-
1
-
-
34247113737
-
Optimal medical therapy with or without PCI for stable coronary disease
-
Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503-16.
-
(2007)
N Engl J Med
, vol.356
, pp. 1503-1516
-
-
Boden, W.E.1
O'Rourke, R.A.2
Teo, K.K.3
-
2
-
-
67149142042
-
A randomized trial of therapies for type 2 diabetes and coronary artery disease
-
Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360:2503-15.
-
(2009)
N Engl J Med
, vol.360
, pp. 2503-2515
-
-
Frye, R.L.1
August, P.2
Brooks, M.M.3
-
3
-
-
44449103671
-
Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches
-
deGoma EM, deGoma RL, Rader DJ. Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol. 2008;51:2199-211.
-
(2008)
J Am Coll Cardiol
, vol.51
, pp. 2199-2211
-
-
Degoma, E.M.1
Degoma, R.L.2
Rader, D.J.3
-
4
-
-
84855171302
-
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
-
Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365:2255-67.
-
(2011)
N Engl J Med
, vol.365
, pp. 2255-2267
-
-
Boden, W.E.1
Probstfield, J.L.2
Anderson, T.3
-
6
-
-
84864845456
-
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
-
Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380:572-80.
-
(2012)
Lancet
, vol.380
, pp. 572-580
-
-
Voight, B.F.1
Peloso, G.M.2
Orho-Melander, M.3
-
7
-
-
75349106253
-
Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia
-
Fazio S, Guyton JR, Polis AB, et al. Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. Am J Cardiol. 2010;105:487-94.
-
(2010)
Am J Cardiol
, vol.105
, pp. 487-494
-
-
Fazio, S.1
Guyton, J.R.2
Polis, A.B.3
-
8
-
-
78649641649
-
Efficacy and tolerability of extended-release niacin/laropiprant in dyslipidemic patients with metabolic syndrome
-
Bays HE, Shah A, Lin J, McCrary Sisk C, Paolini JF, Maccubbin D. Efficacy and tolerability of extended-release niacin/laropiprant in dyslipidemic patients with metabolic syndrome. J Clin Lipidol. 2010;4(6):515-21.
-
(2010)
J Clin Lipidol
, vol.4
, Issue.6
, pp. 515-521
-
-
Bays, H.E.1
Shah, A.2
Lin, J.3
McCrary Sisk, C.4
Paolini, J.F.5
MacCubbin, D.6
-
9
-
-
77950641140
-
Efficacy and safety of extended-release niacin/laropiprant plus statin vs doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia
-
Shah S, Ceska R, Gil-Extremera B, et al. Efficacy and safety of extended-release niacin/laropiprant plus statin vs doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract. 2010;64:727-38.
-
(2010)
Int J Clin Pract
, vol.64
, pp. 727-738
-
-
Shah, S.1
Ceska, R.2
Gil-Extremera, B.3
-
10
-
-
84861309590
-
Consistency of extended-release niacin/laropiprant effects on Lp (a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups
-
Bays HE, Shah A, Lin J, Sisk CM, Dong Q, Maccubbin D. Consistency of extended-release niacin/laropiprant effects on Lp (a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups. Am J Cardiovasc Drugs. 2012;12:197-206.
-
(2012)
Am J Cardiovasc Drugs
, vol.12
, pp. 197-206
-
-
Bays, H.E.1
Shah, A.2
Lin, J.3
Sisk, C.M.4
Dong, Q.5
MacCubbin, D.6
-
11
-
-
77955302309
-
Seeing red: Flushing out instigators of niacin-associated skin toxicity
-
Dunbar RL, Gelfand JM. Seeing red: flushing out instigators of niacin-associated skin toxicity. J Clin Invest. 2010;120:2651-5.
-
(2010)
J Clin Invest
, vol.120
, pp. 2651-2655
-
-
Dunbar, R.L.1
Gelfand, J.M.2
-
12
-
-
77955300428
-
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
-
Hanson J, Gille A, Zwykiel S, et al. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest. 2010;120:2910-9.
-
(2010)
J Clin Invest
, vol.120
, pp. 2910-2919
-
-
Hanson, J.1
Gille, A.2
Zwykiel, S.3
-
13
-
-
84857657538
-
Niacin in cardiovascular disease: Recent preclinical and clinical developments
-
Digby JE, Ruparelia N, Choudhury RP. Niacin in cardiovascular disease: recent preclinical and clinical developments. Arterioscler Thromb Vasc Biol. 2012;32:582-8
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 582-588
-
-
Digby, J.E.1
Ruparelia, N.2
Choudhury, R.P.3
-
14
-
-
67649372666
-
Flushing profile of extended-release niacin/laropiprant vs gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
-
Maccubbin D, Koren MJ, Davidson M, et al. Flushing profile of extended-release niacin/laropiprant vs gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol. 2009;104:74-81.
-
(2009)
Am J Cardiol
, vol.104
, pp. 74-81
-
-
MacCubbin, D.1
Koren, M.J.2
Davidson, M.3
-
15
-
-
0037352280
-
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
-
Tunaru S, Kero J, Schaub A, et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nature Medicine. 2003;9:352-5.
-
(2003)
Nature Medicine
, vol.9
, pp. 352-355
-
-
Tunaru, S.1
Kero, J.2
Schaub, A.3
-
16
-
-
84865330824
-
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression
-
Lauring B, Taggart AK, Tata JR, et al. Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Science Translational Med, 2012;4(148).
-
(2012)
Science Translational Med
, vol.4
, Issue.148
-
-
Lauring, B.1
Taggart, A.K.2
Tata, J.R.3
-
17
-
-
53249145678
-
Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans
-
Lai E, Waters G, Tata J, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol. 2008;2:375-83.
-
(2008)
J Clin Lipidol
, vol.2
, pp. 375-383
-
-
Lai, E.1
Waters, G.2
Tata, J.3
-
18
-
-
79952240405
-
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
-
Lukasova M, Malaval C, Gille A, Kero J, Offermanns S. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest. 2011;121(3):1163-73
-
(2011)
J Clin Invest
, vol.121
, Issue.3
, pp. 1163-1173
-
-
Lukasova, M.1
Malaval, C.2
Gille, A.3
Kero, J.4
Offermanns, S.5
-
19
-
-
0035969564
-
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
-
Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583-92.
-
(2001)
N Engl J Med
, vol.345
, pp. 1583-1592
-
-
Brown, B.G.1
Zhao, X.Q.2
Chait, A.3
-
20
-
-
0023001772
-
Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
-
Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8:1245-55.
-
(1986)
J Am Coll Cardiol
, vol.8
, pp. 1245-1255
-
-
Canner, P.L.1
Berge, K.G.2
Wenger, N.K.3
-
21
-
-
10044281651
-
Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
-
Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA. Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 2004;110:3512-7.
-
(2004)
Circulation
, vol.110
, pp. 3512-3517
-
-
Taylor, A.J.1
Sullenberger, L.E.2
Lee, H.J.3
Lee, J.K.4
Grace, K.A.5
-
22
-
-
77953121328
-
The ARBITER 6-HALTS Trial (Arterial biology for the investigation of the treatment effects of reducing cholesterol 6-HDL and LDL treatment strategies in atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration
-
Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6-HALTS Trial (Arterial biology for the investigation of the treatment effects of reducing cholesterol 6-HDL and LDL treatment strategies in atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration. J Am Coll Cardiol. 2010;55:2721-6.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2721-2726
-
-
Villines, T.C.1
Stanek, E.J.2
Devine, P.J.3
-
23
-
-
77951928738
-
Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease
-
Duggal JK, Singh M, Attri N, et al. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease. J Cardiovasc Pharmacol Ther. 2010;15:158-66.
-
(2010)
J Cardiovasc Pharmacol Ther
, vol.15
, pp. 158-166
-
-
Duggal, J.K.1
Singh, M.2
Attri, N.3
-
24
-
-
77952397461
-
Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
-
Bruckert E, Labreuche J, Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010;210:353-61.
-
(2010)
Atherosclerosis
, vol.210
, pp. 353-361
-
-
Bruckert, E.1
Labreuche, J.2
Amarenco, P.3
-
25
-
-
84864277677
-
Search and rescue for hypotheses surviving AIMHIGH, the niacin therapy earthquake: Still problematic after the primary publication
-
Brinton EA. Search and rescue for hypotheses surviving AIMHIGH, the niacin therapy earthquake: still problematic after the primary publication. J Clin Lipidol. 2012;6:312-7.
-
(2012)
J Clin Lipidol
, vol.6
, pp. 312-317
-
-
Brinton, E.A.1
-
26
-
-
84856217997
-
-
National Heart, Lung, and Blood Institute; Abbott. National Library of Medicine. Accessed 11 Sept 2012
-
National Heart, Lung, and Blood Institute; Abbott. Niacin plus statin to prevent vascular events. In: ClinicalTrials.gov. National Library of Medicine. 2011. http://www.clinicaltrials.gov/ct2/show/NCT00120289. Accessed 11 Sept 2012.
-
(2011)
Niacin Plus Statin to Prevent Vascular Events
-
-
-
27
-
-
84870542306
-
-
University of Oxford; Merck. National Library of Medicine. Accessed 11 Sept 2012
-
University of Oxford; Merck. Treatment of HDL to reduce the incidence of vascular events HPS2-THRIVE. In: ClinicalTrials.gov. National Library of Medicine. 2010. http://www.clinicaltrials.gov/ct2/show/NCT00461630. Accessed 11 Sept 2012.
-
(2010)
Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE
-
-
-
28
-
-
53049099629
-
Cholesteryl ester transfer protein (CETP) inhibitors: Is there life after torcetrapib?
-
Neeli H, Rader DJ. Cholesteryl ester transfer protein (CETP) inhibitors: is there life after torcetrapib? Cardiol Clin. 2008;26: 537-46.
-
(2008)
Cardiol Clin
, vol.26
, pp. 537-546
-
-
Neeli, H.1
Rader, D.J.2
-
29
-
-
1842815777
-
Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
-
Brousseau ME, Schaefer EJ, Wolfe ML, et al. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004;350:1505-15.
-
(2004)
N Engl J Med
, vol.350
, pp. 1505-1515
-
-
Brousseau, M.E.1
Schaefer, E.J.2
Wolfe, M.L.3
-
30
-
-
36348975228
-
Effects of torcetrapib in patients at high risk for coronary events
-
Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109-22.
-
(2007)
N Engl J Med
, vol.357
, pp. 2109-2122
-
-
Barter, P.J.1
Caulfield, M.2
Eriksson, M.3
-
31
-
-
36349016109
-
Illuminating HDL-is it still a viable therapeutic target?
-
Rader DJ. Illuminating HDL-is it still a viable therapeutic target? N Engl J Med. 2007;357:2180-3.
-
(2007)
N Engl J Med
, vol.357
, pp. 2180-2183
-
-
Rader, D.J.1
-
32
-
-
71749117559
-
Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial
-
Barter P. Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. Am J Cardiol. 2009;104(10 Suppl):10E-5E.
-
(2009)
Am J Cardiol
, vol.104
, Issue.10 SUPPL.
-
-
Barter, P.1
-
33
-
-
0037035459
-
Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomized phase II dose-response study
-
de Grooth GJ, Kuivenhoven JA, Stalenhoef AF, et al. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study. Circulation. 2002;105(18):2159-65.
-
(2002)
Circulation
, vol.105
, Issue.18
, pp. 2159-2165
-
-
De Grooth, G.J.1
Kuivenhoven, J.A.2
Stalenhoef, A.F.3
-
34
-
-
17444372760
-
Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
-
Kuivenhoven JA, de Grooth GJ, Kawamura H, et al. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol. 2005;95(9):1085-8.
-
(2005)
Am J Cardiol
, vol.95
, Issue.9
, pp. 1085-1088
-
-
Kuivenhoven, J.A.1
De Grooth, G.J.2
Kawamura, H.3
-
35
-
-
77249100745
-
Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from a 48-week trial
-
Stein EA, Roth EM, Rhyne JM, Burgess T, Kallend D, Robinson JG. Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial. Eur Heart J. 2010;31:480-8.
-
(2010)
Eur Heart J
, vol.31
, pp. 480-488
-
-
Stein, E.A.1
Roth, E.M.2
Rhyne, J.M.3
Burgess, T.4
Kallend, D.5
Robinson, J.G.6
-
36
-
-
80255122648
-
Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomized clinical trial
-
Fayad ZA, Mani V, Woodward M, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomized clinical trial. Lancet. 2011;378:1547-59.
-
(2011)
Lancet
, vol.378
, pp. 1547-1559
-
-
Fayad, Z.A.1
Mani, V.2
Woodward, M.3
-
37
-
-
84859517252
-
Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: The dal-VESSEL randomized clinical trial
-
Luscher TF, Taddei S, Kaski JC, et al. Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial. Eur Heart J. 2012;33:857-65.
-
(2012)
Eur Heart J
, vol.33
, pp. 857-865
-
-
Luscher, T.F.1
Taddei, S.2
Kaski, J.C.3
-
38
-
-
77956513064
-
Biochemical characterization of cholesteryl ester transfer protein inhibitors
-
Ranalletta M, Bierilo KK, Chen Y, et al. Biochemical characterization of cholesteryl ester transfer protein inhibitors. J Lipid Res. 2010;51:2739-52.
-
(2010)
J Lipid Res
, vol.51
, pp. 2739-2752
-
-
Ranalletta, M.1
Bierilo, K.K.2
Chen, Y.3
-
39
-
-
36549078679
-
Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: 2 double-blind, randomized placebocontrolled phase i studies
-
Krishna R, Anderson MS, Bergman AJ, et al. Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: 2 double-blind, randomized placebocontrolled phase I studies. Lancet. 2007;370:1907-14.
-
(2007)
Lancet
, vol.370
, pp. 1907-1914
-
-
Krishna, R.1
Anderson, M.S.2
Bergman, A.J.3
-
40
-
-
58649091088
-
Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
-
Bloomfield D, Carlson GL, Sapre A, et al. Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients. Am Heart J. 2009;157(e352):352-60.
-
(2009)
Am Heart J
, vol.157
, Issue.E352
, pp. 352-360
-
-
Bloomfield, D.1
Carlson, G.L.2
Sapre, A.3
-
41
-
-
80053620685
-
Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia
-
Dansky HM, Bloomfield D, Gibbons P, et al. Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia. Am Heart J. 2011;162:708-16.
-
(2011)
Am Heart J
, vol.162
, pp. 708-716
-
-
Dansky, H.M.1
Bloomfield, D.2
Gibbons, P.3
-
42
-
-
84863232685
-
Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib
-
Krauss RM, Wojnooski K, Orr J, et al. Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib. J Lipid Res. 2012;53:540-7.
-
(2012)
J Lipid Res
, vol.53
, pp. 540-547
-
-
Krauss, R.M.1
Wojnooski, K.2
Orr, J.3
-
43
-
-
77953961808
-
Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
-
Yvan-Charvet L, Kling J, Pagler T, et al. Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler Thromb Vasc Biol. 2010;30:1430-8.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 1430-1438
-
-
Yvan-Charvet, L.1
Kling, J.2
Pagler, T.3
-
44
-
-
80054094687
-
Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters
-
Castro-Perez J, Briand F, Gagen K, et al. Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters. J Lipid Res. 2011;52:1965-73.
-
(2011)
J Lipid Res
, vol.52
, pp. 1965-1973
-
-
Castro-Perez, J.1
Briand, F.2
Gagen, K.3
-
45
-
-
70349213361
-
Design of the DEFINE trial: Determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib
-
Cannon CP, Dansky HM, Davidson M, et al. Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib. Am Heart J. 2009;158(e513):513-19.
-
(2009)
Am Heart J
, vol.158
, Issue.E513
, pp. 513-519
-
-
Cannon, C.P.1
Dansky, H.M.2
Davidson, M.3
-
46
-
-
78549235583
-
Safety of anacetrapib in patients with or at high risk for coronary heart disease
-
Cannon CP, Shah S, Dansky HM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Eng J Med. 2010;363:2406-15.
-
(2010)
N Eng J Med
, vol.363
, pp. 2406-2415
-
-
Cannon, C.P.1
Shah, S.2
Dansky, H.M.3
-
47
-
-
81255125373
-
Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: A randomized controlled trial
-
Nicholls SJ, Brewer HB, Kastelein JJ, et al. Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial. JAMA:J Am Med Assoc. 2011;306:2099-109.
-
(2011)
JAMA: J Am Med Assoc
, vol.306
, pp. 2099-2109
-
-
Nicholls, S.J.1
Brewer, H.B.2
Kastelein, J.J.3
-
49
-
-
0242577955
-
Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
-
Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA. 2003;290:2292-300.
-
(2003)
JAMA
, vol.290
, pp. 2292-2300
-
-
Nissen, S.E.1
Tsunoda, T.2
Tuzcu, E.M.3
-
50
-
-
10744225301
-
Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: A randomized controlled trial
-
Nissen SE, Tuzcu EM, Schoenhagen P, et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA. 2004;291(9):1071-80.
-
(2004)
JAMA
, vol.291
, Issue.9
, pp. 1071-1080
-
-
Nissen, S.E.1
Tuzcu, E.M.2
Schoenhagen, P.3
-
51
-
-
34247397359
-
Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: A randomized controlled trial
-
Tardif JC, Gregoire J, L'Allier PL, et al. Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial. JAMA. 2007;297:1675-82.
-
(2007)
JAMA
, vol.297
, pp. 1675-1682
-
-
Tardif, J.C.1
Gregoire, J.2
L'Allier, P.L.3
-
52
-
-
77953107241
-
A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome
-
Waksman R, Torguson R, Kent KM, et al. A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome. J Am Coll Cardiol. 2010;55:2727-35.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2727-2735
-
-
Waksman, R.1
Torguson, R.2
Kent, K.M.3
-
53
-
-
0029801069
-
Production and characterization of a reconstituted high density lipoprotein for therapeutic applications
-
Lerch PG, Fortsch V, Hodler G, Bolli R. Production and characterization of a reconstituted high density lipoprotein for therapeutic applications. Vox Sang. 1996;71:155-64.
-
(1996)
Vox Sang
, vol.71
, pp. 155-164
-
-
Lerch, P.G.1
Fortsch, V.2
Hodler, G.3
Bolli, R.4
-
54
-
-
58149153296
-
Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque
-
Shaw JA, Bobik A, Murphy A, et al. Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque. Circ Res. 2008;103:1084-91.
-
(2008)
Circ Res
, vol.103
, pp. 1084-1091
-
-
Shaw, J.A.1
Bobik, A.2
Murphy, A.3
-
55
-
-
61549099027
-
Reconstituted high-density lipoprotein increases plasma high-density lipoprotein antiinflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes
-
Patel S, Drew BG, Nakhla S, et al. Reconstituted high-density lipoprotein increases plasma high-density lipoprotein antiinflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes. J Am Coll Cardiol. 2009;53:962-71.
-
(2009)
J Am Coll Cardiol
, vol.53
, pp. 962-971
-
-
Patel, S.1
Drew, B.G.2
Nakhla, S.3
-
56
-
-
73449107142
-
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux
-
Calkin AC, Drew BG, Ono A, et al. Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation. 2009;120:2095-104.
-
(2009)
Circulation
, vol.120
, pp. 2095-2104
-
-
Calkin, A.C.1
Drew, B.G.2
Ono, A.3
-
58
-
-
0022272843
-
A-IMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission
-
Gualandri V, Franceschini G, Sirtori CR, et al. A-IMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission. Am J Hum Genet. 1985;37:1083-97.
-
(1985)
Am J Hum Genet
, vol.37
, pp. 1083-1097
-
-
Gualandri, V.1
Franceschini, G.2
Sirtori, C.R.3
-
59
-
-
0035901577
-
Cardiovascular status of carriers of the apolipoprotein A-I Milano mutant: The Limone sul Garda study
-
Sirtori CR, Calabresi L, Franceschini G, et al. Cardiovascular status of carriers of the apolipoprotein A-I Milano mutant: the Limone sul Garda study. Circulation. 2001;103:1949-54.
-
(2001)
Circulation
, vol.103
, pp. 1949-1954
-
-
Sirtori, C.R.1
Calabresi, L.2
Franceschini, G.3
-
60
-
-
0027994776
-
Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits
-
Ameli S, Hultgardh-Nilsson A, Cercek B, et al. Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits. Circulation. 1994;90:1935-41.
-
(1994)
Circulation
, vol.90
, pp. 1935-1941
-
-
Ameli, S.1
Hultgardh-Nilsson, A.2
Cercek, B.3
-
61
-
-
0032478183
-
Effects of recombinant apolipoprotein A-I Milano on aortic atherosclerosis in apolipoprotein Edeficient mice
-
Shah PK, Nilsson J, Kaul S, et al. Effects of recombinant apolipoprotein A-I Milano on aortic atherosclerosis in apolipoprotein Edeficient mice. Circulation. 1998;97:780-5.
-
(1998)
Circulation
, vol.97
, pp. 780-785
-
-
Shah, P.K.1
Nilsson, J.2
Kaul, S.3
-
62
-
-
0035954267
-
High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein edeficient mice. Potential implications for acute plaque stabilization
-
Shah PK, Yano J, Reyes O, et al. High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein edeficient mice. Potential implications for acute plaque stabilization. Circulation. 2001;103:3047-50.
-
(2001)
Circulation
, vol.103
, pp. 3047-3050
-
-
Shah, P.K.1
Yano, J.2
Reyes, O.3
-
63
-
-
40649126377
-
Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: In vivo assessment by intravascular ultrasound and magnetic resonance imaging
-
Parolini C, Marchesi M, Lorenzon P, et al. Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo assessment by intravascular ultrasound and magnetic resonance imaging. J Am Coll Cardiol. 2008;51:1098-103.
-
(2008)
J Am Coll Cardiol
, vol.51
, pp. 1098-1103
-
-
Parolini, C.1
Marchesi, M.2
Lorenzon, P.3
-
64
-
-
34548179364
-
Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux
-
Weibel GL, Alexander ET, Joshi MR, et al. Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux. Arterioscler Thromb Vasc Biol. 2007;27:2022-9.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 2022-2029
-
-
Weibel, G.L.1
Alexander, E.T.2
Joshi, M.R.3
-
65
-
-
34249082855
-
Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent
-
Lebherz C, Sanmiguel J, Wilson JM, Rader DJ. Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent. Cardiovasc Diabetol. 2007;6:15.
-
(2007)
Cardiovasc Diabetol
, vol.6
, pp. 15
-
-
Lebherz, C.1
Sanmiguel, J.2
Wilson, J.M.3
Rader, D.J.4
-
66
-
-
27644454206
-
Apolipoprotein A-I and the molecular variant apoA-I Milano: Evaluation of the antiatherogenic effects in knock-in mouse model
-
Parolini C, Chiesa G, Gong E, et al. Apolipoprotein A-I and the molecular variant apoA-I Milano: evaluation of the antiatherogenic effects in knock-in mouse model. Atherosclerosis. 2005;183:222-9.
-
(2005)
Atherosclerosis
, vol.183
, pp. 222-229
-
-
Parolini, C.1
Chiesa, G.2
Gong, E.3
-
67
-
-
70349579203
-
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano
-
Alexander ET, Weibel GL, Joshi MR, et al. Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arterioscler Thromb Vasc Biol. 2009;29:1496-501.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1496-1501
-
-
Alexander, E.T.1
Weibel, G.L.2
Joshi, M.R.3
-
68
-
-
67649675003
-
Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo
-
Sacks FM, Rudel LL, Conner A, et al. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo. J Lipid Res. 2009;50:894-907.
-
(2009)
J Lipid Res
, vol.50
, pp. 894-907
-
-
Sacks, F.M.1
Rudel, L.L.2
Conner, A.3
-
69
-
-
77952713824
-
RVX-208: A small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo
-
Bailey D, Jahagirdar R, Gordon A, et al. RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo. J Am Coll Cardiol. 2010;55:2580-9.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2580-2589
-
-
Bailey, D.1
Jahagirdar, R.2
Gordon, A.3
-
70
-
-
79952005101
-
Efficacy and safety of a novel oral inducer of apolipoprotein A-I synthesis in statintreated patients with stable coronary artery disease a randomized controlled trial
-
Nicholls SJ, Gordon A, Johansson J, et al. Efficacy and safety of a novel oral inducer of apolipoprotein A-I synthesis in statintreated patients with stable coronary artery disease a randomized controlled trial. J Am Coll Cardiol. 2011;57:1111-9.
-
(2011)
J Am Coll Cardiol
, vol.57
, pp. 1111-1119
-
-
Nicholls, S.J.1
Gordon, A.2
Johansson, J.3
-
71
-
-
84870493144
-
-
Resverlogix Corp; The Cleveland Clinic. National Library of Medicine. Accessed 11 Sept 2012
-
Resverlogix Corp; The Cleveland Clinic. The study of quantitative serial trends in lipids with apolipoprotein A-I stimulation (SUSTAIN). In: ClinicalTrials.gov. National Library of Medicine. 2012. http://www. clinicaltrials.gov/ct2/show/NCT01423188. Accessed 11 Sept 2012.
-
(2012)
The Study of Quantitative Serial Trends in Lipids with Apolipoprotein A-I Stimulation (SUSTAIN)
-
-
-
73
-
-
26244463785
-
Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
-
Rigamonti E, Helin L, Lestavel S, et al. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res. 2005;97:682-9.
-
(2005)
Circ Res
, vol.97
, pp. 682-689
-
-
Rigamonti, E.1
Helin, L.2
Lestavel, S.3
-
74
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000;275:28240-5.
-
(2000)
J Biol Chem
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
75
-
-
33645502340
-
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
-
Brunham LR, Kruit JK, Iqbal J, et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest. 2006;116:1052-62.
-
(2006)
J Clin Invest
, vol.116
, pp. 1052-1062
-
-
Brunham, L.R.1
Kruit, J.K.2
Iqbal, J.3
-
76
-
-
77950605567
-
Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model
-
Briand F, Treguier M, Andre A, et al. Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. J Lipid Res. 2010;51:763-70.
-
(2010)
J Lipid Res
, vol.51
, pp. 763-770
-
-
Briand, F.1
Treguier, M.2
Andre, A.3
-
77
-
-
84856199142
-
Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: A magnetic resonance imaging study in a model of advanced atherosclerosis
-
Giannarelli C, Cimmino G, Connolly TM, et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: a magnetic resonance imaging study in a model of advanced atherosclerosis. Eur Heart J. 2012;33:264-73.
-
(2012)
Eur Heart J
, vol.33
, pp. 264-273
-
-
Giannarelli, C.1
Cimmino, G.2
Connolly, T.M.3
-
78
-
-
0037072732
-
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
-
Grefhorst A, Elzinga BM, Voshol PJ, et al. Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem. 2002;277:34182-90.
-
(2002)
J Biol Chem
, vol.277
, pp. 34182-34190
-
-
Grefhorst, A.1
Elzinga, B.M.2
Voshol, P.J.3
-
79
-
-
30444447387
-
Different roles of liver X receptor alpha and beta in lipid metabolism: Effects of an alphaselective and a dual agonist in mice deficient in each subtype
-
Lund EG, Peterson LB, Adams AD, et al. Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alphaselective and a dual agonist in mice deficient in each subtype. Biochem Pharmacol. 2006;71:453-63.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 453-463
-
-
Lund, E.G.1
Peterson, L.B.2
Adams, A.D.3
-
80
-
-
84860548049
-
Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
-
Zhang Y, Breevoort SR, Angdisen J, et al. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest. 2012; 122:1688-99.
-
(2012)
J Clin Invest
, vol.122
, pp. 1688-1699
-
-
Zhang, Y.1
Breevoort, S.R.2
Angdisen, J.3
-
81
-
-
79952378989
-
Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels
-
van der Hoorn J, Linden D, Lindahl U, et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011;162:1553-63.
-
(2011)
Br J Pharmacol
, vol.162
, pp. 1553-1563
-
-
Van Der Hoorn, J.1
Linden, D.2
Lindahl, U.3
-
82
-
-
77950911589
-
Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo
-
Yasuda T, Grillot D, Billheimer JT, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010;30:781-6.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 781-786
-
-
Yasuda, T.1
Grillot, D.2
Billheimer, J.T.3
-
83
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215-33.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
84
-
-
77953787211
-
MiR-33 contributes to the regulation of cholesterol homeostasis
-
Rayner KJ, Suarez Y, Davalos A, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570-3.
-
(2010)
Science
, vol.328
, pp. 1570-1573
-
-
Rayner, K.J.1
Suarez, Y.2
Davalos, A.3
-
85
-
-
79960015327
-
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
-
Rayner KJ, Sheedy FJ, Esau CC, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 2011;121:2921-31.
-
(2011)
J Clin Invest
, vol.121
, pp. 2921-2931
-
-
Rayner, K.J.1
Sheedy, F.J.2
Esau, C.C.3
-
86
-
-
80054971110
-
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
-
Rayner KJ, Esau CC, Hussain FN, et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011;478:404-7.
-
(2011)
Nature
, vol.478
, pp. 404-407
-
-
Rayner, K.J.1
Esau, C.C.2
Hussain, F.N.3
|