Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases

Autoimmunity Reviews

Volumn 12, Issue 2, 2012, Pages 218-224

  Perandini, Luiz Augusto ^a   de Sá Pinto, Ana Lúcia ^a   Roschel, Hamilton ^a   Benatti, Fabiana Braga ^a   Lima, Fernanda Rodrigues ^a   Bonfá, Eloisa ^a   Gualano, Bruno ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Exercise training; Fitness; Myositis; Physical activity; Rheumatoid arthritis; Systemic lupus erythematosus

Indexed keywords

CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT;

AEROBIC EXERCISE; ANKYLOSING SPONDYLITIS; ARTHRITIS IMPACT MEASUREMENT SCALES; BONE DISEASE; EXERCISE; HUMAN; INFLAMMATION; METABOLIC DISORDER; MUSCLE MASS; MYOSITIS; OUTCOME ASSESSMENT; RANGE OF MOTION; RESISTANCE TRAINING; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SKELETAL MUSCLE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

AUTOIMMUNE DISEASES; EXERCISE; EXERCISE THERAPY; HUMANS; INFLAMMATION; RHEUMATIC DISEASES;

EID: 84870237259     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2012.06.007     Document Type: Review

References (74)

1. Gualano B., Neves M., Lima F.R., Pinto A.L., Laurentino G., Borges C., et al. Resistance training with vascular occlusion in inclusion body myositis: a case study. Med Sci Sports Exerc 2010, 42(2):250-254.
2. Aytekin E., Caglar N.S., Ozgonenel L., Tutun S., Demiryontar D.Y., Demir S.E. Home-based exercise therapy in patients with ankylosing spondylitis: effects on pain, mobility, disease activity, quality of life, and respiratory functions. Clin Rheumatol 2012, 31(1):91-97.
3. Strömbeck B., Jacobsson L.T. The role of exercise in the rehabilitation of patients with systemic lupus erythematosus and patients with primary Sjögren's syndrome. Curr Opin Rheumatol 2007, 19(2):197-203. [Review. Erratum in: Curr Opin Rheumatol. 2007;19(4):403].
4. Cooney J.K., Law R.J., Matschke V., Lemmey A.B., Moore J.P., Ahmad Y., et al. Benefits of exercise in rheumatoid arthritis. J Aging Res 2011, 13(2011):681640.
5. Alexanderson H., Lundberg I.E. Exercise as a therapeutic modality in patients with idiopathic inflammatory myopathies. Curr Opin Rheumatol 2012, 24(2):201-207.
6. Fukuda W., Omoto A., Oku S., Tanaka T., Tsubouchi Y., Kohno M., et al. Contribution of rheumatoid arthritis disease activity and disability to rheumatoid cachexia. Mod Rheumatol 2010, 20(5):439-443.
7. Machado P., Landewé R., Braun J., Hermann K.G., Baker D., van der Heijde D. Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis. Ann Rheum Dis 2010, 69(8):1465-1470.
8. Machado P., Landewé R., Braun J., Hermann K.G., Baraliakos X., Baker D., et al. A stratified model for health outcomes in ankylosing spondylitis. Ann Rheum Dis 2011, 70(10):1758-1764.
9. Baraut J., Michel L., Verrecchia F., Farge D. Relationship between cytokine profiles and clinical outcomes in patients with systemic sclerosis. Autoimmun Rev 2010, 10(2):65-73.
10. Plazak W., Pasowicz M., Kostkiewicz M., Podolec J., Tomkiewicz-Pajak L., Musial J., et al. Influence of chronic inflammation and autoimmunity on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients. Inflamm Res 2011, 60(10):973-980.
11. Poetker D.M., Reh D.D. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am 2010, 43(4):753-768.
12. de Salles Painelli V., Gualano B., Artioli G.G., de Sá Pinto A.L., Bonfá E., Lancha Junior A.H., et al. The possible role of physical exercise on the treatment of idiopathic inflammatory myopathies. Autoimmun Rev 2009, 8(5):355-359.
13. Nader G.A., Dastmalchi M., Alexanderson H., Grundtman C., Gernapudi R., Esbjörnsson M., et al. A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis. Mol Med 2010, 16(11-12):455-464.
14. Flachenecker P. Autoimmune diseases and rehabilitation. Autoimmun Rev 2012, 11(3):219-225.
15. Petersen A.M., Pedersen B.K. The anti-inflammatory effect of exercise. J Appl Physiol 2005, 98(4):1154-1162.
16. Mathur N., Pedersen B.K. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008, 2008:109502.
17. Gualano B., Ugrinowitsch C., Neves M., Lima F.R., Pinto A.L., Laurentino G., et al. Vascular occlusion training for inclusion body myositis: a novel therapeutic approach. J Vis Exp 2010, 5(40). [pii: 1894].
18. Wiesinger G.F., Quittan M., Graninger M., Seeber A., Ebenbichler G., Sturm B., et al. Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. Br J Rheumatol 1998, 37(12):1338-1342.
19. Wiesinger G.F., Quittan M., Aringer M., Seeber A., Volc-Platzer B., Smolen J., et al. Improvement of physical fitness and muscle strength in polymyositis/dermatomyositis patients by a training programme. Br J Rheumatol 1998, 37(2):196-200.
20. Varjú C., Pethö E., Kutas R., Czirják L. The effect of physical exercise following acute disease exacerbation in patients with dermato/polymyositis. Clin Rehabil 2003, 17(1):83-87.
21. Alexanderson H., Stenström C.H., Jenner G., Lundberg I. The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis. Scand J Rheumatol 2000, 29(5):295-301.
22. Spector S.A., Lemmer J.T., Koffman B.M., Fleisher T.A., Feuerstein I.M., Hurley B.F., et al. Safety and efficacy of strength training in patients with sporadic inclusion body myositis. Muscle Nerve 1997, 20(10):1242-1248.
23. Arnardottir S., Alexanderson H., Lundberg I.E., Borg K. Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction. J Rehabil Med 2003, 35(1):31-35.
24. Harris-Love M.O. Safety and efficacy of submaximal eccentric strength training for a subject with polymyositis. Arthritis Rheum 2005, 53(3):471-474. [15].
25. Alexanderson H., Dastmalchi M., Esbjörnsson-Liljedahl M., Opava C.H., Lundberg I.E. Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis. Arthritis Rheum 2007, 57(5):768-777. [15].
26. Alexanderson H., Stenström C.H., Lundberg I. Safety of a home exercise programme in patients with polymyositis and dermatomyositis: a pilot study. Rheumatology (Oxford) 1999, 38(7):608-611.
27. Omori CH, Silva CA, Sallum AM, Pereira RM, Sá-Pinto AL, Roschel H, Gualano B. Exercise training in juvenile dermatomyositis. Arthritis Care Res (Hoboken); in press.
28. Analay Y., Ozcan E., Karan A., Diracoglu D., Aydin R. The effectiveness of intensive group exercise on patients with ankylosing spondylitis. Clin Rehabil 2003, 17(6):631-636.
29. Altan L., Korkmaz N., Dizdar M., Yurtkuran M. Effect of Pilates training on people with ankylosing spondylitis. Rheumatol Int 2012, 32(7):2093-2099.
30. Karapolat H., Eyigor S., Zoghi M., Akkoc Y., Kirazli Y., Keser G. Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? A randomized controlled study. Eur J Phys Rehabil Med 2009, 45(4):449-457.
31. Shehata M., Schwarzmeier J.D., Hilgarth M., Demirtas D., Richter D., Hubmann R., et al. Effect of combined spa-exercise therapy on circulating TGF-beta1 levels in patients with ankylosing spondylitis. Wien Klin Wochenschr 2006, 118(9-10):266-272.
32. Robb-Nicholson L.C., Daltroy L., Eaton H., Gall V., Wright E., Hartley L.H., et al. Effects of aerobic conditioning in lupus fatigue: a pilot study. Br J Rheumatol 1989, 28(6):500-505.
33. Ramsey-Goldman R., Schilling E.M., Dunlop D., Langman C., Greenland P., Thomas R.J., et al. A pilot study on the effects of exercise in patients with systemic lupus erythematosus. Arthritis Care Res 2000, 13(5):262-269.
34. Tench C.M., McCarthy J., McCurdie I., White P.D., D'Cruz D.P. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology (Oxford) 2003, 42(9):1050-1054.
35. Clarke-Jenssen A.C., Fredriksen P.M., Lilleby V., Mengshoel A.M. Effects of supervised aerobic exercise in patients with systemic lupus erythematosus: a pilot study. Arthritis Rheum 2005, 53(2):308-312. [15].
36. Carvalho M.R., Sato E.I., Tebexreni A.S., Heidecher R.T., Schenkman S., Neto T.L. Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus. Arthritis Rheum 2005, 53(6):838-844. 15.
37. Yuen H.K., Holthaus K., Kamen D.L., Sword D.O., Breland H.L. Using Wii Fit to reduce fatigue among African American women with systemic lupus erythematosus: a pilot study. Lupus 2011, 20(12):1293-1299.
38. Miossi R, Benatti FB, de Sá Pinto AL, Lima FR, Borba EF, Lprado DM, Perandini LA, Gualano B, Bonfá E, Roschel H. Exercise training counterbalances chronotropic incompetence and delayed heart rate recovery in systemic lupus erythematosus: a randomized trial. Arthritis Care Res (Hoboken); in press.
39. Prado D.M., Gualano B., Pinto A.L., Sallum A.M., Perondi M.B., Roschel H., et al. Exercise in a child with systemic lupus erythematosus and antiphospholipid syndrome. Med Sci Sports Exerc 2011, 43(12):2221-2223.
40. Oliveira N.C., dos Santos Sabbag L.M., de Sá Pinto A.L., Borges C.L., Lima F.R. Aerobic exercise is safe and effective in systemic sclerosis. Int J Sports Med 2009, 30(10):728-732.
41. Pinto A.L., Oliveira N.C., Gualano B., Christmann R.B., Painelli V.S., Artioli G.G., et al. Efficacy and safety of concurrent training in systemic sclerosis. J Strength Cond Res 2011, 25(5):1423-1428.
42. Hurkmans E., van der Giesen F.J., Vliet Vlieland T.P., Schoones J., den Ende EC Van Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis. Cochrane Database Syst Rev 2009, 7(4):CD006853.
43. Bilberg A., Ahlmén M., Mannerkorpi K. Moderately intensive exercise in a temperate pool for patients with rheumatoid arthritis: a randomized controlled study. Rheumatology (Oxford) 2005, 44(4):502-508.
44. Neuberger G.B., Aaronson L.S., Gajewski B., Embretson S.E., Cagle P.E., Loudon J.K., et al. Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis. Arthritis Rheum 2007, 57(6):943-952. [15].
45. Baillet A., Payraud E., Niderprim V.A., Nissen M.J., Allenet B., François P., et al. A dynamic exercise programme to improve patients' disability in rheumatoid arthritis: a prospective randomized controlled trial. Rheumatology (Oxford) 2009, 48(4):410-415.
46. van den Berg M.H., Ronday H.K., Peeters A.J., le Cessie S., van der Giesen F.J., Breedveld F.C., et al. Using internet technology to deliver a home-based physical activity intervention for patients with rheumatoid arthritis: a randomized controlled trial. Arthritis Rheum 2006, 55(6):935-945. [15].
47. van den Ende C.H., Hazes J.M., le Cessie S., Mulder W.J., Belfor D.G., Breedveld F.C., et al. Comparison of high and low intensity training in well controlled rheumatoid arthritis. Results of a randomised clinical trial. Ann Rheum Dis 1996, 55(11):798-805.
48. van den Ende C.H., Breedveld F.C., le Cessie S., Dijkmans B.A., de Mug A.W., Hazes J.M. Effect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial. Ann Rheum Dis 2000, 59(8):615-621.
49. Häkkinen A., Sokka T., Kotaniemi A., Hannonen P. A randomized two-year study of the effects of dynamic strength training on muscle strength, disease activity, functional capacity, and bone mineral density in early rheumatoid arthritis. Arthritis Rheum 2001, 44(3):515-522.
50. de Jong Z., Munneke M., Zwinderman A.H., Kroon H.M., Jansen A., Ronday K.H., et al. Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial. Arthritis Rheum 2003, 48(9):2415-2424.
51. Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008, 88(4):1379-1406.
52. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol; in press.
53. Starkie R., Ostrowski S.R., Jauffred S., Febbraio M., Pedersen B.K. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 2003, 17(8):884-886.
54. Sloan R.P., Shapiro P.A., Demeersman R.E., McKinley P.S., Tracey K.J., Slavov I., et al. Aerobic exercise attenuates inducible TNF production in humans. J Appl Physiol 2007, 103(3):1007-1011.
55. Adamopoulos S., Parissis J., Karatzas D., Kroupis C., Georgiadis M., Karavolias G., et al. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J Am Coll Cardiol 2002, 39(4):653-663. [20].
56. Kadoglou N.P., Iliadis F., Angelopoulou N., Perrea D., Ampatzidis G., Liapis C.D., et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil 2007, 14(6):837-843.
57. Ploeger H.E., Takken T., de Greef M.H., Timmons B.W. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev 2009, 15:6-41.
58. Walsh N.P., Gleeson M., Shephard R.J., Gleeson M., Woods J.A., Bishop N.C., et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev 2011, 17:6-63.
59. Walsh N.P., Gleeson M., Pyne D.B., Nieman D.C., Dhabhar F.S., Shephard R.J., et al. Position statement. Part two: maintaining immune health. Exerc Immunol Rev 2011, 17:64-103.
60. Calle M.C., Fernandez M.L. Effects of resistance training on the inflammatory response. Nutr Res Pract 2010, 4(4):259-269.
61. Ogawa K., Sanada K., Machida S., Okutsu M., Suzuki K. Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators Inflamm 2010, 2010:171023.
62. Helmark I.C., Mikkelsen U.R., Børglum J., Rothe A., Petersen M.C., Andersen O., et al. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther 2010, 12(4):R126.
63. Chiba K., Toyama Y., Yoshimura A. IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol 2011, 23(11):701-712.
64. De Paepe B., Creus K.K., De Bleecker J.L. The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies: potential targets for therapy. Clin Dev Immunol 2012, 2012:369432.
65. Appel H., Loddenkemper C., Miossec P. Rheumatoid arthritis and ankylosing spondylitis-pathology of acute inflammation. Clin Exp Rheumatol 2009, 27(4 Suppl. 55):S15-S19.
66. Lee H.M., Sugino H., Nishimoto N. Cytokine networks in systemic lupus erythematosus. J Biomed Biotechnol 2010, 2010:676284.
67. Chun H.Y., Chung J.W., Kim H.A., Yun J.M., Jeon J.Y., Ye Y.M., et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 2007, 27(5):461-466.
68. Sivalingam S.P., Thumboo J., Vasoo S., Thio S.T., Tse C., Fong K.Y. In vivo pro- and anti-inflammatory cytokines in normal and patients with rheumatoid arthritis. Ann Acad Med Singapore 2007, 36(2):96-99.
69. Lundberg I.E., Helmers S.B. The type I interferon system in idiopathic inflammatory myopathies. Autoimmunity 2010, 43(3):239-243.
70. Lundberg I., Ulfgren A.K., Nyberg P., Andersson U., Klareskog L. Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum 1997, 40(5):865-874.
71. Caporali R., Pallavicini F.B., Filippini M., Gorla R., Marchesoni A., Favalli E.G., et al. Treatment of rheumatoid arthritis with anti-TNF-alpha agents: a reappraisal. Autoimmun Rev 2009, 8(3):274-280.
72. Zhu L.J., Yang X., Yu X.Q. Anti-TNF-alpha therapies in systemic lupus erythematosus. J Biomed Biotechnol 2010, 2010:465898.
73. Pedersen B.K., Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 2006, (Suppl. 1):3-63. [c].
74. Booth F.W., Scott E.G., Christian J.C., Marc T.H. Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol 2000, 88:774-787.