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Volumn 192, Issue 4, 2012, Pages 1295-1313

Structure-function dissection of the Frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling

Author keywords

[No Author keywords available]

Indexed keywords

DISHEVELLED PROTEIN; FRIZZLED PROTEIN; WNT PROTEIN;

EID: 84870681305     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.112.144592     Document Type: Article
Times cited : (17)

References (74)
  • 1
    • 0002889298 scopus 로고
    • Allelic variation at the Frizzled locus of Drosophila
    • Adler, P. N., J. Charlton, and C. Vinson, 1987. Allelic variation at the Frizzled locus of Drosophila. Dev. Genet. 8: 99-119
    • (1987) Dev. Genet , vol.8 , pp. 99-119
    • Adler, P.N.1    Charlton, J.2    Vinson, C.3
  • 2
    • 0028245770 scopus 로고
    • The coldsensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis
    • Adler, P. N., J. Charlton, K. H. Jones, and J. Liu, 1994. The coldsensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis. Mech. Dev. 46: 101-107
    • (1994) Mech. Dev , vol.46 , pp. 101-107
    • Adler, P.N.1    Charlton, J.2    Jones, K.H.3    Liu, J.4
  • 3
    • 0031457327 scopus 로고    scopus 로고
    • Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    • Adler, P. N., R. E. Krasnow, and J. Liu, 1997. Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels. Curr. Biol. 7: 940-949
    • (1997) Curr. Biol , vol.7 , pp. 940-949
    • Adler, P.N.1    Krasnow, R.E.2    Liu, J.3
  • 4
    • 12344296412 scopus 로고    scopus 로고
    • Mathematical modeling of planar cell polarity to understand domineering non-autonomy
    • Amonlirdviman, K., N.A. Khare, D. R. P. Tree, W.-S. Chen, J.D. Axelrod et al., 2005. Mathematical modeling of planar cell polarity to understand domineering non-autonomy. Science 307: 423-426
    • (2005) Science , vol.307 , pp. 423-426
    • Amonlirdviman, K.1    Khare, N.A.2    Tree, D.R.P.3    Chen, W.-S.4    Axelrod, J.D.5
  • 5
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers, S., and R. T. Moon, 2009. Proximal events in Wnt signal transduction. Nat. Rev. Mol. Cell Biol. 10: 468-477
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 7
    • 0035873390 scopus 로고    scopus 로고
    • Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signalling
    • Axelrod, J. D., 2001. Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signalling. Genes Dev. 15: 1182-1187
    • (2001) Genes Dev , vol.15 , pp. 1182-1187
    • Axelrod, J.D.1
  • 8
    • 0032529161 scopus 로고    scopus 로고
    • Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    • Axelrod, J. D., J. R. Miller, J. M. Shulman, R. T. Moon, and N. Perrimon, 1998. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12: 2610-2622
    • (1998) Genes Dev , vol.12 , pp. 2610-2622
    • Axelrod, J.D.1    Miller, J.R.2    Shulman, J.M.3    Moon, R.T.4    Perrimon, N.5
  • 9
    • 0031770289 scopus 로고    scopus 로고
    • Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family
    • Barnes, M. R., D. M. Duckworth, and L. J. Beeley, 1998. Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family. Trends Pharmacol. Sci. 19: 399-400
    • (1998) Trends Pharmacol. Sci , vol.19 , pp. 399-400
    • Barnes, M.R.1    Duckworth, D.M.2    Beeley, L.J.3
  • 10
    • 34848842750 scopus 로고    scopus 로고
    • The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
    • Bastock, R., and D. Strutt, 2007. The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development 134: 3055-3064
    • (2007) Development , vol.134 , pp. 3055-3064
    • Bastock, R.1    Strutt, D.2
  • 11
    • 0029994517 scopus 로고    scopus 로고
    • A new member of the frizzled family from Drosophila functions as a Wingless receptor
    • Bhanot, P., M. Brink, C. H. Samos, J.-C. Hsieh, Y. Wang et al., 1996. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382: 225-230
    • (1996) Nature , vol.382 , pp. 225-230
    • Bhanot, P.1    Brink, M.2    Samos, C.H.3    Hsieh, J.-C.4    Wang, Y.5
  • 12
    • 0032588683 scopus 로고    scopus 로고
    • Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
    • Bhanot, P., M. Fish, J. A. Jemison, R. Nusse, J. Nathans et al., 1999. Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Development 126: 4175-4186
    • (1999) Development , vol.126 , pp. 4175-4186
    • Bhanot, P.1    Fish, M.2    Jemison, J.A.3    Nusse, R.4    Nathans, J.5
  • 13
    • 0032434512 scopus 로고    scopus 로고
    • Frizzled and frizzled 2 play a partially redundant role in Wingless signaling and have similar requirements to Wingless in neurogenesis
    • Bhat, K. M., 1998. frizzled and frizzled 2 play a partially redundant role in Wingless signaling and have similar requirements to Wingless in neurogenesis. Cell 95: 1027-1036
    • (1998) Cell , vol.95 , pp. 1027-1036
    • Bhat, K.M.1
  • 14
    • 0032504052 scopus 로고    scopus 로고
    • Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    • Boutros, M., N. Paricio, D. I. Strutt, andM. Mlodzik, 1998. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94: 109-118
    • (1998) Cell , vol.94 , pp. 109-118
    • Boutros, M.1    Paricio, N.2    Strutt, D.I.3    Mlodzik, M.4
  • 15
    • 0034625641 scopus 로고    scopus 로고
    • Signaling specificity by frizzled receptors in Drosophila
    • Boutros, M., J. Mihaly, T. Bouwmeester, and M. Mlodzik, 2000. Signaling specificity by frizzled receptors in Drosophila. Science 288: 1825-1828
    • (2000) Science , vol.288 , pp. 1825-1828
    • Boutros, M.1    Mihaly, J.2    Bouwmeester, T.3    Mlodzik, M.4
  • 16
    • 0033398530 scopus 로고    scopus 로고
    • Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
    • Chen, C.-M., and G. Struhl, 1999. Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development 126: 5441-5452
    • (1999) Development , vol.126 , pp. 5441-5452
    • Chen, C.-M.1    Struhl, G.2
  • 17
    • 8644224065 scopus 로고    scopus 로고
    • Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless
    • Chen, C. M., W. Strapps, A. Tomlinson, and G. Struhl, 2004. Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless. Proc. Natl. Acad. Sci. USA 101: 15961-15966
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15961-15966
    • Chen, C.M.1    Strapps, W.2    Tomlinson, A.3    Struhl, G.4
  • 18
    • 44649101853 scopus 로고    scopus 로고
    • Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling
    • Chen, W.-S., D. Antic, M. Matis, C. Y. Logan, M. Povelones et al., 2008. Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling. Cell 133: 1093-1105
    • (2008) Cell , vol.133 , pp. 1093-1105
    • Chen, W.-S.1    Antic, D.2    Matis, M.3    Logan, C.Y.4    Povelones, M.5
  • 19
    • 36448995359 scopus 로고    scopus 로고
    • High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    • Cherezov, V., D. M. Rosenbaum, M. A. Hanson, S. G. Rasmussen, F. S. Thian et al., 2007. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318: 1258-1265
    • (2007) Science , vol.318 , pp. 1258-1265
    • Cherezov, V.1    Rosenbaum, D.M.2    Hanson, M.A.3    Rasmussen, S.G.4    Thian, F.S.5
  • 20
    • 0036230877 scopus 로고    scopus 로고
    • Dwnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis
    • Cohen, E. D., M.-C. Mariol, R. M. H. Wallace, J. Weyers, Y. G. Kamberov et al., 2002. Dwnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev. Cell 2: 437-448
    • (2002) Dev. Cell , vol.2 , pp. 437-448
    • Cohen, E.D.1    Mariol, M.-C.2    Wallace, R.M.H.3    Weyers, J.4    Kamberov, Y.G.5
  • 21
    • 8444223093 scopus 로고    scopus 로고
    • Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
    • Cong, F., L. Schweizer, and H. Varmus, 2004. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131: 5103-5115
    • (2004) Development , vol.131 , pp. 5103-5115
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 22
    • 0035811492 scopus 로고    scopus 로고
    • Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    • Dann, C. E., J. C. Hsieh, A. Rattner, D. Sharma, J. Nathans et al., 2001. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412: 86-90
    • (2001) Nature , vol.412 , pp. 86-90
    • Dann, C.E.1    Hsieh, J.C.2    Rattner, A.3    Sharma, D.4    Nathans, J.5
  • 23
    • 19344363080 scopus 로고    scopus 로고
    • The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    • Djiane, A., S. Yogev, and M. Mlodzik, 2005. The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. Cell 121: 621-631
    • (2005) Cell , vol.121 , pp. 621-631
    • Djiane, A.1    Yogev, S.2    Mlodzik, M.3
  • 24
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families: Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson, R., M. C. Lagerstrom, L. G. Lundin, and H. B. Schioth, 2003. The G-protein-coupled receptors in the human genome form five main families: phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol. 63: 1256-1272
    • (2003) Mol. Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 25
    • 0002908132 scopus 로고    scopus 로고
    • Mutagenesis
    • Ed. 2, edited by D. B. Roberts. Oxford University Press, Oxford
    • Grigliatti, T. A., 1998. Mutagenesis, pp. 55-83 in Drosophila: A Practical Approach, Ed. 2, edited by D. B. Roberts. Oxford University Press, Oxford
    • (1998) Drosophila: A Practical Approach , pp. 55-83
    • Grigliatti, T.A.1
  • 26
    • 0020004250 scopus 로고
    • A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
    • Gubb, D., and A. García-Bellido, 1982. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J. Embryol. Exp. Morphol. 68: 37-57
    • (1982) J. Embryol. Exp. Morphol , vol.68 , pp. 37-57
    • Gubb, D.1    García-Bellido, A.2
  • 27
    • 51249172681 scopus 로고
    • Extra tarsal joints and abnormal cuticular polarities in various mutants of Drosophila melanogaster
    • Held, L. I., C. M. Duarte, and K. Derakhshanian, 1986. Extra tarsal joints and abnormal cuticular polarities in various mutants of Drosophila melanogaster. Roux's Arch. Dev. Biol. 195: 145-157
    • (1986) Roux's Arch. Dev. Biol , vol.195 , pp. 145-157
    • Held, L.I.1    Duarte, C.M.2    Derakhshanian, K.3
  • 28
    • 0032102670 scopus 로고    scopus 로고
    • A role for Xenopus Frizzled 8 in dorsal development
    • Itoh, K., J. Jacob, and S. Y. Sokol, 1998. A role for Xenopus Frizzled 8 in dorsal development. Mech. Dev. 74: 145-157
    • (1998) Mech. Dev , vol.74 , pp. 145-157
    • Itoh, K.1    Jacob, J.2    Sokol, S.Y.3
  • 29
    • 0030050140 scopus 로고    scopus 로고
    • Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster
    • Jones, K. H., J. Liu, and P. N. Adler, 1996. Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster. Genetics 142: 205-215
    • (1996) Genetics , vol.142 , pp. 205-215
    • Jones, K.H.1    Liu, J.2    Adler, P.N.3
  • 30
    • 0032443021 scopus 로고    scopus 로고
    • Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway
    • Kennerdell, J. R., and R.W. Carthew, 1998. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell 95: 1017-1026
    • (1998) Cell , vol.95 , pp. 1017-1026
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 31
    • 0027954477 scopus 로고
    • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal
    • Klingensmith, J., R. Nusse, and N. Perrimon, 1994. The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8: 118-130
    • (1994) Genes Dev , vol.8 , pp. 118-130
    • Klingensmith, J.1    Nusse, R.2    Perrimon, N.3
  • 32
    • 80054685356 scopus 로고    scopus 로고
    • Yellow submarine of the Wnt/Frizzled signaling: Sub-merging from the G protein harbor to the targets
    • Koval, A., V. Purvanov, D. Egger-Adam, and V. L. Katanaev, 2011. Yellow submarine of the Wnt/Frizzled signaling: sub-merging from the G protein harbor to the targets. Biochem. Pharmacol. 82: 1311-1319
    • (2011) Biochem. Pharmacol , vol.82 , pp. 1311-1319
    • Koval, A.1    Purvanov, V.2    Egger-Adam, D.3    Katanaev, V.L.4
  • 33
    • 0029417002 scopus 로고
    • Dishevelled is a component of the frizzled signaling pathway in Drosophila
    • Krasnow, R. E., L. L. Wong, and P. N. Adler, 1995. dishevelled is a component of the frizzled signaling pathway in Drosophila. Development 121: 4095-4102
    • (1995) Development , vol.121 , pp. 4095-4102
    • Krasnow, R.E.1    Wong, L.L.2    Adler, P.N.3
  • 34
    • 0035910270 scopus 로고    scopus 로고
    • Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes
    • Krogh, A., B. Larsson, G. Von Heijne, and E. L. Sonnhammer, 2001. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305: 567-580
    • (2001) J. Mol. Biol , vol.305 , pp. 567-580
    • Krogh, A.1    Larsson, B.2    von Heijne, G.3    Sonnhammer, E.L.4
  • 35
    • 0036333367 scopus 로고    scopus 로고
    • Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen
    • Lawrence, P. A., J. Casal, and G. Struhl, 2002. Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development 129: 2749-2760
    • (2002) Development , vol.129 , pp. 2749-2760
    • Lawrence, P.A.1    Casal, J.2    Struhl, G.3
  • 36
    • 78751559473 scopus 로고    scopus 로고
    • Wnt signalling: The case of the 'missing' Gprotein
    • Malbon, C. C., 2011. Wnt signalling: the case of the 'missing' Gprotein. Biochem. J. 433: e3-e5
    • (2011) Biochem. J , vol.433
    • Malbon, C.C.1
  • 37
    • 28144441697 scopus 로고    scopus 로고
    • Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2
    • Mathew, D., B. Ataman, J. Chen, Y. Zhang, S. Cumberledge et al., 2005. Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310: 1344-1347
    • (2005) Science , vol.310 , pp. 1344-1347
    • Mathew, D.1    Ataman, B.2    Chen, J.3    Zhang, Y.4    Cumberledge, S.5
  • 38
    • 77955058547 scopus 로고    scopus 로고
    • The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development
    • Mosca, T. J., and T. L. Schwarz, 2010. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat. Neurosci. 13: 935-943
    • (2010) Nat. Neurosci , vol.13 , pp. 935-943
    • Mosca, T.J.1    Schwarz, T.L.2
  • 39
    • 0033040240 scopus 로고    scopus 로고
    • Wingless signaling in the Drosophila embryo: Zygotic requirements and the role of the frizzled genes
    • Müller, H., R. Samanta, and E. Wieschaus, 1999. Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes. Development 126: 577-586
    • (1999) Development , vol.126 , pp. 577-586
    • Müller, H.1    Samanta, R.2    Wieschaus, E.3
  • 40
    • 0035026704 scopus 로고    scopus 로고
    • Predicting deleterious amino acid substitutions
    • Ng, P. C., and S. Henikoff, 2001. Predicting deleterious amino acid substitutions. Genome Res. 11: 863-874
    • (2001) Genome Res , vol.11 , pp. 863-874
    • Ng, P.C.1    Henikoff, S.2
  • 41
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • Palczewski, K., T. Kumasaka, T. Hori, C. A. Behnke, H. Motoshima et al., 2000. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289: 739-745
    • (2000) Science , vol.289 , pp. 739-745
    • Palczewski, K.1    Kumasaka, T.2    Hori, T.3    Behnke, C.A.4    Motoshima, H.5
  • 42
    • 0035989413 scopus 로고    scopus 로고
    • A mutational analysis of dishevelled in Drosophila defines novel domains in the Dishevelled protein as well as novel suppressing alleles of axin
    • Penton, A., A. Wodarz, and R. Nusse, 2002. A mutational analysis of dishevelled in Drosophila defines novel domains in the Dishevelled protein as well as novel suppressing alleles of axin. Genetics 161: 747-762
    • (2002) Genetics , vol.161 , pp. 747-762
    • Penton, A.1    Wodarz, A.2    Nusse, R.3
  • 43
    • 27144533268 scopus 로고    scopus 로고
    • The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling
    • Povelones, M., and R. Nusse, 2005. The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling. EMBO J. 24: 3493-3503
    • (2005) EMBO J , vol.24 , pp. 3493-3503
    • Povelones, M.1    Nusse, R.2
  • 44
    • 27144449757 scopus 로고    scopus 로고
    • Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism
    • Povelones, M., R. Howes, M. Fish, and R. Nusse, 2005. Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism. Genetics 171: 1643-1654
    • (2005) Genetics , vol.171 , pp. 1643-1654
    • Povelones, M.1    Howes, R.2    Fish, M.3    Nusse, R.4
  • 45
    • 0242690871 scopus 로고    scopus 로고
    • Dishevelled phosphorylation, subcellular localisation and multimerisation regulate its role in early embryogenesis
    • Rothbächer, U., M. N. Laurent, M. A. Deardorff, P. S. Klein, K. W. Y. Cho et al., 2000. Dishevelled phosphorylation, subcellular localisation and multimerisation regulate its role in early embryogenesis. EMBO J. 19: 1010-1022
    • (2000) EMBO J , vol.19 , pp. 1010-1022
    • Rothbächer, U.1    Laurent, M.N.2    Deardorff, M.A.3    Klein, P.S.4    Cho, K.W.Y.5
  • 46
    • 77954065271 scopus 로고    scopus 로고
    • I-TASSER: A unified platform for automated protein structure and function prediction
    • Roy, A., A. Kucukural, and Y. Zhang, 2010. I-TASSER: a unified platform for automated protein structure and function prediction. Nat. Protoc. 5: 725-738
    • (2010) Nat. Protoc , vol.5 , pp. 725-738
    • Roy, A.1    Kucukural, A.2    Zhang, Y.3
  • 47
    • 0033636247 scopus 로고    scopus 로고
    • Pathway specificity by the bifunctional receptor Frizzled is determined by affinity for Wingless
    • Rulifson, E. J., C.-H. Wu, and R. Nusse, 2000. Pathway specificity by the bifunctional receptor Frizzled is determined by affinity for Wingless. Mol. Cell 6: 117-126
    • (2000) Mol. Cell , vol.6 , pp. 117-126
    • Rulifson, E.J.1    Wu, C.-H.2    Nusse, R.3
  • 48
    • 0029814396 scopus 로고    scopus 로고
    • The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein
    • Sawa, H., L. Lobel, and H. R. Horvitz, 1996. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev. 10: 2189-2197
    • (1996) Genes Dev , vol.10 , pp. 2189-2197
    • Sawa, H.1    Lobel, L.2    Horvitz, H.R.3
  • 49
    • 0035811039 scopus 로고    scopus 로고
    • Asymmetric co-localisation of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarisation
    • Shimada, Y., T. Usui, S. Yanagawa, M. Takeichi, and T. Uemura, 2001. Asymmetric co-localisation of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarisation. Curr. Biol. 11: 859-863
    • (2001) Curr. Biol , vol.11 , pp. 859-863
    • Shimada, Y.1    Usui, T.2    Yanagawa, S.3    Takeichi, M.4    Uemura, T.5
  • 50
    • 0027948042 scopus 로고
    • Components of wingless signalling in Drosophila
    • Siegfried, E., E. L. Wilder, and N. Perrimon, 1994. Components of wingless signalling in Drosophila. Nature 367: 76-80
    • (1994) Nature , vol.367 , pp. 76-80
    • Siegfried, E.1    Wilder, E.L.2    Perrimon, N.3
  • 51
    • 61849116777 scopus 로고    scopus 로고
    • Electrochemical cues regulate assembly of the Frizzled/ Dishevelled complex at the plasma membrane during planar epithelial polarization
    • Simons, M., W. J. Gault, D. Gotthardt, R. Rohatgi, T. J. Klein et al., 2009. Electrochemical cues regulate assembly of the Frizzled/ Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat. Cell Biol. 11: 286-294
    • (2009) Nat. Cell Biol , vol.11 , pp. 286-294
    • Simons, M.1    Gault, W.J.2    Gotthardt, D.3    Rohatgi, R.4    Klein, T.J.5
  • 52
    • 0035210992 scopus 로고    scopus 로고
    • Transducing properties of Drosophila Frizzled proteins
    • Strapps, W. R., and A. Tomlinson, 2001. Transducing properties of Drosophila Frizzled proteins. Development 128: 4829-4835
    • (2001) Development , vol.128 , pp. 4829-4835
    • Strapps, W.R.1    Tomlinson, A.2
  • 53
    • 0035108427 scopus 로고    scopus 로고
    • Asymmetric localisation of Frizzled and the establishment of cell polarity in the Drosophila wing
    • Strutt, D. I., 2001. Asymmetric localisation of Frizzled and the establishment of cell polarity in the Drosophila wing. Mol. Cell 7: 367-375
    • (2001) Mol. Cell , vol.7 , pp. 367-375
    • Strutt, D.I.1
  • 54
    • 33846228033 scopus 로고    scopus 로고
    • Differential activities of the core planar polarity proteins during Drosophila wing patterning
    • Strutt, D., and H. Strutt, 2007. Differential activities of the core planar polarity proteins during Drosophila wing patterning. Dev. Biol. 302: 181-194
    • (2007) Dev. Biol , vol.302 , pp. 181-194
    • Strutt, D.1    Strutt, H.2
  • 55
    • 54149117229 scopus 로고    scopus 로고
    • Differential stability of Flamingo protein complexes underlies the establishment of planar polarity
    • Strutt, H., and D. Strutt, 2008. Differential stability of Flamingo protein complexes underlies the establishment of planar polarity. Curr. Biol. 18: 1555-1564
    • (2008) Curr. Biol , vol.18 , pp. 1555-1564
    • Strutt, H.1    Strutt, D.2
  • 56
    • 33745637502 scopus 로고    scopus 로고
    • Planar polarity is positively regulated by casein kinase Ie in Drosophila
    • Strutt, H., M. A. Price, and D. Strutt, 2006. Planar polarity is positively regulated by casein kinase Ie in Drosophila. Curr. Biol. 16: 1329-1336
    • (2006) Curr. Biol , vol.16 , pp. 1329-1336
    • Strutt, H.1    Price, M.A.2    Strutt, D.3
  • 57
    • 79954520371 scopus 로고    scopus 로고
    • Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    • Strutt, H., S. J. Warrington, and D. Strutt, 2011. Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains. Dev. Cell 20: 511-525
    • (2011) Dev. Cell , vol.20 , pp. 511-525
    • Strutt, H.1    Warrington, S.J.2    Strutt, D.3
  • 58
    • 84859464757 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
    • Tauriello, D. V., I. Jordens, K. Kirchner, J. W. Slootstra, T. Kruitwagen et al., 2012. Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc. Natl. Acad. Sci. USA 109: E812-E820
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109
    • Tauriello, D.V.1    Jordens, I.2    Kirchner, K.3    Slootstra, J.W.4    Kruitwagen, T.5
  • 59
    • 0034665045 scopus 로고    scopus 로고
    • The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in Frizzled receptors mediates Wnt/beta-catenin signalling
    • Umbhauer, M., A. Djiane, C. Goisset, A. Penzo-Mendez, J. F. Riou et al., 2000. The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in Frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J. 19: 4944-4954
    • (2000) EMBO J , vol.19 , pp. 4944-4954
    • Umbhauer, M.1    Djiane, A.2    Goisset, C.3    Penzo-Mendez, A.4    Riou, J.F.5
  • 60
    • 0033520466 scopus 로고    scopus 로고
    • Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    • Usui, T., Y. Shima, Y. Shimada, S. Hirano, R. W. Burgess et al., 1999. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 98: 585-595
    • (1999) Cell , vol.98 , pp. 585-595
    • Usui, T.1    Shima, Y.2    Shimada, Y.3    Hirano, S.4    Burgess, R.W.5
  • 61
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • Van Amerongen, R., and R. Nusse, 2009. Towards an integrated view of Wnt signaling in development. Development 136: 3205-3214
    • (2009) Development , vol.136 , pp. 3205-3214
    • van Amerongen, R.1    Nusse, R.2
  • 62
    • 0023216739 scopus 로고
    • Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila
    • Vinson, C. R., and P. N. Adler, 1987. Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila. Nature 329: 549-551
    • (1987) Nature , vol.329 , pp. 549-551
    • Vinson, C.R.1    Adler, P.N.2
  • 63
    • 27744535862 scopus 로고    scopus 로고
    • The developmental biology of Dishevelled: An enigmatic protein governing cell fate and cell polarity
    • Wallingford, J. B., and R. Habas, 2005. The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132: 4421-4436
    • (2005) Development , vol.132 , pp. 4421-4436
    • Wallingford, J.B.1    Habas, R.2
  • 64
    • 0030068938 scopus 로고    scopus 로고
    • A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled
    • Wang, Y., J. P. Macke, B. S. Abella, K. Andreasson, P. Worley et al., 1996. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J. Biol. Chem. 271: 4468-4476
    • (1996) J. Biol. Chem , vol.271 , pp. 4468-4476
    • Wang, Y.1    Macke, J.P.2    Abella, B.S.3    Andreasson, K.4    Worley, P.5
  • 65
    • 33645096878 scopus 로고    scopus 로고
    • Structure-function analysis of Frizzleds
    • Wang, H. Y., T. Liu, and C. C. Malbon, 2006. Structure-function analysis of Frizzleds. Cell. Signal. 18: 934-941
    • (2006) Cell. Signal , vol.18 , pp. 934-941
    • Wang, H.Y.1    Liu, T.2    Malbon, C.C.3
  • 66
    • 0034727099 scopus 로고    scopus 로고
    • Arrow encodes an LDL-receptor-related protein essential for Wingless signalling
    • Wehrli, M., S. T. Dougan, K. Caldwell, L. O'keefe, S. Schwartz et al., 2000. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407: 527-530
    • (2000) Nature , vol.407 , pp. 527-530
    • Wehrli, M.1    Dougan, S.T.2    Caldwell, K.3    O'Keefe, L.4    Schwartz, S.5
  • 67
    • 0037229938 scopus 로고    scopus 로고
    • Runnin' with the Dvl: Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    • Wharton, K. A. Jr., 2003. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev. Biol. 253: 1-17
    • (2003) Dev. Biol , vol.253 , pp. 1-17
    • Wharton Jr., K.A.1
  • 68
    • 0344413477 scopus 로고    scopus 로고
    • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
    • Wong, H. C., A. Bourdelas, A. Krauss, H. J. Lee, Y. Shao et al., 2003. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 12: 1251-1260
    • (2003) Mol. Cell , vol.12 , pp. 1251-1260
    • Wong, H.C.1    Bourdelas, A.2    Krauss, A.3    Lee, H.J.4    Shao, Y.5
  • 69
    • 0027361185 scopus 로고
    • Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    • Wong, L. L., and P. N. Adler, 1993. Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. J. Cell Biol. 123: 209-221
    • (1993) J. Cell Biol , vol.123 , pp. 209-221
    • Wong, L.L.1    Adler, P.N.2
  • 70
    • 51449094916 scopus 로고    scopus 로고
    • The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signaling
    • Wu, J., and M. Mlodzik, 2008. The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signaling. Dev. Cell 15: 462-469
    • (2008) Dev. Cell , vol.15 , pp. 462-469
    • Wu, J.1    Mlodzik, M.2
  • 71
    • 19344364294 scopus 로고    scopus 로고
    • Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity
    • Wu, J., T. J. Klein, and M. Mlodzik, 2004. Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol. 2: E158
    • (2004) PLoS Biol , vol.2
    • Wu, J.1    Klein, T.J.2    Mlodzik, M.3
  • 72
    • 37549039500 scopus 로고    scopus 로고
    • Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
    • Wu, J., A. Jenny, I. Mirkovic, and M. Mlodzik, 2008. Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech. Dev. 125: 30-42
    • (2008) Mech. Dev , vol.125 , pp. 30-42
    • Wu, J.1    Jenny, A.2    Mirkovic, I.3    Mlodzik, M.4
  • 73
    • 36749061828 scopus 로고    scopus 로고
    • Template-based modeling and free modeling by I-TASSER in CASP7
    • Zhang, Y., 2007. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins 69(Suppl 8): 108-117
    • (2007) Proteins , vol.69 , Issue.SUPPL. 8 , pp. 108-117
    • Zhang, Y.1
  • 74
    • 0029145518 scopus 로고
    • Frizzled regulates mirror-symmetric pattern formation in the Drosophila eye
    • Zheng, L., J. Zhang, and R. W. Carthew, 1995. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121: 3045-3055
    • (1995) Development , vol.121 , pp. 3045-3055
    • Zheng, L.1    Zhang, J.2    Carthew, R.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.