Mathematical modeling of planar cell polarity to understand domineering nonautonomy

Science

Volumn 307, Issue 5708, 2005, Pages 423-426

  Amonlirdviman, Keith ^a   Khare, Narmada A ^b   Tree, David R P ^b   Chen, Wei Shen ^b   Axelrod, Jeffrey D ^b   Tomlin, Claire J ^a  

^a 496 Lomita Mall   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; DIFFUSION; MATHEMATICAL MODELS; PROTEINS;

CELL CLONES; PLANAR CELL POLARITY (PCP); SUBCELLULAR ASYMMETRY;

CELLS;

BIOLOGY;

ALLELE; ARTICLE; CELL POLARITY; DIFFUSION; DROSOPHILA; EPITHELIUM; MATHEMATICAL MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SIMULATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ANIMALS; CELL MEMBRANE; CELL POLARITY; DIFFUSION; DROSOPHILA; DROSOPHILA PROTEINS; FEEDBACK, BIOCHEMICAL; FRIZZLED RECEPTORS; MATHEMATICS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; WING;

EID: 12344296412     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105471     Document Type: Article

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32. This work was supported by the Defense Advanced Research Projects Agency BioInfoMicro (C.J.T.) and BioComp (C.J.T. and J.D.A) Programs, Stanford's Bio-X IIP (J.D.A. and C.J.T.), NIH R01-CM59823 (J.D.A.), a National Defense Science and Engineering Graduate fellowship (K.A.), a Burt and Deedee McMurtry Stanford Graduate Fellowship (KA) and a PHS grant awarded by the National Cancer Institute, DHHS (W.-S.C). We thank H. McAdams for the initial suggestion of the problem and R. Ghosh for contributions to the mathematical model.