A novel one-pot de-blocking and conjugation reaction step leads to process intensification in the manufacture of PEGylated insulin IN-105

Bioprocess and Biosystems Engineering

Volumn 35, Issue 8, 2012, Pages 1333-1341

  Hazra, Partha ^a   Chatterjee, Amarnath ^a   Shabandri, Qais ^a   Adhikary, Laxmi ^a   Dave, Nitesh ^a   Buddha, Madhavan ^a  

^a Biocon Limited   (India)

Author keywords

Conjugation; IN 105; Insulin; One pot reaction; PEGylated insulin; Process intensification

Indexed keywords

CONJUGATION; IN-105; ONE-POT REACTION; PEGYLATED INSULIN; PROCESS INTENSIFICATION;

ESTERIFICATION; ESTERS; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYETHYLENE GLYCOLS; PURIFICATION;

INSULIN;

INSULIN; LYSINE; MACROGOL;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CIRCULAR DICHROISM; CONJUGATION; CRYSTALLIZATION; DEESTERIFICATION; DRUG CONJUGATION; DRUG MANUFACTURE; DRUG PURIFICATION; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FREEZE DRYING; LIQUID CHROMATOGRAPHY; ONE POT SYNTHESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REACTION TIME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CATALYSIS; HUMANS; INSULIN; LYSINE; POLYETHYLENE GLYCOLS;

EID: 84870334196     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-012-0722-4     Document Type: Article

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