Role of quercetin in vascular physiology

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 12, 2012, Pages 1652-1657

  Chirumbolo, Salvatore ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Anti atherogenic compounds; Endothelium; Enos; Flavonoids; Quercetin; Vascular physiology

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; QUERCETIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIOVASCULAR RISK; CONCENTRATION (PARAMETERS); ENDOTHELIAL DYSFUNCTION; GLUCURONIDATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; GLUTATHIONE; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUERCETIN; UP-REGULATION;

EID: 84870700764     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/y2012-137     Document Type: Article

References (51)

1. Abdalla, S., Zarga, M.A., Afifi, F., Al-Khalil, S., Mahasneh, A., and Sabri, S. 1989. Effects of 3,3'-di-O-methylquercetin on guinea-pig isolated smooth muscle. J. Pharm. Pharmacol. 41(2): 138-141.doi:10.1111/j.2042-7158.1989.tb06413.x. PMID:2568427.
2. Atalik, K.E., Keleş, B., Uyar, Y., Dündar, M.A., Oz, M., and Esen, H.H. 2010. Vasoprotection by melatonin and quercetin in rats treated with cisplatin. Indian J. Exp. Biol. 48(12): 1188-1193.PMID:21250600.
3. Ballard-Croft, C., Locklar, A.C., Keith, B.J., Mentzer, R.M., Jr, and Lasley, R.D. 2008. Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs. Am. J. Physiol. Heart Circ. Physiol. 294(1): H263-H271.doi:10.1152/ajpheart.01067.2007. PMID:17965278.
4. Bhaskar, S., Shalini, V., and Helen, A. 2011. Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway. Immunobiology, 216(3): 367-373. doi:10.1016/j.imbio.2010.07.011.PMID:20828867.
5. Boly, R., Gras, T., Lamkami, T., Guissou, P., Serteyn, D., Kiss, R., and Dubois, J. 2011. Quercetin inhibits a large panel of kinases implicated in cancer cell biology. Int. J. Oncol. 38(3): 833-842.PMID:21206969.
6. Chen, J.X., and Meyrick, B. 2004. Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium. Lab. Invest. 84(2): 182-190. doi:10.1038/labinvest.3700027. PMID:14661033.
7. Chen, C.K., and Pace-Asciak, C.R. 1996. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmacol. 27(2): 363-366. doi:10.1016/0306-3623(95)02001-2. PMID:8919657.
8. Chirumbolo, S. 2010. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm. Allergy Drug Targets, 9(4): 263-285. doi:10.2174/187152810793358741. PMID:20887269.
9. Chirumbolo, S., Marzotto, M., Conforti, A., Vella, A., Ortolani, R., and Bellavite, P. 2010. Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets. Clin. Mol. Allergy, 8(1): 13-24. doi:10.1186/1476-7961-8-13. PMID:20849592.
10. Chiwororo, W.D., and Ojewole, J.A. 2010. Dual effect of quercetin on rat isolated portal vein smooth muscle contractility. Cardiovasc. J. Afr. 21(3): 132-136.PMID:20532450.
11. Dasari, A., Bartholomew, J.N., Volonte, D., and Galbiati, F. 2006. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res. 66(22): 10805-10814. doi:10.1158/0008-5472.CAN-06-1236. PMID:17108117.
12. Dou, D., Guo, Y., Ying, L., Liu, J., Xu, X., Yu, X., and Gao, Y. 2012. Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity. Circ. J. 76(1): 230-237. doi:10.1253/circj.CJ-11-0802. PMID:22122966.
13. Duarte, J., Pérez-Vizcaíno, F., Zarzuelo, A., Jiménez, J., Tamargo, J. 1993. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur. J. Pharmacol. 239(1-3): 1-7. doi:10.1016/0014-2999(93)90968-N. PMID:8223884.
14. Duarte, J., Pérez-Palencia, R., Vargas, F., Ocete, M.A., Pérez- Vizcaino, F., Zarzuelo, A., and Tamargo, J. 2001. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br. J. Pharmacol. 133(1): 117-124. doi:10.1038/sj.bjp.0704064. PMID:11325801.
15. Galindo, P., González-Manzano, S., Zarzuelo, M.J., Gómez-Guzmán, M., Quintela, A.M., González-Paramás, A., et al. 2012. Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats. Food Funct. 3(6): 643-650. doi:10.1039/c2fo10268d. PMID:22441211.
16. Gryglewski, R.J., Korbut, R., Robak, J., and Świ's, J. 1987. On the mechanism of antithrombotic action of flavonoids. Biochem. Pharmacol. 36(3): 317-322. doi:10.1016/0006-2952(87)90288-7.PMID:3101704.
17. Han, J.J., Hao, J., Kim, C.-H., Hong, J.-S., Ahn, H.-Y., and Lee, Y.-S. 2009. Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. J. Vet. Med. Sci. 71(6): 737-743. doi:10.1292/jvms.71.737. PMID:19578281.
18. Huk, I., Rovkovych, V., Nanobash Vili, J., Weigel, G., Neumayer, C., Partyka, L., et al. 1998. Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemiareperfusion injury: an experimental study. Br. J. Surg. 85(8): 1080-1085. doi:10.1046/j.1365-2168.1998.00787.x. PMID:9718001.
19. Ishizawa, K., Yoshizumi, M., Kawai, Y., Terao, J., Kihira, Y., Ikeda, Y., et al. 2011. Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J. Pharmacol. Sci. 115(4): 466-470. doi:10.1254/jphs.10R38FM. PMID:21436601.
20. Kamoun, W.S., Karaa, A., Kresge, N., Merkel, S.M., Korneszczuk, K., and Clemens, M.G. 2006. LPS inhibits endothelin-1-induced endothelial NOS activation in hepatic sinusoidal cells through a negative feedback involving caveolin-1. Hepatology, 43(1): 182-190. doi:10.1002/hep.20940. PMID:16374854.
21. Kelly, G.S. 2011. Quercetin. Monograph. Altern. Med. Rev. 16(2): 172-194.PMID:21649459.
22. Khandelwal, A.R., Hebert, V.Y., Kleinedler, J.J., Rogers, L.K., Ullevig, S.L., Asmis, R., et al. 2012. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J. Nutr. 142(8): 1487-1494. doi:10.3945/jn.112.162628. PMID:22718033.
23. Khoo, N.K., White, C.R., Pozzo-Miller, L., Zhou, F., Constance, C., Inoue, T., et al. 2010. Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Free Radic. Biol. Med. 49(3): 339-347. doi:10.1016/j.freeradbiomed.2010.04.022. PMID:20423726.
24. Kolchin, IuN., Popovich, L.F., Grabovskiǐ, L.A., Luǐk, A.I., and Moǐbenko, A.A. 1990. The effect of the 5-lipoxygenase inhibitor quercetin on the functional and morphologic manifestations of myocardial lesions in ischemia and reperfusion of the heart. Kardiologiia, 30(3): 72-75.PMID:2381127.
25. Kukongviriyapan, U., Sompamit, K., Pannangpetch, P., Kukongviriyapan, V., and Donpunha, W. 2012. Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice. Can. J. Physiol. Pharmacol., 90(10): 1345-1353. doi:10.1139/y2012-101. PMID:22873715.
26. Larson, A.J., Symons, J.D., and Jalili, T. 2012a. Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv. Nutr. 3(1): 39-46.PMID:22332099.
27. Larson, A., Witman, M.A.H., Guo, Y., Ives, S., Richardson, R.S., Bruno, R.S., et al. 2012b. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin- 1: nitric oxide. Nutr. Res. 32(8): 557-564. doi:10.1016/j.nutres.2012.06.018. PMID:22935338.
28. -/-mice. Alcohol. Clin. Exp. Res. 34(9): 1535-1542. doi:10.1111/j.1530-0277.2010.01238.x. PMID:20586760.
29. Li, P.G., Sun, L., Han, X., Ling, S., Gan, W.T., and Xu, J.W. 2012. Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism. Pharmacology, 89(3-4): 220-228. doi:10.1159/000337182. PMID:22488414.
30. Lodi, F., Winterbone, M., Tribolo, S., Needs, P., Hughes, D., and Kroon, P. 2012. Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model. Planta Med. 78(14): 1571-1573. doi:10.1055/s-0032-1315148. PMID:22864987.
31. Loke, W.M., Hodgson, J.M., Proudfoot, J.M., McKinley, A.J., Puddey, I.B., and Croft, K.D. 2008. Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am. J. Clin. Nutr. 88(4): 1018-1025.PMID:18842789.
32. Melzig, M.F. 1996. Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids. Planta Med. 62(1): 20-21. doi:10.1055/s-2006-957788. PMID:8720382.
33. Menendez, C., Jimenez, R., Moreno, L., Galindo, P., Cogolludo, A., Duarte, J., and Perez-Vizcaino, F. 2011. Lack of synergistic interaction between quercetin and catechin in systemic and pulmonary vascular smooth muscle. Br. J. Nutr. 105(9): 1287-1293. doi:10.1017/S0007114510004952. PMID:21144105.
34. Merkel, S.M., Kamoun, W., Karaa, A., Korneszczuk, K., Schrum, L.W., and Clemens, M.G. 2005. LPS inhibits endothelin-1-mediated eNOS translocation to the cell membrane in sinusoidal endothelial cells. Microcirculation, 12(5): 433-442.doi:10.1080/10739680590960377. PMID:16020391.
35. Montenegro, M.F., Neto-Neves, E.M., Dias-Junior, C.A., Ceron, C.S., Castro, M.M., Gomes, V.A., et al. 2010. Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. Naunyn Schmiedebergs Arch. Pharmacol. 382(4): 293-301.doi:10.1007/s00210-010-0546-1. PMID:20694791.
36. Oh, S.J., Kim, O., Lee, J.S., Kim, J.-A., Kim, M.R., Choi, H.S., et al. 2010. Inhibition of angiogenesis by quercetin in tamoxifenresistant breast cancer cells. Food Chem. Toxicol. 48(11): 3227-3234.doi:10.1016/j.fct.2010.08.028. PMID:20804812.
37. Parratt, J.R. 1998. Nitric oxide in sepsis and endotoxaemia. J. Antimicrob. Chemother. 41(Suppl. A): 31-39. doi:10.1093/jac/41.suppl_1.31. PMID:9511084.
38. Pashevin, D.A., Tumanovska, L.V., Dosenko, V.E., Nagibin, V.S., Gurianova, V.L., and Moibenko, A.A. 2011. Antiatherogenic effect of quercetin is mediated by proteasome inhibition in the aorta and circulating leukocytes. Pharmacol. Rep. 63(4): 1009-1018.PMID:22001989.
39. Perez-Vizcaino, F., Duarte, J., Jimenez, R., Santos-Buelga, C., and Osuna, A. 2009. Antihypertensive effects of the flavonoid quercetin. Pharmacol. Rep. 61(1): 67-75.PMID:19307694.
40. Pouysségur, J., Volmat, V., and Lenormand, P. 2002. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem. Pharmacol. 64(5-6): 755-763. doi:10.1016/S0006-2952(02)01135-8. PMID:12213567.
41. Redondo, A., Estrella, N., Lorenzo, A.G., Cruzado, M., and Castro, C. 2012. Quercetin and catechin synergistically inhibit angiotensin II-induced redox-dependent signalling pathways in vascular smooth muscle cells from hypertensive rats. Free Radic. Res. 46(5): 619-627. doi:10.3109/10715762.2012.660527. PMID:22295890.
42. Romero, M., Jiménez, R., Sánchez, M., López-Sepúlveda, R., Zarzuelo, M.J., O'Valle, F., et al. 2009. Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC. Atherosclerosis, 202(1): 58-67. doi:10.1016/j.atherosclerosis.2008.03.007. PMID:18436224.
43. Romero, M., Jiménez, R., Hurtado, B., Moreno, J.M., Rodríguez-Gómez, I., López-Sepúlveda, R., et al. 2010. Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats. Eur. J. Pharmacol. 627(1-3): 242-250. doi:10.1016/j. ejphar.2009.11.006. PMID:19903466.
44. Sánchez, M., Galisteo, M., Vera, R., Villar, I.C., Zarzuelo, A., Tamargo, J., et al. 2006. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J. Hypertens. 24(1): 75-84. doi:10.1097/01.hjh.0000198029.22472.d9. PMID:16331104.
45. Shen, Y., Croft, K.D., Hodgson, J.M., Kyle, R., Lee, I.L., Wang, Y., et al. 2012. Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Biochem. Pharmacol. 84(8): 1036-1044. doi:10.1016/j.bcp.2012.07.016. PMID:22846602.
46. Symeonides, S., and Balk, R.A. 1999. Nitric oxide in the pathogenesis of sepsis. Infect. Dis. Clin. North Am. 13(2): 449-463, x.doi:10.1016/S0891-5520(05)70085-4. PMID:10340177.
47. Vasanthi, H.R., ShriShriMal, N., and Das, D.K. 2012. Phytochemicals from plants to combat cardiovascular disease. Curr. Med. Chem. 19(14): 2242-2251. doi:10.2174/092986712800229078. PMID:22414106.
48. Wang, L., Wang, B., Li, H., Lu, H., Qiu, F., Xiong, L., et al. 2012. Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice. Eur. J. Pharmacol. 690(1-3): 133-141. doi:10.1016/j.ejphar.2012.06.018. PMID:22728078.
49. Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., and Williams, R.L. 2000. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell, 6(4): 909-919. doi:10.1016/S1097-2765(05)00089-4. PMID:11090628.
50. Yi, L., Chen, C.-, Jin, X., Zhang, T., Zhou, Y., Zhang, Q.-, et al. 2012. Differential suppression of intracellular reactive oxygen speciesmediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. Biochimie, 94(9): 2035-2044. doi:10.1016/j.biochi.2012.05.027. PMID:22683914.
51. Zhao, X., Gu, Z., Attele, A.S., and Yuan, C.-S. 1999. Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture. J. Ethnopharmacol. 67(3): 279-285. doi:10.1016/S0378-8741(99)00055-0. PMID:10617062.