Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found

Autoimmunity Reviews

Volumn 12, Issue 2, 2012, Pages 260-269

  Rigopoulou, Eirini I ^a   Roggenbuck, Dirk ^b,c   Smyk, Daniel S ^d   Liaskos, Christos ^d,e   Mytilinaiou, Maria G ^d,e   Feist, Eugen ^f   Conrad, Karsten ^g   Bogdanos, Dimitrios P ^a,d,e  

^a UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^b Lausitz University of Applied Sciences   (Germany)

^c GA GENERIC ASSAYS GMBH   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Asialoglycoprotein receptor; Autoantibody; Autoimmune hepatitis; Biomarker; Liver autoimmunity

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; CHYLOMICRON; GAMMA INTERFERON; IMMUNOGLOBULIN A; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; LECTIN; LOW DENSITY LIPOPROTEIN; TUMOR NECROSIS FACTOR;

AUTOIMMUNITY; BINDING SITE; BIOLOGY; CYTOKINE RELEASE; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS A VIRUS; HEPATITIS B VIRUS; HUMAN; IMMUNOMODULATION; INTERNALIZATION; LIVER DISEASE; LYMPHOCYTE ACTIVATION; PROTEIN BINDING; PROTEIN TRANSPORT; RADIOIMMUNOASSAY; REVIEW; VIRUS ENTRY;

ANIMALS; ASIALOGLYCOPROTEIN RECEPTOR; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; HEPATITIS, AUTOIMMUNE; HUMANS; LIVER; PROTEIN BINDING;

EID: 84870246401     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2012.04.005     Document Type: Review

References (148)

1. Ashwell G., Morell A.G. The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv Enzymol Relat Areas Mol Biol 1974, 41:99-128.
2. Drickamer K. Two distinct classes of carbohydrate-recognition domains in animal lectins. J Biol Chem 1988, 263:9557-9560.
3. Drickamer K. Ca(2+)-dependent sugar recognition by animal lectins. Biochem Soc Trans 1996, 24:146-150.
4. Ashwell G., Harford J. Carbohydrate-specific receptors of the liver. Annu Rev Biochem 1982, 51:531-554.
5. Anonymous Gilbert Ashwell: sweet on science. Nat Med 2008, 14:608.
6. Morell A.G., Van den Hamer C.J., Scheinberg I.H., Ashwell G. Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin labeled with tritium on terminal D-galactose residues. J Biol Chem 1966, 241:3745-3749.
7. Morell A.G., Irvine R.A., Sternlieb I., Scheinberg I.H., Ashwell G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J Biol Chem 1968, 243:155-159.
8. Morell A.G., Gregoriadis G., Scheinberg I.H., Hickman J., Ashwell G. The role of sialic acid in determining the survival of glycoproteins in the circulation. J Biol Chem 1971, 246:1461-1467.
9. Van Den Hamer C.J., Morell A.G., Scheinberg I.H., Hickman J., Ashwell G. Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. J Biol Chem 1970, 245:4397-4402.
10. Baenziger J., Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units. J Biol Chem 1974, 249:7270-7281.
11. Spiess M. The asialoglycoprotein receptor: a model for endocytic transport receptors. Biochemistry 1990, 29:10009-10018.
12. Stockert R.J. The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol Rev 1995, 75:591-609.
13. Diao J., Michalak T.I. Composition, antigenic properties and hepatocyte surface expression of the woodchuck asialoglycoprotein receptor. J Recept Signal Transduct Res 1996, 16:243-271.
14. Kawasaki T., Ashwell G. Isolation and characterization of an avian hepatic binding protein specific for N-acetylglucosamine-terminated glycoproteins. J Biol Chem 1977, 252:6536-6543.
15. Pricer W.E., Hudgin R.L., Ashwell G., Stockert R.J., Morell A.G. A membrane receptor protein for asialoglycoproteins. Methods Enzymol 1974, 34:688-691.
16. Rotundo R.F., Vincent P.A., McKeown-Longo P.J., Blumenstock F.A., Saba T.M. Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor. Am J Physiol 1999, 277:G1189-G1199.
17. Stockert R.J., Kressner M.S., Collins J.C., Sternlieb I., Morell A.G. IgA interaction with the asialoglycoprotein receptor. Proc Natl Acad Sci U S A 1982, 79:6229-6231.
18. Daniels C.K., Schmucker D.L., Jones A.L. Hepatic asialoglycoprotein receptor-mediated binding of human polymeric immunoglobulin A. Hepatology 1989, 9:229-234.
19. Tomana M., Kulhavy R., Mestecky J. Receptor-mediated binding and uptake of immunoglobulin A by human liver. Gastroenterology 1988, 94:762-770.
20. Rifai A., Fadden K., Morrison S.L., Chintalacharuvu K.R. The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes. J Exp Med 2000, 191:2171-2182.
21. Windler E., Greeve J., Levkau B., Kolb-Bachofen V., Daerr W., Greten H. The human asialoglycoprotein receptor is a possible binding site for low-density lipoproteins and chylomicron remnants. Biochem J 1991, 276(Pt 1):79-87.
22. Ishibashi S., Perrey S., Chen Z., Osuga J., Shimada M., Ohashi K., et al. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 1996, 271:22422-22427.
23. Yang J., Bo X.C., Ding X.R., Dai J.M., Zhang M.L., Wang X.H., et al. Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat 2006, 13:158-165.
24. Yang J., Wang F., Tian L., Su J., Zhu X., Lin L., et al. Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface. Arch Virol 2010, 155:881-888.
25. Treichel U., Meyer zum Buschenfelde K.H., Dienes H.P., Gerken G. Receptor-mediated entry of hepatitis B virus particles into liver cells. Arch Virol 1997, 142:493-498.
26. Treichel U., Meyer zum Buschenfelde K.H., Stockert R.J., Poralla T., Gerken G. The asialoglycoprotein receptor mediates hepatic binding and uptake of natural hepatitis B virus particles derived from viraemic carriers. J Gen Virol 1994, 75(Pt 11):3021-3029.
27. Dotzauer A., Gebhardt U., Bieback K., Gottke U., Kracke A., Mages J., et al. Hepatitis A virus-specific immunoglobulin A mediates infection of hepatocytes with hepatitis A virus via the asialoglycoprotein receptor. J Virol 2000, 74:10950-10957.
28. Marth J.D., Grewal P.K. Mammalian glycosylation in immunity. Nat Rev Immunol 2008, 8:874-887.
29. Guy C.S., Rankin S.L., Michalak T.I. Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology 2011, 54:1043-1050.
30. Weis W.I., Taylor M.E., Drickamer K. The C-type lectin superfamily in the immune system. Immunol Rev 1998, 163:19-34.
31. Trowbridge I.S., Collawn J.F., Hopkins C.R. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol 1993, 9:129-161.
32. Schwartz A.L., Fridovich S.E., Knowles B.B., Lodish H.F. Characterization of the asialoglycoprotein receptor in a continuous hepatoma line. J Biol Chem 1981, 256:8878-8881.
33. Strous G.J., Du Maine A., Zijderhand-Bleekemolen J.E., Slot J.W., Schwartz A.L. Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. J Cell Biol 1985, 101:531-539.
34. Schwartz A.L., Bolognesi A., Fridovich S.E. Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells. J Cell Biol 1984, 98:732-738.
35. Schwartz A.L., Fridovich S.E., Lodish H.F. Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line. J Biol Chem 1982, 257:4230-4237.
36. Weigel P.H. Characterization of the asialoglycoprotein receptor on isolated rat hepatocytes. J Biol Chem 1980, 255:6111-6120.
37. Lee Y.C., Townsend R.R., Hardy M.R., Lonngren J., Arnarp J., Haraldsson M., et al. Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features. J Biol Chem 1983, 258:199-202.
38. Hardy M.R., Townsend R.R., Parkhurst S.M., Lee Y.C. Different modes of ligand binding to the hepatic galactose/N-acetylgalactosamine lectin on the surface of rabbit hepatocytes. Biochemistry 1985, 24:22-28.
39. Chiu M.H., Tamura T., Wadhwa M.S., Rice K.G. In vivo targeting function of N-linked oligosaccharides with terminating galactose and N-acetylgalactosamine residues. J Biol Chem 1994, 269:16195-16202.
40. Breitfeld P.P., Rup D., Schwartz A.L. Influence of the N-linked oligosaccharides on the biosynthesis, intracellular routing, and function of the human asialoglycoprotein receptor. J Biol Chem 1984, 259:10414-10421.
41. Baenziger J., Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine-linked oligosaccharide units. J Biol Chem 1974, 249:7260-7269.
42. Inamoto T., Brown W.R. IgG is associated with the asialoglycoprotein receptor in the human liver. Hepatology 1991, 14:1070-1075.
43. Huang L., Soldevila G., Leeker M., Flavell R., Crispe I.N. The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1994, 1:741-749.
44. Huang L., Sye K., Crispe I.N. Proliferation and apoptosis of B220+CD4-CD8-TCR alpha beta intermediate T cells in the liver of normal adult mice: implication for lpr pathogenesis. Int Immunol 1994, 6:533-540.
45. Guy C.S., Wang J., Michalak T.I. Hepatocytes as cytotoxic effector cells can induce cell death by CD95 ligand-mediated pathway. Hepatology 2006, 43:1231-1240.
46. Guy C.S., Rankin S.L., Wang J., Michalak T.I. Hepatocytes can induce death of contacted cells via perforin-dependent mechanism. Hepatology 2008, 47:1691-1701.
47. Grewal P.K., Uchiyama S., Ditto D., Varki N., Le D.T., Nizet V., et al. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med 2008, 14:648-655.
48. Rumjantseva V., Grewal P.K., Wandall H.H., Josefsson E.C., Sorensen A.L., Larson G., et al. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med 2009, 15:1273-1280.
49. Grewal P.K. The Ashwell-Morell receptor. Methods Enzymol 2010, 479:223-241.
50. Sorensen A.L., Rumjantseva V., Nayeb-Hashemi S., Clausen H., Hartwig J.H., Wandall H.H., et al. Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood 2009, 114:1645-1654.
51. Wu G.Y., Wu C.H. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988, 263:14621-14624.
52. Zhang X., Lin S.M., Chen T.Y., Liu M., Ye F., Chen Y.R., et al. Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro. Arch Virol 2011, 156:637-645.
53. Becker S., Spiess M., Klenk H.D. The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus. J Gen Virol 1995, 76(Pt 2):393-399.
54. Wu G.Y., Zhan P., Sze L.L., Rosenberg A.R., Wu C.H. Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression. J Biol Chem 1994, 269:11542-11546.
55. Diao J., Michalak T.I. Virus-induced anti-asialoglycoprotein receptor autoimmunity in experimental hepadnaviral hepatitis. Hepatology 1997, 25:689-696.
56. Diao J., Churchill N.D., Michalak T.I. Complement-mediated cytotoxicity and inhibition of ligand binding to hepatocytes by woodchuck hepatitis virus-induced autoantibodies to asialoglycoprotein receptor. Hepatology 1998, 27:1623-1631.
57. Diao J., Slaney D.M., Michalak T.I. Modulation of the outcome and severity of hepadnaviral hepatitis in woodchucks by antibodies to hepatic asialoglycoprotein receptor. Hepatology 2003, 38:629-638.
58. Burgess J.B., Baenziger J.U., Brown W.R. Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis. Hepatology 1992, 15:702-706.
59. Eisenberg C., Seta N., Appel M., Feldmann G., Durand G., Feger J. Asialoglycoprotein receptor in human isolated hepatocytes from normal liver and its apparent increase in liver with histological alterations. J Hepatol 1991, 13:305-309.
60. Treichel U., Paietta E., Poralla T., Meyer zum Buschenfelde K.H., Stockert R.J. Effects of cytokines on synthesis and function of the hepatic asialoglycoprotein receptor. J Cell Physiol 1994, 158:527-534.
61. Marshall J.S., Green A.M., Pensky J., Williams S., Zinn A., Carlson D.M. Measurement of circulating desialylated glycoproteins and correlation with hepatocellular damage. J Clin Invest 1974, 54:555-562.
62. Nakaya R., Kohgo Y., Mogi Y., Nakajima M., Kato J., Niitsu Y. Regulation of asialoglycoprotein receptor synthesis by inflammation-related cytokines in HepG2 cells. J Gastroenterol 1994, 29:24-30.
63. Poralla T., Treichel U., Lohr H., Fleischer B. The asialoglycoprotein receptor as target structure in autoimmune liver diseases. Semin Liver Dis 1991, 11:215-222.
64. Bogdanos D.P., Mieli-Vergani G., Vergani D. Autoantibodies and their antigens in autoimmune hepatitis. Semin Liver Dis 2009, 29:241-253.
65. Bogdanos D.P., Baum H., Vergani D. Antimitochondrial and other autoantibodies. Clin Liver Dis 2003, 7:759-777. [vi].
66. Bogdanos D.P., Komorowski L. Disease-specific autoantibodies in primary biliary cirrhosis. Clin Chim Acta 2011, 412:502-512.
67. Bogdanos D.P., Dalekos G.N. Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s. Curr Med Chem 2008, 15:2285-2292.
68. Santodomingo-Garzon T., Swain M.G. Role of NKT cells in autoimmune liver disease. Autoimmun Rev 2011, 10:793-800.
69. Liu H., Norman G.L., Shums Z., Worman H.J., Krawitt E.L., Bizzaro N., et al. PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis. J Autoimmun 2010, 35:436-442.
70. Oliveira L.C., Porta G., Marin M.L., Bittencourt P.L., Kalil J., Goldberg A.C. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev 2011, 10:189-193.
71. Duarte-Rey C., Pardo A.L., Rodriguez-Velosa Y., Mantilla R.D., Anaya J.M., Rojas-Villarraga A. HLA class II association with autoimmune hepatitis in Latin America: a meta-analysis. Autoimmun Rev 2009, 8:325-331.
72. Invernizzi P. Geoepidemiology of autoimmune liver diseases. J Autoimmun 2010, 34:J300-J306.
73. Bogdanos D.P., Choudhuri K., Vergani D. Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences. Liver 2001, 21:225-232.
74. Bogdanos D.P., Baum H., Grasso A., Okamoto M., Butler P., Ma Y., et al. Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis. J Hepatol 2004, 40:31-39.
75. Bogdanos D.P., Baum H., Gunsar F., Arioli D., Polymeros D., Ma Y., et al. Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity. Scand J Gastroenterol 2004, 39:981-987.
76. Bogdanos D.P., Baum H., Okamoto M., Montalto P., Sharma U.C., Rigopoulou E.I., et al. Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic. Hepatology 2005, 42:458-465.
77. Bogdanos D.P., Baum H., Sharma U.C., Grasso A., Ma Y., Burroughs A.K., et al. Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis. J Hepatol 2002, 36:14-21.
78. Bogdanos D.P., Lenzi M., Okamoto M., Rigopoulou E.I., Muratori P., Ma Y., et al. Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51. Int J Immunopathol Pharmacol 2004, 17:83-92.
79. Bogdanos D.P., Mieli-Vergani G., Vergani D. Virus, liver and autoimmunity. Dig Liver Dis 2000, 32:440-446.
80. Bogdanos D.P., Smyk D.S., Rigopoulou E.I., Mytilinaiou M.G., Heneghan M.A., Selmi C., et al. Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun May 2012, 38(2-3):J156-169.
81. Bogdanos D.P., Vergani D. Origin of cross-reactive autoimmunity in primary biliary cirrhosis. Liver Int 2006, 26:633-635.
82. Bogdanos D.P., Vergani D. Bacteria and primary biliary cirrhosis. Clin Rev Allergy Immunol 2009, 36:30-39.
83. Kerkar N., Choudhuri K., Ma Y., Mahmoud A., Bogdanos D.P., Muratori L., et al. Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J Immunol 2003, 170:1481-1489.
84. Christen U., Holdener M., Hintermann E. Animal models for autoimmune hepatitis. Autoimmun Rev 2007, 6:306-311.
85. Moritoki Y., Lian Z.X., Ohsugi Y., Ueno Y., Gershwin M.E. B cells and autoimmune liver diseases. Autoimmun Rev 2006, 5:449-457.
86. Diamantis I., Boumpas D.T. Autoimmune hepatitis: evolving concepts. Autoimmun Rev 2004, 3:207-214.
87. Hintermann E., Holdener M., Bayer M., Loges S., Pfeilschifter J.M., Granier C., et al. Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. J Autoimmun 2011, 37:242-253.
88. Longhi M.S., Ma Y., Mieli-Vergani G., Vergani D. Aetiopathogenesis of autoimmune hepatitis. J Autoimmun 2010, 34:7-14.
89. Carambia A., Herkel J. CD4 T cells in hepatic immune tolerance. J Autoimmun 2010, 34:23-28.
90. Hopf U., Meyer zum Buschenfelde K.H., Arnold W. Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med 1976, 294:578-582.
91. Gerken G., Manns M., Ramadori G., Poralla T., Dienes H.P., Meyer zum Buschenfelde K.H. Liver membrane autoantibodies in chronic active hepatitis. Studies on mechanically and enzymatically isolated rabbit hepatocytes. J Hepatol 1987, 5:65-74.
92. McFarlane I.G., Wojcicka B.M., Zucker G.M., Eddleston A.L., Williams R. Purification and characterization of human liver-specific membrane lipoprotein (LSP). Clin Exp Immunol 1977, 27:381-390.
93. Helin H., Uibo R., Paronen I., Krohn K. Immunohistochemical localization of human liver specific protein using rabbit antisera and the avidin-biotin complex technique. Clin Exp Immunol 1985, 59:371-376.
94. Lohse A.W., Manns M., Dienes H.P., Meyer zum Buschenfelde K.H., Cohen I.R. Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity. Hepatology 1990, 11:24-30.
95. Meyer zum Buschenfelde K.H., Hopf U. Studies on the pathogenesis of experimental chronic active hepatitis in rabbits. I. Induction of the disease and protective effect of allogeneic liver specific proteins. Br J Exp Pathol 1974, 55:498-508.
96. McFarlane I.G., Hegarty J.E., McSorley C.G., McFarlane B.M., Williams R. Antibodies to liver-specific protein predict outcome of treatment withdrawal in autoimmune chronic active hepatitis. Lancet 1984, 2:954-956.
97. Poralla T., Manns M., Dienes H.P., Dippold W., Hutteroth T.H., Meyer zum Buschenfelde K.H. Analysis of liver-specific protein LSP using murine monoclonal antibodies. Eur J Clin Invest 1987, 17:360-367.
98. Frazer I.H., Jordan T.W., Collins E.C., Andrews P., Mackay I.R. Antibody to liver membrane antigens in chronic active hepatitis. IV. Exclusion of specific reactivity to polypeptides and glycolipids by immunoblotting. Hepatology 1987, 7:4-10.
99. Wiedmann K.H., Trejdosiewicz L.K., Goodall A.H., Thomas H.C. Analysis of the antigenic composition of liver specific lipoprotein using murine monoclonal antibodies. Gut 1985, 26:510-517.
100. McFarlane I.G., McFarlane B.M., Major G.N., Tolley P., Williams R. Identification of the hepatic asialo-glycoprotein receptor (hepatic lectin) as a component of liver specific membrane lipoprotein (LSP). Clin Exp Immunol 1984, 55:347-354.
101. McFarlane B.M., McSorley C.G., McFarlane I.G., Williams R. A radioimmunoassay for detection of circulating antibodies reacting with the hepatic asialoglycoprotein receptor protein. J Immunol Methods 1985, 77:219-228.
102. McFarlane B.M., McSorley C.G., Vergani D., McFarlane I.G., Williams R. Serum autoantibodies reacting with the hepatic asialoglycoprotein receptor protein (hepatic lectin) in acute and chronic liver disorders. J Hepatol 1986, 3:196-205.
103. McFarlane B.M., Sipos J., Gove C.D., McFarlane I.G., Williams R. Antibodies against the hepatic asialoglycoprotein receptor perfused in situ preferentially attach to periportal liver cells in the rat. Hepatology 1990, 11:408-415.
104. Treichel U., Gerken G., Rossol S., Rotthauwe H.W., Meyer zum Buschenfelde K.H., Poralla T. Autoantibodies against the human asialoglycoprotein receptor: effects of therapy in autoimmune and virus-induced chronic active hepatitis. J Hepatol 1993, 19:55-63.
105. Treichel U., McFarlane B.M., Seki T., Krawitt E.L., Alessi N., Stickel F., et al. Demographics of anti-asialoglycoprotein receptor autoantibodies in autoimmune hepatitis. Gastroenterology 1994, 107:799-804.
106. Treichel U., Poralla T., Hess G., Manns M., Meyer zum Buschenfelde K.H. Autoantibodies to human asialoglycoprotein receptor in autoimmune-type chronic hepatitis. Hepatology 1990, 11:606-612.
107. Czaja A.J., Pfeifer K.D., Decker R.H., Vallari A.S. Frequency and significance of antibodies to asialoglycoprotein receptor in type 1 autoimmune hepatitis. Dig Dis Sci 1996, 41:1733-1740.
108. Dejica D., Treichel U., Par A., Chira O., Meyer zum Buschenfelde K.H. Anti asialoglycoprotein receptor antibodies and soluble interleukin-2 receptor levels as marker for inflammation in autoimmune hepatitis. Z Gastroenterol 1997, 35:15-21.
109. Lohse A.W., Gerken G., Mohr H., Lohr H.F., Treichel U., Dienes H.P., et al. Relation between autoimmune liver diseases and viral hepatitis: clinical and serological characteristics in 859 patients. Z Gastroenterol 1995, 33:527-533.
110. Yoshioka M., Mizuno M., Morisue Y., Shimada M., Hirai M., Nasu J., et al. Anti-asialoglycoprotein receptor autoantibodies, detected by a capture-immunoassay, are associated with autoimmune liver diseases. Acta Med Okayama 2002, 56:99-105.
111. Bedlow A.J., Donaldson P.T., McFarlane B.M., Lombard M., McFarlane I.G., Williams R. Autoreactivity to hepatocellular antigens in primary biliary cirrhosis and primary sclerosing cholangitis. J Clin Lab Immunol 1989, 30:103-109.
112. Vento S., McFarlane B.M., Vento T.G., Ranieri S., Rondanelli E.G., McFarlane I.G., et al. Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B. J Autoimmun 1988, 1:299-307.
113. McFarlane B.M., Bridger C.B., Smith H.M., Antonov K.A., Naoumov N., Williams R., et al. Autoimmune mechanisms in chronic hepatitis B and delta virus infections. Eur J Gastroenterol Hepatol 1995, 7:615-621.
114. Lohr H., Treichel U., Poralla T., Manns M., Meyer zum Buschenfelde K.H. Liver-infiltrating T helper cells in autoimmune chronic active hepatitis stimulate the production of autoantibodies against the human asialoglycoprotein receptor in vitro. Clin Exp Immunol 1992, 88:45-49.
115. Lohr H., Treichel U., Poralla T., Manns M., Meyer zum Buschenfelde K.H., Fleischer B. The human hepatic asialoglycoprotein receptor is a target antigen for liver-infiltrating T cells in autoimmune chronic active hepatitis and primary biliary cirrhosis. Hepatology 1990, 12:1314-1320.
116. Hausdorf G., Roggenbuck D., Feist E., Buttner T., Jungblut P.R., Conrad K., et al. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA-revival of a disease-activity marker in autoimmune hepatitis. Clin Chim Acta 2009, 408:19-24.
117. Poralla T., Ramadori G., Dienes H.P., Manns M., Gerken G., Dippold W., et al. Liver cell damage caused by monoclonal antibody against an organ-specific membrane antigen in vivo and in vitro. J Hepatol 1987, 4:373-380.
118. Gonzales C., Cochrane A.M., Eddleston A.L., Williams R. Mechanisms responsible for antibody-dependent, cell-mediated cytotoxicity to isolated hepatocytes in chronic active hepatitis. Gut 1979, 20:385-388.
119. Cochrane A.M., Moussouros A., Thomsom A.D., Eddleston A.L., Wiiliams R. Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet 1976, 1:441-444.
120. Meyer zum Buschenfelde K.H., Treichel U., Lohr H., Fleischer B., Poralla T. Human asialoglycoprotein receptor as an autoantigen in chronic hepatitis. Immunol Res 1991, 10:497-502.
121. Vento S., Hegarty J.E., Bottazzo G., Macchia E., Williams R., Eddleston A.L. Antigen specific suppressor cell function in autoimmune chronic active hepatitis. Lancet 1984, 1:1200-1204.
122. Vento S., Eddleston A.L. Cellular mechanisms of hepatocyte damage and regulatory mechanisms in autoimmune chronic active hepatitis. Springer Semin Immunopathol 1990, 12:67-72.
123. Longhi M.S., Hussain M.J., Bogdanos D.P., Quaglia A., Mieli-Vergani G., Ma Y., et al. Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. Hepatology 2007, 46:472-484.
124. Longhi M.S., Ma Y., Bogdanos D.P., Cheeseman P., Mieli-Vergani G., Vergani D. Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease. J Hepatol 2004, 41:31-37.
125. Longhi M.S., Ma Y., Mitry R.R., Bogdanos D.P., Heneghan M., Cheeseman P., et al. Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis. J Autoimmun 2005, 25:63-71.
126. Ma Y., Bogdanos D.P., Hussain M.J., Underhill J., Bansal S., Longhi M.S., et al. Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2. Gastroenterology 2006, 130:868-882.
127. Vergani D., Choudhuri K., Bogdanos D.P., Mieli-Vergani G. Pathogenesis of autoimmune hepatitis. Clin Liver Dis 2002, 6:727-737.
128. Vergani D., Longhi M.S., Bogdanos D.P., Ma Y., Mieli-Vergani G. Autoimmune hepatitis. Semin Immunopathol 2009, 31:421-435.
129. Hajoui O., Martin S., Alvarez F. Study of antigenic sites on the asialoglycoprotein receptor recognized by autoantibodies. Clin Exp Immunol 1998, 113:339-345.
130. Treichel U., Schreiter T., Meyer zum Buschenfelde K.H., Stockert R.J. High-yield purification and characterization of human asialoglycoprotein receptor. Protein Expr Purif 1995, 6:251-255.
131. Roggenbuck D., Reinhold D., Wex T., Goihl A., von Arnim U., Malfertheiner P., et al. Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease. Clin Chim Acta 2011, 412:718-724.
132. Schreiter T., Liu C., Gerken G., Treichel U. Detection of circulating autoantibodies directed against the asialoglycoprotein receptor using recombinant receptor subunit H1. J Immunol Methods 2005, 301:1-10.
133. Meier M., Bider M.D., Malashkevich V.N., Spiess M., Burkhard P. Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. J Mol Biol 2000, 300:857-865.
134. Roggenbuck D., Hausdorf G., Martinez-Gamboa L., Reinhold D., Buttner T., Jungblut P.R., et al. Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease. Gut 2009, 58:1620-1628.
135. Bogdanos D.P., Rigopoulou E.I., Smyk D.S., Roggenbuck D., Reinhold D., Forbes A., et al. Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies. Autoimmun Rev 2011, 11:143-148.
136. Hajoui O., Debray D., Martin S., Alvarez F. Auto-antibodies to the asialoglycoprotein receptor in sera of children with auto-immune hepatitis. Eur J Pediatr 2000, 159:310-313.
137. Gregorio G.V., Portmann B., Reid F., Donaldson P.T., Doherty D.G., McCartney M., et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology 1997, 25:541-547.
138. Johnson P.J., McFarlane I.G., McFarlane B.M., Williams R. Auto-immune features in patients with idiopathic chronic active hepatitis who are seronegative for conventional auto-antibodies. J Gastroenterol Hepatol 1990, 5:244-251.
139. Johnson P.J., McFarlane I.G. Meeting report: International Autoimmune Hepatitis Group. Hepatology 1993, 18:998-1005.
140. Alvarez F., Berg P.A., Bianchi F.B., Bianchi L., Burroughs A.K., Cancado E.L., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999, 31:929-938.
141. Vergani D., Alvarez F., Bianchi F.B., Cancado E.L., Mackay I.R., Manns M.P., et al. Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group. J Hepatol 2004, 41:677-683.
142. Hennes E.M., Zeniya M., Czaja A.J., Pares A., Dalekos G.N., Krawitt E.L., et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 2008, 48:169-176.
143. Hilgard P., Schreiter T., Stockert R.J., Gerken G., Treichel U. Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis. Hepatology 2004, 39:1398-1407.
144. Husa P., Chalupa P., Stroblova H., Husova L., Slesinger P., Zajic J. Autoantibodies to asialoglycoprotein receptor in chronic hepatitis C patients. Acta Virol 2001, 45:7-11.
145. Sasaki M., Yamauchi K., Tokushige K., Isono E., Komatsu T., Zeniya M., et al. Clinical significance of autoantibody to hepatocyte membrane antigen in type 1 autoimmune hepatitis. Am J Gastroenterol 2001, 96:846-851.
146. Mytilinaiou M.G., Roggenbuck D., Grammatikopoulos A., Davies E.T., Romanidou O., Rigopoulou E.I., et al. Anti-asialoglycoprotein receptor antibody measured by ELISA is a specific marker of liver autoimmunity and mirrors disease activity in patients with autoimmune hepatitis. Hepatology 2011, 54:919A.
147. Vergani D., Mieli-Vergani G. Autoimmune hepatitis. Autoimmun Rev 2003, 2:241-247.
148. Madej T., Addess K.J., Fong J.H., Geer L.Y., Geer R.C., Lanczycki C.J., et al. MMDB: 3D structures and macromolecular interactions. Nucleic Acids Res 2012, 40:D461-D464.