Methylprednisolone in acute spinal cord injury: A tarnished standard

Journal of Neurosurgical Anesthesiology

Volumn 20, Issue 2, 2008, Pages 140-142

  Miller, Sanford M ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE; PLACEBO;

CLINICAL TRIAL; DATA ANALYSIS; DRUG EFFICACY; DRUG MEGADOSE; FACE VALIDITY; FOLLOW UP; HUMAN; INTERNAL CONSISTENCY; MOTOR PERFORMANCE; PARAPLEGIA; PATIENT CARE; PRIORITY JOURNAL; SHORT SURVEY; SPINAL CORD INJURY; STANDARD; STATISTICAL ANALYSIS; TREATMENT DURATION; TREATMENT OUTCOME;

ACUTE DISEASE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; METHYLPREDNISOLONE; NEUROPROTECTIVE AGENTS; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOVERY OF FUNCTION; RESEARCH DESIGN; SPINAL CORD INJURIES; STATISTICS AS TOPIC; UNITED STATES;

EID: 41149101245     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ana.0000314442.40952.0d     Document Type: Short Survey

References (22)

1. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. Results of Second National Spinal Cord Injury Study. N Engl J Med. 1990;322:1405-1411.
2. Bracken MB, Shepard MJ, Collins WF Jr, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the Second National Acute Spinal Cord Injury Study. J Neurosurg. 1992;76:23-31.
3. Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA. 1997;277:1597-1604.
4. Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. J Neurosurg. 1998;89:699-706.
5. Otani K, Abe H, Kadoya S, et al. Beneficial effects of methylprednisolone sodium succinate in the treatment of acute spinal cord injury. Sekitsui Sekizui. 1994;7:633-647.
6. Nesathurai S. Steroids and spinal cord injury: revisiting the NASCIS 2 and NASCIS 3 trials. J Trauma. 1998;45:1088-1093.
7. Heary RF, Vaccaro AR, Mesa JJ, et al. Steroids and gunshot wounds to the spine. Neurosurgery. 1997;41:576-583; discussion 583-584.
8. Prendergast MR, Saxe JM, Ledgerwood AM, et al. Massive steroids do not reduce the zone of injury after penetrating spinal cord injury. J Trauma. 1994;37:576-579; discussion 579-580.
9. George ER, Scholten DJ, Buechler CM, et al. Failure of methylprednisolone to improve the outcome of spinal cord injuries. Am Surg. 1995;61:659-663; discussion 663-664.
10. Gerhart KA, Johnson RL, Menconi J, et al. Utilization and effectiveness of methylprednisolone in a population-based sample of spinal cord injured persons. Paraplegia. 1995;33:316-21.
11. Pointillart V, Petitjean ME, Wiart L, et al. Pharmacological therapy of spinal cord injury during the acute phase. Spinal Cord. 2000;38:71-76.
12. Coleman WP, Benzel D, Cahill DW, et al. A critical appraisal of the reporting of the National Acute Spinal Cord Injury Studies (II and III) of methylprednisolone in acute spinal cord injury. J Spinal Disord. 2000;13:185-199.
13. Hurlbert RJ. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg. 2000;93:1-7.
14. Riou B, Landais P, Vivien B, et al. Distribution of the probability of survival is a strategic issue for randomized trials in critically ill patients. Anesthesiology. 2001;95:56-63.
15. Bracken MB, Holford TR. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosurg. 1993;79:500-507.
16. Pollard ME, Apple DF. Factors associated with improved neurologic outcomes in patients with incomplete tetraplegia. Spine. 2003;28:33-39.
17. Galandiuk S, Raque G, Appel S, et al. The two-edged sword of large-dose steroids for spinal cord trauma. Ann Surg. 1993;218:419-425; discussion 425-427.
18. Gerndt SJ, Rodriguez JL, Pawlik JW, et al. Consequences of high-dose steroid therapy for acute spinal cord injury. J Trauma. 1997;42:279-284.
19. Hadley MN, Walters BC, Grabb PA, et al. Guidelines for the management of acute cervical spine and spinal cord injuries. Clin Neurosurg. 2002;49:407-498.
20. Bracken MB. Methylprednisolone and spinal cord injury. J Neurosurg. 2000;93:175-179.
21. Bracken MB. Methylprednisolone and acute spinal cord injury: an update of the randomized evidence. Spine. 2001;26:S47-S54.
22. Qian T, Campagnolo D, Kirshblum S. High-dose methylprednisolone may do more harm for spinal cord injury. Med Hypotheses. 2000;55:452-453.