Novel quinoline and naphthalene derivatives as potent antimycobacterial agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1854-1867

  Upadhayaya, Ram Shankar ^a   Vandavasi, Jaya Kishore ^a   Kardile, Ramakant A ^a   Lahore, Santosh V ^a   Dixit, Shailesh S ^a   Deokar, Hemantkumar S ^a   Shinde, Popat D ^a   Sarmah, Manash P ^a   Chattopadhyaya, Jyoti ^b  

^a Institute of Molecular Medicine   (India)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anti tuberculosis drugs; ATP synthase; Mefloquine; Naphthalene; Quinoline; TMC207

Indexed keywords

1 (1H 1,2,4 TRIAZOL 3 YLAMINO) 3 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 5 YLAMINO) 3 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY]PROPAN 2 OL; 1 (1H TETRAZOL 5 YLAMINO) 3 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY]PROPAN 2 OL; 1 (2 AMINOETHYLAMINO) 3 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY]PROPAN 2 OL; 1 (4 BENZHYDRYLPIPERAZIN 1 YL) 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 (4 BENZYLPIPERAZIN 1 YL) 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 (6 BROMO 2 METHOXY 3 QUINOLINYL) 4 DIMETHYLAMINO 2 (1 NAPHTHYL) 1 PHENYL 2 BUTANOL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 (1H IMIDAZOL 1 YL)PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 (1H PYRAZOL 1 YL)PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 (2 METHOXYETHYLAMINO)PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 (3METHYL 1H PYRAZOL 1 YL)PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 [(2 HYDROXYETHYL)(METHYL)AMINO]PROPAN 2 OL; 1 [(6 BROMO 2 METHYLQUINOLIN 4 YL)(PYRIDIN 4 YL)METHOXY] 3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 [4 (3 METHOXYPHENYL)PIPERAZIN 1 YL] 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 3 [NAPHTHALEN 1 YL(PHENYL)METHOXY]PROPAN 2 OL; 1 [NAPHTHALEN 1 YL(PHENYL)METHOXY] 3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 [NAPHTHALEN 1 YL(PHENYL)METHOXY] 3 [4 [3 (TRIFLUOROMETHYL)PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; AMINO ACID; ANTIMYCOBACTERIAL AGENT; HYDROXYL GROUP; ISONIAZID; MEFLOQUINE; NAPHTHALENE DERIVATIVE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BINDING SITE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; NAPHTHALENES; QUINOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949488931     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.024     Document Type: Article

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