The use of simvastatin in bone regeneration

Medicina Oral, Patologia Oral y Cirugia Bucal

Volumn 14, Issue 9, 2009, Pages

  Park, Jun Beom ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bone regeneration; Carrier; Dosage; Simvastatin

Indexed keywords

CALCIUM SULFATE; GELATIN; INTERLEUKIN 6; INTERLEUKIN 8; POLYGLACTIN; SIMVASTATIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; BONE DENSITY; BONE GROWTH; BONE REGENERATION; CANCELLOUS BONE; COMPRESSIVE STRENGTH; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; RAT; REVIEW; RISK BENEFIT ANALYSIS;

ANIMALS; BONE REGENERATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; SIMVASTATIN;

EID: 69949089672     PISSN: 16984447     EISSN: 16986946     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Jadhav SB, Jain GK. Statins and osteoporosis: new role for old drugs. J Pharm Pharmacol. 2006;58:3-18. (Pubitemid 43041991)
2. Gutierrez GE, Lalka D, Garrett IR, Rossini G, Mundy GR. Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int. 2006;17:1033-1042 (Pubitemid 43869919)
3. Yamashita M, Otsuka F, Mukai T, Otani H, Inagaki K, Miyoshi T, et al. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. J Endocrinol. 2008;196:601-613
4. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286:1946-1949 (Pubitemid 129515901)
5. Fernández-Tresguerres-Hernández-Gil I, Alobera-Gracia MA, Del-Canto-Pingarrón M, Blanco-Jerez L. Physiological bases of bone regeneration I. Histology and physiology of bone tissue. Med Oral Patol Oral Cir Bucal. 2006;11:E47-51.
6. Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K, Izumi Y. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res. 2006;85:520-523 (Pubitemid 43945489)
7. Takenaka M, Hirade K, Tanabe K, Akamatsu S, Dohi S, Matsuno H, et al. Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells. Biochem Biophys Res Commun. 2003;301:198-203. (Pubitemid 36268867)
8. Wu Z, Liu C, Zang G, Sun H. The effect of simvastatin on remodelling of the alveolar bone following tooth extraction. Int J Oral Maxillofac Surg. 2008;37:170-176 (Pubitemid 351220967)
9. Ozeç I, Kiliç E, Gümüş C, Göze F. Effect of local simvastatin application on mandibular defects. J Craniofac Surg. 2007;18:546-550 (Pubitemid 46849954)
10. Nyan M, Sato D, Oda M, Machida T, Kobayashi H, Nakamura T, et al. Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci. 2007;104:384-386 (Pubitemid 47378426)
11. Yoshinari M, Hayakawa T, Matsuzaka K, Inoue T, Oda Y, Shimono M, et al. Oxygen plasma surface modification enhances immobilization of simvastatin acid. Biomed Res. 2006;27:29-36.
12. Maritz FJ, Conradie MM, Hulley PA, Gopal R, Hough S. Effect of statins on bone mineral density and bone histomorphometry in rodents. Arterioscler Thromb Vasc Biol. 2001;21:1636-1641 (Pubitemid 34215584)
13. Wang JW, Xu SW, Yang DS, Lv RK. Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int. 2007;18:1641-1650
14. Montagnani A, Gonnelli S, Cepollaro C, Pacini S, Campagna MS, Franci MB, et al. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study. Bone. 2003;32:427-433 (Pubitemid 36410317)
15. Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol. 2005;19:117-125 (Pubitemid 40204354)
16. Başarir K, Erdemli B, Can A, Erdemli E, Zeyrek T. Osseointegration in arthroplasty: can simvastatin promote bone response to implants. Int Orthop. 2007.
17. Thylin MR, McConnell JC, Schmid MJ, Reckling RR, Ojha J, Bhattacharyya I, et al. Effects of simvastatin gels on murine calvarial bone. J Periodontol. 2002;73:1141-1148 (Pubitemid 35256265)
18. Ayukawa Y, Okamura A, Koyano K. Simvastatin promotes osteogenesis around titanium implants. Clin Oral Implants Res. 2004;15:346-350
19. Anbinder AL, Prado Fde A, Prado Mde A, Balducci I, Rocha RF. The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats. Braz Oral Res. 2007;21:247-252
20. Oxlund H, Andreassen TT. Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone. 2004;34:609-618 (Pubitemid 38393796)