Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2

Toxicology

Volumn 303, Issue , 2013, Pages 9-15

  Hirsova, Petra ^a   Karlasova, Gabriela ^a   Dolezelova, Eva ^b   Cermanova, Jolana ^a   Zagorova, Marie ^a   Kadova, Zuzana ^a   Hroch, Milos ^a   Sispera, Ludek ^a   Tomsik, Pavel ^a   Lenicek, Martin ^a   Vitek, Libor ^a   Pavek, Petr ^b   Kucera, Otto ^a   Cervinkova, Zuzana ^a   Micuda, Stanislav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Bile acids; Bile formation; Cholestasis; Epigallocatechin gallate

Indexed keywords

BILE ACID; CHOLEST 4 EN 3 ONE; CHOLESTEROL 7ALPHA MONOOXYGENASE; EPIGALLOCATECHIN GALLATE; ETHINYLESTRADIOL; GLUTATHIONE; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID SYNTHESIS; BILE FLOW; BILIARY EXCRETION; CELL MEMBRANE PERMEABILITY; CHOLESTASIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; ILEUM; INTRAHEPATIC BILE DUCT; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CATECHIN; CHOLESTASIS; CHOLESTENONES; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DOWN-REGULATION; ETHINYL ESTRADIOL; FEMALE; GLUTATHIONE; HEPATOCYTES; HOMEOSTASIS; ILEUM; PERMEABILITY; RATS; RATS, WISTAR; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 84870490561     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.10.018     Document Type: Article

References (39)

1. Adachi R., Honma Y., Masuno H., Kawana K., Shimomura I., Yamada S., Makishima M. Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. J. Lipid Res. 2005, 46:46-57.
2. Annaba F., Kumar P., Dudeja A.K., Saksena S., Gill R.K., Alrefai W.A. Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G467-G473.
3. Brcakova E., Fuksa L., Cermanova J., Kolouchova G., Hroch M., Hirsova P., Martinkova J., Staud F., Micuda S. Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biol. Pharm. Bull. 2009, 32:1978-1985.
4. Chen L., Lee M.J., Li H., Yang C.S. Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab. Dispos. 1997, 25:1045-1050.
5. Chiang J.Y. Bile acids: regulation of synthesis. J. Lipid Res. 2009, 50:1955-1966.
6. Dawson P.A., Haywood J., Craddock A.L., Wilson M., Tietjen M., Kluckman K., Maeda N., Parks J.S. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J. Biol. Chem. 2003, 278:33920-33927.
7. Esteller A. Physiology of bile secretion. World J. Gastroenterol. 2008, 14:5641-5649.
8. Fiorucci S., Clerici C., Antonelli E., Orlandi S., Goodwin B., Sadeghpour B.M., Sabatino G., Russo G., Castellani D., Willson T.M., Pruzanski M., Pellicciari R., Morelli A. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J. Pharmacol. Exp. Ther. 2005, 313:604-612.
9. Geier A., Dietrich C.G., Gerloff T., Haendly J., Kullak-Ublick G.A., Stieger B., Meier P.J., Matern S., Gartung C. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Biochim. Biophys. Acta 2003, 1609:87-94.
10. Hirsova P., Kolouchova G., Dolezelova E., Cermanova J., Hyspler R., Kadova Z., Micuda S. Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats. Eur. J. Pharmacol. 2012, 691:38-45.
11. Hong J., Lambert J.D., Lee S.H., Sinko P.J., Yang C.S. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem. Biophys. Res. Commun. 2003, 310:222-227.
12. Jemnitz K., Heredi-Szabo K., Janossy J., Ioja E., Vereczkey L., Krajcsi P. ABCC2/Abcc2: a multispecific transporter with dominant excretory functions. Drug Metab. Rev. 2010, 42:402-436.
13. Johnson D.R., Klaassen C.D. Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicol. Sci. 2002, 67:182-189.
14. Kand'ar R., Zakova P., Lotkova H., Kucera O., Cervinkova Z. Determination of reduced and oxidized glutathione in biological samples using liquid chromatography with fluorimetric detection. J. Pharm. Biomed. Anal. 2007, 43:1382-1387.
15. Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., Tontonoz P., Kliewer S., Willson T.M., Edwards P.A. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 2002, 277:2908-2915.
16. Kobayashi H., Tanaka Y., Asagiri K., Asakawa T., Tanikawa K., Kage M., Yagi M. The antioxidant effect of green tea catechin ameliorates experimental liver injury. Phytomedicine 2010, 17:197-202.
17. Kobayashi M., Saitoh H., Tadano K., Takahashi Y., Hirano T. Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats. J. Pharmacol. Exp. Ther. 2004, 309:1029-1035.
18. Lee M.S., Park J.Y., Freake H., Kwun I.S., Kim Y. Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells. Br. J. Nutr. 2008, 99:1182-1185.
19. Lenicek M., Juklova M., Zelenka J., Kovar J., Lukas M., Bortlik M., Vitek L. Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption. Clin. Chem. 2008, 54:1087-1088.
20. Li G., Lin W., Araya J.J., Chen T., Timmermann B.N., Guo G.L. A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicol. Appl. Pharmacol. 2012, 258:268-274.
21. Mazzanti G., Menniti-Ippolito F., Moro P.A., Cassetti F., Raschetti R., Santuccio C., Mastrangelo S. Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur. J. Clin. Pharmacol. 2009, 65:331-341.
22. Micuda S., Fuksa L., Brcakova E., Osterreicher J., Cermanova J., Cibicek N., Mokry J., Staud F., Martinkova J. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. J. Gastroenterol. Hepatol. 2008, 23:e225-e230.
23. Modica S., Petruzzelli M., Bellafante E., Murzilli S., Salvatore L., Celli N., Di Tullio G., Palasciano G., Moustafa T., Halilbasic E., Trauner M., Moschetta A. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012, 142:355-365. e351-354.
24. Netsch M.I., Gutmann H., Luescher S., Brill S., Schmidlin C.B., Kreuter M.H., Drewe J. Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality. Planta Med. 2005, 71:135-141.
25. Nies A.T., Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch. 2007, 453:643-659.
26. Rahner C., Stieger B., Landmann L. Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver. Gastroenterology 1996, 110:1564-1578.
27. Ramesh E., Jayakumar T., Elanchezhian R., Sakthivel M., Geraldine P., Thomas P.A. Green tea catechins, alleviate hepatic lipidemic-oxidative injury in Wistar rats fed an atherogenic diet. Chem. Biol. Interact. 2009, 180:10-19.
28. Ren Y., Deng F., Zhu H., Wan W., Ye J., Luo B. Effect of epigallocatechin-3-gallate on iron overload in mice with alcoholic liver disease. Mol. Biol. Rep. 2011, 38:879-886.
29. Ruiz M.L., Villanueva S.S., Luquita M.G., Ikushiro S., Mottino A.D., Catania V.A. Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2. Drug Metab. Dispos. 2007, 35:2060-2066.
30. Singh B.N., Shankar S., Srivastava R.K. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharmacol. 2011, 82:1807-1821.
31. Stickel F., Kessebohm K., Weimann R., Seitz H.K. Review of liver injury associated with dietary supplements. Liver Int. 2011, 31:595-605.
32. Stieger B. Role of the bile salt export pump, BSEP, in acquired forms of cholestasis. Drug Metab. Rev. 2010, 42:437-445.
33. Tipoe G.L., Leung T.M., Liong E.C., Lau T.Y., Fung M.L., Nanji A.A. Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology 2010, 273:45-52.
34. Tomsik P., Sispera L., Rezacova M., Niang M., Stoklasova A., Cerman J., Knizek J., Brcakova E., Cermanova J., Micuda S. Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis. J. Gastroenterol. Hepatol. 2008, 23:1934-1940.
35. Trauner M., Arrese M., Soroka C.J., Ananthanarayanan M., Koeppel T.A., Schlosser S.F., Suchy F.J., Keppler D., Boyer J.L. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997, 113:255-264.
36. Yang T.T., Koo M.W. Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci. 2000, 66:411-423.
37. Zhong Z., Froh M., Lehnert M., Schoonhoven R., Yang L., Lind H., Lemasters J.J., Thurman R.G. Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 285:G1004-G1013.
38. Zhu Y., Li F., Guo G.L. Tissue-specific function of farnesoid X receptor in liver and intestine. Pharmacol. Res. 2011, 63:259-265.
39. Zinchuk V., Zinchuk O., Okada T. Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Microsc. Res. Tech. 2005, 67:65-70.