Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease

Clinica Chimica Acta

Volumn 412, Issue 9-10, 2011, Pages 718-724

  Roggenbuck, Dirk ^a   Reinhold, Dirk ^b   Wex, Thomas ^b   Goihl, Alexander ^b   von Arnim, Ulrike ^b   Malfertheiner, Peter ^b   Büttner, Thomas ^a   Porstmann, Tomas ^c   Porstmann, Silvia ^c   Liedvogel, Bodo ^d   Bogdanos, Dimitrios P ^e   Laass, Martin W ^f   Conrad, Karsten ^f  

^a GA GENERIC ASSAYS GMBH   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c Seramun Diagnostica GmbH   (Germany)

^d DIARECT AG   (Germany)

^e KING S COLLEGE HOSPITAL   (United Kingdom)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Autoantigen; Crohn's disease; Inflammatory bowel disease; Pancreatic autoantibody; Zymogen granule membrane glycoprotein GP2

Indexed keywords

ANTIBODY TO MANNAN OF SACCHAROMYCES CEREVISIAE; AUTOANTIBODY; GLYCOPROTEIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PANCREATIC AUTOANTIBODY; UNCLASSIFIED DRUG; ZYMOGEN GRANULE MEMBRANE GLYCOPROTEIN 2;

ADULT; AGED; ANTIGEN ANTIBODY REACTION; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; CROHN DISEASE; DISEASE MARKER; FEMALE; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; ANIMALS; AUTOANTIBODIES; BACULOVIRIDAE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL LINE; CROHN DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GPI-LINKED PROTEINS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MANNANS; MIDDLE AGED; PANCREAS; SACCHAROMYCES CEREVISIAE; SEROLOGIC TESTS; YOUNG ADULT;

SACCHAROMYCES CEREVISIAE; SPODOPTERA FRUGIPERDA;

EID: 79951720546     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.12.029     Document Type: Article

References (35)

1. Logan I., Bowlus C.L. The geoepidemiology of autoimmune intestinal diseases. Autoimmun Rev 2010, 9:A372-A378.
2. Baumgart D.C., Carding S.R. Inflammatory bowel disease: cause and immunobiology. Lancet 2007, 369:1627-1631.
3. Danese S., Sans M., Fiocchi C. Inflammatory bowel disease: the role of environmental factors. Autoimmun Rev 2004, 3:394-400.
4. Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000, 68:7010-7017.
5. Franchimont D., Vermeire S., El Housni H., et al. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004, 53:987-992.
6. Ina K., Itoh J., Fukushima K., et al. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 1999, 163:1081-1090.
7. Roggenbuck D., Hausdorf G., Martinez-Gamboa L., et al. Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease. Gut 2009, 58:1620-1628.
8. Stöcker W., Otte M., Ulrich S., et al. Autoimmunity to pancreatic juice in Crohn's disease. Results of an autoantibody screening in patients with chronic inflammatory bowel disease. Scand J Gastroenterol 1987, 139:41-52.
9. Seibold F., Weber P., Jenss H., Wiedmann K.H. Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease. Gut 1991, 32:1192-1197.
10. Ronzio R.A., Kronquist K.E., Lewis D.S., MacDonald R.J., Mohrlok S.H., O'Donnell J.J. Glycoprotein synthesis in the adult rat pancreas. IV. Subcellular distribution of membrane glycoproteins. Biochim Biophys Acta 1978, 508:65-84.
11. LeBel D., Beattie M. The major protein of pancreatic zymogen granule membranes (GP-2) is anchored via covalent bonds to phosphatidylinositol. Biochem Biophys Res Commun 1988, 154:818-823.
12. Rindler M.J., Hoops T.C. The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate. Eur J Cell Biol 1990, 53:154-163.
13. Terahara K., Yoshida M., Igarashi S., et al. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol 2008, 180:7840-7846.
14. Hase K., Kawano K., Nochi T., et al. Uptake through glycoprotein 2 of FimH1 bacteria by M cells initiates mucosal immune response. Nature 2009, 462:226-231.
15. Säemann M.D., Weichhart T., Zeyda M., et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005, 115:468-475.
16. Pak J., Pu Y., Zhang Z.T., Hasty D.L., Wu X.R. Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin 1a and 1b receptors. J Biol Chem 2001, 276:9924-9930.
17. Conrad K., Schmechta H., Klafki A., et al. Serological differentiation of inflammatory bowel diseases. Eur J Gastroenterol Hepatol 2002, 14:129-135.
18. Bossuyt X. Serologic markers in inflammatory bowel disease. Clin Chem 2006, 52:171-181.
19. Ferrante M., Henckaerts L., Joossens M., Pierik M., Joossens S., Dotan N., Norman G.L., et al. New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 2007, 56:1394-1403.
20. Zhou F., Xia B., Wang F., et al. The prevalence and diagnostic value of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease in mainland China. Clin Chim Acta 2010, 411:1461-1465.
21. Lennard-Jones J.E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989, 170:2-6.
22. Wong S.M.E., Lowe A.W. Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. Gene 1996, 171:311-312.
23. Zöphel K., Wunderlich G., Kotzerke J., von Landenberg P., Roggenbuck D. M22 based (manual) ELISA for TSH-receptor antibody (TRAb) measurement is more sensitive than 2nd generation TRAb assays. Clin Chim Acta 2009, 403:266.
24. Seibold F., Mörk H., Tanza S., et al. Pancreatic autoantibodies in Crohn's disease: a family study. Gut 1997, 40:481-484.
25. Nakamura R.M., Matsutani M., Barry M. Advances in clinical laboratory tests for inflammatory bowel disease. Clin Chim Acta 2003, 335:9-20.
26. Shapira Y., Agmon-Levin N., Shoenfeld Y. Defining and analyzing geoepidemiology and human autoimmunity. J Autoimmun 2010, 34:J168-J177.
27. Aulinger-Stöcker K, Probst C, Komorowski L. Detection of Crohn's disease specific autoantigens against exocrine pancreas by IIF using the newly identified proteoglycans CUZD1 and GP2 as recombinant target antigens. UEGW 2008, abstract.
28. Lakatos P.L., Altorjay I., Szamosi T., et al. Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort. Inflamm Bowel Dis 2009, 15:365-374.
29. Hausdorf G., Roggenbuck D., Feist E., et al. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA-Revival of a disease-activity marker in autoimmune hepatitis. Clin Chim Acta 2009, 408:19-24.
30. OpDeBeéck K, Vermeire S, Rutgeerts P, Bossuyt X. Antibodies to GP2, the major zymogen granule membrane glycoprotein, in inflammatory bowel diseases. Gut. doi:10.1136/gut.2010.233148.
31. Darfeuille-Michaud A., Boudeau J., Bulois P., et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004, 127:412-421.
32. García Rodríguez L.A., Ruigómez A., Panés J. Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease. Gastroenterology 2006, 130:1588-1594.
33. Round J.L., O'Connell R.M., Mazmanian S.K. Coordination of tolerogenic immune responses by the commensal microbiota. J Autoimmun 2010, 34:J220-J225.
34. Fukuoka S.I., Freedman S.D., Yu H., Sukhatme V.P., Scheele G.A. GP2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Proc Natl Acad Sci USA 1992, 89:1189-1193.
35. Cuadrado E. Granulocyte/monocyte apheresis as immunotherapic tool: cellular adsorption and immune modulation. Autoimmun Rev 2009, 8:292-296.