Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells

Food and Chemical Toxicology

Volumn 48, Issue 11, 2010, Pages 3227-3234

  Oh, Soo Jin ^a   Kim, Ok ^b   Lee, Jong Suk ^c   Kim, Jung Ae ^c   Kim, Mi Ra ^b   Choi, Hong Seok ^b   Shim, Jeong Hyun ^d   Kang, Keon Wook ^b   Kim, Young Chul ^a  

^a Seoul National University   (South Korea)

^b Chosun University   (South Korea)

^c Yeungnam University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

Angiogenesis; Pin1; Quercetin; Tamoxifen resistant breast cancer; VEGF

Indexed keywords

APIGENIN; AURANTIIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MORIN; NARINGENIN; PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C JUN; QUERCETIN; SILIBININ; TAMOXIFEN; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL STRAIN MCF 7; CHICK; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG EFFICACY; EMBRYO; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; REPORTER GENE; TUMOR VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; ANTIOXIDANTS; BLOOD VESSELS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDYLPROLYL ISOMERASE; QUERCETIN; TAMOXIFEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77957331031     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.08.028     Document Type: Article

References (38)

1. Ali S., Coombes R.C. Endocrine-responsive breast cancer and strategies for combating resistance. Nat. Rev. Cancer 2002, 2:101-112.
2. Ansó E., Zuazo A., Irigoyen M., Urdaci M.C., Rouzaut A., Martínez-Irujo J.J. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. Biochem. Pharmacol. 2010, 79:1600-1609.
3. Auerbach R., Kubai L., Knighton D., Folkman J. A simple procedure for the long-term cultivation of chicken embryos. Dev. Biol. 1974, 41:391-394.
4. Bao L., Sauter G., Sowadski J., Lu K.P., Wang D. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am. J. Pathol. 2004, 164:1727-1737.
5. Bayer E., Goettsch S., Mueller J.W., Griewel B., Guiberman E., Mayr L.M., Bayer P. Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding. J. Biol. Chem. 2003, 278:26183-26193.
6. Choi H.K., Yang J.W., Roh S.H., Han C.Y., Kang K.W. Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells. Endocrinol. Relat. Cancer 2007, 14:293-303.
7. Clemons M., Danson S., Howell A. Tamoxifen ('Nolvadex'): a review. Cancer Treat. Rev. 2002, 28:165-180.
8. Deschner E.E., Ruperto J., Wong G., Newmark H.L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 1991, 12:1193-1196.
9. Gulati N., Laudet B., Zohrabian V.M., Murali R., Jhanwar-Uniyal M. The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer. Res. 2006, 26:1177-1181.
10. Hwang M.K., Song N.R., Kang N.J., Lee K.W., Lee H.J. Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin. Int. J. Biochem. Cell Biol. 2009, 41:1592-1600.
11. Jeong H.G., Pokharel Y.R., Lim S.C., Hwang Y.P., Han E.H., Yoon J.H., Ahn S.G., Lee K.Y., Kang K.W. Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis. J. Immunol. 2009, 183:6689-6697.
12. Kerbel R.S. Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000, 21(3):505-515.
13. Kim M.R., Choi H.K., Cho K.B., Kim H.S., Kang K.W. Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells. Cancer Sci. 2009, 100(10):1834-1841.
14. Kim M.R., Choi H.S., Heo T.H., Hwang S.W., Kang K.W. Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells. Biochem. Biophys. Res. Commun. 2008, 369(2):547-553.
15. Kim M.R., Choi H.S., Yang J.W., Park B.C., Kim J.A., Kang K.W. Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression. Mol. Cancer Ther. 2009, 8:2163-2171.
16. Kim S.K., Yang J.W., Kim M.R., Roh S.H., Kim H.G., Lee K.Y., Jeong H.G., Kang K.W. Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Radic. Biol. Med. 2008, 45:537-546.
17. Knowlden J.M., Hutcheson I.R., Jones H.E., Madden T., Gee J.M., Harper M.E., Barrow D., Wakeling A.E., Nicholson R.I. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 2003, 144:1032-1044.
18. Lee D.H., Lee Y.J. Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. J. Cell. Biochem. 2008, 105:546-553.
19. Lu K.P. Pinning down cell signaling, cancer and Alzheimer's disease. Trends. Biochem. Sci. 2004, 29:200-209.
20. Luo H., Jiang B.H., King S.M., Chen Y.C. Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. Nutr. Cancer 2008, 60:800-809.
21. Marson L.P., Kurian K.M., Miller W.R., Dixon J.M. The effect of tamoxifen on breast tumour vascularity. Breast Cancer Res. Treat. 2001, 66:9-15.
22. Monje P., Hernández-Losa J., Lyons R.J., Castellone M.D., Gutkind J.S. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. J. Biol. Chem. 2005, 280(42):35081-35084.
23. Moon Y.J., Wang X., Morris M.E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol. In Vitro 2006, 20:187-210.
24. Mueller S.O., Clark J.A., Myers P.H., Korach K.S. Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology 2002, 143:2357-2365.
25. Petrangeli E., Lubrano C., Ortolani F., Ravenna L., Vacca A., Sciacchitano S., Frati L., Gulino A. Estrogen receptors: new perspectives in breast cancer management. J. Steroid. Biochem. Mol. Biol. 1994, 49:327-331.
26. Presta L.G., Chen H., O'Connor S.J., Chisholm V., Meng Y.G., Krummen L., Winkler M., Ferrara N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997, 57:4593-4599.
27. Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J. Nutr. Biochem. 2007, 18:427-442.
28. Ribatti D., Vacca A. Models for studying angiogenesis in vivo. Int. J. Biol. Markers 1999, 14:207-213.
29. Rose C., Thorpe S.M., Andersen K.W., Pedersen B.V., Mouridsen H.T., Blichert-Toft M., Rasmussen B.B. Beneficial effect of adjuvant tamoxifen therapy in primary breast cancer patients with high oestrogen receptor values. Lancet 1985, 1:16-19.
30. Ryo A., Liou Y.C., Lu K.P., Wulf G. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J. Cell Sci. 2003, 116(Pt 5):773-783.
31. Ryo A., Liou Y.C., Wulf G., Nakamura M., Lee S.W., Lu K.P. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell Biol. 2002, 22(15):5281-5295.
32. Ryo A., Uemura H., Ishiguro H., Saitoh T., Yamaguchi A., Perrem K., Kubota Y., Lu K.P., Aoki I. Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin. Cancer Res. 2005, 15:7523-7531.
33. Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends. Mol. Med. 2002, 8(4 Suppl):S62-S67.
34. Tan W.F., Lin L.P., Li M.H., Zhang Y.X., Tong Y.G., Xiao D., Ding J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur. J. Pharmacol. 2003, 459(2-3):255-262.
35. Wulf G.M., Ryo A., Wulf G.G., Lee S.W., Niu T., Petkova V., Lu K.P. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 2001, 20(13):3459-3472.
36. Xie K., Wei D., Shi Q., Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor, Cytokine. Growth Factor Rev. 2004, 15(5):297-324.
37. You H., Zheng H., Murray S.A., Yu Q., Uchida T., Fan D., Xiao Z.X. IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. J. Cell Biochem. 2002, 84(2):211-216.
38. Yuan Z.P., Chen L.J., Fan L.Y., Tang M.H., Yang G.L., Yang H.S., Du X.B., Wang G.Q., Yao W.X., Zhao Q.M., Ye B., Wang R., Diao P., Zhang W., Wu H.B., Zhao X., Wei Y.Q. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin. Cancer Res. 2006, 12(10):3193-3199.