메뉴 건너뛰기




Volumn 32, Issue 12, 2012, Pages 2091-2099

Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis

Author keywords

brain ischemia; capillaries; microcirculation; no reflow; reperfusion; thrombolysis

Indexed keywords

FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84870617639     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.139     Document Type: Review
Times cited : (181)

References (96)
  • 2
    • 0042623437 scopus 로고    scopus 로고
    • Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    • Pfefferkorn T, Rosenberg GA. Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 2003; 34: 2025-2030.
    • (2003) Stroke , vol.34 , pp. 2025-2030
    • Pfefferkorn, T.1    Rosenberg, G.A.2
  • 3
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinasemediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinasemediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 2007; 27: 697-709.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 4
    • 84874633647 scopus 로고    scopus 로고
    • The capillary index score: Rethinking the acute ischemic stroke treatment algorithm. Results from theBorgess Medical Center Acute Ischemic Stroke Registry
    • doi:10.1136/neurintsurg-2011-010146 (in press)
    • Al-Ali F, Jefferson A, Barrow T, Cree T, Louis S, Luke K et al. The capillary index score: rethinking the acute ischemic stroke treatment algorithm. Results from theBorgess Medical Center Acute Ischemic Stroke Registry. J Neurointerv Surg; doi:10.1136/neurintsurg-2011-010146 (in press).
    • J Neurointerv Surg
    • Al-Ali, F.1    Jefferson, A.2    Barrow, T.3    Cree, T.4    Louis, S.5    Luke, K.6
  • 5
    • 70349332662 scopus 로고    scopus 로고
    • No-reflow phenomenon in patients with acute myocardial infarction: Its pathophysiology and clinical implications
    • Ito H. No-reflow phenomenon in patients with acute myocardial infarction: its pathophysiology and clinical implications. Acta Med Okayama 2009; 63: 161-168.
    • (2009) Acta Med Okayama , vol.63 , pp. 161-168
    • Ito, H.1
  • 6
    • 77950573904 scopus 로고    scopus 로고
    • Microvascular obstruction: Underlying pathophysiology and clinical diagnosis
    • Bekkers SC, Yazdani SK, Virmani R, Waltenberger J. Microvascular obstruction: underlying pathophysiology and clinical diagnosis. J Am Coll Cardiol 2010; 55: 1649-1660.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1649-1660
    • Bekkers, S.C.1    Yazdani, S.K.2    Virmani, R.3    Waltenberger, J.4
  • 7
    • 0025947863 scopus 로고
    • Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons
    • del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991; 22: 1276-1283.
    • (1991) Stroke , vol.22 , pp. 1276-1283
    • Del Zoppo, G.J.1    Schmid-Schonbein, G.W.2    Mori, E.3    Copeland, B.R.4    Chang, C.M.5
  • 9
    • 0017239838 scopus 로고
    • Microcirculatory obstruction in focal cerebral ischemia: An electron microscopic investigation in monkeys
    • Little JR, Kerr FWL, TM Sundt. Microcirculatory obstruction in focal cerebral ischemia: an electron microscopic investigation in monkeys. Stroke 1976; 7: 25-30.
    • (1976) Stroke , vol.7 , pp. 25-30
    • Little, J.R.1    Fwl, K.2    Sundt, T.M.3
  • 10
    • 0016790028 scopus 로고
    • Microcirculatory obstruction in focal cerebral ischemia Relationship to neuronal alterations
    • Little JR, Kerr FW, Sundt Jr. TM. Microcirculatory obstruction in focal cerebral ischemia. Relationship to neuronal alterations. Mayo Clin Proc 1975; 50: 264-270.
    • (1975) Mayo Clin Proc , vol.50 , pp. 264-270
    • Little, J.R.1    Kerr, F.W.2    Sundt Jr., T.M.3
  • 11
    • 17544389353 scopus 로고    scopus 로고
    • Capillary patency after transient middle cerebral artery occlusion of 2 h duration
    • Li PA, Vogel J, Smith M, He QP, Kuschinsky W, Siesjo BK. Capillary patency after transient middle cerebral artery occlusion of 2 h duration. Neurosci Lett 1998; 253: 191-194.
    • (1998) Neurosci Lett , vol.253 , pp. 191-194
    • Li, P.A.1    Vogel, J.2    Smith, M.3    He, Q.P.4    Kuschinsky, W.5    Siesjo, B.K.6
  • 12
    • 0032585007 scopus 로고    scopus 로고
    • Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction
    • Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W et al. Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res 1998; 804: 36-44.
    • (1998) Brain Res , vol.804 , pp. 36-44
    • Li, P.A.1    Gisselsson, L.2    Keuker, J.3    Vogel, J.4    Smith, M.L.5    Kuschinsky, W.6
  • 13
    • 0030828060 scopus 로고    scopus 로고
    • Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat
    • Tsuchidate R, He QP, Smith ML, Siesjo BK. Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1997; 17: 1066-1073.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1066-1073
    • Tsuchidate, R.1    He, Q.P.2    Smith, M.L.3    Siesjo, B.K.4
  • 15
    • 0028000627 scopus 로고
    • Brain microvessels: Factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat)
    • Garcia JH, Liu KF, Yoshida Y, Chen S, Lian J. Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat). Am J Pathol 1994; 145: 728-740.
    • (1994) Am J Pathol , vol.145 , pp. 728-740
    • Garcia, J.H.1    Liu, K.F.2    Yoshida, Y.3    Chen, S.4    Lian, J.5
  • 16
    • 0043071539 scopus 로고    scopus 로고
    • Cerebral microvessel responses to focal ischemia
    • del Zoppo GJ, Mabuchi T. Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab 2003; 23: 879-894.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 879-894
    • Del Zoppo, G.J.1    Mabuchi, T.2
  • 17
    • 0022653970 scopus 로고
    • Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period
    • Hallenbeck JM, Dutka AJ, Tanishima T, Kochanek PM, Kumaroo KK, Thompson CB et al. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 1986; 17: 246-253.
    • (1986) Stroke , vol.17 , pp. 246-253
    • Hallenbeck, J.M.1    Dutka, A.J.2    Tanishima, T.3    Kochanek, P.M.4    Kumaroo, K.K.5    Thompson, C.B.6
  • 18
    • 33845547792 scopus 로고    scopus 로고
    • Pathophysiology and therapy of experimental stroke
    • Hossmann KA. Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol 2006; 26: 1055-1081.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 1055-1081
    • Hossmann, K.A.1
  • 19
    • 0036789743 scopus 로고    scopus 로고
    • Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion
    • Liu S, Connor J, Peterson S, Shuttleworth CW, Liu KJ. Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J Cereb Blood Flow Metab 2002; 22: 1222-1230.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1222-1230
    • Liu, S.1    Connor, J.2    Peterson, S.3    Shuttleworth, C.W.4    Liu, K.J.5
  • 20
    • 0009879279 scopus 로고    scopus 로고
    • Microcirculatory disturbances in cerebral ischemia
    • Ginsberg MD, Bogousslavsky J (eds) Blackwell Science: Malden, MA
    • Dirnagl U, Lindauer U. Microcirculatory disturbances in cerebral ischemia. In: Ginsberg MD, Bogousslavsky J (eds) Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management vol. 1. Blackwell Science: Malden, MA, 1998, pp 343-357.
    • (1998) Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management , vol.1 , pp. 343-357
    • Dirnagl, U.1    Lindauer, U.2
  • 21
    • 74049107279 scopus 로고    scopus 로고
    • Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: A proof of concept using CT in acute ischemic stroke patients
    • Soares BP, Tong E, Hom J, Cheng SC, Bredno J, Boussel L et al. Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients. Stroke 2010; 41: e34-e40.
    • (2010) Stroke , vol.41
    • Soares, B.P.1    Tong, E.2    Hom, J.3    Cheng, S.C.4    Bredno, J.5    Boussel, L.6
  • 22
    • 68749100880 scopus 로고    scopus 로고
    • Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)
    • De Silva DA, Fink JN, Christensen S, Ebinger M, Bladin C, Levi CR et al. Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET). Stroke 2009; 40: 2872-2874.
    • (2009) Stroke , vol.40 , pp. 2872-2874
    • De Silva, D.A.1    Fink, J.N.2    Christensen, S.3    Ebinger, M.4    Bladin, C.5    Levi, C.R.6
  • 24
    • 0015345963 scopus 로고
    • Impaired microvascular filling after focal cerebral ischemia in the monkey
    • Crowell RM, Olsson Y. Impaired microvascular filling after focal cerebral ischemia in the monkey. Modification by treatment. Neurology 1972; 22: 500-504.
    • (1972) Modification by Treatment. Neurology , vol.22 , pp. 500-504
    • Crowell, R.M.1    Olsson, Y.2
  • 25
    • 0036217242 scopus 로고    scopus 로고
    • Albumin therapy of transient focal cerebral ischemia: In vivo analysis of dynamic microvascular responses
    • Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, Riyamongkol P et al. Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses. Stroke 2002; 33: 1077-1084.
    • (2002) Stroke , vol.33 , pp. 1077-1084
    • Belayev, L.1    Pinard, E.2    Nallet, H.3    Seylaz, J.4    Liu, Y.5    Riyamongkol, P.6
  • 26
    • 0023922466 scopus 로고
    • Effect of prazosin on microvascular perfusion during middle cerebral artery ligation in the rat
    • Anwar M, Buchweitz-Milton E, Weiss HR. Effect of prazosin on microvascular perfusion during middle cerebral artery ligation in the rat. Circ Res 1988; 63: 27-34.
    • (1988) Circ Res , vol.63 , pp. 27-34
    • Anwar, M.1    Buchweitz-Milton, E.2    Weiss, H.R.3
  • 27
    • 0012026125 scopus 로고    scopus 로고
    • Evolution of the brain leison induced by experimental focal ischemia
    • Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B (eds) Academic Press: San Diego, CA
    • Garcia JH. Evolution of the brain leison induced by experimental focal ischemia. In: Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B (eds) Primer on Cerebrovascular Diseases. Academic Press: San Diego, CA, 1997, pp 107-111.
    • (1997) Primer on Cerebrovascular Diseases , pp. 107-111
    • Garcia, J.H.1
  • 28
    • 84867545887 scopus 로고    scopus 로고
    • The cerebral microvasculature and responses to ischemia
    • Mohr JP, Wolf PA, Grotta JC, Moskowitz MA, Mayberg MR. R vK (eds), Elsevier: Philadelphia
    • del Zoppo GJ, Hamann GF. The cerebral microvasculature and responses to ischemia. In: Mohr JP, Wolf PA, Grotta JC, Moskowitz MA, Mayberg MR. R vK (eds) Stroke: Pathophysiology, Diagnosis and Management. 5th edn. (Elsevier: Philadelphia, 2011, pp 16-28.
    • (2011) Stroke: Pathophysiology Diagnosis and Management. 5th Edn , pp. 16-28
    • Del Zoppo, G.J.1    Hamann, G.F.2
  • 29
    • 0028390146 scopus 로고
    • Microvascular changes during cerebral ischemia and reperfusion
    • del Zoppo GJ. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 1994; 6: 47-96.
    • (1994) Cerebrovasc Brain Metab Rev , vol.6 , pp. 47-96
    • Del Zoppo, G.J.1
  • 30
    • 4644233023 scopus 로고    scopus 로고
    • Three-dimensional structural changes in cerebral microvessels after transient focal cerebral ischemia in rats: Scanning electron microscopic study of corrosion casts
    • Ohtake M, Morino S, Kaidoh T, Inoue T. Three-dimensional structural changes in cerebral microvessels after transient focal cerebral ischemia in rats: scanning electron microscopic study of corrosion casts. Neuropathology 2004; 24: 219-227.
    • (2004) Neuropathology , vol.24 , pp. 219-227
    • Ohtake, M.1    Morino, S.2    Kaidoh, T.3    Inoue, T.4
  • 31
  • 32
    • 0033573539 scopus 로고    scopus 로고
    • Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats
    • Zhang ZG, Chopp M, Goussev A, Lu D, Morris D, Tsang W et al. Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats. J Neurosci 1999; 19: 10898-10907.
    • (1999) J Neurosci , vol.19 , pp. 10898-10907
    • Zhang, Z.G.1    Chopp, M.2    Goussev, A.3    Lu, D.4    Morris, D.5    Tsang, W.6
  • 33
    • 0032189318 scopus 로고    scopus 로고
    • Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation
    • Choudhri TF, Hoh BL, Zerwes HG, Prestigiacomo CJ, Kim SC, Connolly Jr. ES et al. Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. J Clin Invest 1998; 102: 1301-1310.
    • (1998) J Clin Invest , vol.102 , pp. 1301-1310
    • Choudhri, T.F.1    Hoh, B.L.2    Zerwes, H.G.3    Prestigiacomo, C.J.4    Kim, S.C.5    Connolly Jr., E.S.6
  • 34
    • 0034623186 scopus 로고    scopus 로고
    • Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy
    • Morris DC, Davies K, Zhang Z, Chopp M. Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy. Brain Res 2000; 876: 31-36.
    • (2000) Brain Res , vol.876 , pp. 31-36
    • Morris, D.C.1    Davies, K.2    Zhang, Z.3    Chopp, M.4
  • 35
    • 0027932440 scopus 로고
    • Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion
    • discussion 1853-1844
    • Okada Y, Copeland BR, Fitridge R, Koziol JA, del Zoppo GJ. Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion. Stroke 1994; 25: 1847-1853discussion 1853-1844.
    • (1994) Stroke , vol.25 , pp. 1847-1853
    • Okada, Y.1    Copeland, B.R.2    Fitridge, R.3    Koziol, J.A.4    Del Zoppo, G.J.5
  • 36
    • 0034017791 scopus 로고    scopus 로고
    • Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke
    • Ritter LS, Orozco JA, Coull BM, McDonagh PF, Rosenblum WI. Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke 2000; 31: 1153-1161.
    • (2000) Stroke , vol.31 , pp. 1153-1161
    • Ritter, L.S.1    Orozco, J.A.2    Coull, B.M.3    McDonagh, P.F.4    Rosenblum, W.I.5
  • 37
    • 0023724397 scopus 로고
    • Perfused microvascular morphometry during middle cerebral artery occlusion
    • Buchweitz-Milton E, Weiss HR. Perfused microvascular morphometry during middle cerebral artery occlusion. Am J Physiol 1988; 255: H623-H628.
    • (1988) Am J Physiol , vol.255
    • Buchweitz-Milton, E.1    Weiss, H.R.2
  • 38
    • 0032982145 scopus 로고    scopus 로고
    • Quantitation of microvascular plasma perfusion and neuronal microtubule-associated protein in ischemic mouse brain by laser-scanning confocal microscopy
    • Zhang Z, Davies K, Prostak J, Fenstermacher J, Chopp M. Quantitation of microvascular plasma perfusion and neuronal microtubule-associated protein in ischemic mouse brain by laser-scanning confocal microscopy. J Cereb Blood Flow Metab 1999; 19: 68-78.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 68-78
    • Zhang, Z.1    Davies, K.2    Prostak, J.3    Fenstermacher, J.4    Chopp, M.5
  • 39
    • 0023061276 scopus 로고
    • Granulocytes as active participants in acute myocardial ischemia and infarction
    • Schmid-Schonbein GW, Engler RL. Granulocytes as active participants in acute myocardial ischemia and infarction. Am J Cardiovasc Pathol 1987; 1: 15-30.
    • (1987) Am J Cardiovasc Pathol , vol.1 , pp. 15-30
    • Schmid-Schonbein, G.W.1    Engler, R.L.2
  • 40
    • 0026729653 scopus 로고
    • Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons
    • Mori E, del Zoppo GJ, Chambers JD, Copeland BR, Arfors KE. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke 1992; 23: 712-718.
    • (1992) Stroke , vol.23 , pp. 712-718
    • Mori, E.1    Del Zoppo, G.J.2    Chambers, J.D.3    Copeland, B.R.4    Arfors, K.E.5
  • 41
    • 0030029825 scopus 로고    scopus 로고
    • Acute focal ischemia-induced alterations in MAP2 immunostaining: Description of temporal changes and utilization as a marker forvolumetric assessment of acute brain injury
    • Dawson DA, Hallenbeck JM. Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker forvolumetric assessment of acute brain injury. J Cereb Blood Flow Metab 1996; 16: 170-174.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 170-174
    • Dawson, D.A.1    Hallenbeck, J.M.2
  • 44
    • 23144443656 scopus 로고    scopus 로고
    • Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: Microdialysis and positron emission tomography study in nonhuman primates
    • Frykholm P, Hillered L, Langstrom B, Persson L, Valtysson J, Enblad P. Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: microdialysis and positron emission tomography study in nonhuman primates. J Neurosurg 2005; 102: 1076-1084.
    • (2005) J Neurosurg , vol.102 , pp. 1076-1084
    • Frykholm, P.1    Hillered, L.2    Langstrom, B.3    Persson, L.4    Valtysson, J.5    Enblad, P.6
  • 45
    • 1542376859 scopus 로고    scopus 로고
    • Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats
    • Liu S, Shi H, Liu W, Furuichi T, Timmins GS, Liu KJ. Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2004; 24: 343-349.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 343-349
    • Liu, S.1    Shi, H.2    Liu, W.3    Furuichi, T.4    Timmins, G.S.5    Liu, K.J.6
  • 46
    • 70949083465 scopus 로고    scopus 로고
    • Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels
    • Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ et al. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci 2009; 29: 14553-14570.
    • (2009) J Neurosci , vol.29 , pp. 14553-14570
    • Tsai, P.S.1    Kaufhold, J.P.2    Blinder, P.3    Friedman, B.4    Drew, P.J.5    Karten, H.J.6
  • 47
    • 12844258979 scopus 로고    scopus 로고
    • Focal cerebral ischemia preferentially affects neurons distant from their neighboring microvessels
    • Mabuchi T, Lucero J, Feng A, Koziol JA, del Zoppo GJ. Focal cerebral ischemia preferentially affects neurons distant from their neighboring microvessels. J Cereb Blood Flow Metab 2005; 25: 257-266.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 257-266
    • Mabuchi, T.1    Lucero, J.2    Feng, A.3    Koziol, J.A.4    Del Zoppo, G.J.5
  • 48
    • 0017717816 scopus 로고
    • Regions of cerebral ischemia located by pyridine nucleotide fluorescence
    • Welsh FA, O'Connor MJ, Langfitt TW. Regions of cerebral ischemia located by pyridine nucleotide fluorescence. Science 1977; 198: 951-953.
    • (1977) Science , vol.198 , pp. 951-953
    • Welsh, F.A.1    O'Connor, M.J.2    Langfitt, T.W.3
  • 49
    • 78650910604 scopus 로고    scopus 로고
    • Temporary [corrected] cerebral ischemia results in swollen astrocytic end-feet that compress microvessels and lead to delayed [corrected] focal cortical infarction
    • Ito U, Hakamata Y, Kawakami E, Oyanagi K. Temporary [corrected] cerebral ischemia results in swollen astrocytic end-feet that compress microvessels and lead to delayed [corrected] focal cortical infarction. J Cereb Blood Flow Metab 2011; 31: 328-338.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 328-338
    • Ito, U.1    Hakamata, Y.2    Kawakami, E.3    Oyanagi, K.4
  • 50
    • 69949172891 scopus 로고    scopus 로고
    • Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
    • Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 2009; 15: 1031-1037.
    • (2009) Nat Med , vol.15 , pp. 1031-1037
    • Yemisci, M.1    Gursoy-Ozdemir, Y.2    Vural, A.3    Can, A.4    Topalkara, K.5    Dalkara, T.6
  • 51
    • 0030716198 scopus 로고    scopus 로고
    • Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationshipsduring ischemia and early recirculation
    • Belayev L, Zhao W, Busto R, Ginsberg MD. Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationshipsduring ischemia and early recirculation. J Cereb Blood Flow Metab 1997; 17: 1266-1280.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1266-1280
    • Belayev, L.1    Zhao, W.2    Busto, R.3    Ginsberg, M.D.4
  • 52
    • 18744434897 scopus 로고    scopus 로고
    • Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: A brain proton magnetic resonance spectroscopic imaging study
    • Nicoli F, Lefur Y, Denis B, Ranjeva JP, Confort-Gouny S, Cozzone PJ. Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study. Stroke 2003; 34: e82-e87.
    • (2003) Stroke , vol.34
    • Nicoli, F.1    Lefur, Y.2    Denis, B.3    Ranjeva, J.P.4    Confort-Gouny, S.5    Cozzone, P.J.6
  • 53
    • 0027397693 scopus 로고
    • Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat
    • Garcia JH, Yoshida Y, Chen H, Li Y, Zhang ZG, Lian J et al. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 1993; 142: 623-635.
    • (1993) Am J Pathol , vol.142 , pp. 623-635
    • Garcia, J.H.1    Yoshida, Y.2    Chen, H.3    Li, Y.4    Zhang, Z.G.5    Lian, J.6
  • 54
    • 51849083386 scopus 로고    scopus 로고
    • Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing postischemic microvascular perfusion
    • Wong CH, Bozinovski S, Hertzog PJ, Hickey MJ, Crack PJ. Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing postischemic microvascular perfusion. J Neurochem 2008; 107: 241-252.
    • (2008) J Neurochem , vol.107 , pp. 241-252
    • Wong, C.H.1    Bozinovski, S.2    Hertzog, P.J.3    Hickey, M.J.4    Crack, P.J.5
  • 55
    • 0034085158 scopus 로고    scopus 로고
    • Integrin alpha(IIb) beta (3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia
    • discussion1409-1410
    • Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF et al. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke 2000; 31: 1402-1409discussion 1409-1410.
    • (2000) Stroke , vol.31 , pp. 1402-1409
    • Abumiya, T.1    Fitridge, R.2    Mazur, C.3    Copeland, B.R.4    Koziol, J.A.5    Tschopp, J.F.6
  • 56
    • 17144422857 scopus 로고    scopus 로고
    • CD40/ CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/ reperfusion
    • Ishikawa M, Vowinkel T, Stokes KY, Arumugam TV, Yilmaz G, Nanda A et al. CD40/ CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/ reperfusion. Circulation 2005; 111: 1690-1696.
    • (2005) Circulation , vol.111 , pp. 1690-1696
    • Ishikawa, M.1    Vowinkel, T.2    Stokes, K.Y.3    Arumugam, T.V.4    Yilmaz, G.5    Nanda, A.6
  • 57
    • 33745332030 scopus 로고    scopus 로고
    • Facilitation of postischemic reperfusion with alpha-PBN: Assessment using NMR and Doppler flow techniques
    • Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR et al. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques. Am J Physiol 1997; 272: H1986-H1995.
    • (1997) Am J Physiol , vol.272
    • Schulz, J.B.1    Panahian, N.2    Chen, Y.I.3    Beal, M.F.4    Moskowitz, M.A.5    Rosen, B.R.6
  • 58
    • 78650645093 scopus 로고    scopus 로고
    • Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
    • Fernandez-Klett F, Offenhauser N, Dirnagl U, Priller J, Lindauer U. Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci USA 2010; 107: 22290-22295.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22290-22295
    • Fernandez-Klett, F.1    Offenhauser, N.2    Dirnagl, U.3    Priller, J.4    Lindauer, U.5
  • 59
    • 78049253786 scopus 로고    scopus 로고
    • Pericyte-mediated regulation of capillary diameter: A component of neurovascular coupling in health and disease
    • pii 5
    • Hamilton NB, Attwell D, Hall CN. Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics 2010; 2: pii: 5.
    • (2010) Front Neuroenergetics , vol.2
    • Hamilton, N.B.1    Attwell, D.2    Hall, C.N.3
  • 61
    • 0030670117 scopus 로고    scopus 로고
    • Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization
    • Zhao W, Belayev L, Ginsberg MD. Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization. J Cereb Blood Flow Metab 1997; 17: 1281-1290.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1281-1290
    • Zhao, W.1    Belayev, L.2    Ginsberg, M.D.3
  • 62
    • 0034889456 scopus 로고    scopus 로고
    • Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia
    • Liu KF, Li F, Tatlisumak T, Garcia JH, Sotak CH, Fisher M et al. Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia. Stroke 2001; 32: 1897-1905.
    • (2001) Stroke , vol.32 , pp. 1897-1905
    • Liu, K.F.1    Li, F.2    Tatlisumak, T.3    Garcia, J.H.4    Sotak, C.H.5    Fisher, M.6
  • 63
    • 0033858805 scopus 로고    scopus 로고
    • Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia
    • discussion 1981
    • Gursoy-Ozdemir Y, Bolay H, Saribas O, Dalkara T. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 2000; 31: 1974-1980discussion 1981.
    • (2000) Stroke , vol.31 , pp. 1974-1980
    • Gursoy-Ozdemir, Y.1    Bolay, H.2    Saribas, O.3    Dalkara, T.4
  • 64
    • 2542551340 scopus 로고    scopus 로고
    • Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia
    • Gursoy-Ozdemir Y, Can A, Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004; 35: 1449-1453.
    • (2004) Stroke , vol.35 , pp. 1449-1453
    • Gursoy-Ozdemir, Y.1    Can, A.2    Dalkara, T.3
  • 65
    • 33749860102 scopus 로고    scopus 로고
    • Bidirectional control of CNS capillary diameter by pericytes
    • Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature 2006; 443: 700-704.
    • (2006) Nature , vol.443 , pp. 700-704
    • Peppiatt, C.M.1    Howarth, C.2    Mobbs, P.3    Attwell, D.4
  • 66
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci 2011; 14: 1398-1405.
    • (2011) Nat Neurosci , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 69
    • 79953283190 scopus 로고    scopus 로고
    • Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    • Yaseen MA, Srinivasan VJ, Sakadzic S, Radhakrishnan H, Gorczynska I, Wu W et al. Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation. J Cereb Blood Flow Metab 2011; 31: 1051-1063.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 1051-1063
    • Yaseen, M.A.1    Srinivasan, V.J.2    Sakadzic, S.3    Radhakrishnan, H.4    Gorczynska, I.5    Wu, W.6
  • 70
    • 77956323278 scopus 로고    scopus 로고
    • Twophoton high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    • Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K et al. Twophoton high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods 2010; 7: 755-759.
    • (2010) Nat Methods , vol.7 , pp. 755-759
    • Sakadzic, S.1    Roussakis, E.2    Yaseen, M.A.3    Mandeville, E.T.4    Srinivasan, V.J.5    Arai, K.6
  • 71
    • 0026508278 scopus 로고
    • A new model of temporary focal neocortical ischemia in the rat
    • Buchan AM, Xue D, Slivka A. A new model of temporary focal neocortical ischemia in the rat. Stroke 1992; 23: 273-279.
    • (1992) Stroke , vol.23 , pp. 273-279
    • Buchan, A.M.1    Xue, D.2    Slivka, A.3
  • 72
    • 0030725897 scopus 로고    scopus 로고
    • The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat
    • Nakai A, Kuroda S, Kristian T, Siesjo BK. The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. Neurobiol Dis 1997; 4: 288-300.
    • (1997) Neurobiol Dis , vol.4 , pp. 288-300
    • Nakai, A.1    Kuroda, S.2    Kristian, T.3    Siesjo, B.K.4
  • 73
    • 0021932513 scopus 로고
    • Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema
    • Shigeno T, Teasdale GM, McCulloch J, Graham DI. Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema. J Neurosurg 1985; 63: 272-277.
    • (1985) J Neurosurg , vol.63 , pp. 272-277
    • Shigeno, T.1    Teasdale, G.M.2    McCulloch, J.3    Graham, D.I.4
  • 74
    • 0024414013 scopus 로고
    • Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion
    • Nagasawa H, Kogure K. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 1989; 20: 1037-1043.
    • (1989) Stroke , vol.20 , pp. 1037-1043
    • Nagasawa, H.1    Kogure, K.2
  • 75
    • 0031154065 scopus 로고    scopus 로고
    • Blood flow in the cerebral capillary network: A review emphasizing observations with intravital microscopy
    • Hudetz AG. Blood flow in the cerebral capillary network: a review emphasizing observations with intravital microscopy. Microcirculation 1997; 4: 233-252.
    • (1997) Microcirculation , vol.4 , pp. 233-252
    • Hudetz, A.G.1
  • 76
    • 84856460295 scopus 로고    scopus 로고
    • The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism
    • Jespersen SN, Ostergaard L. The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism. J Cereb Blood Flow Metab 2012; 32: 264-277.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 264-277
    • Jespersen, S.N.1    Ostergaard, L.2
  • 77
    • 0036263336 scopus 로고    scopus 로고
    • Moment analysis of microflow histogram in focal ischemic lesion to evaluate microvascular derangement after small pial arterial occlusion in rats
    • Tomita Y, Tomita M, Schiszler I, Amano T, Tanahashi N, Kobari M et al. Moment analysis of microflow histogram in focal ischemic lesion to evaluate microvascular derangement after small pial arterial occlusion in rats. J Cereb Blood Flow Metab 2002; 22: 663-669.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 663-669
    • Tomita, Y.1    Tomita, M.2    Schiszler, I.3    Amano, T.4    Tanahashi, N.5    Kobari, M.6
  • 78
    • 34247880466 scopus 로고    scopus 로고
    • Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging
    • Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke 2007; 38: 1336-1344.
    • (2007) Stroke , vol.38 , pp. 1336-1344
    • Bardutzky, J.1    Shen, Q.2    Henninger, N.3    Schwab, S.4    Duong, T.Q.5    Fisher, M.6
  • 79
    • 0034116078 scopus 로고    scopus 로고
    • Probability of metabolic tissue recovery after thrombolytic treatment of experimental stroke: A magnetic resonancespectroscopic imaging study in rat brain
    • Franke C, Brinker G, Pillekamp F, Hoehn M. Probability of metabolic tissue recovery after thrombolytic treatment of experimental stroke: a magnetic resonancespectroscopic imaging study in rat brain. J Cereb Blood Flow Metab 2000; 20: 583-591.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 583-591
    • Franke, C.1    Brinker, G.2    Pillekamp, F.3    Hoehn, M.4
  • 81
    • 0036901539 scopus 로고    scopus 로고
    • Thrombolytic treatment of clot embolism in rat: Comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator
    • Niessen F, Hilger T, Hoehn M, Hossmann KA. Thrombolytic treatment of clot embolism in rat: comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator. Stroke 2002; 33: 2999-3005.
    • (2002) Stroke , vol.33 , pp. 2999-3005
    • Niessen, F.1    Hilger, T.2    Hoehn, M.3    Hossmann, K.A.4
  • 82
    • 0034701019 scopus 로고    scopus 로고
    • Brain embolism is a dynamic process with variable characteristics
    • Babikian VL, Caplan LR. Brain embolism is a dynamic process with variable characteristics. Neurology 2000; 54: 797-801.
    • (2000) Neurology , vol.54 , pp. 797-801
    • Babikian, V.L.1    Caplan, L.R.2
  • 83
    • 0029880131 scopus 로고    scopus 로고
    • Microthromboemboli in acute infarcts: Analysis of 40 autopsy cases
    • Heye N, Cervos-Navarro J. Microthromboemboli in acute infarcts: analysis of 40 autopsy cases. Stroke 1996; 27: 431-434.
    • (1996) Stroke , vol.27 , pp. 431-434
    • Heye, N.1    Cervos-Navarro, J.2
  • 85
    • 77953002524 scopus 로고    scopus 로고
    • Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization
    • Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature 2010; 465: 478-482.
    • (2010) Nature , vol.465 , pp. 478-482
    • Lam, C.K.1    Yoo, T.2    Hiner, B.3    Liu, Z.4    Grutzendler, J.5
  • 87
    • 34248995460 scopus 로고    scopus 로고
    • Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion
    • Shi H, Liu KJ. Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. Front Biosci 2007; 12: 1318-1328.
    • (2007) Front Biosci , vol.12 , pp. 1318-1328
    • Shi, H.1    Liu, K.J.2
  • 88
    • 66149114779 scopus 로고    scopus 로고
    • Perfluorocarbon emulsions as a promising technology: A review of tissue and vascular gas dynamics
    • Spiess BD. Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics. J Appl Physiol 2009; 106: 1444-1452.
    • (2009) J Appl Physiol , vol.106 , pp. 1444-1452
    • Spiess, B.D.1
  • 89
    • 0842332370 scopus 로고    scopus 로고
    • Ischemic stunning of the brain: Early recanalization without immediate clinical improvement in acute ischemic stroke
    • Alexandrov AV, Hall CE, Labiche LA, Wojner AW, Grotta JC. Ischemic stunning of the brain: early recanalization without immediate clinical improvement in acute ischemic stroke. Stroke 2004; 35: 449-452.
    • (2004) Stroke , vol.35 , pp. 449-452
    • Alexandrov, A.V.1    Hall, C.E.2    Labiche, L.A.3    Wojner, A.W.4    Grotta, J.C.5
  • 90
    • 0028140288 scopus 로고
    • Reperfusion after thrombolytic therapy in ischemic stroke measured by single-photon emission computed tomography
    • Baird AE, Donnan GA, Austin MC, Fitt GJ, Davis SM, McKay WJ. Reperfusion after thrombolytic therapy in ischemic stroke measured by single-photon emission computed tomography. Stroke 1994; 25: 79-85.
    • (1994) Stroke , vol.25 , pp. 79-85
    • Baird, A.E.1    Donnan, G.A.2    Austin, M.C.3    Fitt, G.J.4    Davis, S.M.5    McKay, W.J.6
  • 92
    • 27644486681 scopus 로고    scopus 로고
    • Revascularization end points in stroke interventional trials: Recanalization versus reperfusion in IMS-I
    • Khatri P, Neff J, Broderick JP, Khoury JC, Carrozzella J, Tomsick T. Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke 2005; 36: 2400-2403.
    • (2005) Stroke , vol.36 , pp. 2400-2403
    • Khatri, P.1    Neff, J.2    Broderick, J.P.3    Khoury, J.C.4    Carrozzella, J.5    Tomsick, T.6
  • 94
    • 33845298309 scopus 로고    scopus 로고
    • Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study
    • Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006; 60: 508-517.
    • (2006) Ann Neurol , vol.60 , pp. 508-517
    • Albers, G.W.1    Thijs, V.N.2    Wechsler, L.3    Kemp, S.4    Schlaug, G.5    Skalabrin, E.6
  • 95
    • 62949243315 scopus 로고    scopus 로고
    • MR and CT monitoring of recanalization reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!
    • Soares BP, Chien JD, Wintermark M. MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: everything that recanalizes does not necessarily reperfuse! Stroke 2009; 40: S24-S27.
    • (2009) Stroke , vol.40
    • Soares, B.P.1    Chien, J.D.2    Wintermark, M.3
  • 96
    • 0017623724 scopus 로고
    • Cortical evoked potential and extracellular K and H at critical levels of brain ischemia
    • Astrup J, Symon L, Branston NM, Lassen NA. Cortical evoked potential and extracellular K and H at critical levels of brain ischemia. Stroke 1977; 8: 51-57.
    • (1977) Stroke , vol.8 , pp. 51-57
    • Astrup, J.1    Symon, L.2    Branston, N.M.3    Lassen, N.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.