The role of excitatory neurotransmitter glutamate in brain physiology and pathology

Asian Journal of Pharmaceutical and Clinical Research

Volumn 5, Issue 2, 2012, Pages 1-7

  Shanmuga Sundaram, R ^a   Gowtham, L ^b   Nayak, Bhabani S ^a  

^a Jeypore College of Pharmacy   (India)

^b PSG COLLEGE OF PHARMACY   (India)

Author keywords

Excitatory amino acid; Excitotoxicity; Glutamate; Neurodegeneration; Oxidative stress; Reactive oxygen species

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CALCIUM ION; ENDONUCLEASE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; IONOTROPIC RECEPTOR; LEVACECARNINE; MECOBALAMIN; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICOTINAMIDE; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; PHOSPHATIDYLSERINE; PROTEIN KINASE C; PYCNOGENOL; REACTIVE OXYGEN METABOLITE; UBIDECARENONE;

BRAIN DEVELOPMENT; CALCIUM CELL LEVEL; CEREBROVASCULAR ACCIDENT; ENZYME ACTIVATION; EXCITOTOXICITY; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; NUTRITIONAL VALUE; OXIDATIVE STRESS; REVIEW;

EID: 84870275487     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (85)

1. Curtis DR, Watkins JC. The excitation and depression of spinal neurones by structurally related amino acids. J Neurochem 1960; 6: 117-41.
2. Hayashi T. Effects of sodium glutamate on the nervous system. Keio J Med 1954; 3: 183-92.
3. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984; 42: 1-11.
4. Ottersen OP, Storm MJ. Neurons containing or accumulating transmitter amino acids. In: Bjorklund A, Hokfelt T, Kuhar MJ, editors. Handbook of Chemical Neuroanatomy: Classical Transmitters and Transmitter Receptors in the CNS, Vol. 3, Part II, Amsterdam: Elsevier; 1984. p. 141-246.
5. Collingridge GL, Lester RAJ. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 1989; 40: 143-210.
6. Headley PM, Grillner S. Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends Pharmacol Sci 1990; 11: 205-211.
7. Hosli E, Hosli L. Receptors for neurotransmitters on astrocytes in the mammalian central nervous system. Prog Neurobiol 1993; 40: 477-506.
8. Steinhauser C, Gallo V. News on glutamate receptors in glial cells. Trends Neuro Sci 1996; 19: 339-45.
9. Vernadakis A. Glia-neuron intercommunications and synaptic plasticity. Prog Neurobiol 1996; 49: 185-214.
10. Shelton MK, McCarthy KD. Mature hippocampal astrocytes exhibit functional metabotropic and ionotropic glutamate receptors in situ. Glia 1999; 26: 1-11.
11. Bergles DE, Roberts JD, Somogyi P, Jahr CE, Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 2000; 405: 187-91.
12. Moriyama Y, Hayashi M, Yamada H, Yatsushiro S, Ishio S, Yamamoto A. Synaptic-like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones. J Exp Biol 2000; 203: 117-25.
13. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1998; 1: 623-34.
14. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death, Annu Rev Neurosci. 1990; 13: 171-82.
15. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15: 961-66.
16. Coyle JT, Bird SJ, Evans RH, Gulley RL, Nadler JV, Nicklas WJ, et al. Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Neurosci Res Prog Bull 1981; 19: 1-427.
17. Olney JW. Excitotoxic amino acids and neuropsychiatric disorders. Annu Rev Pharmacol Toxicol 1990; 30: 47-71.
18. Choi DW, Maulucci-Gedde C, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci 1987; 7: 357-368.
19. Rothman SM, Thurston JH, Hauhari RE. Delayed neurotoxicity of excitatory amino acids in vitro. Neurosci 1987; 22: 471-480.
20. Kato K, Puttfarcken PS, Lyons WE, Coyle JT. Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures. J Pharmacol Exp Ther 1991; 256: 402-411.
21. Birnbaumer L, Campbell KP, Catterall WA, Harpold MM, Hofmann F, Horne WA, et al. The naming of voltage-gated calcium channels. Neuron 1994; 13: 505-6.
22. +-dependent glutamate uptake. J Neurosci 1998; 19: 9620-8.
23. Obrenovitch TP, Urenjak J. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog Neurobiol 1997; 51: 39-87.
24. Meldrum BS. The glutamate synapse as a therapeutic target: perspectives for the future. In: Ottersen OP, Langmoen IA, Gjerstad L, editors. Progress in Brain Research. vol. 116. Netherlands: Elsevier Science B. V Amsterdam; 1998. p. 413-30.
25. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 5th ed. New Delhi: Elsevier India Pvt Ltd.; 2006. p. 490-501.
26. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci 1987; 10: 299-302.
27. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990; 13: 171-82.
28. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. In: Trends in Pharmacological Sciences. UK: Elsevier Science Ltd: 1990. p. 379-87.
29. Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 1994; 17: 31-108.
30. Michaelis EK. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1998; 54: 369-415.
31. Miller RJ. G-protein linked glutamate receptors. Seminars Neurosci 1994; 6: 105-15.
32. Hynd MR, Scott HL, Dodd PR. Glutamate-mediated excitotoxicity and neurodegeneration in AD. Neurochem Int 2004; 45: 583-95.
33. Stone WT, Addae JI. The pharmacological manipulation of glutamate receptors and neuroprotection. Eur J Pharmacol 2002; 447: 285-96.
34. Laube B, Kuhse J, Betz H. Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci 1998; 18: 2954-61.
35. Hayashi T, Umemori H, Mishina M, Yamamoto T. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature (Lond.) 1999; 397: 72-6.
36. Lujan R, Nusser Z, Roberts JDB, Shigemoto R, Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci 1996; 8: 1488-1500.
37. Lujan R, Roberts JDB, Shigemoto R, Ohishi H, Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1à, mGluR2 and mGluR5, relative to neurotransmitter release sites. J Chem Neuroanat 1997; 13: 219-41.
38. Shigemoto R, Kulik A, Roberts JDB, Ohishi H, Nusse Z, Kaneko T, et al. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature (Lond.) 1996; 381: 523-5.
39. Seal RP, Amara SG. Excitatory amino acid transporters: a family in flux. Annu Rev Pharmacol Toxicol 1999; 39: 431-56.
40. Kataoka Y, Morii H., Watanabe Y, Ohmori H. A postsynaptic excitatory amino acid transporter with chloride conductance functionally regulated by neuronal activity in cerebellar Purkinje cells. J Neurosci 1997; 17: 7017-24.
41. Lehre KP, Danbolt NC. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci 1998; 18: 51-7.
42. Hack N, Balazs R. Selective stimulation of excitatory amino acid receptor subtypes and the survival of granule cells in culture: effect of quisqualate and AMPA. Neurochem Int 1994; 25: 235-41.
43. Yano S, Tokumitsu H, Soderling TR. Calcium promotes cell survival through Ca M-k kinase activation of the protein-kinase-B pathway. Nature (Lond.) 1998; 396: 584-7.
44. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science (Washington DC) 1999; 283: 70-4.
45. Suzuki K, Martin PM. Neurotoxicants and developing brain. In: Harry GJ, editor. Developmental Neurotoxicology. Boca Raton: CRC Press; 1994. p. 9-32.
46. Hirsch SR, Garey LJ, Belleroche J. A pivotal role for glutamate in the pathogenesis of schizophrenia, and its cognitive dysfunction. Pharmacol Biochem Behavior 1997; 56: 797-802.
47. Gong SL, Xia FQ, et al. Harmful effects of MSG on function of hypothalamus-pituitary-target gland system. Biomed Environ 1995; 8: 310-17.
48. Trocho C, Rardo R, et al. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci 1998; 63: 337-349.
49. Kenessey A, Yen S-H, et al. Detection of D-aspartate in tau proteins associated with Alzheimer paired helical filaments. Brain Res 1995; 675: 183-9.
50. Fisher GH, Aniello AD, et al. Quantification of D-asparate in normal and Alzheimer brains. Neurosci Lett 1992; 143: 215-218.
51. Suzuki K, Martin PM. Neurotoxicants and The Developing Brain. In: Harry GT, editor. Developmental Neurotoxicology, Baco Raton: CRC Press; 1994. p. 9-32.
52. Olney JW. Excitotoxic food additives: functional teratological aspects. Progress Brain Res 1988; 73: 283-294.
53. Brody JR, et al. Effect of micro-injections of L-glutamate into the hypothalamus on attack and flight behavior in cats. Nature 1969; 224: 1330-45.
54. Wong PT, Neo LH, et al. Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice. Pharmacol Biochem Behav 1997; 57: 383-8.
55. Klingberg H, Brankack J, Klingberg F. Long-term effects on behavior after post-natal treatment with monosodium L-glutamate. Biomed Biochem ACTA 1987; 46: 705-711.
56. Freider B, Grimm VE. Prenatal monosodium glutamate (MSG) treatment given through the mother's diet causes behavioral deficits in rat off spring. Int J Neurisci 1984; 23: 117-26.
57. Frieder B, Grimm VE. Prenatal monosodium glutamate causes long-lasting cholinergic and adrenergic changes in various brain regions. J Neurochem 1987; 48: 1359-65.
58. Kubo T, Kohira R, et al. Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats. Brain Res 1993; 616: 311-4.
59. Bakke JL, Lawrence J, et al. Late endocrine effects of administering monosodium glutamate to neonatal rats. Neuroendocrinology 1978; 26: 220-8.
60. Maiter D, Underwood LE, et al. Neonatal treatment with monosodium glutamate: effects of prolonged growth hormone (GH)-releasing hormone deficiency on pulsatile GH secretion and growth in female rats. Endocrinology 1991; 128: 1100-6.
61. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. New Eng J Med 1994; 330: 613-22.
62. Dawson TM, Dawson VL, Synder SH. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 1992; 32: 297-311.
63. Trout JJ, Koeniq H, Goldstone AD, Iqbal Z, Lu CY, Siddiqui F. NMDA receptor excitotoxicity involves activation of polyamine synthesis: protection by alpha-difluoromethylornithine. J Neurochem 1993; 60: 352-5.
64. Beal MF. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses. Ann Neurol 1992; 31: 119-30.
65. Meldrum BS. Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc Brain Metab Rev 1990; 2: 27-57.
66. Chan PH, Fishman RA. Free fatty acids, oxygen free radicals, and membrane alterations in brain ischemia and injury. In: Plum F, Pulsinelli W, editor. Cerebrovascular diseases. New York: Raven Press; 1985. p. 161-71.
67. Choi DW. Excitotoxic cell death. J Neurobiol 1992; 23: 1261-76.
68. Leigh PN, Meldrum BS. Excitotoxicity in amyotrophic lateral sclerosis. Neurology 1996; 47: S221-S227.
69. Ludolph AC, Meyer T, Riepe MW, Völkel H. Amyotrophic lateral sclerosis and glutamate. Restor Neurol Neurosci 1998; 13: 59-67.
70. Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995; 38: 73-84.
71. Rothstein JD, Kuncl RW. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J Neurochem 1995; 65: 643-51
72. Hirata A, Nakamura R, Kwak S, Nagata N, Kamakura K. AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA. Brain Res 1997; 771: 37-44.
73. Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. Faseb J 1990; 4: 1624-33.
74. Oka A, Belliveau NJ, Rosenberg PA, Volpe JJ. Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms and prevention. J Neurosis 1993; 13: 1441-53.
75. Vornov JJ, Coyle JT. Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice. J Neurochem 1991; 56: 996-1006.
76. Sagara Y, Dargusch R, Chambers D, Davis J, Schubert D, Maher P. Cellular mechanisms of resistance to chronic oxidative stress. Free Radic Biol Med 1998; 24: 1375-89.
77. Tan S, Wood M, Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 1998; 71: 95-105.
78. Dawson VL, Dawson TM, et al. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 1993; 13: 2651-61.
79. Williams LR. Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic treatment. Cerebrovasc Brain Metab Rev 1995; 7: 55-73.
80. Domenico E, Pellegrini-Giampietro, et al. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci 1990; 10: 1035-41.
81. Mundy WR, Freudenrich TM, Kodavanti PR. Aluminum potentiates glutamate-induced calcium accumulation and iron-induced oxygen free radical formation in primary neuronal cultures. Mol Chem Neuropathol 1997; 32: 41-57.
82. Aarala JT, Loikkanen JJ, et al. Lead amplifies glutamate-induced oxidative stress. Free Radical Biol Med 1995; 19: 689-693.
83. Lipton SA, Nicotera P. Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium 1998; 23: 165-71.
84. Beal MF, Hyman BT, Koroschetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends in Neurosci 1993; 16: 125-31.
85. Rodriguez MC, Obeso JA, Olanow CW. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann Neurol 1998; 44 (Supp 1): S175-S188.