Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation

Journal of Orthopaedic Research

Volumn 31, Issue 1, 2013, Pages 73-80

  Burton, Lyndsey ^a   Paget, Daniel ^a   Binder, Nikolaus B ^a   Bohnert, Krista ^a   Nestor, Bryan J ^a   Sculco, Thomas P ^a   Santambrogio, Laura ^b   Ross, F Patrick ^a   Goldring, Steven R ^a   Purdue, P Edward ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

caspase 1; interleukin 1 ; NALP3 inflammasome; periprosthetic osteolysis

Indexed keywords

COLONY STIMULATING FACTOR 1; CRYOPYRIN; GENTAMICIN BONE CEMENT; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALVARIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MACROPHAGE; MECHANICAL STRESS; MOUSE; NONHUMAN; ORTHOPEDIC PROSTHESIS; OSTEOCLAST; OSTEOCLASTOGENESIS; PATHOGENESIS; PERIPROSTHETIC OSTEOLYSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSTHESIS FAILURE; PROTEIN FUNCTION;

ANIMALS; ARTHROPLASTY, REPLACEMENT; BONE CEMENTS; CARRIER PROTEINS; CASPASES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED NOD; MICE, MUTANT STRAINS; MONOCYTES; OSTEOLYSIS; PHAGOCYTOSIS; POLYMETHYL METHACRYLATE; PROSTHESIS FAILURE; RANK LIGAND; SKULL;

EID: 84870247923     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22190     Document Type: Article

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