Protection of hepatic cells from apoptosis induced by ischemia/ reperfusion injury by protein therapeutics

Hepatology Research

Volumn 37, Issue 2, 2007, Pages 133-142

  Nagai, Shinya ^a,b   Asoh, Sadamitsu ^a   Kobayashi, Yasuhiro ^a   Shidara, Yujiro ^c   Mori, Takashi ^a,d   Suzuki, Misao ^e   Moriyama, Yukichi ^b   Ohta, Shigeo ^a  

^a Graduate School of Medicine   (Japan)

^b NIPPON MEDICAL SCHOOL MUSASHI KOSUGI HOSPITAL   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bcl xL; Necrosis; Protein therapeutics; Protein transduction domain; Transplantation

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE; DIGOXIGENIN; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; EOSIN; HEMATOXYLIN; PROTEIN BCL XL; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; LIVER BLOOD VESSEL; LIVER CELL; LIVER ISCHEMIA; LIVER VEIN; MALE; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN DOMAIN; REPERFUSION; REPERFUSION INJURY; TRANSGENIC MOUSE; TREATMENT OUTCOME; WESTERN BLOTTING;

EID: 33947113002     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00022.x     Document Type: Article

References (39)

1. Kang KJ. Mechanism of hepatic ischemia/reperfusion injury and protection against reperfusion injury. Transplant Proc 2002; 34: 2659-61.
2. Kurokawa T, Nonami T, Harada A, Nakao A, Takagi H. Mechanism and prevention of ischemia-reperfusion injury of the liver. Semin Surg Oncol 1996; 12: 179-82.
3. Shibayama Y, Asaka S, Nishijima A. Mechanism of liver injury following ischemia. Exp Mol Pathol 1991; 55: 251-60.
4. Zhou W, McCollum MO, Levine BA, Olson MS. Inflammation and platelet-activating factor production during hepatic ischemia/ reperfusion. Hepatology 1992; 16: 1236-40.
5. Selzner M, Rudiger HA, Selzner N, Thomas DW, Sindram D, Clavien PA. Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion. J Hepatol 2002; 36: 218-25.
6. Cursio R, Gugenheim J, Ricci JE et al. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J 1999; 13: 253-61.
7. Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis? Hepatology 2001; 33: 397-405.
8. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 1999; 67: 1099-105.
9. Denicourt C, Dowdy SF. Protein transduction technology offers novel therapeutic approach for brain ischemia. Trends Pharmacol Sci 2003; 24: 216-18.
10. L. J Biol Chem 2000; 275: 37240-5.
11. Asoh S, Ohsawa I, Mori T et al. Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci USA 2002; 99: 17107-12.
12. Ozaki D, Sudo K, Asoh S, Yamagata K, Ito H, Ohta S. Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. Biochem Biophys Res Commun 2004; 313: 522-7.
13. Asoh S, Mori T, Nagai S et al. Zonal necrosis prevented by transduction of the artificial anti-death FNK protein. Cell Death Differ 2005; 12: 384-94.
14. Kitayama H, Tsujimura T, Matsumura I et al. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase. Blood 1996; 88: 995-1004.
15. Takeuchi T, Nomura T, Tsujita M et al. Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting. Biochem Biophys Res Commun 2002; 293: 953-7.
16. Asoh S, Mori T, Ohta S. Practicable recovery of plasmids carrying cDNAs encoding anti-apoptotic factors that had been introduced by particle bombardment into 5-week-old rat hippocampal slices. Neurosci Lett 1999; 272: 62-6.
17. Burkhart CA, Norris MD, Haber M. A simple method for the isolation of genomic DNA from mouse tail free of real-time PCR inhibitors. J Biochem Biophys Methods 2002; 52: 145-9.
18. Yadav SS, Sindram D, Perry DK, Clavien PA. Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathway. Hepatology 1999; 30: 1223-31.
19. Yadav SS, Gao W, Harland RC, Clavien PA. A new and simple technique of total hepatic ischemia in the mouse. Transplantation 1998; 65: 1433-6.
20. Rappaport AM. Acinar units and the pathophysiology of the liver. In: Rouiller C, eds. The Liver. Morphology, Biochemistry, Physiology, Vol. I. London: Academic, 1963; 265-328.
21. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989; 10: 292-9.
22. Sudo K, Asoh S, Ohsawa I et al. The anti-cell death FNK protein protects cells from death induced by freezing and thawing. Biochem Biophys Res Commun 2005; 330: 850-6.
23. Jonas EA, Hickman JA, Chachar M et al. Pro-apoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proc Natl Acad Sci USA 2004; 101: 13590-5.
24. Basañez G, Zhang J, Chau BN et al. Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes. J Biol Chem 2001; 276: 31083-91.
25. Morin D, Pires F, Plin C, Tillement JP. Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver. Biochem Pharmacol 2004; 68: 2065-73.
26. Contreras JL, Vilatoba M, Eckstein C, Bilbao G, Anthony-Thompson J, Eckhoff DE. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. Surgery 2004; 136: 390-400.
27. Mueller TH, Kienle K, Beham A, Geissler EK, Jauch KW, Rentsch M. Caspase 3 inhibition improves survival and reduces early graft injury after ischemia and reperfusion in rat liver transplantation. Transplantation 2004; 78: 1267-73.
28. Proskuryakov SY, Konoplyannikov AG, Gabai VL. Necrosis: A specific form of programmed cell death? Exp Cell Res 2003; 283: 1-16.
29. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 2003; 125: 1246-57.
30. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125: 917-36.
31. Bilbao G, Contreras JL, Eckhoff DE et al. Curiel, Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the anti-apoptotic Bcl-2 gene. Ann Surg 1999; 230: 185-93.
32. Rymsa B, Wang JF, de Groot H. O2-. release by activated Kupffer cells upon hypoxia-reoxygenation. Am J Physiol 1991; 261: G602-7.
33. Harrison R. Structure and function of xanthine oxidoreductase: Where are we now? Free Rad Biol Med 2002; 33: 774-97.
34. Engerson TD, McKelvey TG, Rhyne DB, Boggio EB, Snyder SJ, Jones HP. Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues. J Clin Invest 1987; 79: 1564-70.
35. Jaeschke H, Mitchell JR. Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. Biochem Biophys Res Commun 1989; 160: 140-7.
36. Ozaki M, Deshpande SS, Angkeow P et al. Inhibition of the Rac1 GTPase protects against non-lethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J 2000; 14: 418-29.
37. Di Meo S, Venditti P. Mitochondria in exercise-induced oxidative stress. Biol Signals Recept 2001; 10: 125-40.
38. Jassem W, Fuggle SV, Rela M, Koo DD, Heaton ND. The role of mitochondria in ischemia/reperfusion injury. Transplantation 2002; 73: 493-9.
39. 2+ influx. J Neurosci Res 2001; 63: 377-87.