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Volumn 6, Issue 11, 2012, Pages

Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

Author keywords

[No Author keywords available]

Indexed keywords

NANOBODY; UNCLASSIFIED DRUG; VARIANT SURFACE GLYCOPROTEIN;

EID: 84870731528     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001902     Document Type: Article
Times cited : (19)

References (35)
  • 1
    • 0031969369 scopus 로고    scopus 로고
    • Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms
    • Beschin A, Brys L, Magez S, Radwanska M, De Baetselier P, (1998) Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms. J Leukoc Biol 63: 429-439.
    • (1998) J Leukoc Biol , vol.63 , pp. 429-439
    • Beschin, A.1    Brys, L.2    Magez, S.3    Radwanska, M.4    de Baetselier, P.5
  • 2
    • 0030006457 scopus 로고    scopus 로고
    • In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression
    • Darji A, Beschin A, Sileghem M, Heremans H, Brys L, et al. (1996) In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression. Infect Immun 64: 1937-1943.
    • (1996) Infect Immun , vol.64 , pp. 1937-1943
    • Darji, A.1    Beschin, A.2    Sileghem, M.3    Heremans, H.4    Brys, L.5
  • 3
    • 44949219210 scopus 로고    scopus 로고
    • Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses
    • Radwanska M, Guirnalda P, De Trez C, Ryffel B, Black S, et al. (2008) Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses. PLoS Pathog 4: e1000078.
    • (2008) PLoS Pathog , vol.4
    • Radwanska, M.1    Guirnalda, P.2    de Trez, C.3    Ryffel, B.4    Black, S.5
  • 4
    • 79959833610 scopus 로고    scopus 로고
    • T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis
    • Bockstal V, Guirnalda P, Caljon G, Goenka R, Telfer JC, et al. (2011) T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis. PLoS Pathog 7: e1002089.
    • (2011) PLoS Pathog , vol.7
    • Bockstal, V.1    Guirnalda, P.2    Caljon, G.3    Goenka, R.4    Telfer, J.C.5
  • 5
    • 0037345508 scopus 로고    scopus 로고
    • Antigenic variation and the African trypanosome genome
    • Donelson JE, (2003) Antigenic variation and the African trypanosome genome. Acta Trop 85: 391-404.
    • (2003) Acta Trop , vol.85 , pp. 391-404
    • Donelson, J.E.1
  • 6
    • 4143141923 scopus 로고    scopus 로고
    • Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries
    • Pays E, Vanhamme L, Perez-Morga D, (2004) Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries. Curr Opin Microbiol 7: 369-374.
    • (2004) Curr Opin Microbiol , vol.7 , pp. 369-374
    • Pays, E.1    Vanhamme, L.2    Perez-Morga, D.3
  • 7
    • 0035339841 scopus 로고    scopus 로고
    • Control and function of the bloodstream variant surface glycoprotein expression sites in Trypanosoma brucei
    • Vanhamme L, Lecordier L, Pays E, (2001) Control and function of the bloodstream variant surface glycoprotein expression sites in Trypanosoma brucei. Int J Parasitol 31: 523-531.
    • (2001) Int J Parasitol , vol.31 , pp. 523-531
    • Vanhamme, L.1    Lecordier, L.2    Pays, E.3
  • 8
    • 0035222844 scopus 로고    scopus 로고
    • Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite
    • Barry JD, McCulloch R, (2001) Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite. Adv Parasitol 49: 1-70.
    • (2001) Adv Parasitol , vol.49 , pp. 1-70
    • Barry, J.D.1    McCulloch, R.2
  • 9
    • 0019429981 scopus 로고
    • Variant specific antigens of Trypanosoma brucei exist in solution as glycoprotein dimers
    • Auffret CA, Turner MJ, (1981) Variant specific antigens of Trypanosoma brucei exist in solution as glycoprotein dimers. Biochem J 193: 647-650.
    • (1981) Biochem J , vol.193 , pp. 647-650
    • Auffret, C.A.1    Turner, M.J.2
  • 11
    • 0034755438 scopus 로고    scopus 로고
    • Functional heavy-chain antibodies in Camelidae
    • Nguyen VK, Desmyter A, Muyldermans S, (2001) Functional heavy-chain antibodies in Camelidae. Adv Immunol 79: 261-296.
    • (2001) Adv Immunol , vol.79 , pp. 261-296
    • Nguyen, V.K.1    Desmyter, A.2    Muyldermans, S.3
  • 12
    • 0344447084 scopus 로고    scopus 로고
    • Potent enzyme inhibitors derived from dromedary heavy-chain antibodies
    • Lauwereys M, Arbabi Ghahroudi M, Desmyter A, Kinne J, Holzer W, et al. (1998) Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J 17: 3512-3520.
    • (1998) EMBO J , vol.17 , pp. 3512-3520
    • Lauwereys, M.1    Arbabi Ghahroudi, M.2    Desmyter, A.3    Kinne, J.4    Holzer, W.5
  • 13
    • 1842531211 scopus 로고    scopus 로고
    • Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei
    • Engstler M, Thilo L, Weise F, Grünfelder CG, Schwarz H, et al. (2004) Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei. J Cell Sci 117: 1105-1115.
    • (2004) J Cell Sci , vol.117 , pp. 1105-1115
    • Engstler, M.1    Thilo, L.2    Weise, F.3    Grünfelder, C.G.4    Schwarz, H.5
  • 14
    • 0018763999 scopus 로고
    • Inactivation or elimination of potentially trypanolytic, complement-activating immune complexes by pathogenic trypanosomes
    • Balber AE, Bangs JD, Jones SM, Proia RL, (1979) Inactivation or elimination of potentially trypanolytic, complement-activating immune complexes by pathogenic trypanosomes. Infect Immun 24: 617-627.
    • (1979) Infect Immun , vol.24 , pp. 617-627
    • Balber, A.E.1    Bangs, J.D.2    Jones, S.M.3    Proia, R.L.4
  • 15
    • 0032029353 scopus 로고    scopus 로고
    • Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite
    • O'Beirne C, Lowry CM, Voorheis HP, (1998) Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite. Mol Biochem Parasitol 91: 165-193.
    • (1998) Mol Biochem Parasitol , vol.91 , pp. 165-193
    • O'Beirne, C.1    Lowry, C.M.2    Voorheis, H.P.3
  • 16
    • 79959851947 scopus 로고    scopus 로고
    • High affinity nanobodies against the Trypanosoma brucei VSG are potent trypanolytic agents that block endocytosis
    • Stijlemans B, Caljon G, Natesan SK, Saerens D, Conrath K, et al. (2011) High affinity nanobodies against the Trypanosoma brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog 7: e1002072.
    • (2011) PLoS Pathog , vol.7
    • Stijlemans, B.1    Caljon, G.2    Natesan, S.K.3    Saerens, D.4    Conrath, K.5
  • 17
    • 0031267747 scopus 로고    scopus 로고
    • Comparison of llama VH sequences from conventional and heavy chain antibodies
    • Vu KB, Ghahroudi MA, Wyns L, Muyldermans S, (1997) Comparison of llama VH sequences from conventional and heavy chain antibodies. Mol Immunol 34: 1121-1131.
    • (1997) Mol Immunol , vol.34 , pp. 1121-1131
    • Vu, K.B.1    Ghahroudi, M.A.2    Wyns, L.3    Muyldermans, S.4
  • 18
    • 20444413418 scopus 로고    scopus 로고
    • Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH
    • Conrath K, Vincke C, Stijlemans B, Schymkowitz J, Decanniere K, et al. (2005) Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH. J Mol Biol 350: 112-125.
    • (2005) J Mol Biol , vol.350 , pp. 112-125
    • Conrath, K.1    Vincke, C.2    Stijlemans, B.3    Schymkowitz, J.4    Decanniere, K.5
  • 19
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei
    • Cross GA, (1975) Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitol 71: 393-417.
    • (1975) Parasitol , vol.71 , pp. 393-417
    • Cross, G.A.1
  • 20
    • 0014884946 scopus 로고
    • Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose
    • Lanham SM, Godfrey DG, (1970) Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp Parasitol 28: 521-534.
    • (1970) Exp Parasitol , vol.28 , pp. 521-534
    • Lanham, S.M.1    Godfrey, D.G.2
  • 21
    • 10644287538 scopus 로고    scopus 로고
    • Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen
    • Saerens D, Kinne J, Bosmans E, Wernery U, Muyldermans S, et al. (2004) Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen. J Biol Chem 279: 51965-51972.
    • (2004) J Biol Chem , vol.279 , pp. 51965-51972
    • Saerens, D.1    Kinne, J.2    Bosmans, E.3    Wernery, U.4    Muyldermans, S.5
  • 22
    • 36849056018 scopus 로고    scopus 로고
    • Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens
    • Saerens D, Stijlemans B, Baral TN, Nguyen Thi GT, Wernery U, et al. (2008) Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens. J Immunol Methods 329: 138-150.
    • (2008) J Immunol Methods , vol.329 , pp. 138-150
    • Saerens, D.1    Stijlemans, B.2    Baral, T.N.3    Nguyen Thi, G.T.4    Wernery, U.5
  • 23
    • 0030767656 scopus 로고    scopus 로고
    • Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
    • Arbabi Ghahroudi M, Desmyter A, Wyns L, Hamers R, Muyldermans S, (1997) Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS lett 414: 521-526.
    • (1997) FEBS Lett , vol.414 , pp. 521-526
    • Arbabi Ghahroudi, M.1    Desmyter, A.2    Wyns, L.3    Hamers, R.4    Muyldermans, S.5
  • 24
    • 9144220168 scopus 로고    scopus 로고
    • Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm
    • Stijlemans B, Conrath K, Cortez-Retamozo V, Van Xong H, Wyns L, et al. (2004) Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. J Biol Chem 279: 1256-1261.
    • (2004) J Biol Chem , vol.279 , pp. 1256-1261
    • Stijlemans, B.1    Conrath, K.2    Cortez-Retamozo, V.3    van Xong, H.4    Wyns, L.5
  • 25
    • 0034812589 scopus 로고    scopus 로고
    • Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the Camelidae
    • Conrath KE, Lauwereys M, Galleni M, Matagne A, Frere JM, et al. (2001) Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the Camelidae. Antimicrob Agents Chemother 45: 2807-2812.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2807-2812
    • Conrath, K.E.1    Lauwereys, M.2    Galleni, M.3    Matagne, A.4    Frere, J.M.5
  • 26
    • 0141530903 scopus 로고    scopus 로고
    • Clathrin-mediated endocytosis is essential in Trypanosoma brucei
    • Allen CL, Goulding D, Field MC, (2003) Clathrin-mediated endocytosis is essential in Trypanosoma brucei. EMBO J 22: 4991-5002.
    • (2003) EMBO J , vol.22 , pp. 4991-5002
    • Allen, C.L.1    Goulding, D.2    Field, M.C.3
  • 27
    • 1842614354 scopus 로고    scopus 로고
    • A differential role for actin during the life cycle of Trypanosoma brucei
    • Garcia-Salcedo JA, Perez-Morga D, Gijon P, Dilbeck V, Pays E, et al. (2004) A differential role for actin during the life cycle of Trypanosoma brucei. EMBO J 23: 780-789.
    • (2004) EMBO J , vol.23 , pp. 780-789
    • Garcia-Salcedo, J.A.1    Perez-Morga, D.2    Gijon, P.3    Dilbeck, V.4    Pays, E.5
  • 28
    • 18944401002 scopus 로고    scopus 로고
    • Developmental variation in Rab11-dependent trafficking in Trypanosoma brucei
    • Hall BS, Smith E, Langer W, Jacobs LA, Goulding D, et al. (2005) Developmental variation in Rab11-dependent trafficking in Trypanosoma brucei. Eukaryot Cell 4: 971-980.
    • (2005) Eukaryot Cell , vol.4 , pp. 971-980
    • Hall, B.S.1    Smith, E.2    Langer, W.3    Jacobs, L.A.4    Goulding, D.5
  • 29
    • 77957909777 scopus 로고    scopus 로고
    • Identification and characterization of an unusual class I myosin involved in vesicle traffic in Trypanosoma brucei
    • Spitznagel D, O'Rourke JF, Leddy N, Hanrahan O, Nolan DP, (2010) Identification and characterization of an unusual class I myosin involved in vesicle traffic in Trypanosoma brucei. PLoS One 5: e12282.
    • (2010) PLoS One , vol.5
    • Spitznagel, D.1    O'Rourke, J.F.2    Leddy, N.3    Hanrahan, O.4    Nolan, D.P.5
  • 30
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • Teeling JL, French RR, Cragg MS, van den Brakel J, Pluyter M, et al. (2004) Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 104: 1793-1800.
    • (2004) Blood , vol.104 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3    van den Brakel, J.4    Pluyter, M.5
  • 31
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling JL, Mackus WJ, Wiegman LJ, van den Brakel JH, Beers SA, et al. (2006) The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol 177: 362-371.
    • (2006) J Immunol , vol.177 , pp. 362-371
    • Teeling, J.L.1    Mackus, W.J.2    Wiegman, L.J.3    van den Brakel, J.H.4    Beers, S.A.5
  • 32
    • 0025750132 scopus 로고
    • Structural characterization of the asparagine-linked oligosaccharides from Trypanosoma brucei type II and type III variant surface glycoproteins
    • Zamze SE, Ashford DA, Wooten EW, Rademacher TW, Dwek RA, (1991) Structural characterization of the asparagine-linked oligosaccharides from Trypanosoma brucei type II and type III variant surface glycoproteins. J Biol Chem 266: 20244-20261.
    • (1991) J Biol Chem , vol.266 , pp. 20244-20261
    • Zamze, S.E.1    Ashford, D.A.2    Wooten, E.W.3    Rademacher, T.W.4    Dwek, R.A.5
  • 33
    • 3142689962 scopus 로고    scopus 로고
    • Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A
    • Leal S, Acosta-Serrano A, Morris J, Cross GA, (2004) Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A. J Biol Chem 279: 28979-28988.
    • (2004) J Biol Chem , vol.279 , pp. 28979-28988
    • Leal, S.1    Acosta-Serrano, A.2    Morris, J.3    Cross, G.A.4
  • 34
    • 0034495966 scopus 로고    scopus 로고
    • The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro
    • Pearson TW, Beecroft RP, Welburn SC, Ruepp S, Roditi I, et al. (2000) The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro. Mol Biochem Parasitol 111: 333-349.
    • (2000) Mol Biochem Parasitol , vol.111 , pp. 333-349
    • Pearson, T.W.1    Beecroft, R.P.2    Welburn, S.C.3    Ruepp, S.4    Roditi, I.5
  • 35
    • 84857016910 scopus 로고    scopus 로고
    • Expression and extracellular release of a functional anti-trypanosome Nanobody(R) in Sodalis glossinidius, a bacterial symbiont of the tsetse fly
    • De Vooght L, Caljon G, Stijlemans B, De Baetselier P, Coosemans M, et al. (2012) Expression and extracellular release of a functional anti-trypanosome Nanobody(R) in Sodalis glossinidius, a bacterial symbiont of the tsetse fly. Microb Cell Fact 11: 23.
    • (2012) Microb Cell Fact , vol.11 , pp. 23
    • de Vooght, L.1    Caljon, G.2    Stijlemans, B.3    de Baetselier, P.4    Coosemans, M.5


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