Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells

Acta Biomaterialia

Volumn 9, Issue 1, 2013, Pages 4916-4925

  Vallés, Gema ^a,b   Pérez, Concepción ^c   Boré, Alba ^a,b   Martín Saavedra, Francisco ^a,b   Saldaña, Laura ^a,b   Vilaboa, Nuria ^a,b  

^a HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

IL 6; Osteoblast; Osteolysis; Simvastatin; Wear particles

Indexed keywords

BONE; CYTOLOGY; GENE EXPRESSION; METAL IMPLANTS; ORTHOPEDICS; OSTEOBLASTS; TITANIUM;

GENES EXPRESSION; INTERLEUKIN6 (IL6); METAL PARTICLE; OSTEOBLASTIC CELLS; OSTEOLYSIS; PRIMARY OSTEOBLASTS; SIMVASTATIN; TI PARTICLES; TITANIUM PARTICLES; WEAR PARTICLES;

ARTHROPLASTY;

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL; GERANYLGERANYL PYROPHOSPHATE; INTERLEUKIN 6; MESSENGER RNA; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TITANIUM;

APOPTOSIS; ARTICLE; ATTENUATION; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; MACROPHAGE; OSTEOBLAST; OSTEOSARCOMA CELL; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN INDUCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 84870238152     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.08.027     Document Type: Article

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