Reaction modelling and simulation to assess the integrated use of transketolase and ω-transaminase for the synthesis of an aminotriol

Biocatalysis and Biotransformation

Volumn 24, Issue 6, 2006, Pages 449-457

  Chen, B H ^a   Sayar, A ^a   Kaulmann, U ^a   Dalby, P A ^a   Ward, J M ^a   Woodley, J M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

transaminase; Multistep synthesis; One pot synthesis; Reaction modelling; Transketolase

Indexed keywords

ALDEHYDES; BIOCATALYSTS; CHARACTERIZATION; PH; REACTION KINETICS;

MULTISTEP SYNTHESIS; ONE-POT SYNTHESIS; TRANSKETOLASE-TRANSAMINASE;

BIOSYNTHESIS;

ALDEHYDE; AMINE; AMINOTRANSFERASE; AMINOTRIOL; KETOL; OMEGA TRANSAMINASE; TRANSKETOLASE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME DEGRADATION; PH; PROCESS MODEL; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 33845529927     PISSN: 10242422     EISSN: 10292446     Source Type: Journal    
DOI: 10.1080/10242420601068668     Document Type: Article

References (23)

1. Bhattacharya, S and Schiavone, M and Gomes, J and Bhattacharya, SK. (2004) Cascade of bioreactors in series for conversion of 3-phospho-D-glycerate into D-ribulose-1,5-bisphosphate: Kinetic parameters of enzymes and operation variables J Biotechnol, 111, pp. 203-217.
2. Bongs, J and Hahn, D and Schorken, U and Sprenger, GA and Kragl, U and Wandrey, C. (1997) Continuous production of erythrulose using transketolase in a membrane reactor Biotechnol Lett, 19, pp. 213-215.
3. Bruggink, A and Schoevaart, R and Kieboom, T. (2003) Concepts of nature in organic synthesis: Cascade catalysis and multistep conversions in concert Org Process Res Dev, 7, pp. 622-640.
4. Dalby, PA. (2003) Optimising enzyme function by directed evolution Curr Opin Struct Biol, 13, pp. 500-505.
5. Dalby, PA and Lye, GJ and Woodley, JM.(2005) One-pot synthesis and the integration of chemical and biocatalytic conversions. In Handbook of Chiral Chemicals 2nd edn. (pp. 419-428). Boca Raton: CRC Press.
6. Datta, AG and Racker, E. (1959) Participation of an active glycolaldehyde-enzyme in the transketolase-catalyzed reaction Arch Biochem Biophys, 82, pp. 489-491.
7. Gyamerah, M and Willetts, AJ. (1997) Kinetics of overexpressed transketolase from Escherichia coli JM 107/pQR 700 Enzyme Microb Technol, 20, pp. 127-134.
8. Hobbs, GR and Mitra, RK and Chauhan, RP and Woodley, JM and Lilly, MD. (1996) Enzyme-catalysed carbon-carbon bond formation: Large-scale production of Escherichia coli transketolase J Biotechnol, 45, pp. 173-179.
9. Ingram CU, Bommer M, Smith MEB, Dalby PA, Ward JM, Hailes H, Lye GJ. 2006. One-pot synthesis of amino-alcohols using a de-novo transketolase and alanine:pYruvate transaminase pathway in Escherichia coli Biotechnol Bioeng (in press).
10. Lilly, MD and Chauhan, R and French, C and Gyamerah, M and Hobbs, GR and Humphrey, A and Isupov, M and Littlechild, JA and Mitra, RK and Morris, KG and Rupprecht, M and Turner, NJ and Ward, JM and Willetts, AJ and Woodley, JM. (1996) Carbon-carbon bond synthesis: The impact of rDNA technology on the production and use of E-coli transketolase Ann N Y Acad Sci, 782, pp. 513-525.
11. Lye, GJ and Dalby, PA and Woodley, JM. (2002) Better biocatalytic processes faster: New tools for the implementation of biocatalysis in organic synthesis Org Process Res Dev, 6, pp. 434-440.
12. Mitra RK. 1997. Carbon-carbon bond formation: Reactor selection for transketolase catalysed biotransformations. PhD Thesis, University of London.
13. Mitra, RK and Woodley, JM and Lilly, MD. (1998) Escherichia coli transketolase-catalyzed carbon-carbon bond formation: Biotransformation characterization for reactor evaluation and selection Enzyme Microb Technol, 22, pp. 64-70.
14. Mitra, RK and Woodley, JM and Lilly, MD. (1999) Process design implications of aldehyde properties on transketolase-catalysed condensations Biocatal Biotransform, 17, pp. 21-36.
15. Mizanur, RM and Takeshita, K and Moshino, H and Takada, G and Izumori, K. (2001) Production of L-erythrose via L-erythrulose from erythritol using microbial and enzymatic reactions J Biosci Bioeng, 923, pp. 237-241.
16. Pamies, O and Backvall, JE. (2003) Combination of enzymes and metal catalysts. A powerful approach in asymmetric catalysis Chem Rev, 103, pp. 3247-3261.
17. Pontremoli, S and Bonsignore, A and Grazi, E and Horecker, BL. (1960) A coupled reaction catalyzed by the enzymes transketolase and transaldolase J Biol Chem, 235, pp. 1881-1887.
18. Schoemaker, HE and Mink, D and Wubbolts, MG. (2003) Dispelling the myths -biocatalysis in industrial synthesis Science, 299, pp. 1694-1697.
19. Sheldon, RA. (2005) Green solvents for sustainable organic synthesis: state of the art Green Chem, 7, pp. 267-278.
20. Shin, JS and Kim, BG. (1998) Kinetic modeling of omega-transamination for enzymatic kinetic resolution of alpha-methylbenzylamine Biotechnol Bioeng, 60, pp. 534-540.
21. Vasic-Racki, D and Bongs, J and Schorken, U and Sprenger, GA and Liese, A. (2003) Modeling of reaction kinetics for reactor selection in the case of L-erythrulose synthesis Bioprocess Biosyst Eng, 25, pp. 285-290.
22. Westerhuis, JA and Boelens, HFM and Iron, D and Rothenberg, G. (2004) Model selection and optimal sampling in high-throughput experimentation Anal Chem, 76, pp. 3171-3178.
23. Woodley, JM and Mitra, RK and Lilly, MD. (1996) Carbon-carbon bond synthesis - reactor design and operation for transketolase-catalyzed biotransformations. Enzyme Engineering XIII Ann N Y Acad Sci, 799, pp. 434-445.