Significance of sterol structural specificity: Desmosterol cannot replace cholesterol in lipid rafts

Journal of Biological Chemistry

Volumn 281, Issue 1, 2006, Pages 348-355

  Vainio, Saara ^a   Jansen, Maurice ^a   Koivusalo, Mirkka ^a   Róg, Tomasz ^b,d   Karttunen, Mikko ^b   Vattulainen, Ilpo ^c,e   Ikonen, Elina ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b AALTO UNIVERSITY   (Finland)

^c HELSINKI INSTITUTE OF PHYSICS   (Finland)

^d JAGIELLONIAN UNIVERSITY   (Poland)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL BONDS; CHOLESTEROL; COMPUTER SIMULATION; MATHEMATICAL MODELS; MOLECULAR DYNAMICS;

DESMOSTEROL; LIPID RAFTS; STEROLS;

LIPIDS;

CHOLESTEROL; DESMOSTEROL; INSULIN RECEPTOR; STEROL; ALBUMINOID; ANTIDIABETIC AGENT; DETERGENT; DIAGNOSTIC AGENT; INSULIN; RADIOACTIVE IODINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID RAFT; MAMMAL CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SOLUBILIZATION; STEROL ANALYSIS; STEROL SYNTHESIS; ANIMAL; CELL FRACTIONATION; CHEMISTRY; CHO CELL; HAMSTER; LIPID BILAYER; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA;

ALBUMINS; ANIMALS; CHO CELLS; CHOLESTEROL; CRICETINAE; DESMOSTEROL; DETERGENTS; HYPOGLYCEMIC AGENTS; INSULIN; IODINE RADIOISOTOPES; LIPID BILAYERS; MEMBRANE MICRODOMAINS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 33644871685     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509530200     Document Type: Article

References (53)

1. Sankaram, M. B., and Thompson, T. E. (1990) Biochemistry 29, 10670-10675
2. Smaby, J. M., Momsen, M., Kulkarni, V. S., and Brown, R. E. (1996) Biochemistry 35, 5696-5704
3. Edidin, M. (2003) Annu. Rev. Biophys. Biomol. Struct. 32, 257-283
4. Simons, K., and Ikonen, E. (1997) Nature 387, 569-572
5. Brown, D. A., and London, E. (1997) Biochem. Biophys. Res. Commun. 240, 1-7
6. Brown, D. A., and Rose, J. K. (1992) Cell 68, 533-544
7. Ahmed, S. N., Brown, D. A., and London, E. (1997) Biochemistry 36, 10944-10953
8. Baumgart, T., Hess, S. T., and Webb, W. W. (2003) Nature 425, 821-824
9. Silvius, J. R., del Giudice, D., and Lafleur, M. (1996) Biochemistry 35, 15198-15208
10. Friedrichson, T., and Kurzchalia, T. V. (1998) Nature 394, 802-805
11. Varma, R., and Mayor, S. (1998) Nature 394, 798-801
12. Bacia, K., Schwille, P., and Kurzchalia, T. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3272-3277
13. Wang, J., Megha, and London, E. (2004) Biochemistry 43, 1010-1018
14. Zuckermann, M. J., Ipsen, J. H., Miao, L., Mouritsen, O. G., Nielsen, M., Polson, J., Thewalt, J., Vattulainen, I., and Zhu, H. (2004) Methods Enzymol. 383, 198-229
15. Huster, D., Scheidt, H. A., Arnold, K., Herrmann, A., and Muller, P. (2005) Biophys. J. 88, 1838-1844
16. Lusa, S., Heino, S., and Ikonen, E. (2003) J. Biol. Chem. 278, 19844-19851
17. Xu, X., Bittman, R., Duportail, G., Heissler, D., Vilcheze, C., and London, E. (2001) J. Biol. Chem. 276, 33540-33546
18. Lin, D. S., Connor, W. E., Wolf, D. P., Neuringer, M., and Hachey, D. L. (1993) J. Lipid Res. 34, 491-499
19. Mutka, A. L., Lusa, S., Linder, M. D., Jokitalo, E., Kopra, O., Jauhiainen, M., and Ikonen, E. (2004) J. Biol. Chem. 279, 48654-48662
20. Waterham, H. R., Koster, J., Romeijn, G. J., Hennekam, R. C., Vreken, P., Andersson, H. C., FitzPatrick, D. R., Kelley, R. I., and Wanders, R. J. (2001) Am. J. Hum. Genet. 69, 685-694
21. FitzPatrick, D. R., Keeling, J. W., Evans, M. J., Kan, A. E., Bell, J. E., Porteous, M. E., Mills, K., Winter, R. M., and Clayton, P. T. (1998) Am. J. Med. Genet. 75, 145-152
22. Wechsler, A., Brafman, A., Shafir, M., Heverin, M., Gottlieb, H., Damari, G., Gozlan-Kelner, S., Spivak, I., Moshkin, O., Fridman, E., Becker, Y., Skaliter, R., Einat, P., Faerman, A., Bjorkhem, I., and Feinstein, E. (2003) Science 302, 2087
23. Wenz, J. J., and Barrantes, F. J. (2003) Biochemistry 42, 14267-14276
24. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 98, 241-260
25. Arreaza, G., Melkonian, K. A., LaFevre-Bernt, M., and Brown, D. A. (1994) J. Biol. Chem. 269, 19123-19127
26. Heino, S., Lusa, S., Somerharju, P., Ehnholm, C., Olkkonen, V. M., and Ikonen, E. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8375-8380
27. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
28. Ohvo-Rekila, H., Akerlund, B., and Slotte, J. P. (2000) Chem. Phys. Lipids 105, 167-178
29. Vainio, S., Bykov, I., Hermansson, M., Jokitalo, E., Somerharju, P., and Ikonen, E. (2005) Biochem. J. 391, 465-472
30. Vainio, S., Heino, S., Mansson, J. E., Fredman, P., Kuismanen, E., Vaarala, O., and Ikonen, E. (2002) EMBO Rep. 3, 95-100
31. Lindahl, E., Hess, B., and van der Spoel, D. (2001) J. Mol. Model. 7, 306-317
32. Berger, O., Edholm, O., and Jahnig, F. (1997) Biophys. J. 72, 2002-2013
33. Tieleman, D. P., and Berendsen, H. J. C. (1996) J. Chem. Phys. 105, 4871-4880
34. Holtje, M., Forster, T., Brandt, B., Engels, T., von Rybinski, W., and Holtje, H. D. (2001) Biochim. Biophys. Acta 1511, 156-167
35. Berendsen, H. J. C., Postma, J. P. M., and van Gunsteren, W. F. (1981) in Intermolecular Forces (Pullman, B., ed) Reider, Dordrecht, The Netherlands
36. Hess, B., Bekker, H., Berendsen, H. J. C., and Fraaije, J. G. E. M. (1997) J. Comput. Chem. 18, 1463-1472
37. Berendsen, H. J. C., Postma, J. P. M., Vangunsteren, W. F., Dinola, A., and Haak, J. R. (1984) J. Chem. Phys. 81, 3684-3690
38. Essmann, U., Perera, L., Berkowitz, M. L., Darden, T., Lee, H., and Pedersen, L. G. (1995) J. Chem. Phys. 103, 8577-8593
39. Falck, E., Patra, M., Karttunen, M., Hyvonen, M. T., and Vattulainen, I. (2004) Biophys. J. 87, 1076-1091
40. Falck, E., Patra, M., Karttunen, M., Hyvonen, M. T., and Vattulainen, I. (2004) J. Chem. Phys. 121, 12676-12689
41. Xu, X., and London, E. (2000) Biochemistry 39, 843-849
42. Lentz, B. R. (1993) Chem. Phys. Lipids 64, 99-116
43. Repakova, J., Holopainen, J. M., Morrow, M. R., McDonald, M. C., Capkova, P., and Vattulainen, I. (2005) Biophys. J. 88, 3398-3410
44. Johnson, W. J., Fischer, R. T., Phillips, M. C., and Rothblat, G. H. (1995) J. Biol. Chem. 270, 25037-25046
45. Phillips, J. E., Rodrigueza, W. V., and Johnson, W. J. (1998) J. Lipid Res. 39, 2459-2470
46. Grimmer, S., Ying, M., Walchli, S., van Deurs, B., and Sandvig, K. (2005) Traffic 6, 144-156
47. Stuven, E., Porat, A., Shimron, F., Fass, E., Kaloyanova, D., Brugger, B., Wieland, F. T., Elazar, Z., and Helms, J. B. (2003) J. Biol. Chem. 278, 53112-53122
48. Róg, T., and Pasenkiewicz-Gierula, M. (2004) Biophys. Chem. 107, 151-164
49. Rog, T., and Pasenkiewicz-Gierula, M. (2003) Biophys. J. 84, 1818-1826
50. Scheidt, H. A., Huster, D., and Gawrisch, K. (2005) Biophys. J. 89, 2504-2512
51. Lutjohann, D., Brzezinka, A., Barth, E., Abramowski, D., Staufenbiel, M., von Bergmann, K., Beyreuther, K., Multhaup, G., and Bayer, T. A. (2002) J. Lipid Res. 43, 1078-1085
52. Rog, T., Murzyn, K., Gurbiel, R., Takaoka, Y., Kusumi, A., and Pasenkiewicz-Gierula, M. (2004) J. Lipid Res. 45, 326-336
53. Patra, M., Karttunen, M., Hyvonen, M. T., Falck, E., Lindqvist, P., and Vattulainen, I. (2003) Biophys. J. 84, 3636-3645