Antimetastatic potentials of phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases

Integrative Cancer Therapies

Volumn 11, Issue 3, 2012, Pages 267-278

  Tseng, Hsu Hung ^a   Chen, Pei Ni ^b   Kuo, Wu Hsien ^c   Wang, Jhih Wei ^b   Chu, Shu Chen ^d   Hsieh, Yih Shou ^b,e  

^a TIAN SHENG MEMORIAL HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

invasion; matrix metalloproteinase; metastasis; Phyllanthus urinaria; urokinase plasminogen activator

Indexed keywords

ANTIMETASTATIC AGENT; AURANTIIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; GALLIC ACID; GALLIC ACID METHYL ESTER; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; PLASMINOGEN ACTIVATOR INHIBITOR 1; RUTOSIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INVASION; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEWIS CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS URINARIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; WESTERN BLOTTING; ZYMOGRAPHY;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG NEOPLASMS; MALE; MEDICINE, TRADITIONAL; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PEPTIDE HYDROLASES; PHYLLANTHUS; PLANT EXTRACTS;

EID: 84870452019     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735411417128     Document Type: Article

References (42)

1. Rao SK, Rao PS. Alteration in the radiosensitivity of HeLa cells by dichloromethane extract of guduchi (Tinospora cordifolia). Integr Cancer Ther. 2010 ; 9: 378-384
2. Wang N, Feng Y, Lau EP, et al. F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration. Integr Cancer Ther. 2010 ; 9: 354-364
3. Fang SH, Rao YK, Tzeng YM. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008 ; 116: 333-340
4. Bendaoud H, Romdhane M, Souchard JP, Cazaux S, Bouajila J. Chemical composition and anticancer and antioxidant activities of Schinus molle L. and Schinus terebinthifolius Raddi berries essential oils. J Food Sci. 2010 ; 75: C466 - C472
5. Liu M, Liu RH, Song BB, et al. Antiangiogenetic effects of 4 varieties of grapes in vitro. J Food Sci. 2010 ; 75: T99 - T104
6. Calixto JB, Santos AR, Cechinel Filho V, Yunes RA. A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev. 1998 ; 18: 225-258 (Pubitemid 28346388)
7. Huang ST, Yang RC, Lee PN, et al. Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. Int Immunopharmacol. 2006 ; 6: 870-879
8. Chularojmontri L, Wattanapitayakul SK, Herunsalee A, Charuchongkolwongse S, Niumsakul S, Srichairat S. Antioxidative and cardioprotective effects of Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity. Biol Pharm Bull. 2005 ; 28: 1165-1171 (Pubitemid 41327579)
9. Chudapongse N, Kamkhunthod M, Poompachee K. Effects of Phyllanthus urinaria extract on HepG2 cell viability and oxidative phosphorylation by isolated rat liver mitochondria. J Ethnopharmacol. 2010 ; 130: 315-319
10. Cechinel-Filho V, Santos AR, Calixto JB, Delle-Monache F, Miguel OG, Yunes RA. Triterpenes from Phyllanthus sellowianus roots. Planta Med. 1998 ; 64: 194 (Pubitemid 128725305)
11. Yang CM, Cheng HY, Lin TC, Chiang LC, Lin CC. Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in vitro. Phytother Res. 2007 ; 21: 1182-1186
12. Yang CM, Cheng HY, Lin TC, Chiang LC, Lin CC. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. J Ethnopharmacol. 2007 ; 110: 555-558
13. Shin MS, Kang EH, Lee YI. A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes. Antiviral Res. 2005 ; 67: 163-168 (Pubitemid 41254200)
14. Chi JH, Parsa AT. Intramedullary spinal cord metastasis: clinical management and surgical considerations. Neurosurg Clin N Am. 2006 ; 17: 45-50 (Pubitemid 43163206)
15. Hirai T, Matsumoto H, Yamashita K, et al. Surgical oncotaxis: excessive surgical stress and postoperative complications contribute to enhancing tumor metastasis, resulting in a poor prognosis for cancer patients. Ann Thorac Cardiovasc Surg. 2005 ; 11: 4-6
16. Vayalil PK, Katiyar SK. Treatment of epigallocatechin-3-gallate inhibits matrix metalloproteinases-2 and -9 via inhibition of activation of mitogen-activated protein kinases, c-jun and NF-kappaB in human prostate carcinoma DU-145 cells. Prostate. 2004 ; 59: 33-42 (Pubitemid 38387841)
17. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol. 2000 ; 18: 1135-1149 (Pubitemid 30123793)
18. Yang SF, Chen MK, Hsieh YS, et al. Antimetastatic effects of on oral cancer via a down-regulation of metastasis-associated proteases. Food Chem Toxicol. 2010 ; 48: 1052-1058
19. Baricos WH, Cortez SL, el-Dahr SS, Schnaper HW. ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade. Kidney Int. 1995 ; 47: 1039-1047
20. Ho ML, Chen PN, Chu SC, et al. Peonidin 3-glucoside inhibits lung cancer metastasis by downregulation of proteinases activities and MAPK pathway. Nutr Cancer. 2010 ; 62: 505-516
21. Hsiao YC, Kuo WH, Chen PN, et al. Flavanone and 2′-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 ; 167: 193-206
22. Chen PN, Hsieh YS, Chiou HL, Chu SC. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact. 2005 ; 156: 141-150
23. Westermarck J, Kahari VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999 ; 13: 781-792 (Pubitemid 29220691)
24. Chen PN, Kuo WH, Chiang CL, Chiou HL, Hsieh YS, Chu SC. Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact. 2006 ; 163: 218-229
25. Wong BS, Hsiao YC, Lin TW, et al. The in vitro and in vivo apoptotic effects of Mahonia oiwakensis on human lung cancer cells. Chem Biol Interact. 2009 ; 180: 165-174
26. Chu SC, Yang SF, Liu SJ, Kuo WH, Chang YZ, Hsieh YS. In vitro and in vivo antimetastatic effects of Terminalia catappa L. leaves on lung cancer cells. Food Chem Toxicol. 2007 ; 45: 1194-1201
27. Chen PN, Chu SC, Chiou HL, Chiang CL, Yang SF, Hsieh YS. Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. Nutr Cancer. 2005 ; 53: 232-243
28. Attiga FA, Fernandez PM, Weeraratna AT, Manyak MJ, Patierno SR. Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. Cancer Res. 2000 ; 60: 4629-4637 (Pubitemid 32103650)
29. Lin CH, Hsiao YM, Ou CC, et al. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metalloproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells. J Agric Food Chem. 2010 ; 58: 12014-12021
30. Ho E, Ames BN. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci U S A. 2002 ; 99: 16770-16775 (Pubitemid 36034048)
31. Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004 ; 70: 211-219 (Pubitemid 38445186)
32. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005 ; 55: 10-30 (Pubitemid 40310185)
33. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol. 1993 ; 9: 541-573
34. Bohle AS, Kalthoff H. Molecular mechanisms of tumor metastasis and angiogenesis. Langenbecks Arch Surg. 1999 ; 384: 133-140 (Pubitemid 29227304)
35. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog. 2004 ; 40: 143-149
36. Ye Y, Chou GX, Wang H, Chu JH, Fong WF, Yu ZL. Effects of sesquiterpenes isolated from largehead atractylodes rhizome on growth, migration, and differentiation of b16 melanoma cells. Integr Cancer Ther. 2011 ; 10: 92-100
37. Sen T, Moulik S, Dutta A, et al. Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. Life Sci. 2009 ; 84: 194-204
38. Karsdal MA, Larsen L, Engsig MT, et al. Matrix metalloproteinase- dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem. 2002 ; 277: 44061-44067 (Pubitemid 36157833)
39. Aguirre Ghiso JA, Alonso DF, Farias EF, Gomez DE, de Kier Joffe EB. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur J Biochem. 1999 ; 263: 295-304 (Pubitemid 29337018)
40. Kim D, Kim S, Koh H, et al. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 2001 ; 15: 1953-1962 (Pubitemid 32848799)
41. Lee HY, Crawley S, Hokari R, Kwon S, Kim YS. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int J Oncol. 2010 ; 36: 941-953
42. Kelloff GJ. Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res. 2000 ; 78: 199-334