Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 4, 2011, Pages 1051-1063

  Yaseen, Mohammad A ^a   Srinivasan, Vivek J ^a   Sakadžić, Sava ^a   Radhakrishnan, Harsha ^a   Gorczynska, Iwona ^b   Wu, Weicheng ^a   Fujimoto, James G ^b   Boas, David A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Electrical Engineering and Computer Science   (United States)

Author keywords

cerebral blood flow; fMRI; microscopy; optical imaging; oxygen

Indexed keywords

OXYGEN;

ANESTHESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGEN TENSION; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN FUNCTION; CONTROLLED STUDY; FLOW MEASUREMENT; FOURIER ANALYSIS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; MALE; MICROSCOPY; MICROVASCULATURE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OXYGEN EXTRACTION FRACTION; OXYGEN TISSUE LEVEL; PHOSPHORESCENCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; SOMATOSENSORY STIMULATION;

ANIMALS; ARTERIOLES; CAPILLARIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGICAL PHENOMENA; MAGNETIC RESONANCE IMAGING; MALE; MICROSCOPY, CONFOCAL; OXYGEN; OXYGEN CONSUMPTION; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; SOMATOSENSORY CORTEX; TOMOGRAPHY, OPTICAL COHERENCE; VENULES;

EID: 79953283190     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.227     Document Type: Article

References (46)

1. 2 during functional activation using oxygen phosphorescence quenching. J Cereb Blood Flow Metab 21:511-6 (Pubitemid 32422871)
2. Atwell D, Iadecola C (2002) The neural basis of functional brain imaging signals. Trends Neurosci 25:621-5 (Pubitemid 35356509)
3. Bartlett K, Saka M, Jones M (2008) Polarographic electrode measures of cerebral tissue oxygenation: implications for functional brain imaging. Sensors 8:7649-70
4. Boas DA, Strangman G, Culver JP, Hoge RD, Jasdzewski G, Poldrack RA, Rosen BR, Mandeville JB (2003) Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Phys Med Biol 48:2405-18 (Pubitemid 37020986)
5. Buxton RB (2001) The elusive initial dip. Neuroimage 13:953-8 (Pubitemid 32553527)
6. Buxton RB (2010) Interpreting oxygenation-based neuro-imaging signals: the importance and the challenge of understanding brain oxygen metabolism. Front Neuro-energetics 2:8
7. Devor A, Tian P, Nishimura N, Teng IC, Hillman EMC, Narayanan SN, Ulbert I, Boas DA, Kleinfeld D, Dale AM (2007) Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci 27: 4452-9 (Pubitemid 46640720)
8. Duling BR, Berne RM (1970) Longitudinal gradients in periarteriolar oxygen tension: a possible mechanism for the participation of oxygen in local regulation of blood flow. Cir Res 27:669-78
9. Duling BR, Damon DH (1987) An examination of the measurement of flow heterogeneity in striated muscle. Cir Res 60:1-13 (Pubitemid 17056925)
10. Dunn AK, Devor A, Dale AM, Boas DA (2005) Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage 27:279-90 (Pubitemid 41074831)
11. Dunphy I, Vinogradov SA, Wilson DF (2002) Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence. Anal Bio-chem 310:191-8 (Pubitemid 35388261)
12. Finikova OS, Lebedev AY, Aprelev A, Troxler T, Gao F, Garnacho C, Muro S, Hochstrasser RM, Vinogradov SA (2008) Oxygen microscopy by two-photon-excited phos phorescence. ChemPhysChem 9:1673-9
13. Franceschini MA, Thaker S, Themelis G, Krishnamoorthy KK, Bortfeld H, Diamond SG, Boas DA, Arvin K, Grant EP (2007) Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatr Res 61:546-51 (Pubitemid 46650005)
14. Gray LH, Steadman JM (1964) Determination of the oxyhaemoglobin dissociation curves for mouse and rat blood. J Physiol (Cambridge) 175:161-71
15. Hillman EMC, Devor A, Bouchard MB, Dunn AK, Krauss GW, Skoch J, Backsai BJ, Dale AM, Boas DA (2007) Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage 35:89-104 (Pubitemid 46240938)
16. Hyder F (2009) Dynamic imaging of brain function. In: Dynamic Brain Imaging: Multi-Modal Methods and In Vivo Applications (Hyder F, ed), Totowa, NJ: Humana Press, pp 3-21
17. Kasischke KA, Lambert EM, Panepento B, Sun A, Gelbard HA, Burgess RW, Foster TH, Nedergaard M (2010) Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab In Press
18. Kim T, Hendrich KS, Masamoto K, Kim S-G (2007) Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI. J Cereb Blood Flow Metab 27: 1235-47 (Pubitemid 46808710)
19. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng H-M, Brady TJ, Rosen BR (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675-9
20. Lee S-P, Duong TQ, Yang G, Iadecola C, Kim S-G (2001) Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: implications for BOLD fMRI. Magn Reson Med 45:791-800 (Pubitemid 32402021)
21. Leitgeb R, Hitzenberger CK, Fercher AF (2003) Performance of Fourier domain versus time domain optical coherence tomography. Opt Express 11:889-94
22. 2 coupling measured with calibrated BOLD fMRI: sources of bias. Neuroimage 36:1110-22 (Pubitemid 47001721)
23. Lindauer U, Royl G, Leithner C, Kühl M, Gold L, Gethmann J, Kohl-Bareis M, Villringer A, Dirnagl U (2001) No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation. Neuroimage 13:988-1001 (Pubitemid 32553531)
24. Masamoto K, Vazquez A, Wang P, Kim S-G (2009) Brain tissue oxygen consumption and supply induced by neural activation: determined under suppressed hemo-dynamic response conditions in the anesthetized rat cerebral cortex. In: Oxygen Transport to Tissue XXX (Liss P, Hansell P, Bruley DF et al, eds), New York, NY: Springer Science+Business Media, LLC, pp 287-92
25. Pries AR, Secomb TW, Gaehtgens P (1995) Structure and hemodynamics of microvascular networks: heterogeneity and correlations. Am J Physiol 269:H1713-22
26. Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9:677-85
27. Riera JJ, Schousboe A, Waagepetersen HS, Howarth C, Hyder F (2008) The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism. Neuroimage 40:1436-59
28. Rumsey WL, Vanderkooi JM, Wilson DF (1988) Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue. Science 241:1649-51
29. Sakadzić S, Roussakis E, Yaseen MA, Mandeville ET, Devor A, Lo EH, Vinogradov SA, Boas DA (2010) Imaging of oxygen partial pressure in cerebral vasculature and tissue using a two-photon-enhanced phosphorescent nanoprobe. Nat Methods 7:755-9
30. Sakadzić S, Yuan S, Dilekoz E, Ruvinskaya S, Vinogradov SA, Ayata C, Boas DA (2009) Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt 48:D169-77
31. Shmuel A, Yacoub E, Pfeuffer J, Van de Moortele P-F, Adriany G, Hu X, Ugurbil K (2002) Sustained negative BOLD, blood flow and oxygen consumption and its coupling to the positive response in the human brain. Neuron 36:1195-210 (Pubitemid 36044518)
32. Shonat RD, Johnson PC (1997) Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol 272:H2233-40
33. 2 in spontaneously breathing animals. Neuroimage 25:850-8 (Pubitemid 40461723)
34. Silva AC, Lee S-P, Yang G, Iadecola C, Kim S-G (1999) Simultaneous blood oxygenation level-dependent and cerebral blood flow functional magnetic resonance imaging during forepaw stimulation in the rat. J Cereb Blood Flow Metab 19:871-9 (Pubitemid 30173388)
35. Sokoloff L (1992) The brain as a chemical machine. In: Progress in Brain Research (Yu ACH, Hertz L, Norenberg MD et al, eds), Amsterdam: Elsevier Science, pp 19-33 (Pubitemid 23026633)
36. Sokoloff L (2008) The physiological and biochemical bases of functional brain imaging. Cogn Neurodyn 2:1-5 (Pubitemid 351191298)
37. Srinivasan VJ, Sakadzić S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA (2009) Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Opt Lett 34:3086-8
38. Srinivasan VJ, Sakadzić S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA (2010) Quantitative cerebral blood flow with optical coherence tomography. Opt Express 18:2477-94
39. Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EMC, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJA, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A (2010) Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci USA 107:15246-51
40. Vafaee MS, Gjedde A (2004) Spatially dissociated flow-metabolism coupling in brain activation. Neuroimage 21:507-15 (Pubitemid 38229913)
41. Vanzetta I, Grinvald A (1999) Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science 286:1555-8
42. Vazquez AL, Fukuda M, Tasker ML, Masamoto K, Kim S-G (2010) Changes in cerebral arterial, tissue, and venous oxygenation with evoked neural stimulation: implications for hemoglobin-based functional neuroimaging. J Cereb Blood Flow Metab 30:428-39
43. 2 measurements. Neuroimage 42:49-59
44. Vinogradov SA, Lo L-W, Wilson DF (1999) Dendritic poly-glutamic porphyrins: probing porphyrin protection by oxygen-dependent quenching of phosphorescence. Chem Eur J 5:1338-47
45. Vovenko EP (1999) Distribution of oxygen tension on the surface of arterioles, capillaries, and venules of brain cortex and in tissue in normoxia: an experimental study on rats. Pfluegers Archiv Eur J Physiol 437:617-23
46. Yaseen MA, Srinivasan VJ, Sakadzić S, Wu W, Ruvinskaya S, Vinogradov SA, Boas DA (2009) Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Opt Express 17:22341-50