Quercetin induces rapid eNOS phosphorylation and vasodilation by an akt-independent and PKA-dependent mechanism

Pharmacology

Volumn 89, Issue 3-4, 2012, Pages 220-228

  Li, Peng Gao ^a   Sun, Li ^b   Han, Xin ^b   Ling, Shuang ^b   Gan, Wo Ting ^b   Xu, Jin Wen ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Endothelial cells; eNOS; Phosphorylation; PKA; Quercetin

Indexed keywords

ANGIOTENSIN II; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FORSKOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; PROTEIN KINASE B; QUERCETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; VASCULAR RING; VASODILATATION;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; CATTLE; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 84859405175     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000337182     Document Type: Article

References (27)

1. Hisamoto K, Ohmichi M, Kanda Y, Adachi K, Nishio Y, Hayakawa J, Mabuchi S, Takahashi K, Tasaka K, Miyamoto Y, Taniguchi N, Murata Y: Induction of endothelial nitricoxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells. J Biol Chem 2001; 276: 47642-47649.
2. Mineo C, Yuhanna IS, Quon MJ, Shaul PW: High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. J Biol Chem 2003; 278: 9142-9149. (Pubitemid 36800395)
3. Bernier SG, Haldar S, Michel T: Bradykininregulated interactions of the mitogen-Activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem 2000; 275: 30707-30715.
4. Michell BJ, Chen Zp, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE: Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001; 276: 17625-17628.
5. Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H: Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: Role of protein kinase A. J Biol Chem 2002; 277: 3388-3396. (Pubitemid 34953207)
6. Lorenz M, Wessler S, Follmann E, Michae -lis W, Dusterhoft T, Baumann G, Stangl K, Stangl V: A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH- kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 2004; 279: 6190-6195. (Pubitemid 38220652)
7. Liu D, Homan LL, Dillon JS: Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5 -monophosphate-dependent mechanism. Endocrinology 2004; 145: 5532-5539. (Pubitemid 39564593)
8. Xu JW, Ikeda K, Yamori Y: Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. FEBS Lett 2004; 574: 176-180. (Pubitemid 39200916)
9. Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T, Aromaa A: Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002; 76: 560-568. (Pubitemid 34920833)
10. Geleijnse JM, Launer LJ, Van Der Kuip DA, Hofman A, Witteman JC: Inverse association of tea and flavonoid intakes with incident myocardial infarction: The Rotterdam Study. Am J Clin Nutr 2002; 75: 880-886. (Pubitemid 34441257)
11. Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD: Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 2008; 88: 1018-1025.
12. Benito S, Lopez D, Sáiz MP, Buxaderas S, Sánchez J, Puig-Parellada P, Mitjavila MT: A flavonoid-rich diet increases nitric oxide production in rat aorta. Br J Pharmacol 2002; 135: 910-916. (Pubitemid 34214449)
13. Galisteo M, García-Saura MF, Jiménez R, Villar IC, Wangensteen R, Zarzuelo A, Vargas F, Duarte J: Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil. Planta Med 2004; 70: 334-341. (Pubitemid 38594605)
14. Suri S, Liu XH, Rayment S, Hughes DA, Kroon PA, Needs PW, Taylor MA, Tribolo S, Wilson VG: Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 2010; 159: 566-575.
15. Rendig SV, Symons JD, Longhurst JC, Amsterdam EA: Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries. J Cardiovasc Pharmacol 2001; 38: 219-227. (Pubitemid 32667148)
16. Angelone T, Pasqua T, Di Majo D, Quintieri AM, Filice E, Amodio N, Tota B, Giammanco M, Cerra MC: Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols. Nutr Metab Cardiovasc Dis 2011; 21: 362-371.
17. Khoo NK, White CR, Pozzo-Miller L, Zhou F, Constance C, Inoue T, Patel RP, Parks DA: Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Free Radic Biol Med 2010; 49: 339-347.
18. Xu JW, Ikeda K, Yamori Y: Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Hypertension 2004; 44: 217-222. (Pubitemid 39014241)
19. Kojima H, Hirotani M, Nakatsubo N, Kikuchi K, Urano Y, Higuchi T, Hirata Y, Nagano T: Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore. Anal Chem 2001; 73: 1967-1973. (Pubitemid 32862401)
20. Bae SW, Kim HS, Cha YN, Park YS, Jo SA, Jo I: Rapid increase in endothelial nitric oxide production by bradykinin is mediated by protein kinase A signaling pathway. Biochem Biophys Res Commun 2003; 306: 981-987. (Pubitemid 36776227)
21. Michell BJ, Harris MB, Chen ZP, Ju H, Venema VJ, Blackstone MA, et al: Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem 2002; 277: 42344-42351. (Pubitemid 35257555)
22. Kuppusamy UR, Das NP: Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. Biochem Pharmacol 1992; 44: 1307-1315.
23. Nikaido T, Ohmoto T, Sankawa U, Hamanaka T, Totsuka K: Inhibition of cyclic AMP phosphodiesterase by flavonoids. Planta Med 1982; 46: 162-166. (Pubitemid 13170358)
24. Beretz A, Anton R, Stoclet JC: Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Experientia 1978; 34: 1054-1055. (Pubitemid 8390309)
25. Filippa N, Sable CL, Filloux C, Hemmings B, Van Obberghen E: Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 1999; 19: 4989-5000. (Pubitemid 29289538)
26. Enserink JM, Christensen AE, De Rooij J, van Triest M, Schwede F, Genieser HG, et al: A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 2002; 4: 901-906. (Pubitemid 35331366)
27. Vuchak LA, Tsygankova OM, Prendergast GV, Meinkoth JL: Protein kinase A and BRaf mediate extracellular signal-regulated kinase activation by thyrotropin. Mol Pharmacol 2009; 76: 1123-1129.