Process and purification for manufacture of a modified insulin intended for oral delivery

Journal of Chromatography A

Volumn 1177, Issue 2, 2008, Pages 282-286

  Dave, Nitesh ^a   Hazra, Partha ^a   Khedkar, Anand ^a   Manjunath, H S ^a   Iyer, Harish ^a   Suryanarayanan, Shrikumar ^a  

^a Biocon Limited   (India)

Author keywords

Conjugation; Manufacturing; Oral insulin; Purification; RP HPLC

Indexed keywords

BIOAVAILABILITY; CONJUGATION; ORAL INSULIN;

CRYSTALLIZATION; ENZYME KINETICS; ION CHROMATOGRAPHY; MEDICAL PROBLEMS; PHYSIOLOGICAL MODELS; PURIFICATION;

INSULIN;

IN 105; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DRUG CONJUGATION; DRUG MANUFACTURE; DRUG PURIFICATION; FREEZE DRYING; ION EXCHANGE CHROMATOGRAPHY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLIZATION; FREEZE DRYING; HUMANS; HYDROPHOBICITY; HYPOGLYCEMIC AGENTS; INSULIN; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 37349114891     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.07.036     Document Type: Article

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