Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 10, 1997, Pages 1066-1073

  Tsuchidate, Ryoichi ^b   He, Qing Ping ^a   Smith, Maj Lis ^a   Siesjö, Bo K ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CBF; Focal ischemia; Recirculation; Reperfusion damage

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BIOENERGY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0030828060     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199710000-00008     Document Type: Article

References (53)

1. Almeida A, Allen KL, Bates TE, Clark JB (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 65:1968-1703
2. Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 12:723-725
3. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
4. Bogaert YE, Rosenthal RE, Fiskum G (1994) Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Radic Biol Med 16:811-819
5. Buchan AM, Xue D, Slivka A (1991) A new model of temporary focal neocortical ischemia in the rat. Stroke 23:273-279
6. Chopp M, Zhang RL, Chen H, Li Y, Jiang N, Rusche JR (1994) Postischemic administration of an Anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25:869-876
7. Dahlgren M, Ingvar M, Yokoyama H, Siesjö BK (1981) Influence of nitrous oxide on local cerebral blood flow in awake, minimally restrained rats. J Cereb Blood Flow Metab 1:233-236
8. De Girolami U, Crowell RM, Marcoux FW (1984) Selective necrosis and total necrosis in focal cerebral ischemia. Neuropathologic observations on experimental middle cerebral artery occlusion in the macaque monkey. J Neuropath Exp Neurol 43:57-71
9. del Zoppo GJ, Schmid-Schönbein GW, Mori E, Copeland BR, Change C-M (1991) Polymorphonuclear leucocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22:1276-1283
10. del Zoppo GJ (1994) Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 6:47-96
11. Dirnagl U (1993) Cerebral ischemia: the microcirculation as trigger and target; neurobiology of ischemic brain damage. In: Progress in Brain Research, Vol 96 (Kogure K, Hossmann KA, Siesjö BK, eds), Amsterdam, Elsevier, pp 49-65
12. Eklöf B, Siesjö BK (1973) Cerebral blood flow in ischemia caused by carotid artery ligation in the rat. Acta Physiol Scand 87:69-77
13. Feuerstein GZ, Liu T, Barone FC (1994) Cytokines, inflamation, and brain injury; role of tumor necrosis factor-a. Celebrovasc Brain Metab Rev 6:341-360
14. Folbergrová J, Zhao Q, Katsura K, Siesjö BK. (1995) N-tert-butyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA 92:5057-5061
15. Garcia J, Liu K, Yoshida Y, Lian J, Chen S, del Zoppo GJ (1994) Influx of leukocytes and platelets in an evolving brain infarct. Am J Pathol 144:188-199
16. Hakim AM (1987) The cerebral ischemic penumbra. Can J Neurol Sci 14:557-559
17. Hallenbeck (1996) Inflammatory reactions at the blood-endothelial interface in acute stroke. Adv Neurol 71:281-297
18. Heiss W-D (1992) Experimental evidence of ischemic thresholds and functional recovery. Stroke 23:1668-1672
19. Hossmann KA (1994) Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol 4:23-36
20. Jacewicz M, Tanabe J, Pulsinelli WA (1992) The CBF threshold and dynamics for focal cerebral infarction in spontaneously hypertensive rats. J Cereb Blood Flow Metab 12:359-370
21. Kaplan B, Brim S, Tanabe J, Jacewicz M, Wang XJ, Pulsinelli W (1991) Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22:1032-1039
22. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
23. Kontos HA (1985) Oxygen radicals in cerebral vascular injury. Circ Res 57:508-516
24. Kontos HA (1989) Oxygen radicals in cerebral ischemia. Cerebrovascular Diseases New York, Raven Press, pp 365-371
25. Kuroiwa T, Shibutani M, Okeda R (1988) Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia. Acta Neuropathol 76:62-70
26. Kuroda S, Katsura K, Tsuchidate R, Siesjö BK (1996a) Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury. Acta Physiol Scand 156:149-150
27. Kuroda S, Katsura K, Hillered L, Bates TE, Siesjö BK (1996b) Delayed treatment with α-Phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient in the rat. Neurobiologv of Disease 3:149-157
28. Kågström E, Smith M-L, Siesjö BK (1983a) Local cerebral blood flow in the recovery period following complete cerebral ischemia in rat. J Cereb Blood Flow Metab 3:170-182
29. Kågström E, Smith M-L, Siesjö BK (1983b) Recirculation in the rat brain following incomplete ischemia. J Cereb Blood Flow Metab 3:183-192
30. Marcoux FW, Morawetz RB, Crowell RM, DeGirolami U, Halsey JH (1982) Differential regional vulnerability in transient focal cerebral ischemia. Stroke 13:339-346
31. Matsuo Y, Onodera H, Shiga Y, Shozuhara H, Ninomiya M, Kihara T, Tamatani T, Miyasaka M, Kogure K (1994) Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat. Brain Res 656:344-352
32. Memezawa H, Minamisawa H, Smith M-L, Siesjö BK (1992a) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78
33. Memezawa H, Smith M-L, Siesjö BK (1992b) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559
34. Mies G, Ishimaru S, Xie Y, Seo K, Hossmann K-A (1991) Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat. J Cereb Blood Flow Metab 11:753-761
35. Nagasawa H, Kogure K (1989) Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20:1037-1043
36. Nagasawa H, Kogure K (1990) Uncoupling of blood flow and glucose metabolism in the neighboring postischemic edematous brain area. Adv in Neurol 52:63-71
37. Paschen W, Mies G, Hossmann K-A (1992) Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils. Exp Neurol 117: 325-333
38. Pulsinelli W, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498
39. Pulsinelli W (1992) Pathophysiology of acute ischemic stroke. Lancet 339:533-536
40. Pulsinelli W, Sarokin A, Buchan A (1993) Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia; neurobiology of ischemic brain damage. In: Progress in Brain Research, Vol 96 (Kogure K, Hossmann KA, Siesjö BK, eds). Amsterdam, Elsevier, pp 125-135
41. Sakurada O, Kennedy C, Jehle J, Brown JD, Carbin GL, Sokoloff L (1978) Measurement of local cerebral blood flow with iodo[14C]antipyrine. Am J Physiol 234:H59-66
42. Shigeno T, Teasdale GM, McCulloch J, Graham DI (1985) Recirculation model following MCA occlusion in rats. J Neurosurg 63:272-277
43. Siesjö BK (1992a) Pathophysiology and treatment of focal cerebral ischemia. 1. Pathophysiology. J Neurosurg 77:169-184
44. Siesjö BK (1992b) Pathophysiology and treatment of focal cerebral ischemia. II. Mechanisms of damage and treatment. J Neurosurg 77:337-354
45. Siesjö BK, Katsura K, Zhao Q, Folbergrová J, Pahlmark K, Siesjö P, Smith M-L (1995) Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma 12:943-956
46. Siesjö BK, Siesjö P (1996) Mechanisms of secondary brain injury. Euro J Anaesthes 13:247-268
47. Steen PA, Michenfelder JD, Milde JH (1979) Incomplete versus complete cerebral ischemia: improved outcome with a minimal blood flow. Ann Neurol 6:389-398
48. 14C] ioduantipyrine autoradiographic study. Brain Res 691:160-168
49. Tyson GW, Teasdale GM, Graham DI, McCulloch J (1984) Focal cerebral ischemia in the rat: Topography of hemodynamic and histopathological changes. Ann Neurol 15:559-567
50. Zaidan E, Sims NR (1994) The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J Neurochem 63:1812-1819
51. Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, Anderson DC (1995) Anti-intracellular Adhesion Molecule-1 Antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 26:1438-1443
52. Zhao Q, Memezawa H, Smith M-L, Siesjö BK (1994a) Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament. Brain Res 649:253-259
53. Zhao Q, Pahlmark K, Smith M-L, Siesjö BK (1994b) Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152:349-350