G protein-coupled estrogen receptor: A new therapeutic target in stroke and traumatic brain/spinal cord injury?

Critical Care Medicine

Volumn 40, Issue 12, 2012, Pages 3323-3325

  Prossnitz, Eric R ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

estrogen; G protein coupled receptor 30; inflammation; neuroprotection; neurotrauma

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

APOPTOSIS; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTUSION; DEGENERATIVE DISEASE; EDITORIAL; ESTROGEN THERAPY; GENE THERAPY; HEART INFARCTION; HUMAN; MULTIPLE SCLEROSIS; NERVE CELL; NEUROPROTECTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION; REPERFUSION INJURY; SPINAL CORD INJURY; STEM CELL; TISSUE INJURY; TRAUMATIC BRAIN INJURY;

ANIMALS; ESTROGEN RECEPTOR ALPHA; MALE; NEUROPROTECTIVE AGENTS; RECEPTORS, G-PROTEIN-COUPLED; SPINAL CORD; SPINAL CORD INJURIES;

EID: 84870163292     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31826be998     Document Type: Editorial

References (21)

1. Center for Disease Control and Prevention Spinal Cord Injury (SCI): Fact Sheet. Available at: http://www.cdc.gov/TraumaticBrainInjury/scifacts.html. Accessed July 6, 2012
2. Rabchevsky AG, Patel SP, Springer JE: Pharmacological interventions for spinal cord injury: Where do we stand? How might we step forward? Pharmacol Ther 2011; 132:15-29
3. Tohda C, Kuboyama T: Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacol Ther 2011; 132:57-71
4. Kwon BK, Okon EB, Plunet W, et al: A systematic review of directly applied biologic therapies for acute spinal cord injury. J Neurotrauma 2011; 28:1589-1610
5. Kwon BK, Okon E, Hillyer J, et al: A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. J Neurotrauma 2011; 28:1545-1588
6. Miller SM: Methylprednisolone in acute spinal cord injury: A tarnished standard. J Neurosurg Anesthesiol 2008; 20:140-142
7. Samantaray S, Sribnick EA, Das A, et al: Neuroprotective efficacy of estrogen in experimental spinal cord injury in rats. Ann N Y Acad Sci 2010; 1199:90-94
8. Carroll JC, Rosario ER: The potential use of hormone-based therapeutics for the treatment of Alzheimer's disease. Curr Alzheimer Res 2012; 9:18-34
9. Simpkins JW, Singh M, Brock C, et al: Neuroprotection and Estrogen Receptors. Neuroendocrinology 2012; 96:119-130
10. Simpkins JW, Rajakumar G, Zhang YQ, et al: Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 1997; 87:724-730
11. Edwards DP: Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol 2005; 67:335-376
12. Revankar CM, Cimino DF, Sklar LA, et al: A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005; 307:1625-1630
13. Bologa CG, Revankar CM, Young SM, et al: Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol 2006; 2:207-212
14. Prossnitz ER, Barton M: The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 2011; 7:715-726
15. Prossnitz ER, Arterburn JB, Smith HO, et al: Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 2008; 70:165-190
16. Lebesgue D, Traub M, De Butte-Smith M, et al: Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats. PLoS ONE 2010; 5:e8642
17. Blasko E, Haskell CA, Leung S, et al: Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol 2009; 214:67-77
18. Hu R, Sun H, Zhang Q, et al: G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Crit Care Med 2012; 40:3230-3237
19. Brunsing RL, Prossnitz ER: Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunol 2011; 134:93-106
20. Ismailoglu O, Oral B, Görgülü A, et al: Neuroprotective effects of tamoxifen on experimental spinal cord injury in rats. J Clin Neurosci 2010; 17:1306-1310
21. Filardo EJ, Quinn JA, Bland KI, et al: Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 2000; 14:1649-1660