Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb-drug interaction

Fitoterapia

Volumn 83, Issue 8, 2012, Pages 1415-1419

  Liu, Cong ^a   Cao, Yun Feng ^b,c   Fang, Zhong Ze ^c,d   Zhang, Yan Yan ^c   Hu, Cui Min ^d   Sun, Xiao Yu ^c   Huang, Ting ^b   Zeng, Jia ^b   Fan, Xu Ran ^c   Hong, Mo ^c  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF PLANNED PARENTHOOD RESEARCH   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Deoxyschizandrin; Herb drug interaction; UDP glucuronosyltransferases (UGTs)

Indexed keywords

DEOXYSCHIZANDRIN; GLUCURONOSYLTRANSFERASE 1A3; LIGNAN; SCHISANTHERIN A; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG STRUCTURE; ENZYME INHIBITION; HERB DRUG INTERACTION; IC 50; INHIBITION KINETICS; PRIORITY JOURNAL;

CYCLOOCTANES; DIOXOLES; GLUCURONOSYLTRANSFERASE; HERB-DRUG INTERACTIONS; LIGNANS; MOLECULAR STRUCTURE; POLYCYCLIC COMPOUNDS; PROTEIN ISOFORMS;

EID: 84870839500     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.08.004     Document Type: Article

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