Emodin-6-O-β-d-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo

Food and Chemical Toxicology

Volumn 52, Issue , 2013, Pages 97-104

  Lee, Wonhwa ^a   Ku, Sae Kwang ^b   Kim, Tae Hoon ^b   Bae, Jong Sup ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Daegu Haany University   (South Korea)

Author keywords

Barrier integrity; Emodin 6 O d glucoside; HMGB1; Inflammation; Sepsis

Indexed keywords

ANTIINFLAMMATORY AGENT; EMODIN 6 O BETA DEXTRO GLUCOSIDE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CECUM LIGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE PERFORATION; LEUKOCYTE MIGRATION INHIBITION; LIGATION; MALE; MOUSE; NONHUMAN; SEPSIS; SURVIVAL RATE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CECUM; CELL ADHESION; CELL MOVEMENT; CYTOSKELETON; DISEASE MODELS, ANIMAL; EMODIN; GLUCOSIDES; HMGB1 PROTEIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LIGATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; NF-KAPPA B; SEPSIS; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; MUS; POLYGONUM CUSPIDATUM;

EID: 84870544257     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.10.061     Document Type: Article

References (35)

1. Aggarwal B.B., Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opinion on Therapeutic Targets 2006, 10:87-118.
2. Akeson A.L., Woods C.W. A fluorometric assay for the quantitation of cell adherence to endothelial cells. Journal of Immunological Methods 1993, 163:181-185.
3. Andersson U., Tracey K.J. HMGB1 is a therapeutic target for sterile inflammation and infection. Annual Review of Immunology 2011, 29:139-162.
4. Andersson U., Wang H., Palmblad K., Aveberger A.C., Bloom O., Erlandsson-Harris H., Janson A., Kokkola R., Zhang M., Yang H., Tracey K.J. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. The Journal of Experimental Medicine 2000, 192:565-570.
5. Bae J.S. Role of high mobility group box 1 in inflammatory disease: focus on sepsis. Archieves of Pharmacal Research 2012, 35:1511-1523.
6. Bae J.S., Lee W., Rezaie A.R. Polyphosphate elicits proinflammatory responses that are counteracted by activated protein C in both cellular and animal models. Journal of Thrombosis and Haemostasis 2012.
7. Bae J.S., Rezaie A.R. Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood 2011, 118:3952-3959.
8. Bae J.W., Bae J.S. Barrier protective effects of lycopene in human endothelial cells. Inflammation Research: Official Journal of the European Histamine Research Society 2011, 60:751-758.
9. Calixto J.B., Campos M.M., Otuki M.F., Santos A.R. Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Medica 2004, 70:93-103.
10. Chaudry I.H., Wichterman K.A., Baue A.E. Effect of sepsis on tissue adenine nucleotide levels. Surgery 1979, 85:205-211.
11. Demirezer L.O., Kuruuzum-Uz A., Bergere I., Schiewe H.J., Zeeck A. The structures of antioxidant and cytotoxic agents from natural source: anthraquinones and tannins from roots of Rumex patientia. Phytochemistry 2001, 58:1213-1217.
12. Freise H., Bruckner U.B., Spiegel H.U. Animal models of sepsis. Journal of Investigative Surgery: The Official Journal of the Academy of Surgical Research 2001, 14:195-212.
13. Friedl J., Puhlmann M., Bartlett D.L., Libutti S.K., Turner E.N., Gnant M.F., Alexander H.R. Induction of permeability across endothelial cell monolayers by tumor necrosis factor (TNF) occurs via a tissue factor-dependent mechanism: relationship between the procoagulant and permeability effects of TNF. Blood 2002, 100:1334-1339.
14. Hansson G.K., Libby P. The immune response in atherosclerosis: a double-edged sword. Nature Reviews. Immunology 2006, 6:508-519.
15. Hofbauer R., Moser D., Salfinger H., Frass M., Kapiotis S. Sufentanil inhibits migration of human leukocytes through human endothelial cell monolayers. Anesthesia and Analgesia 1998, 87:1181-1185.
16. Karantonis F.F., Nikiteas N., Perrea D., Vlachou A., Giamarellos-Bourboulis E.J., Tsigris C., Kostakis A. Evaluation of the effects of laparotomy and laparoscopy on the immune system in intra-abdominal sepsis - a review. Journal of Investigative Surgery: The Official Journal of the Academy of Surgical Research 2008, 21:330-339.
17. Kim I., Moon S.O., Kim S.H., Kim H.J., Koh Y.S., Koh G.Y. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. The Journal of Biological Chemistry 2001, 276:7614-7620.
18. Kim T.H., Ku S.K., Bae J.S. Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses. Food and Chemical Toxicology 2012, 50:1118-1123.
19. Lee W., Kim T.H., Ku S.K., Min K.J., Lee H.S., Kwon T.K., Bae J.S. Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models. Toxicology and Applied Pharmacology 2012, 262:91-98.
20. Lee W., Ku S.K., Bae J.W., Bae J.S. Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models. Food and Chemical Toxicology 2012, 50:1826-1833.
21. Marui N., Offermann M.K., Swerlick R., Kunsch C., Rosen C.A., Ahmad M., Alexander R.W., Medford R.M. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. The Journal of Clinical Investigation 1993, 92:1866-1874.
22. Mesters R.M., Helterbrand J., Utterback B.G., Yan B., Chao Y.B., Fernandez J.A., Griffin J.H., Hartman D.L. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications. Critical Care Medicine 2000, 28:2209-2216.
23. Mullins G.E., Sunden-Cullberg J., Johansson A.S., Rouhiainen A., Erlandsson-Harris H., Yang H., Tracey K.J., Rauvala H., Palmblad J., Andersson J., Treutiger C.J. Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1. Scandinavian Journal of Immunology 2004, 60:566-573.
24. Nightingale K., Dimitrov S., Reeves R., Wolffe A.P. Evidence for a shared structural role for HMG1 and linker histones B4 and H1 in organizing chromatin. EMBO Journal 1996, 15:548-561.
25. Nooteboom A., Hendriks T., Otteholler I., van der Linden C.J. Permeability characteristics of human endothelial monolayers seeded on different extracellular matrix proteins. Mediators of Inflammation 2000, 9:235-241.
26. Park J.S., Svetkauskaite D., He Q., Kim J.Y., Strassheim D., Ishizaka A., Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. The Journal of Biological Chemistry 2004, 279:7370-7377.
27. Petrache I., Birukova A., Ramirez S.I., Garcia J.G., Verin A.D. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. American Journal of Respiratory Cell and Molecular Biology 2003, 28:574-581.
28. Sappington P.L., Yang R., Yang H., Tracey K.J., Delude R.L., Fink M.P. HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002, 123:790-802.
29. Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195.
30. Schnittler H.J., Schneider S.W., Raifer H., Luo F., Dieterich P., Just I., Aktories K. Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress. Pflugers Archiv: European Journal of Physiology 2001, 442:675-687.
31. Schouten M., Wiersinga W.J., Levi M., van der Poll T. Inflammation, endothelium, and coagulation in sepsis. Journal of Leukocyte Biology 2008, 83:536-545.
32. Wang H., Bloom O., Zhang M., Vishnubhakat J.M., Ombrellino M., Che J., Frazier A., Yang H., Ivanova S., Borovikova L., Manogue K.R., Faist E., Abraham E., Andersson J., Andersson U., Molina P.E., Abumrad N.N., Sama A., Tracey K.J. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999, 285:248-251.
33. Wang H., Liao H., Ochani M., Justiniani M., Lin X., Yang L., Al-Abed Y., Metz C., Miller E.J., Tracey K.J., Ulloa L. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nature Medicine 2004, 10:1216-1221.
34. Yang H., Ochani M., Li J., Qiang X., Tanovic M., Harris H.E., Susarla S.M., Ulloa L., Wang H., DiRaimo R., Czura C.J., Roth J., Warren H.S., Fink M.P., Fenton M.J., Andersson U., Tracey K.J. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:296-301.
35. Yang H., Tracey K.J. Targeting HMGB1 in inflammation. Biochimica et Biophysica Acta 2010, 1799:149-156.