메뉴 건너뛰기




Volumn 21, Issue 3, 2010, Pages 132-136

Dual effect of quercetin on rat isolated portal vein smooth muscle contractility

Author keywords

cAMP dependent protein kinases; Dual effects; Endothelium dependent relaxing factor; Prostacyclin; Quercetin; Rat isolated portal vein

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; CYCLIC AMP; ENDOTHELIUM DERIVED RELAXING FACTOR; FLAVONOID; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; PRAZOSIN; QUERCETIN; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE INHIBITOR; VASODILATOR AGENT;

EID: 77953295538     PISSN: 19951892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (32)
  • 1
    • 0036968559 scopus 로고    scopus 로고
    • Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells
    • Saponara S, Sgaragli G., Fusi F. Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br J Pharmacol 2002; 135: 1819-1827.
    • (2002) Br J Pharmacol , vol.135 , pp. 1819-1827
    • Saponara, S.1    Sgaragli, G.2    Fusi, F.3
  • 3
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study
    • Hertog MG., Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993; 342: 1007-1011.
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 4
    • 0028925089 scopus 로고
    • Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study
    • Hertog MG., Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Int Med 1995; 155: 381-386.
    • (1995) Arch Int Med , vol.155 , pp. 381-386
    • Hertog, M.G.1    Kromhout, D.2    Aravanis, C.3    Blackburn, H.4    Buzina, R.5    Fidanza, F.6
  • 5
    • 0345487505 scopus 로고    scopus 로고
    • Alcohol and mortality in middle-aged men from eastern france
    • Renaud SC, Gueguen R, Schenker J, D'Houtaud A. Alcohol and mortality in middle-aged men from eastern France. Epidemiology 1998; 9: 184-188. (Pubitemid 28157617)
    • (1998) Epidemiology , vol.9 , Issue.2 , pp. 184-188
    • Renaud, S.C.1    Gueguen, R.2    Schenker, J.3    D'Houtaud, A.4
  • 6
    • 0345425742 scopus 로고    scopus 로고
    • Wine, beer, and mortality in middle-aged men from eastern France
    • Renaud SC, Gueguen R, Siest G., Salamon R. Wine, beer, and mortality in middle-aged men from eastern France. Arch Int Med 1999; 159: 1865-1870.
    • (1999) Arch Int Med , vol.159 , pp. 1865-1870
    • Renaud, S.C.1    Gueguen, R.2    Siest, G.3    Salamon, R.4
  • 7
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer
    • Middleton E (jun), Kandaswami C, Theoharides CT. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000; 52: 673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, C.T.3
  • 8
    • 0029981730 scopus 로고    scopus 로고
    • Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta
    • Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol, 1996; 27: 363-366.
    • (1996) Gen Pharmacol , vol.27 , pp. 363-366
    • Chen, C.K.1    Pace-Asciak, C.R.2
  • 9
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related bioflavonoids
    • Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 1995; 33: 1061-1080.
    • (1995) Food Chem Toxicol , vol.33 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 12
    • 0018699668 scopus 로고
    • Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices
    • Ferrell JE, Sing PDC, Loew G., King R, Mansour JM, Mansour TE. Structure-activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices. Molec Pharmacol 1979; 16: 556-568. (Pubitemid 10245880)
    • (1979) Molecular Pharmacology , vol.16 , Issue.2 , pp. 556-568
    • Ferrell Jr., J.E.1    Chang Sing, P.D.G.2    Loew, G.3
  • 13
    • 0021259185 scopus 로고
    • Modification of platelet function and arachidonic acid metabolism by bioflavonoids: Structure-activity relations
    • Landolfi R, Mower RL, Steiner M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids: structure-activity relations. Biochem Pharmacol 1984; 33: 1525-1530.
    • (1984) Biochem Pharmacol , vol.33 , pp. 1525-1530
    • Landolfi, R.1    Mower, R.L.2    Steiner, M.3
  • 14
    • 0018645327 scopus 로고
    • Phloretin and related compounds inhibit agonist-stimulated cAMP accumulation in cultured cells of CNS origin
    • Ortmann R, Nutto D, Waldmeyer J. Phloretin and related compounds inhibit agonist-stimulated cAMP accumulation in cultured cells of CNS origin. Biochem Pharmacol 1979; 28: 2357-2361.
    • (1979) Biochem Pharmacol , vol.28 , pp. 2357-2361
    • Ortmann, R.1    Nutto, D.2    Waldmeyer, J.3
  • 15
    • 0019524376 scopus 로고
    • Inhibition of lung cyclic AMP- And cyclic GMP-phosphodiesterase by flavonoids and other chromone-like compounds
    • Ruckstuhl M, Landry Y. Inhibition of lung cyclic AMP- and cyclic GMP-phosphodiesterase by flavonoids and other chromone-like compounds. Biochem Pharmacol 1981; 30: 697-702.
    • (1981) Biochem Pharmacol , vol.30 , pp. 697-702
    • Ruckstuhl, M.1    Landry, Y.2
  • 16
    • 0000565478 scopus 로고
    • Dietary oestrogens: A biologically active background for oestrogen action
    • Hochberg RB, Naftolin F, eds New York: Raven Press
    • Whitten PL, Naftolin F. Dietary oestrogens: a biologically active background for oestrogen action. In: Hochberg RB, Naftolin F, eds. The New Biology of Steroid Hormones. New York: Raven Press, 1991: 155-167.
    • (1991) The New Biology of Steroid Hormones , pp. 155-167
    • Whitten, P.L.1    Naftolin, F.2
  • 18
    • 0023897154 scopus 로고
    • Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine-threonine protein kinases
    • Hagiwara M, Inoue S, Tanaka T, Nunoki K, Ito M, Hidaka H. Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine-threonine protein kinases. Bioch Pharmacol 1988; 37: 2987-2999.
    • (1988) Bioch Pharmacol , vol.37 , pp. 2987-2999
    • Hagiwara, M.1    Inoue, S.2    Tanaka, T.3    Nunoki, K.4    Ito, M.5    Hidaka, H.6
  • 19
    • 0036082198 scopus 로고    scopus 로고
    • Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries
    • Pérez-Vizcaíno F, Ibarra M, Cogolludo AL, Duarte J, Zaragozaírnaéz F, Moreno L, et al. Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Therapeut 2002; 302(1): 66-72.
    • (2002) J Pharmacol Exp Therapeut , vol.302 , Issue.1 , pp. 66-72
    • Pérez-Vizcaíno, F.1    Ibarra, M.2    Cogolludo, A.L.3    Duarte, J.4    Zaragozaírnaéz, F.5    Moreno, L.6
  • 21
    • 0018099484 scopus 로고
    • Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase
    • Beretz A, Anton R, Stoclet J. Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Experientia 1978; 34: 1054-1055. (Pubitemid 8390309)
    • (1978) Experientia , vol.34 , Issue.8 , pp. 1054-1055
    • Beretz, A.1    Anton, R.2    Stoclet, J.C.3
  • 22
    • 0001426293 scopus 로고
    • Inhibition of rat isolated aorta contraction by flavonoids. Possible correlation with cAMP-phosphodiesterase inhibition
    • Beretz A, Stoclet J, Anton R. Inhibition of rat isolated aorta contraction by flavonoids. Possible correlation with cAMP-phosphodiesterase inhibition. Planta Medica 1980; 39: 236.
    • (1980) Planta Medica , vol.39 , pp. 236
    • Beretz, A.1    Stoclet, J.2    Anton, R.3
  • 23
    • 0020630879 scopus 로고
    • Inhibition of rat heart phosphodiesterase by some rotenoids and isoflavonoids
    • Petkov E, Uzunov P, Kostova I, Somleva T, Ognyanov I. Inhibition of rat heart phosphodiesterase by some rotenoids and isoflavonoids. Planta Medica 1983; 47: 237-239. (Pubitemid 13096867)
    • (1983) Planta Medica , vol.47 , Issue.4 , pp. 237-239
    • Petkov, E.1    Uzunov, P.2    Kostova, I.3
  • 24
    • 0027306056 scopus 로고
    • Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships
    • Duarte J, Pérez-Vizcaíno F, Jimenez J, Tamargo J, Zarzuelo A. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. Gen Pharmacol 1993; 24: 857-862.
    • (1993) Gen Pharmacol , vol.24 , pp. 857-862
    • Duarte, J.1    Pérez-Vizcaíno, F.2    Jimenez, J.3    Tamargo, J.4    Zarzuelo, A.5
  • 26
    • 0033969547 scopus 로고    scopus 로고
    • Relaxation of flavones and flavonols in rat isolated thoracic aorta: Mechanism of action and structure-activity relationships
    • Chan ECH, Pannangpetch P, Woodman OL. Relaxation of flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol 2000; 35: 326-333.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 326-333
    • Chan, E.C.H.1    Pannangpetch, P.2    Woodman, O.L.3
  • 27
    • 0011253580 scopus 로고    scopus 로고
    • Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships
    • DOI 10.1016/0306-3623(95)02010-1
    • Herrera MD, Zarcuelo A, Jimdnez J, Marhuenda E, Duarte J. Effects of flavonoids on rat aortic smooth muscle contractility: structure-activity relationships. Gen Pharmacol 1996; 27(2): 273-277. (Pubitemid 26129187)
    • (1996) General Pharmacology , vol.27 , Issue.2 , pp. 273-277
    • Herrera, M.D.1    Zarzuelo, A.2    Jimenez, J.3    Marhuenda, E.4    Duarte, J.5
  • 29
    • 0030699308 scopus 로고    scopus 로고
    • Depolarization-dependent effect of flavonoids in rat uterine smooth muscle contraction elicited by CaCl2
    • DOI 10.1016/S0306-3623(97)00002-5, PII S0306362397000025
    • Revuelta MP, Cantabrana B, Hidalgo A. Depolarization-dependent effect of flavonoids in rat uterine smooth muscle contraction elicited by CaCI2. Gen Pharmacol 1997; 29(5): 847-857. (Pubitemid 27475177)
    • (1997) General Pharmacology , vol.29 , Issue.5 , pp. 847-857
    • Revuelta, M.P.1    Cantabrana, B.2    Hidalgo, A.3
  • 31
    • 33646802988 scopus 로고    scopus 로고
    • Effect of quercetin on altered vascular reactivity in aortae isolated from streptozotocin-induced diabetic rats
    • Ajay M, Achike FI, Mustafa AM, Mustafa MR. Effect of quercetin on altered vascular reactivity in aortae isolated from streptozotocin-induced diabetic rats. Diabetes Res Clin Prac 2006; 73: 1-7.
    • (2006) Diabetes Res Clin Prac , vol.73 , pp. 1-7
    • Ajay, M.1    Achike, F.I.2    Mustafa, A.M.3    Mustafa, M.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.