Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94

Journal of Virology

Volumn 76, Issue 3, 2002, Pages 998-1003

  Gershburg, Edward ^a   Pagano, Joseph S ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; BENZIMIDAVIR; BENZIMIDAZOLE DERIVATIVE; DNA POLYMERASE; EPSTEIN BARR VIRUS DNA POLYMERASE PROCESSIVITY FACTOR; PROTEIN KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL LINE; CYTOLYSIS; DRUG EFFECT; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS; VIRUS REACTIVATION; VIRUS REPLICATION;

EID: 0036143222     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.3.998-1003.2002     Document Type: Article

References (43)

1. Identification of a DNA-binding protein of human herpesvirus 6, a putative DNA polymerase stimulatory factor
2. Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma
3. Cellular transcription factors recruit viral replication proteins to activate the Epstein-Barr virus origin of lyric DNA replication, oriLyt
4. Establishment in continuous culture of a new type of lymphocyte from a 'Burkitt like' malignant lymphoma (line DG-75)
5. Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: Evidence for specificity of interaction
6. A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and is recruited to the nucleus after infection
7. A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro
8. Development of novel benzimidazole riboside compounds for treatment of cytomegalovirus disease
9. Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus
10. Benzimidazole ribonucleosides: A new class of antivirals with potent and selective activity against human cytomegalovirus
11. High Epstein-Barr virus serum load and elevated titers of anti-ZEBRA antibodies in patients with EBV-harboring tumor cells of Hodgkin's disease
12. Immunobiochemical characterization with monoclonal antibodies of Epstein-Barr virus-associated early antigens in chemically induced cells
13. trans-acting requirements for replication of Epstein-Barr virus ori-Lyt
14. The Epstein-Barr virus pol catalytic subunit physically interacts with the BBLF4-BSLF1-BBLF2/3 complex
15. The herpes simplex virus type 1 UL42 gene product: A subunit of DNA polymerase that functions to increase processivity
16. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines
17. The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22
18. Epstein-Barr virus-encoded protein kinase BGLF4 mediates hyperphosphorylation of cellular elongation factor 1delta (EF-1delta): EF-1delta is universally modified by conserved protein kinases of herpesviruses in mammalian cells
19. Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative diseases
20. L13 gene of herpes simplex virus 1
21. Benzimidazoles for the treatment of human cytomegalovirus infections
22. Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56
23. Viral protein kinases and protein phosphatases
24. Epstein-Barr virus and human T-cell lymphomas
25. Serine protein kinase associated with varicellazoster virus ORF 47
26. UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: Glycoproteins E and I
27. The UL13 protein kinase and the infected cell type are determinants of posttranslational modification of ICP0
28. Epstein-Barr virus: Therapy of active and latent infection
29. Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells
30. The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22
31. Epstein-Barr virus infection in nasopharyngeal carcinoma
32. Antiviral therapy: Current options and challenges
33. Biochemical characterization of two Epstein-Barr virus early antigen-associated phosphopolypeptides
34. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
35. Cross-linking of cell surface immunoglobulins induces Epstein-Barr virus in Burkitt's lymphoma lines
36. Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein
37. Purification and characterization of the DNA-binding activity of the Epstein-Barr virus DNA polymerase accessory protein BMRF1 gene products, as expressed in insect cells by using the baculovirus system
38. Functional interaction between Epstein-Barr virus DNA polymerase catalytic subunit and its accessory subunit in vitro
39. Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product
40. Functional analysis of human cytomegalovirus polymerase accessory protein
41. Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation
42. Inhibition of Epstein-Barr virus replication by a benzimidazole L-riboside: Novel antiviral mechanism of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
43. Functional and physical interaction between the Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1: Effects on EBV transcription and lyric replication