Cytosolic, Autocrine Alpha-1 Proteinase Inhibitor (A1PI) Inhibits Caspase-1 and Blocks IL-1β Dependent Cytokine Release in Monocytes

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Wang, Yonggang ^a   He, Yong ^a   Abraham, Bindu ^a   Rouhani, Farshid N ^b   Brantly, Mark L ^b   Scott, Dorothy E ^a   Reed, Jennifer L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NIGERICIN; TUMOR NECROSIS FACTOR ALPHA;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE RELEASE; CYTOSOL; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; INFANT; LOWER RESPIRATORY TRACT INFECTION; LUNG ALVEOLUS MACROPHAGE; MONOCYTE; PROTEIN EXPRESSION;

ALPHA 1-ANTITRYPSIN; AUTOCRINE COMMUNICATION; CASPASE 1; CELLS, CULTURED; CYTOSOL; GLYCOSYLATION; HUMANS; INTERLEUKIN-1BETA; LUNG; MONOCYTES; PROTEIN BINDING; TRANSFECTION;

EID: 84870606823     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051078     Document Type: Article

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