Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models

Toxicology and Applied Pharmacology

Volumn 262, Issue 1, 2012, Pages 91-98

  Lee, Wonhwa ^a,b   Kim, Tae Hoon ^c   Ku, Sae Kwang ^c   Min, Kyoung jin ^d   Lee, Hyun Shik ^a   Kwon, Taeg Kyu ^d   Bae, Jong Sup ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Daegu Haany University   (South Korea)

^d Keimyung University   (South Korea)

Author keywords

Barrier integrity; Endothelium; HMGB1; Inflammation; Withaferin A

Indexed keywords

ACETIC ACID; CARBOXYMETHYLCELLULOSE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; WITHAFERIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DISRUPTION; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RESISTANCE; VASCULITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAPILLARY PERMEABILITY; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; DISEASE MODELS, ANIMAL; FEMALE; HMGB1 PROTEIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LEUKOCYTES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED ICR; WITHANOLIDES;

ANIMALIA; MUS; WITHANIA SOMNIFERA;

EID: 84861747433     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.04.025     Document Type: Article

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