Effect of pravastatin, simvastatin and atorvastatin on the phagocytic activity of mouse peritoneal macrophages

Experimental and Molecular Pathology

Volumn 80, Issue 2, 2006, Pages 160-164

  Djaldetti, Meir ^a,b   Salman, Hertzel ^a,b   Bergman, Michael ^a,b   Bessler, Hanna ^a,b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Mitogen response; Peritoneal macrophages; Phagocytosis; Statins

Indexed keywords

ATORVASTATIN; CONCANAVALIN A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LATEX; LIPIDAL; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; PRAVASTATIN; SIMVACOR; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; MACROPHAGE FUNCTION; MITOGENESIS; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; SPLEEN CELL;

ANIMALS; CELL PROLIFERATION; CONCANAVALIN A; HEPTANOIC ACIDS; LECTINS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICROSPHERES; MITOGENS; PHAGOCYTOSIS; PRAVASTATIN; PYRROLES; SIMVASTATIN; SPLEEN;

ANIMALIA;

EID: 33644507078     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexmp.2005.09.009     Document Type: Article

References (27)

1. A. Aderem, and D.M. Underhill Mechanisms of phagocytosis in macrophages Annu. Rev. Immunol. 17 1999 593 623
2. L.A. Allen, and A. Aderem Mechanism of phagocytosis Curr. Opin. Immunol. 8 1996 36 40
3. P.C. Calder, J.A. Bond, D.J. Harvey, S. Gordon, and E.A. Newsholme Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis Biochem. J. 269 1990 807 814
4. M.P. Dabrowski, W.E. Peel, and A.E. Thomson Plasma membrane cholesterol regulates human lymhocytic cytotoxic function Eur. J. Immunol. 10 1980 821 827
5. M. Djaldetti, H. Salman, M. Bergman, R. Djaldetti, and H. Bessler Phagocytosis-The mighty weapon of the silent warriors Microsc. Res. Tech. 57 2002 421 431
6. M. Fukami, N. Maeda, J. Fukushige, Y. Kogure, Y. Shimada, T. Ogawa, and T. Tsujita Effect of HMG-CoA reductase inhibitors on skeletal muscles of rabbits Res. Exp. Med. (Berl.) 193 1993 263 273
7. J. Gatfield, and J. Pieters Essential role for cholesterol in entry of mycobacteria into macrophages Science 288 2000 1647 1650
8. O. Grip, S. Janciauskiene, and S. Lindgren Pravastatin down-regulates inflammatory mediators in human monocytes in vitro Eur. J. Pharmacol. 410 2000 83 92
9. D.Z. Hillyard, A.J. Cameron, A.H. McIntyre, M.H. Hadden, H.E. Marshal, N. Johnston, and A.G. Jardine Inhibition of proliferation and signaling mechanisms in human lymphocytes by fluvastatin Clin. Exp. Pharmacol. Physiol. 29 2002 673 678
10. V. Hinkovska-Galcheva, L. Boxer, P.J. Mansfield, A.D. Schreiber, and J.A. Shayman Enhanced phagocytosis through inhibition of de novo ceramide synthesis J. Biol. Chem. 278 2003 974 982
11. D. Hulse, J.R. Kusel, N.G. O'Donnell, and P.C. Wilkinson Effect of anaesthetics on membrane mobility and locomotor responses of human neutrophils FEMS Immunol. Med. Microbiol. 8 1994 241 248
12. S. Kew, T. Banerjee, A.M. Minihane, Y.E. Finnegan, C.M. Williams, and P.C. Calder Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y Am. J. Clin. Nutr. 77 2003 1096 1097
13. C. Kirsch, G.P. Eckert, and W.E. Mueller Statin effects on cholesterol micro-domains in brain plasma membranes Biochem. Pharmacol. 65 2003 843 856
14. G.I. Klebanov, L.I. Ivanova, E.M. Turkmenova, and Iu.A. Vladimirov Effect of cholesterol on the physical state and function of lymphocyte membranes Biofizika 31 1986 73 78
15. M. Koter, M. Broncel, J. Chojnowska-Jezierska, K. Klikcznska, and I. Franiak The effect of atorvastatin on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia Eur. J. Clin. Pharmacol. 58 2002 501 506
16. K. Kwiatkowska, and A. Sobota Signaling pathways in phagocytosis Bioassays 21 1999 422 431
17. S. Li, R. Dudezak, and E. Koller Effect of statins on lipoprotein receptor expression in cell lines from human mast cells and basophils Eur. J. Clin. Pharmacol. 59 2003 507 516
18. I. Morita, I. Sato, L. Ma, and S. Murota Enhancement of membrane fluidity in cholesterol-poor endothelial cells pretreated with simvastatin Endothelium 5 1997 107 113
19. S. Muller, V. Masson, S. Droesh, M. Donner, and J.F. Stoltz Phagocytosis and membrane fluidity: application to the evaluation of opsonizing properties of fibronectin Biorheology 26 1989 323 330
20. R. Paoletti, S. Bellosta, and F. Bernini Pharmacological control of phagocytic function: inhibition of cholesterol accumulation Ann. N. Y. Acad. Sci. 832 1997 322 329
21. G. Paragh, E. Kovacs, and I. Seres Altered signal pathway in granulocytes from patients with hypercholesterolemia J. Lipid Res. 40 1999 1728 1733
22. R.A. Rabini, J. Antosiewicz, R. Staffolani, M. Polenta, I. Testa, and L. Mazzanti Effect of HMG-CoA reductase inhibitors on the erythrocyte membrane Boll. Soc. Ital. Biol. Sper. 67 1991 129 135
23. R.A. Rabini, M. Polenta, and J. Antosiewicz Effect of hydroxymethylglutaryl-CoA reductase inhibitors on the functional properties of erythrocyte membranes Exp. Mol. Pathol. 59 1993 51 57
24. A.J. Schroit, S. Rottem, and R. Gallily Motion of spin-labeled fatty acids in murine macrophages. Relation to cellular phagocytic activity Biochim. Biophys. Acta 426 1976 499 512
25. I. Seres, M. Freyss-Beguin, A. Mohacsi, B. Kozlovsky, J. Simon, M.A. Devynck, and T. Fulop Jr. Alteration of lymphocyte membrane phospholipids and intracellular free calcium concentrations in hyperlipidemic subjects Atherosclerosis 121 1966 175 183
26. A.A. Spector, and M.A. Yorek Membrane lipid composition and cellular function J. Lipid Res. 26 1985 1015 1035
27. S. Spika, I. Dey, C. Buda, J. Csongor, G. Szegedi, and T. Farkas The mechanism of inhibitory effect of eicosapentaenoic acid on phagocytic activity and chemotaxis of human neuthrophil granulocytes Clin. Immunol. Immunopathol. 79 1996 224 228