메뉴 건너뛰기




Volumn 86, Issue 24, 2012, Pages 13360-13370

The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; AZACITIDINE; BORTEZOMIB; HISTONE DEACETYLASE INHIBITOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G ANTIBODY; NUTLIN 3; PROTEIN NA; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VPR PROTEIN;

EID: 84870704593     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01850-12     Document Type: Article
Times cited : (67)

References (102)
  • 1
    • 0035124377 scopus 로고    scopus 로고
    • Epstein-Barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies
    • Adamson AL, Kenney S. 2001. Epstein-Barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies. J. Virol. 75:2388-2399.
    • (2001) J. Virol. , vol.75 , pp. 2388-2399
    • Adamson, A.L.1    Kenney, S.2
  • 2
    • 0032506210 scopus 로고    scopus 로고
    • Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product
    • Adamson AL, Kenney SC. 1998. Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product. Virology 251:187-197.
    • (1998) Virology , vol.251 , pp. 187-197
    • Adamson, A.L.1    Kenney, S.C.2
  • 3
    • 0037039363 scopus 로고    scopus 로고
    • Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1
    • Adler B, et al. 2002. Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1. Proc. Natl. Acad. Sci. U. S. A. 99:437-442.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 437-442
    • Adler, B.1
  • 4
    • 0019410144 scopus 로고
    • Activation of the Epstein-Barr virus genome by 5-aza-cytidine in latently infected human lymphoid lines
    • Ben-Sasson SA, Klein G. 1981. Activation of the Epstein-Barr virus genome by 5-aza-cytidine in latently infected human lymphoid lines. Int. J. Cancer 28:131-135.
    • (1981) Int. J. Cancer , vol.28 , pp. 131-135
    • Ben-sasson, S.A.1    Klein, G.2
  • 5
    • 80052273503 scopus 로고    scopus 로고
    • ATM protein kinase: the linchpin of cellular defenses to stress
    • Bhatti S, et al. 2011. ATM protein kinase: the linchpin of cellular defenses to stress. Cell. Mol. Life Sci. 68:2977-3006.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 2977-3006
    • Bhatti, S.1
  • 6
    • 19944397140 scopus 로고    scopus 로고
    • BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186
    • Bhende PM, Seaman WT, Delecluse HJ, Kenney SC. 2005. BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186. J. Virol. 79:7338-7348.
    • (2005) J. Virol. , vol.79 , pp. 7338-7348
    • Bhende, P.M.1    Seaman, W.T.2    Delecluse, H.J.3    Kenney, S.C.4
  • 7
    • 70449566787 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A bypasses p53 inactivation in aMYCmodel of lymphomagenesis
    • Bieging KT, Amick AC, Longnecker R. 2009. Epstein-Barr virus LMP2A bypasses p53 inactivation in aMYCmodel of lymphomagenesis. Proc. Natl. Acad. Sci. U. S. A. 106:17945-17950.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 17945-17950
    • Bieging, K.T.1    Amick, A.C.2    Longnecker, R.3
  • 8
    • 0036284985 scopus 로고    scopus 로고
    • Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus
    • Borza CM, Hutt-Fletcher LM. 2002. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat. Med. 8:594-599.
    • (2002) Nat. Med. , vol.8 , pp. 594-599
    • Borza, C.M.1    Hutt-fletcher, L.M.2
  • 9
    • 60549116871 scopus 로고    scopus 로고
    • The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma
    • Bose S, et al. 2009. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. J. Pathol. 217:345-352.
    • (2009) J. Pathol. , vol.217 , pp. 345-352
    • Bose, S.1
  • 10
    • 84855265398 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis
    • doi: 10.1371/journal.ppat.1002418
    • Cai Q, et al. 2011. Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS Pathog. 7:e1002418. doi: 10.1371/journal.ppat.1002418.
    • (2011) PLoS Pathog. , vol.7
    • Cai, Q.1
  • 11
    • 79955034796 scopus 로고    scopus 로고
    • Heterochromatin and the DNA damage response: the need to relax
    • Cann KL, Dellaire G. 2011. Heterochromatin and the DNA damage response: the need to relax. Biochem. Cell Biol. 89:45-60.
    • (2011) Biochem. Cell Biol. , vol.89 , pp. 45-60
    • Cann, K.L.1    Dellaire, G.2
  • 12
    • 67651007508 scopus 로고    scopus 로고
    • Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase
    • Chang PC, et al. 2009. Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Res. 69:5681-5689.
    • (2009) Cancer Res. , vol.69 , pp. 5681-5689
    • Chang, P.C.1
  • 13
    • 47749134215 scopus 로고    scopus 로고
    • Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression
    • Chang SS, et al. 2008. Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression. J. Virol. 82:7745-7751.
    • (2008) J. Virol. , vol.82 , pp. 7745-7751
    • Chang, S.S.1
  • 14
    • 0141891251 scopus 로고    scopus 로고
    • Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptormediated ataxia telangiectasia mutated (ATM) kinase activation
    • Chen K, Albano A, Ho A, Keaney JF, Jr. 2003. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptormediated ataxia telangiectasia mutated (ATM) kinase activation. J. Biol. Chem. 278:39527-39533.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39527-39533
    • Chen, K.1    Albano, A.2    Ho, A.3    Keaney Jr., J.F.4
  • 15
    • 0034011617 scopus 로고    scopus 로고
    • A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro
    • Chen MR, Chang SJ, Huang H, Chen JY. 2000. A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro. J. Virol. 74:3093-3104.
    • (2000) J. Virol. , vol.74 , pp. 3093-3104
    • Chen, M.R.1    Chang, S.J.2    Huang, H.3    Chen, J.Y.4
  • 16
    • 0023036072 scopus 로고
    • Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter
    • Chevallier-Greco A, et al. 1986. Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J. 5:3243-3249.
    • (1986) EMBO J. , vol.5 , pp. 3243-3249
    • Chevallier-greco, A.1
  • 17
    • 84862646923 scopus 로고    scopus 로고
    • p53 and Sp1 cooperate to regulate the expression of Epstein-Barr viral Zta protein
    • Chua HH, et al. 2012. p53 and Sp1 cooperate to regulate the expression of Epstein-Barr viral Zta protein. J. Med. Virol. 84:1279-1288.
    • (2012) J. Med. Virol. , vol.84 , pp. 1279-1288
    • Chua, H.H.1
  • 18
    • 0023503201 scopus 로고
    • Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency
    • Countryman J, Jenson H, Seibl R, Wolf H, Miller G. 1987. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J. Virol. 61:3672-3679.
    • (1987) J. Virol. , vol.61 , pp. 3672-3679
    • Countryman, J.1    Jenson, H.2    Seibl, R.3    Wolf, H.4    Miller, G.5
  • 19
    • 1642457437 scopus 로고
    • Activation of expression of latent Epstein- Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA
    • Countryman J, Miller G. 1985. Activation of expression of latent Epstein- Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA. Proc. Natl. Acad. Sci. U. S. A. 82: 4085-4089.
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 4085-4089
    • Countryman, J.1    Miller, G.2
  • 20
    • 0034974152 scopus 로고    scopus 로고
    • Epstein-Barr virus immediateearly protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation
    • Darr CD, Mauser A, Kenney S. 2001. Epstein-Barr virus immediateearly protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation. J. Virol. 75:6135-6142.
    • (2001) J. Virol. , vol.75 , pp. 6135-6142
    • Darr, C.D.1    Mauser, A.2    Kenney, S.3
  • 22
    • 77955847245 scopus 로고    scopus 로고
    • Multiple roles of ATM in monitoring and maintaining DNA integrity
    • Derheimer FA, Kastan MB. 2010. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 584:3675-3681.
    • (2010) FEBS Lett. , vol.584 , pp. 3675-3681
    • Derheimer, F.A.1    Kastan, M.B.2
  • 23
    • 63449134294 scopus 로고    scopus 로고
    • Methylation-dependent binding of the Epstein-Barr virus BZLF1 protein to viral promoters
    • doi:10.1371/journal.ppat.1000356
    • Dickerson SJ, et al. 2009. Methylation-dependent binding of the Epstein-Barr virus BZLF1 protein to viral promoters. PLoS Pathog. 5:e1000356. doi:10.1371/journal.ppat.1000356.
    • (2009) PLoS Pathog. , vol.5
    • Dickerson, S.J.1
  • 24
    • 77952677694 scopus 로고    scopus 로고
    • Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner
    • Ellis AL, Wang Z, Yu X, Mertz JE. 2010. Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner. J. Virol. 84:6139-6152.
    • (2010) J. Virol. , vol.84 , pp. 6139-6152
    • Ellis, A.L.1    Wang, Z.2    Yu, X.3    Mertz, J.E.4
  • 25
    • 0034099654 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway
    • Fahmi H, Cochet C, Hmama Z, Opolon P, Joab I. 2000. Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J. Virol. 74:5810-5818.
    • (2000) J. Virol. , vol.74 , pp. 5810-5818
    • Fahmi, H.1    Cochet, C.2    Hmama, Z.3    Opolon, P.4    Joab, I.5
  • 27
    • 0034660443 scopus 로고    scopus 로고
    • The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators
    • Feederle R, et al. 2000. The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBO J. 19:3080-3089.
    • (2000) EMBO J. , vol.19 , pp. 3080-3089
    • Feederle, R.1
  • 28
    • 0037086080 scopus 로고    scopus 로고
    • Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors
    • Feng WH, Israel B, Raab-Traub N, Busson P, Kenney SC. 2002. Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res. 62:1920-1926.
    • (2002) Cancer Res. , vol.62 , pp. 1920-1926
    • Feng, W.H.1    Israel, B.2    Raab-traub, N.3    Busson, P.4    Kenney, S.C.5
  • 29
    • 33749031579 scopus 로고    scopus 로고
    • Valproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expression
    • Feng WH, Kenney SC. 2006. Valproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expression. Cancer Res. 66:8762-8769.
    • (2006) Cancer Res. , vol.66 , pp. 8762-8769
    • Feng, W.H.1    Kenney, S.C.2
  • 30
    • 62749155744 scopus 로고    scopus 로고
    • MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infectedcell survival
    • Forte E, Luftig MA. 2009. MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infectedcell survival. J. Virol. 83:2491-2499.
    • (2009) J. Virol. , vol.83 , pp. 2491-2499
    • Forte, E.1    Luftig, M.A.2
  • 31
    • 0036143222 scopus 로고    scopus 로고
    • Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBVencoded protein kinase and effects of the L-riboside benzimidazole 1263W94
    • Gershburg E, Pagano JS. 2002. Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBVencoded protein kinase and effects of the L-riboside benzimidazole 1263W94. J. Virol. 76:998-1003.
    • (2002) J. Virol. , vol.76 , pp. 998-1003
    • Gershburg, E.1    Pagano, J.S.2
  • 32
    • 0022353117 scopus 로고
    • Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion
    • Greenspan JS, et al. 1985. Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion. N. Engl. J. Med. 313:1564-1571.
    • (1985) N. Engl. J. Med. , vol.313 , pp. 1564-1571
    • Greenspan, J.S.1
  • 33
    • 0025324027 scopus 로고
    • Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.
    • Gregory CD, Rowe M, Rickinson AB. 1990. Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line. J. Gen. Virol. 71:1481-1495.
    • (1990) J. Gen. Virol. , vol.71 , pp. 1481-1495
    • Gregory, C.D.1    Rowe, M.2    Rickinson, A.B.3
  • 34
    • 0025666546 scopus 로고
    • The enhancer factor R of Epstein-Barr virus (EBV) is a sequence-specific DNA binding protein
    • Gruffat H, Manet E, Rigolet A, Sergeant A. 1990. The enhancer factor R of Epstein-Barr virus (EBV) is a sequence-specific DNA binding protein. Nucleic Acids Res. 18:6835-6843.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 6835-6843
    • Gruffat, H.1    Manet, E.2    Rigolet, A.3    Sergeant, A.4
  • 35
    • 70449633670 scopus 로고    scopus 로고
    • Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints
    • Gruhne B, Sompallae R, Masucci MG. 2009. Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. Oncogene 28:3997-4008.
    • (2009) Oncogene , vol.28 , pp. 3997-4008
    • Gruhne, B.1    Sompallae, R.2    Masucci, M.G.3
  • 36
    • 78650378982 scopus 로고    scopus 로고
    • ATM activation in the presence of oxidative stress
    • Guo Z, Deshpande R, Paull TT. 2010. ATM activation in the presence of oxidative stress. Cell Cycle 9:4805-4811.
    • (2010) Cell Cycle , vol.9 , pp. 4805-4811
    • Guo, Z.1    Deshpande, R.2    Paull, T.T.3
  • 38
    • 79955431211 scopus 로고    scopus 로고
    • The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2-and p53-dependent manner
    • Hagemeier SR, Barlow EA, Kleman AA, Kenney SC. 2011. The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2-and p53-dependent manner. J. Virol. 85:4318-4329.
    • (2011) J. Virol. , vol.85 , pp. 4318-4329
    • Hagemeier, S.R.1    Barlow, E.A.2    Kleman, A.A.3    Kenney, S.C.4
  • 39
    • 0023889721 scopus 로고
    • A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen
    • Hardwick JM, Lieberman PM, Hayward SD. 1988. A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen. J. Virol. 62:2274-2284.
    • (1988) J. Virol. , vol.62 , pp. 2274-2284
    • Hardwick, J.M.1    Lieberman, P.M.2    Hayward, S.D.3
  • 40
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • Hickson I, et al. 2004. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64:9152-9159.
    • (2004) Cancer Res. , vol.64 , pp. 9152-9159
    • Hickson, I.1
  • 41
    • 66149120222 scopus 로고    scopus 로고
    • Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
    • Hoglund A, Nilsson LM, Forshell LP, Maclean KH, Nilsson JA. 2009. Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113:4281-4288.
    • (2009) Blood , vol.113 , pp. 4281-4288
    • Hoglund, A.1    Nilsson, L.M.2    Forshell, L.P.3    Maclean, K.H.4    Nilsson, J.A.5
  • 42
    • 2342520167 scopus 로고    scopus 로고
    • The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1
    • Hong GK, et al. 2004. The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1. J. Virol. 78:4983-4992.
    • (2004) J. Virol. , vol.78 , pp. 4983-4992
    • Hong, G.K.1
  • 43
    • 84862846436 scopus 로고    scopus 로고
    • Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1
    • Hong YS, et al. 2012. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. Int. J. Oncol. 41:76-82.
    • (2012) Int. J. Oncol. , vol.41 , pp. 76-82
    • Hong, Y.S.1
  • 44
    • 83755196626 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway
    • doi:10.1186/1756-0500-4-551
    • Husaini R, Ahmad M, Soo-Beng Khoo A. 2011. Epstein-Barr virus latent membrane protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway. BMC Res. Notes 4:551. doi:10.1186/1756-0500-4-551.
    • (2011) BMC Res. Notes , vol.4 , pp. 551
    • Husaini, R.1    Ahmad, M.2    Khoo, A.S.B.3
  • 45
    • 0038243113 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors activate p21(WAF1) expression via ATM
    • Ju R, Muller MT. 2003. Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. Cancer Res. 63:2891-2897.
    • (2003) Cancer Res. , vol.63 , pp. 2891-2897
    • Ju, R.1    Muller, M.T.2
  • 46
    • 2942654609 scopus 로고    scopus 로고
    • Production of high-titer Epstein-Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system
    • Kanda T, Yajima M, Ahsan N, Tanaka M, Takada K. 2004. Production of high-titer Epstein-Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system. J. Virol. 78:7004-7015.
    • (2004) J. Virol. , vol.78 , pp. 7004-7015
    • Kanda, T.1    Yajima, M.2    Ahsan, N.3    Tanaka, M.4    Takada, K.5
  • 47
    • 0024550905 scopus 로고
    • The Epstein-Barr virus (EBV) BZLF1 immediateearly gene product differentially affects latent versus productive EBV promoters
    • Kenney S, et al. 1989. The Epstein-Barr virus (EBV) BZLF1 immediateearly gene product differentially affects latent versus productive EBV promoters. J. Virol. 63:1729-1736.
    • (1989) J. Virol. , vol.63 , pp. 1729-1736
    • Kenney, S.1
  • 48
    • 34249064632 scopus 로고    scopus 로고
    • Epstein-Barr virus and its replication
    • Knipe DM, et al (ed), 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA
    • Kieff E, Rickinson AB. 2007. Epstein-Barr virus and its replication, p 2603-2654. In Knipe DM, et al (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
    • (2007) Fields virology , pp. 2603-2654
    • Kieff, E.1    Rickinson, A.B.2
  • 49
    • 79956143950 scopus 로고    scopus 로고
    • p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    • Kim T, et al. 2011. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208:875-883.
    • (2011) J. Exp. Med. , vol.208 , pp. 875-883
    • Kim, T.1
  • 50
    • 14844336913 scopus 로고    scopus 로고
    • Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment
    • Kudoh A, et al. 2005. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J. Biol. Chem. 280:8156-8163.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8156-8163
    • Kudoh, A.1
  • 51
    • 11144245265 scopus 로고    scopus 로고
    • Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo
    • Laichalk LL, Thorley-Lawson DA. 2005. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J. Virol. 79:1296-1307.
    • (2005) J. Virol. , vol.79 , pp. 1296-1307
    • Laichalk, L.L.1    Thorley-lawson, D.A.2
  • 52
    • 77955514570 scopus 로고    scopus 로고
    • Transcription of the Epstein-Barr virus lytic cycle activator BZLF-1 during oxidative stress induction
    • Lassoued S, Gargouri B, El Feki Ael F, Attia H, Van Pelt J. 2010. Transcription of the Epstein-Barr virus lytic cycle activator BZLF-1 during oxidative stress induction. Biol. Trace Elem. Res. 137:13-22.
    • (2010) Biol. Trace Elem. Res. , vol.137 , pp. 13-22
    • Lassoued, S.1    Gargouri, B.2    Ael, F.E.F.3    Attia, H.4    Pelt, J.V.5
  • 53
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. 1992. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12:5041-5049.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5041-5049
    • Lees-miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 54
    • 84861302962 scopus 로고    scopus 로고
    • SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function
    • Li R, et al. 2012. SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function. J. Virol. 86:5412-5421.
    • (2012) J. Virol. , vol.86 , pp. 5412-5421
    • Li, R.1
  • 55
    • 80054896036 scopus 로고    scopus 로고
    • Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication
    • Li R, et al. 2011. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe 10:390-400.
    • (2011) Cell Host Microbe , vol.10 , pp. 390-400
    • Li, R.1
  • 56
    • 78650635322 scopus 로고    scopus 로고
    • Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells
    • Li X, Feng J, Sun R. 2011. Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. J. Virol. 85:715-724.
    • (2011) J. Virol. , vol.85 , pp. 715-724
    • Li, X.1    Feng, J.2    Sun, R.3
  • 57
    • 0025255970 scopus 로고
    • The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions
    • Lieberman PM, Hardwick JM, Sample J, Hayward GS, Hayward SD. 1990. The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions. J. Virol. 64:1143-1155.
    • (1990) J. Virol. , vol.64 , pp. 1143-1155
    • Lieberman, P.M.1    Hardwick, J.M.2    Sample, J.3    Hayward, G.S.4    Hayward, S.D.5
  • 58
    • 0018384722 scopus 로고
    • Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate
    • Luka J, Kallin B, Klein G. 1979. Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate. Virology 94:228-231.
    • (1979) Virology , vol.94 , pp. 228-231
    • Luka, J.1    Kallin, B.2    Klein, G.3
  • 59
    • 84864386364 scopus 로고    scopus 로고
    • An Epstein-Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model
    • Ma SD, et al. 2012. An Epstein-Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model. J. Virol. 86:7976-7987.
    • (2012) J. Virol. , vol.86 , pp. 7976-7987
    • Ma, S.D.1
  • 60
    • 0023897222 scopus 로고
    • The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig
    • Maly FE, et al. 1988. The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig. J. Immunol. 140:2334-2339.
    • (1988) J. Immunol. , vol.140 , pp. 2334-2339
    • Maly, F.E.1
  • 61
    • 0024545871 scopus 로고
    • Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines
    • Maly FE, et al. 1989. Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines. J. Immunol. 142:1260-1267.
    • (1989) J. Immunol. , vol.142 , pp. 1260-1267
    • Maly, F.E.1
  • 62
    • 0024381772 scopus 로고
    • 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line Rael
    • Masucci MG, et al. 1989. 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line Rael. J. Virol. 63:3135-3141.
    • (1989) J. Virol. , vol.63 , pp. 3135-3141
    • Masucci, M.G.1
  • 63
    • 0026601829 scopus 로고
    • Missense mutations and a deletion of the p53 gene in human gastric cancer
    • Matozaki T, et al. 1992. Missense mutations and a deletion of the p53 gene in human gastric cancer. Biochem. Biophys. Res. Commun. 182: 215-223.
    • (1992) Biochem. Biophys. Res. Commun. , vol.182 , pp. 215-223
    • Matozaki, T.1
  • 64
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, et al. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1
  • 65
    • 0026335966 scopus 로고
    • Early events in Epstein-Barr virus genome expression after activation: regulation by second messengers of B cell activation
    • Mellinghoff I, et al. 1991. Early events in Epstein-Barr virus genome expression after activation: regulation by second messengers of B cell activation. Virology 185:922-928.
    • (1991) Virology , vol.185 , pp. 922-928
    • Mellinghoff, I.1
  • 66
    • 77950805340 scopus 로고    scopus 로고
    • Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant
    • Meng Q, Hagemeier SR, Kuny CV, Kalejta RF, Kenney SC. 2010. Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant. J. Virol. 84:4524-4533.
    • (2010) J. Virol. , vol.84 , pp. 4524-4533
    • Meng, Q.1    Hagemeier, S.R.2    Kuny, C.V.3    Kalejta, R.F.4    Kenney, S.C.5
  • 67
    • 0028088994 scopus 로고
    • An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
    • Miller CL, Lee JH, Kieff E, Longnecker R. 1994. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc. Natl. Acad. Sci. U. S. A. 91:772-776.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 772-776
    • Miller, C.L.1    Lee, J.H.2    Kieff, E.3    Longnecker, R.4
  • 68
    • 0027211796 scopus 로고
    • Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes
    • Miller CL, Longnecker R, Kieff E. 1993. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes. J. Virol. 67:3087-3094.
    • (1993) J. Virol. , vol.67 , pp. 3087-3094
    • Miller, C.L.1    Longnecker, R.2    Kieff, E.3
  • 69
    • 65549158745 scopus 로고    scopus 로고
    • TORC2, a coactivator of cAMP-response elementbinding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein
    • Murata T, et al. 2009. TORC2, a coactivator of cAMP-response elementbinding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. J. Biol. Chem. 284:8033-8041.
    • (2009) J. Biol. Chem. , vol.284 , pp. 8033-8041
    • Murata, T.1
  • 70
    • 0036500131 scopus 로고    scopus 로고
    • Epstein-Barr virus RNA confers resistance to interferon-alpha-induced apoptosis in Burkitt's lymphoma
    • Nanbo A, Inoue K, Adachi-Takasawa K, Takada K. 2002. Epstein-Barr virus RNA confers resistance to interferon-alpha-induced apoptosis in Burkitt's lymphoma. EMBO J. 21:954-965.
    • (2002) EMBO J. , vol.21 , pp. 954-965
    • Nanbo, A.1    Inoue, K.2    Adachi-takasawa, K.3    Takada, K.4
  • 72
    • 78650217703 scopus 로고    scopus 로고
    • An ATM/Chk2-mediated DNA damageresponsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells
    • Nikitin PA, et al. 2010. An ATM/Chk2-mediated DNA damageresponsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell Host Microbe 8:510-522.
    • (2010) Cell Host Microbe , vol.8 , pp. 510-522
    • Nikitin, P.A.1
  • 73
    • 0029656132 scopus 로고    scopus 로고
    • Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein
    • Nonkwelo C, Skinner J, Bell A, Rickinson A, Sample J. 1996. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J. Virol. 70:623-627.
    • (1996) J. Virol. , vol.70 , pp. 623-627
    • Nonkwelo, C.1    Skinner, J.2    Bell, A.3    Rickinson, A.4    Sample, J.5
  • 74
    • 0037385685 scopus 로고    scopus 로고
    • Latent membrane protein 1 inhibits Epstein-Barr virus lytic cycle induction and progress via different mechanisms
    • Prince S, et al. 2003. Latent membrane protein 1 inhibits Epstein-Barr virus lytic cycle induction and progress via different mechanisms. J. Virol. 77:5000-5007.
    • (2003) J. Virol. , vol.77 , pp. 5000-5007
    • Prince, S.1
  • 75
    • 80051527422 scopus 로고    scopus 로고
    • Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis
    • doi:10.1038/cddis.2011.67
    • Pujals A, et al. 2011. Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis. Cell Death Dis. 2:e184. doi:10.1038/cddis.2011.67.
    • (2011) Cell Death Dis. , vol.2
    • Pujals, A.1
  • 76
    • 0031694397 scopus 로고    scopus 로고
    • The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes
    • Ragoczy T, Heston L, Miller G. 1998. The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes. J. Virol. 72:7978-7984.
    • (1998) J. Virol. , vol.72 , pp. 7978-7984
    • Ragoczy, T.1    Heston, L.2    Miller, G.3
  • 77
    • 34249064632 scopus 로고    scopus 로고
    • Epstein-Barr virus
    • Knipe DM, et al (ed), 5th ed. Lippincott Williams & Williams, Philadelphia, PA
    • Rickenson AB, Kieff E. 2007. Epstein-Barr virus, p 2655-2700. In Knipe DM, et al (ed), Fields virology, 5th ed. Lippincott Williams & Williams, Philadelphia, PA.
    • (2007) Fields virology , pp. 2655-2700
    • Rickenson, A.B.1    Kieff, E.2
  • 78
    • 80052286938 scopus 로고    scopus 로고
    • Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency
    • Robinson AR, Kwek SS, Hagemeier SR, Wille CK, Kenney SC. 2011. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. J. Virol. 85:8940-8953.
    • (2011) J. Virol. , vol.85 , pp. 8940-8953
    • Robinson, A.R.1    Kwek, S.S.2    Hagemeier, S.R.3    Wille, C.K.4    Kenney, S.C.5
  • 79
    • 84860904972 scopus 로고    scopus 로고
    • The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1
    • doi: 10.1371/journal.ppat.1002516
    • Robinson AR, Kwek SS, Kenney SC. 2012. The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1. PLoS Pathog. 8:e1002516. doi: 10.1371/journal.ppat.1002516.
    • (2012) PLoS Pathog. , vol.8
    • Robinson, A.R.1    Kwek, S.S.2    Kenney, S.C.3
  • 80
    • 0024379416 scopus 로고
    • The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle
    • Rooney CM, Rowe DT, Ragot T, Farrell PJ. 1989. The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle. J. Virol. 63:3109-3116.
    • (1989) J. Virol. , vol.63 , pp. 3109-3116
    • Rooney, C.M.1    Rowe, D.T.2    Ragot, T.3    Farrell, P.J.4
  • 81
    • 0029053611 scopus 로고
    • Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein- 1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression
    • Rowe M, et al. 1995. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein- 1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression. Eur. J. Immunol. 25:1374-1384.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1374-1384
    • Rowe, M.1
  • 82
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 83
    • 0035118229 scopus 로고    scopus 로고
    • Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD
    • III
    • Schultz DC, Friedman JR, Rauscher FJ III. 2001. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev. 15:428-443.
    • (2001) Genes Dev. , vol.15 , pp. 428-443
    • Schultz, D.C.1    Friedman, J.R.2    Rauscher, F.J.3
  • 84
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y, Prives C. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 85
    • 79959405603 scopus 로고    scopus 로고
    • Bortezomib induction of C/EBPbeta mediates Epstein-Barr virus lytic activation in Burkitt lymphoma
    • Shirley CM, et al. 2011. Bortezomib induction of C/EBPbeta mediates Epstein-Barr virus lytic activation in Burkitt lymphoma. Blood 117: 6297-6303.
    • (2011) Blood , vol.117 , pp. 6297-6303
    • Shirley, C.M.1
  • 86
    • 0031435944 scopus 로고    scopus 로고
    • DNA damage induces phosphorylation of the amino terminus of p53
    • Siliciano JD, et al. 1997. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11:3471-3481.
    • (1997) Genes Dev. , vol.11 , pp. 3471-3481
    • Siliciano, J.D.1
  • 87
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Smith J, Tho LM, Xu N, Gillespie DA. 2010. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res. 108:73-112.
    • (2010) Adv. Cancer Res. , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 88
    • 0024590981 scopus 로고
    • Synchronous and sequential activation of latently infected Epstein-Barr virus genomes
    • Takada K, Ono Y. 1989. Synchronous and sequential activation of latently infected Epstein-Barr virus genomes. J. Virol. 63:445-449.
    • (1989) J. Virol. , vol.63 , pp. 445-449
    • Takada, K.1    Ono, Y.2
  • 89
    • 0022646563 scopus 로고
    • trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment
    • Takada K, Shimizu N, Sakuma S, Ono Y. 1986. trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment. J. Virol. 57:1016-1022.
    • (1986) J. Virol. , vol.57 , pp. 1016-1022
    • Takada, K.1    Shimizu, N.2    Sakuma, S.3    Ono, Y.4
  • 90
    • 34249910944 scopus 로고    scopus 로고
    • Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication
    • Tarakanova VL, et al. 2007. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe 1:275-286.
    • (2007) Cell Host Microbe , vol.1 , pp. 275-286
    • Tarakanova, V.L.1
  • 91
    • 0033555260 scopus 로고    scopus 로고
    • A role for ATR in the DNA damage-induced phosphorylation of p53
    • Tibbetts RS, et al. 1999. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:152-157.
    • (1999) Genes Dev. , vol.13 , pp. 152-157
    • Tibbetts, R.S.1
  • 92
    • 10744221485 scopus 로고    scopus 로고
    • vivo activation of the p53 pathway by smallmolecule antagonists of MDM2
    • Vassilev LT, et al. 2004. In vivo activation of the p53 pathway by smallmolecule antagonists of MDM2. Science 303:844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1
  • 94
    • 0033865629 scopus 로고    scopus 로고
    • Hairy leukoplakia: an unusual combination of transforming and permissive Epstein- Barr virus infections
    • Webster-Cyriaque J, Middeldorp J, Raab-Traub N. 2000. Hairy leukoplakia: an unusual combination of transforming and permissive Epstein- Barr virus infections. J. Virol. 74:7610-7618.
    • (2000) J. Virol. , vol.74 , pp. 7610-7618
    • Webster-cyriaque, J.1    Middeldorp, J.2    Raab-traub, N.3
  • 95
    • 0034667460 scopus 로고    scopus 로고
    • Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies
    • Westphal EM, Blackstock W, Feng W, Israel B, Kenney SC. 2000. Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies. Cancer Res. 60:5781-5788.
    • (2000) Cancer Res. , vol.60 , pp. 5781-5788
    • Westphal, E.M.1    Blackstock, W.2    Feng, W.3    Israel, B.4    Kenney, S.C.5
  • 96
    • 0025818270 scopus 로고
    • Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240
    • Wiman KG, Magnusson KP, Ramqvist T, Klein G. 1991. Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240. Oncogene 6:1633-1639.
    • (1991) Oncogene , vol.6 , pp. 1633-1639
    • Wiman, K.G.1    Magnusson, K.P.2    Ramqvist, T.3    Klein, G.4
  • 97
    • 84860341318 scopus 로고    scopus 로고
    • Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin- 2 in Kaposi sarcoma tumor cells
    • Ye F, Lattif AA, Xie J, Weinberg A, Gao S. 2012. Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin- 2 in Kaposi sarcoma tumor cells. Cell Cycle 11:1393-1399.
    • (2012) Cell Cycle , vol.11 , pp. 1393-1399
    • Ye, F.1    Lattif, A.A.2    Xie, J.3    Weinberg, A.4    Gao, S.5
  • 98
    • 79958065575 scopus 로고    scopus 로고
    • Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency
    • doi:10.1371/journal.ppat.1002054
    • Ye F, et al. 2011. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 7:e1002054. doi:10.1371/journal.ppat.1002054.
    • (2011) PLoS Pathog. , vol.7
    • Ye, F.1
  • 99
    • 0029830047 scopus 로고    scopus 로고
    • Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cellspecific mechanism
    • Zalani S, Holley-Guthrie E, Kenney S. 1996. Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cellspecific mechanism. Proc. Natl. Acad. Sci. U. S. A. 93:9194-9199.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 9194-9199
    • Zalani, S.1    Holley-guthrie, E.2    Kenney, S.3
  • 100
    • 33845388985 scopus 로고    scopus 로고
    • TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner
    • Zhang S, et al. 2006. TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner. Cell Cycle 5:2787-2795.
    • (2006) Cell Cycle , vol.5 , pp. 2787-2795
    • Zhang, S.1
  • 101
    • 79959343390 scopus 로고    scopus 로고
    • Two-phase dynamics of p53 in the DNA damage response
    • Zhang XP, Liu F, Wang W. 2011. Two-phase dynamics of p53 in the DNA damage response. Proc. Natl. Acad. Sci. U. S. A. 108:8990-8995.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 8990-8995
    • Zhang, X.P.1    Liu, F.2    Wang, W.3
  • 102
    • 0014943020 scopus 로고
    • EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx
    • zur Hausen H, et al. 1970. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056-1058.
    • (1970) Nature , vol.228 , pp. 1056-1058
    • Hausen, H.Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.