-
1
-
-
78449281377
-
Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170, 000 participants in 26 randomised trials
-
Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, Peto R, Barnes EH, Keech A, Simes J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170, 000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670-81.
-
(2010)
Lancet.
, vol.376
, Issue.9753
, pp. 1670-1681
-
-
Baigent, C.1
Blackwell, L.2
Emberson, J.3
Holland, L.E.4
Reith, C.5
Bhala, N.6
Peto, R.7
Barnes, E.H.8
Keech, A.9
Simes, J.10
-
2
-
-
27744522317
-
The forgotten majority: Unfinished business in cardiovascular risk reduction
-
Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction. J Am Coll Cardiol. 2005;46(7):1225-8.
-
(2005)
J Am Coll Cardiol.
, vol.46
, Issue.7
, pp. 1225-1228
-
-
Libby, P.1
-
3
-
-
0024501678
-
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies
-
Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs Jr DR, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989;79(1):8-15.
-
(1989)
Circulation.
, vol.79
, Issue.1
, pp. 8-15
-
-
Gordon, D.J.1
Probstfield, J.L.2
Garrison, R.J.3
Neaton, J.D.4
Castelli, W.P.5
Knoke, J.D.6
Jacobs Jr., D.R.7
Bangdiwala, S.8
Tyroler, H.A.9
-
4
-
-
0024449985
-
High-density lipoprotein - The clinical implications of recent studies
-
Gordon DJ, Rifkind BM. High-density lipoprotein-the clinical implications of recent studies. N Engl J Med. 1989;321(19):1311-6.
-
(1989)
N Engl J Med.
, vol.321
, Issue.19
, pp. 1311-1316
-
-
Gordon, D.J.1
Rifkind, B.M.2
-
5
-
-
0017384270
-
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
-
Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977;62(5):707-14.
-
(1977)
Am J Med.
, vol.62
, Issue.5
, pp. 707-714
-
-
Gordon, T.1
Castelli, W.P.2
Hjortland, M.C.3
Kannel, W.B.4
Dawber, T.R.5
-
6
-
-
34748887666
-
HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
-
Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, Kastelein JJ, Bittner V, Fruchart JC. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007;357(13):1301-10.
-
(2007)
N Engl J Med.
, vol.357
, Issue.13
, pp. 1301-1310
-
-
Barter, P.1
Gotto, A.M.2
LaRosa, J.C.3
Maroni, J.4
Szarek, M.5
Grundy, S.M.6
Kastelein, J.J.7
Bittner, V.8
Fruchart, J.C.9
-
7
-
-
0025322265
-
Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
-
Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest. 1990;85:1234-41.
-
(1990)
J Clin Invest.
, vol.85
, pp. 1234-1241
-
-
Badimon, J.J.1
Badimon, L.2
Fuster, V.3
-
8
-
-
0024550898
-
High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits
-
Badimon JJ, Badimon L, Galvez A, Dische R, Fuster V. High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits. Lab Invest. 1989;60(3):455-61.
-
(1989)
Lab Invest.
, vol.60
, Issue.3
, pp. 455-461
-
-
Badimon, J.J.1
Badimon, L.2
Galvez, A.3
Dische, R.4
Fuster, V.5
-
9
-
-
27644535714
-
Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits
-
Nicholls SJ, Cutri B, Worthley SG, Kee P, Rye KA, Bao S, Barter PJ. Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 2005;25(11):2416-21.
-
(2005)
Arterioscler Thromb Vasc Biol.
, vol.25
, Issue.11
, pp. 2416-2421
-
-
Nicholls, S.J.1
Cutri, B.2
Worthley, S.G.3
Kee, P.4
Rye, K.A.5
Bao, S.6
Barter, P.J.7
-
10
-
-
0028025262
-
Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse
-
Plump AS, Scott CJ, Breslow JL. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci (USA). 1994;91:9607-11.
-
(1994)
Proc Natl Acad Sci (USA).
, vol.91
, pp. 9607-9611
-
-
Plump, A.S.1
Scott, C.J.2
Breslow, J.L.3
-
11
-
-
0025902231
-
Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
-
Rubin EM, Krauss RM, Spangler EA, Verstuyft JG, Clift SM. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature. 1991;353:265-7.
-
(1991)
Nature.
, vol.353
, pp. 265-267
-
-
Rubin, E.M.1
Krauss, R.M.2
Spangler, E.A.3
Verstuyft, J.G.4
Clift, S.M.5
-
12
-
-
0035856550
-
Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content
-
Rong JX, Li J, Reis ED, Choudhury RP, Dansky HM, Elmalem VI, Fallon JT, Breslow JL, Fisher EA. Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation. 2001;104:2447-52.
-
(2001)
Circulation.
, vol.104
, pp. 2447-2452
-
-
Rong, J.X.1
Li, J.2
Reis, E.D.3
Choudhury, R.P.4
Dansky, H.M.5
Elmalem, V.I.6
Fallon, J.T.7
Breslow, J.L.8
Fisher, E.A.9
-
13
-
-
0035954267
-
High-dose recombinant apolipoprotein A-IMilano mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein E-deficient mice
-
Shah PK, Yano J, Reyes O, Chyu K-Y, Kaul S, Bisgaier CL, Drake S, Cercek B. High-dose recombinant apolipoprotein A-IMilano mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein E-deficient mice. Circulation. 2001;103:3047-50.
-
(2001)
Circulation.
, vol.103
, pp. 3047-3050
-
-
Shah, P.K.1
Yano, J.2
Reyes, O.3
Chyu, K.-Y.4
Kaul, S.5
Bisgaier, C.L.6
Drake, S.7
Cercek, B.8
-
14
-
-
36048984001
-
HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease
-
Brewer Jr HB. HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease. Curr Cardiol Rep. 2007;9(6):486-92.
-
(2007)
Curr Cardiol Rep.
, vol.9
, Issue.6
, pp. 486-492
-
-
Brewer Jr., H.B.1
-
15
-
-
6344253356
-
Antiinflammatory properties of HDL
-
Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, Fogelman AM. Antiinflammatory properties of HDL. Circ Res. 2004;95(8):764-72.
-
(2004)
Circ Res.
, vol.95
, Issue.8
, pp. 764-772
-
-
Barter, P.J.1
Nicholls, S.2
Rye, K.A.3
Anantharamaiah, G.M.4
Navab, M.5
Fogelman, A.M.6
-
16
-
-
0037038239
-
Effects of the amount and intensity of exercise on plasma lipoproteins
-
Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med. 2002;347(19):1483- 92.
-
(2002)
N Engl J Med.
, vol.347
, Issue.19
, pp. 1483-1492
-
-
Kraus, W.E.1
Houmard, J.A.2
Duscha, B.D.3
Knetzger, K.J.4
Wharton, M.B.5
McCartney, J.S.6
Bales, C.W.7
Henes, S.8
Samsa, G.P.9
Otvos, J.D.10
-
17
-
-
33846863146
-
Statins, highdensity lipoprotein cholesterol, and regression of coronary atherosclerosis
-
Nicholls SJ, Tuzcu EM, Sipahi I, Grasso AW, Schoenhagen P, Hu T, Wolski K, Crowe T, Desai MY, Hazen SL, et al. Statins, highdensity lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA. 2007;297(5):499-508.
-
(2007)
JAMA
, vol.297
, Issue.5
, pp. 499-508
-
-
Nicholls, S.J.1
Tuzcu, E.M.2
Sipahi, I.3
Grasso, A.W.4
Schoenhagen, P.5
Hu, T.6
Wolski, K.7
Crowe, T.8
Desai, M.Y.9
Hazen, S.L.10
-
18
-
-
69649099195
-
Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the air force/texas coronary atherosclerosis prevention study)
-
Cui Y, Watson DJ, Girman CJ, Shapiro DR, Gotto AM, Hiserote P, Clearfield MB. Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study). Am J Cardiol. 2009;104(6):829-34.
-
(2009)
Am J Cardiol.
, vol.104
, Issue.6
, pp. 829-834
-
-
Cui, Y.1
Watson, D.J.2
Girman, C.J.3
Shapiro, D.R.4
Gotto, A.M.5
Hiserote, P.6
Clearfield, M.B.7
-
19
-
-
2542497645
-
Effect of atorvastatin on high density lipoprotein cholesterol and its relationship with coronary events: A subgroup analysis of the GREek atorvastatin and coronary-heart-disease evaluation (GREACE) Study
-
Athyros VG, Mikhailidis DP, Papageorgiou AA, Symeonidis AN, Mercouris BR, Pehlivanidis A, Bouloukos VI, Elisaf M. Effect of atorvastatin on high density lipoprotein cholesterol and its relationship with coronary events: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study. Curr Med Res Opin. 2004;20(5):627-37.
-
(2004)
Curr Med Res Opin.
, vol.20
, Issue.5
, pp. 627-637
-
-
Athyros, V.G.1
Mikhailidis, D.P.2
Papageorgiou, A.A.3
Symeonidis, A.N.4
Mercouris, B.R.5
Pehlivanidis, A.6
Bouloukos, V.I.7
Elisaf, M.8
-
20
-
-
77952708442
-
Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
-
Jun. M, Foote C, Lv J, Neal B, Patel A, Nicholls SJ, Grobbee DE, Cass A, Chalmers J, Perkovic V. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 375(9729):1875-84.
-
Lancet.
, vol.375
, Issue.9729
, pp. 1875-1884
-
-
Jun, M.1
Foote, C.2
Lv, J.3
Neal, B.4
Patel, A.5
Nicholls, S.J.6
Grobbee, D.E.7
Cass, A.8
Chalmers, J.9
Perkovic, V.10
-
21
-
-
0023001772
-
Fifteen year mortality in coronary drug project patients: Long-term benefit with niacin
-
Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ, Friedewald W. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8(6):1245-55.
-
(1986)
J Am Coll Cardiol.
, vol.8
, Issue.6
, pp. 1245-1255
-
-
Canner, P.L.1
Berge, K.G.2
Wenger, N.K.3
Stamler, J.4
Friedman, L.5
Prineas, R.J.6
Friedewald, W.7
-
22
-
-
0035969564
-
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
-
Brown BG, Zhao X-Q, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583-92.
-
(2001)
N Engl J Med.
, vol.345
, pp. 1583-1592
-
-
Brown, B.G.1
Zhao, X.-Q.2
Chait, A.3
Fisher, L.D.4
Cheung, M.C.5
Morse, J.S.6
Dowdy, A.A.7
Marino, E.K.8
Bolson, E.L.9
Alaupovic, P.10
-
23
-
-
10044281651
-
Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
-
Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 2004;110(23):3512-7.
-
(2004)
Circulation.
, vol.110
, Issue.23
, pp. 3512-3517
-
-
Taylor, A.J.1
Sullenberger, L.E.2
Lee, H.J.3
Lee, J.K.4
Grace, K.A.5
-
24
-
-
72049129430
-
Extended-release niacin or ezetimibe and carotid intima-media thickness
-
Taylor AJ, Villines TC, Stanek EJ, Devine PJ, Griffen L, Miller M, Weissman NJ, Turco M. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med. 2009;361(22):2113-22.
-
(2009)
N Engl J Med.
, vol.361
, Issue.22
, pp. 2113-2122
-
-
Taylor, A.J.1
Villines, T.C.2
Stanek, E.J.3
Devine, P.J.4
Griffen, L.5
Miller, M.6
Weissman, N.J.7
Turco, M.8
-
25
-
-
84855171302
-
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
-
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011.
-
(2011)
N Engl J Med.
-
-
-
26
-
-
0242577955
-
Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
-
Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA. 2003;290(17):2292-300.
-
(2003)
JAMA
, vol.290
, Issue.17
, pp. 2292-2300
-
-
Nissen, S.E.1
Tsunoda, T.2
Tuzcu, E.M.3
Schoenhagen, P.4
Cooper, C.J.5
Yasin, M.6
Eaton, G.M.7
Lauer, M.A.8
Sheldon, W.S.9
Grines, C.L.10
-
27
-
-
34247397359
-
Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: A randomized controlled trial
-
Tardif JC, Gregoire J, L'Allier PL, Ibrahim R, Lesperance J, Heinonen TM, Kouz S, Berry C, Basser R, Lavoie MA, et al. Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial. JAMA. 2007;297(15):1675-82.
-
(2007)
JAMA
, vol.297
, Issue.15
, pp. 1675-1682
-
-
Tardif, J.C.1
Gregoire, J.2
L'Allier, P.L.3
Ibrahim, R.4
Lesperance, J.5
Heinonen, T.M.6
Kouz, S.7
Berry, C.8
Basser, R.9
Lavoie, M.A.10
-
28
-
-
77953107241
-
A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome
-
Waksman R, Torguson R, Kent KM, Pichard AD, Suddath WO, Satler LF, Martin BD, Perlman TJ, Maltais JA, Weissman NJ, et al. A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome. J Am Coll Cardiol. 2010;55(24):2727-35.
-
(2010)
J Am Coll Cardiol.
, vol.55
, Issue.24
, pp. 2727-2735
-
-
Waksman, R.1
Torguson, R.2
Kent, K.M.3
Pichard, A.D.4
Suddath, W.O.5
Satler, L.F.6
Martin, B.D.7
Perlman, T.J.8
Maltais, J.A.9
Weissman, N.J.10
-
30
-
-
0037327033
-
Cholesteryl ester transfer protein. A novel target for raising HDL and inhibiting atherosclerosis
-
Barter PJ, Chapman MJ, Hennekens CH, Rader DJ, Tall AR. Cholesteryl ester transfer protein. A novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:160-7.
-
(2003)
Arterioscler Thromb Vasc Biol.
, vol.23
, pp. 160-167
-
-
Barter, P.J.1
Chapman, M.J.2
Hennekens, C.H.3
Rader, D.J.4
Tall, A.R.5
-
31
-
-
73349122606
-
Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community
-
Vasan RS, Pencina MJ, Robins SJ, Zachariah JP, Kaur G, D'Agostino RB, Ordovas JM. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation. 2009;120(24):2414-20.
-
(2009)
Circulation.
, vol.120
, Issue.24
, pp. 2414-2420
-
-
Vasan, R.S.1
Pencina, M.J.2
Robins, S.J.3
Zachariah, J.P.4
Kaur, G.5
D'Agostino, R.B.6
Ordovas, J.M.7
-
32
-
-
76649140069
-
Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: The ludwigshafen risk and cardiovascular health study
-
Ritsch A, Scharnagl H, Eller P, Tancevski I, Duwensee K, Demetz E, Sandhofer A, Boehm BO, Winkelmann BR, Patsch JR, et al. Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study. Circulation. 2010;121(3):366-74.
-
(2010)
Circulation.
, vol.121
, Issue.3
, pp. 366-374
-
-
Ritsch, A.1
Scharnagl, H.2
Eller, P.3
Tancevski, I.4
Duwensee, K.5
Demetz, E.6
Sandhofer, A.7
Boehm, B.O.8
Winkelmann, B.R.9
Patsch, J.R.10
-
33
-
-
4544230882
-
Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: The prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study
-
Boekholdt SM, Kuivenhoven JA, Wareham NJ, Peters RJ, Jukema JW, Luben R, Bingham SA, Day NE, Kastelein JJ, Khaw KT. Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study. Circulation. 2004;110(11):1418-23.
-
(2004)
Circulation.
, vol.110
, Issue.11
, pp. 1418-1423
-
-
Boekholdt, S.M.1
Kuivenhoven, J.A.2
Wareham, N.J.3
Peters, R.J.4
Jukema, J.W.5
Luben, R.6
Bingham, S.A.7
Day, N.E.8
Kastelein, J.J.9
Khaw, K.T.10
-
34
-
-
45349105911
-
Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
-
Thompson A, Di Angelantonio E, Sarwar N, Erqou S, Saleheen D, Dullaart RP, Keavney B, Ye Z, Danesh J. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. Jama. 2008;299(23):2777-88.
-
(2008)
Jama.
, vol.299
, Issue.23
, pp. 2777-2788
-
-
Thompson, A.1
Di Angelantonio, E.2
Sarwar, N.3
Erqou, S.4
Saleheen, D.5
Dullaart, R.P.6
Keavney, B.7
Ye, Z.8
Danesh, J.9
-
35
-
-
0032570684
-
Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits
-
Sugano M, Makino N, Sawada S, Otsuka S, Watanabe M, Okamoto H, Kamada M, Mizushima A. Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J Biol Chem. 1998;273(9):5033-6.
-
(1998)
J Biol Chem.
, vol.273
, Issue.9
, pp. 5033-5036
-
-
Sugano, M.1
Makino, N.2
Sawada, S.3
Otsuka, S.4
Watanabe, M.5
Okamoto, H.6
Kamada, M.7
Mizushima, A.8
-
36
-
-
0033822810
-
Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis
-
Rittershaus CW, Miller DP, Thomas LJ, Picard MD, Honan CM, Emmett CD, Pettey CL, Adari H, Hammond RA, Beattie DT, et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20(9):2106-12.
-
(2000)
Arterioscler Thromb Vasc Biol.
, vol.20
, Issue.9
, pp. 2106-2112
-
-
Rittershaus, C.W.1
Miller, D.P.2
Thomas, L.J.3
Picard, M.D.4
Honan, C.M.5
Emmett, C.D.6
Pettey, C.L.7
Adari, H.8
Hammond, R.A.9
Beattie, D.T.10
-
37
-
-
0034644214
-
A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
-
Okamoto H, Yonemori F, Wakitani K, Minowa T, Maeda K, Shinkai H. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature. 2000;406(6792):203-7.
-
(2000)
Nature.
, vol.406
, Issue.6792
, pp. 203-207
-
-
Okamoto, H.1
Yonemori, F.2
Wakitani, K.3
Minowa, T.4
Maeda, K.5
Shinkai, H.6
-
38
-
-
1842815777
-
Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
-
Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004;350(15):1505-15.
-
(2004)
N Engl J Med.
, vol.350
, Issue.15
, pp. 1505-1515
-
-
Brousseau, M.E.1
Schaefer, E.J.2
Wolfe, M.L.3
Bloedon, L.T.4
Digenio, A.G.5
Clark, R.W.6
Mancuso, J.P.7
Rader, D.J.8
-
39
-
-
36348975228
-
Effects of torcetrapib in patients at high risk for coronary events
-
This is a clinical outcomes trial demonstrating adverse clinical events with torcetrapib
-
Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, Lopez-Sendon J, Mosca L, Tardif JC, Waters DD et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357(21):2109-22. This is a clinical outcomes trial demonstrating adverse clinical events with torcetrapib.
-
(2007)
N Engl J Med.
, vol.357
, Issue.21
, pp. 2109-2122
-
-
Barter, P.J.1
Caulfield, M.2
Eriksson, M.3
Grundy, S.M.4
Kastelein, J.J.5
Komajda, M.6
Lopez-Sendon, J.7
Mosca, L.8
Tardif, J.C.9
Waters, D.D.10
-
40
-
-
34447265547
-
Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomised, double-blind trial
-
This is a serial cIMTstudy with torcetrapib
-
Bots ML, Visseren FL, Evans GW, Riley WA, Revkin JH, Tegeler CH, Shear CL, Duggan WT, Vicari RM, Grobbee DE et al. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet. 2007;370(9582):153-60. This is a serial cIMTstudy with torcetrapib.
-
(2007)
Lancet.
, vol.370
, Issue.9582
, pp. 153-160
-
-
Bots, M.L.1
Visseren, F.L.2
Evans, G.W.3
Riley, W.A.4
Revkin, J.H.5
Tegeler, C.H.6
Shear, C.L.7
Duggan, W.T.8
Vicari, R.M.9
Grobbee, D.E.10
-
41
-
-
34247241088
-
Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
-
This is a serial cIMT study with torcetrapib
-
Kastelein JJ, van Leuven SI, Burgess L, Evans GW, Kuivenhoven JA, Barter PJ, Revkin JH, Grobbee DE, Riley WA, Shear CL et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med. 2007;356(16):1620-30. This is a serial cIMT study with torcetrapib.
-
(2007)
N Engl J Med.
, vol.356
, Issue.16
, pp. 1620-1630
-
-
Kastelein, J.J.1
Van Leuven, S.I.2
Burgess, L.3
Evans, G.W.4
Kuivenhoven, J.A.5
Barter, P.J.6
Revkin, J.H.7
Grobbee, D.E.8
Riley, W.A.9
Shear, C.L.10
-
42
-
-
34047106220
-
Effect of torcetrapib on the progression of coronary atherosclerosis
-
This is a serial coronary intravascular ultrasound study with torcetrapib
-
Nissen SE, Tardif JC, Nicholls SJ, Revkin JH, Shear CL, Duggan WT, Ruzyllo W, Bachinsky WB, Lasala GP, Tuzcu EM. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med. 2007;356(13):1304-16. This is a serial coronary intravascular ultrasound study with torcetrapib.
-
(2007)
N Engl J Med.
, vol.356
, Issue.13
, pp. 1304-1316
-
-
Nissen, S.E.1
Tardif, J.C.2
Nicholls, S.J.3
Revkin, J.H.4
Shear, C.L.5
Duggan, W.T.6
Ruzyllo, W.7
Bachinsky, W.B.8
Lasala, G.P.9
Tuzcu, E.M.10
-
43
-
-
33846424247
-
The failure of torcetrapib: Was it the molecule or the mechanism?
-
Tall AR, Yvan-Charvet L, Wang N. The failure of torcetrapib: was it the molecule or the mechanism? Arterioscler Thromb Vasc Biol. 2007;27(2):257-60.
-
(2007)
Arterioscler Thromb Vasc Biol.
, vol.27
, Issue.2
, pp. 257-260
-
-
Tall, A.R.1
Yvan-Charvet, L.2
Wang, N.3
-
44
-
-
58149386896
-
Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: Insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation)
-
Shows slowing of disease progression with increasing HDL-C in torcetrapib patients
-
Nicholls SJ, Tuzcu EM, Brennan DM, Tardif JC, Nissen SE. Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation. 2008;118(24):2506-14. Shows slowing of disease progression with increasing HDL-C in torcetrapib patients.
-
(2008)
Circulation.
, vol.118
, Issue.24
, pp. 2506-2514
-
-
Nicholls, S.J.1
Tuzcu, E.M.2
Brennan, D.M.3
Tardif, J.C.4
Nissen, S.E.5
-
45
-
-
71749117559
-
Lessons learned from the investigation of lipid level management to understand its impact in atherosclerotic events (ILLUMINATE) trial
-
Shows reduced cardiovascular event rates with increasing HDL-C in torcetrapib patients
-
Barter P. Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. Am J Cardiol. 2009;104(10 Suppl):10E-15E. Shows reduced cardiovascular event rates with increasing HDL-C in torcetrapib patients.
-
(2009)
Am J Cardiol.
, vol.104
, Issue.10 SUPPL.
-
-
Barter, P.1
-
46
-
-
71749117374
-
The pharmacology and off-target effects of some cholesterol ester transfer protein inhibitors
-
Shows off-target toxicities of torcetrapib
-
Vergeer M, Stroes ES. The pharmacology and off-target effects of some cholesterol ester transfer protein inhibitors. Am J Cardiol. 2009;104(10 Suppl):32E-38E. Shows off-target toxicities of torcetrapib.
-
(2009)
Am J Cardiol.
, vol.104
, Issue.10 SUPPL.
-
-
Vergeer, M.1
Stroes, E.S.2
-
47
-
-
48149106322
-
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
-
Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, et al. Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol. 2008;154(7):1465-73.
-
(2008)
Br J Pharmacol.
, vol.154
, Issue.7
, pp. 1465-1473
-
-
Forrest, M.J.1
Bloomfield, D.2
Briscoe, R.J.3
Brown, P.N.4
Cumiskey, A.M.5
Ehrhart, J.6
Hershey, J.C.7
Keller, W.J.8
Ma, X.9
McPherson, H.E.10
-
48
-
-
77249100745
-
Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from a 48-week trial
-
Stein EA, Roth EM, Rhyne JM, Burgess T, Kallend D, Robinson JG. Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial. Eur Heart J. 2010;31(4):480-8.
-
(2010)
Eur Heart J.
, vol.31
, Issue.4
, pp. 480-488
-
-
Stein, E.A.1
Roth, E.M.2
Rhyne, J.M.3
Burgess, T.4
Kallend, D.5
Robinson, J.G.6
-
49
-
-
67649304458
-
Safety and tolerability of dalcetrapib
-
Stein EA, Stroes ES, Steiner G, Buckley BM, Capponi AM, Burgess T, Niesor EJ, Kallend D, Kastelein JJ. Safety and tolerability of dalcetrapib. Am J Cardiol. 2009;104(1):82-91.
-
(2009)
Am J Cardiol.
, vol.104
, Issue.1
, pp. 82-91
-
-
Stein, E.A.1
Stroes, E.S.2
Steiner, G.3
Buckley, B.M.4
Capponi, A.M.5
Burgess, T.6
Niesor, E.J.7
Kallend, D.8
Kastelein, J.J.9
-
50
-
-
84861097804
-
-
http://www.escardio.org/congresses/esc-2011/congress-reports/Pages/ 706-3-dal-VESSEL.aspx
-
http://www.escardio.org/congresses/esc-2011/congress-reports/Pages/ 706-3-dal-VESSEL.aspx [http://www.escardio.org/congresses/esc-2011/congress- reports/Pages/706-3-dal-VESSEL.aspx]
-
-
-
-
51
-
-
80255122648
-
Safety and efficacy of dalcetrapib on atherosclerotic disease using novel noninvasive multimodality imaging (dal-PLAQUE): A randomised clinical trial
-
Fayad ZA, Mani V, Woodward M, Kallend D, Abt M, Burgess T, Fuster V, Ballantyne CM, Stein EA, Tardif JC, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel noninvasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. Lancet. 2011;378(9802):1547-59.
-
(2011)
Lancet.
, vol.378
, Issue.9802
, pp. 1547-1559
-
-
Fayad, Z.A.1
Mani, V.2
Woodward, M.3
Kallend, D.4
Abt, M.5
Burgess, T.6
Fuster, V.7
Ballantyne, C.M.8
Stein, E.A.9
Tardif, J.C.10
-
52
-
-
70749131522
-
Rationale and design of the dal-OUTCOMES trial: Efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome
-
e893
-
Schwartz GG, Olsson AG, Ballantyne CM, Barter PJ, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJ, Shah PK, et al. Rationale and design of the dal-OUTCOMES trial: efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome. Am Heart J. 2009;158(6):896-901. e893.
-
(2009)
Am Heart J.
, vol.158
, Issue.6
, pp. 896-901
-
-
Schwartz, G.G.1
Olsson, A.G.2
Ballantyne, C.M.3
Barter, P.J.4
Holme, I.M.5
Kallend, D.6
Leiter, L.A.7
Leitersdorf, E.8
McMurray, J.J.9
Shah, P.K.10
-
53
-
-
78549235583
-
Safety of anacetrapib in patients with or at high risk for coronary heart disease
-
Cannon CP, Shah S, Dansky HM, Davidson M, Brinton EA, Gotto AM, Stepanavage M, Liu SX, Gibbons P, Ashraf TB, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med. 2010;363(25):2406-15.
-
(2010)
N Engl J Med.
, vol.363
, Issue.25
, pp. 2406-2415
-
-
Cannon, C.P.1
Shah, S.2
Dansky, H.M.3
Davidson, M.4
Brinton, E.A.5
Gotto, A.M.6
Stepanavage, M.7
Liu, S.X.8
Gibbons, P.9
Ashraf, T.B.10
-
54
-
-
81855206655
-
Evacetrapib is a novel, potent and selective inhibitor of cholesteryl ester transfer protein that elevates high-density lipoprotein cholesterol without inducing aldosterone or increasing blood pressure
-
Shows preclinical data for evacetrapib
-
Cao G, Beyer TP, Zhang Y, Schmidt RJ, Chen YQ, Cockerham SL, Zimmerman KM, Karathanasis SK, Cannady EA, Fields T et al. Evacetrapib is a novel, potent and selective inhibitor of cholesteryl ester transfer protein that elevates high-density lipoprotein cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011. Shows preclinical data for evacetrapib.
-
(2011)
J Lipid Res.
-
-
Cao, G.1
Beyer, T.P.2
Zhang, Y.3
Schmidt, R.J.4
Chen, Y.Q.5
Cockerham, S.L.6
Zimmerman, K.M.7
Karathanasis, S.K.8
Cannady, E.A.9
Fields, T.10
-
55
-
-
81255125373
-
Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: A randomized controlled trial
-
Shows phase 2 lipid efficacy, safety, and tolerability of evacetrapib
-
Nicholls SJ, Brewer HB, Kastelein JJ, Krueger KA, Wang MD, Shao M, Hu B, McErlean E, Nissen SE. Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial. JAMA. 2011;306(19):2099-109. Shows phase 2 lipid efficacy, safety, and tolerability of evacetrapib.
-
(2011)
JAMA
, vol.306
, Issue.19
, pp. 2099-2109
-
-
Nicholls, S.J.1
Brewer, H.B.2
Kastelein, J.J.3
Krueger, K.A.4
Wang, M.D.5
Shao, M.6
Hu, B.7
McErlean, E.8
Nissen, S.E.9
-
56
-
-
78650054881
-
Modulating cholesteryl ester transfer protein activity maintains efficient pre-beta-HDL formation and increases reverse cholesterol transport
-
Niesor EJ, Magg C, Ogawa N, Okamoto H, von der Mark E, Matile H, Schmid G, Clerc RG, Chaput E, Blum-Kaelin D, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-beta-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2011;51(12):3443-54.
-
(2011)
J Lipid Res.
, vol.51
, Issue.12
, pp. 3443-3454
-
-
Niesor, E.J.1
Magg, C.2
Ogawa, N.3
Okamoto, H.4
Von Der Mark, E.5
Matile, H.6
Schmid, G.7
Clerc, R.G.8
Chaput, E.9
Blum-Kaelin, D.10
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