Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury

ORL

Volumn 69, Issue 1, 2006, Pages 43-50

  Staecker, Hinrich ^a   Liu, Wei ^b   Malgrange, Brigitte ^d   Lefebvre, Philippe P ^d   Van De Water, Thomas R ^c  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antiapoptotic protein; Auditory hair cells; Auditory neurons; Cell death; Cochlea; Otoprotection; Ototoxins; Oxidative stress; Trophic support

Indexed keywords

ADENOVIRUS VECTOR; CISPLATIN; GREEN FLUORESCENT PROTEIN; NEOMYCIN; NEUROTROPHIN; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL MEMBRANE POTENTIAL; CELL PROTECTION; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; EAR INJURY; EAR PROTECTION; EXPLANT; GENETIC TRANSDUCTION; HAIR CELL; MITOCHONDRIAL MEMBRANE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPIRAL GANGLION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; CISPLATIN; GENES, BCL-2; GENETIC VECTORS; HAIR CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOMYCIN; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; SIMPLEXVIRUS; SPIRAL GANGLION;

EID: 33845804749     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096716     Document Type: Article

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