Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity

Gene Therapy

Volumn 19, Issue 12, 2012, Pages 1141-1149

  Kashio, A ^a   Sakamoto, T ^a   Kakigi, A ^a   Suzuki, M ^b   Suzukawa, K ^a   Kondo, K ^a   Sato, Y ^c   Asoh, S ^c   Ohta, S ^c   Yamasoba, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c Graduate School of Medicine   (Japan)

Author keywords

aminoglycoside; apoptosis; cochlea; protein therapy; topical application

Indexed keywords

AGENTS ACTING ON THE AUDITORY AND VESTIBULAR SYSTEMS; AMINOGLYCOSIDE; CASPASE 9; ETACRYNIC ACID; GELATIN SPONGE; KANAMYCIN; PROTEIN DERIVATIVE; TAT FNK PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; COCHLEA FENESTRA; COCHLEA INJURY; DRUG DIFFUSION; DRUG DISTRIBUTION; ENZYME ACTIVATION; EVOKED BRAIN STEM AUDITORY RESPONSE; FEASIBILITY STUDY; GUINEA PIG; HAIR CELL; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MITOCHONDRION; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; AMINOGLYCOSIDES; ANIMALS; APOPTOSIS; CASPASE 9; COCHLEA; ETHACRYNIC ACID; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GENE PRODUCTS, TAT; GUINEA PIGS; HAIR CELLS, AUDITORY; KANAMYCIN; LABYRINTH DISEASES; NEUROPROTECTIVE AGENTS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT FUSION PROTEINS; ROUND WINDOW, EAR;

CAVIA; RATTUS;

EID: 84870838621     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.204     Document Type: Article

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