Aerobic exercise attenuates inducible TNF production in humans

Journal of Applied Physiology

Volumn 103, Issue 3, 2007, Pages 1007-1011

  Sloan, Richard P ^a,b   Shapiro, Peter A ^c   DeMeersman, Ronald E ^c   McKinley, Paula S ^a,b   Tracey, Kevin J ^d   Slavov, Iordan ^a,b   Fang, Yixin ^a,b   Flood, Pamela D ^c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Exercise; Inflammation; Laboratory study

Indexed keywords

LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR;

ADULT; AEROBIC CAPACITY; AEROBIC EXERCISE; ARTICLE; BLOOD ANALYSIS; BODY MASS; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; SITTING;

ADULT; EXERCISE; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548405976     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00147.2007     Document Type: Article

References (23)

1. American Heart Association. Exercise Testing and Training of Apparently Healthy Individuals. A Handbook for Physicians. Dallas, TX: American Heart Association, 1972.
2. Belge KU, Dayyani F, Horelt A, Siedlar M, Frankenberger M, Frankenberger B, Espevik T, Ziegler-Heitbrock L. The proinflammatory CD14+-CD16+-DR++- monocytes are a major source of TNF. J Immunol 168: 3536-3542, 2002.
3. Buchfuhrer MJ, Hansen JE, Robinson TE, Sue DY, Wasserman K, Whipp B. Optimizing the exercise protocol for cardiopulmonary assessment. J Appl Physiol 55: 1550-1564, 1983.
4. Devaraj S, O'Keefe G, Jialal I. Defining the proinflammatory phenotype using high sensitive C-reactive protein levels as the biomarker. J Clin Endocrinol Metab 90: 4549-4554, 2005.
5. Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiology 13: 561-568, 2002.
6. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99: 3092-3095, 1999.
7. King DE, Carek P, Mainous AG 3rd, Pearson WS. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc 35: 575-581, 2003.
8. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, Castillo MC, Reighard AE, Vanderah E. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 20: 201-209, 2006.
9. 2max in asymptomatic men. J Appl Physiol 102: 1374-1379, 2006.
10. Kwaijtaal M, van Diest R, Bar FW, van der Ven AJ, Bruggeman CA, de Baets MH, Appels A. Inflammatory markers predict late cardiac events in patients who are exhausted after percutaneous coronary intervention. Atherosclerosis 182: 341-348, 2005.
11. Lakka TA, Lakka HM, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. Eur Heart J 26: 2018-2025, 2005.
12. Michelsen KS, Doherty TM, Shah PK, Arditi M. TLR signaling: an emerging bridge from innate immunity to atherogenesis. J Immunol 173: 5901-5907, 2004.
13. Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K, Iizuka K, Kawaguchi H, Kitabatake A. Can exercise training with weight loss lower serum C-reactive protein levels? Arterioscler Thromb Vasc Biol 24: 1868-1873, 2004.
14. Pearson TA, Bazzarre TL, Daniels SR, Fair JM, Fortmann SP, Franklin BA, Goldstein LB, Hong Y, Mensah GA, Sallis JF Jr, Smith S Jr, Stone NJ, Taubert KA. American Heart Association guide for improving cardiovascular health at the community level: a statement for public health practitioners, healthcare providers, and health policy makers from the American Heart Association Expert Panel on Population and Prevention Science. Circulation 107: 645-651, 2003.
15. Pearson TA, Blair SN, Daniels SR, Eckel RH, Fair JM, Fortmann SP, Franklin BA, Goldstein LB, Greenland P, Grundy SM, Hong Y, Houston Miller N, Lauer RM, Ockene IS, Sacco RL, Sallis JF Jr, Smith SC Jr, Stone NJ, Taubert KA. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. Circulation 106: 388-391, 2002.
16. Rajavashisth TB, Liao JK, Galis ZS, Tripathi S, Laufs U, Tripathi J, Chai NN, Xu XP, Jovinge S, Shah PK, Libby P. Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase. J Biol Chem 274: 11924-11929, 1999.
17. Rauramaa R, Halonen P, Vaisanen SB, Lakka TA, Schmidt-Trucksass A, Berg A, Penttila IM, Rankinen T, Bouchard C. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med 140: 1007-1014, 2004.
18. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126, 1999.
19. Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 117: 289-296, 2007.
20. Tracey KJ. The inflammatory reflex. Nature 420: 853-859, 2002.
21. Uzui H, Harpf A, Liu M, Doherty TM, Shukla A, Chai NN, Tripathi PV, Jovinge S, Wilkin DJ, Asotra K, Shah PK, Rajavashisth TB. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation 106: 3024-3030, 2002.
22. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421: 384-388, 2003.
23. Zeng M, Zhang H, Lowell C, He P. Tumor necrosis factor-α-induced leukocyte adhesion and microvessel permeability. Am J Physiol Heart Circ Physiol 283: H2420-H2430, 2002.