY720; Neuroinflammation; Neuroprotection

Indexed keywords

CYCLIC AMP; FINGOLIMOD; FINGOLIMOD PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RECEPTOR BLOCKING AGENT; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG; W 146;

ADULT ANIMAL; ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; FEMALE; IN VITRO STUDY; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; CELL DEATH; CELLS, CULTURED; FEMALE; IMMUNOSUPPRESSIVE AGENTS; LYSOPHOSPHOLIPIDS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOPHOSPHATES; PROPYLENE GLYCOLS; RATS; SPHINGOSINE;

EID: 84870859661     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.10.004     Document Type: Article

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