EndothelinA-endothelinB receptor cross talk in endothelin-1-induced contraction of smooth muscle

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 5, 2012, Pages 483-494

  Rapoport, Robert M ^a   Zuccarello, Mario ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

contraction; endothelin A receptor; endothelin B receptor; endothelin receptor antagonist; endothelin receptor cross talk; endothelin 1; smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; 4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; 5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; ALPHA [[1 BUTYL 5 [2 [(2 CARBOXYPHENYL)METHOXY] 4 METHOXYPHENYL] 1H PYRAZOL 4 YL]METHYLENE] 6 METHOXY 1,3 BENZODIOXOLE 5 PROPANOIC ACID; ATRASENTAN; BOSENTAN; BQ 610; BQ 928; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N ACETYL 10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLGLYCYLLEUCYLASPARTYLISOLEUCYLISOLEUCYLTRYPTOPHAN; PROSTAGLANDIN F2 ALPHA; SARAFOTOXIN S6C; SB 209760; UNCLASSIFIED DRUG;

BASILAR ARTERY; BRONCHUS; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM; EPITHELIUM; GUINEA PIG; HUMAN; INTESTINE PRESSURE; JUGULAR VEIN; LUNG RESISTANCE; MESENTERIC VEIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY ARTERY; RABBIT; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; TRACHEA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; RECEPTOR CROSS-TALK; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B;

EID: 84870054258     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31826f32c1     Document Type: Review

References (84)

1. Clozel M, Flores S. Endothelin receptors as drug targets in chronic cardiovascular diseases: the rational for dual antagonism. Drug Dev Res. 2006;67:825-834.
2. Mickley EJ, Gray GA, Webb DJ. Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries. Br J Pharmacol. 1997;120:1376-1382. (Pubitemid 27149690)
3. Watts SW. Endothelin receptors: what's new and what do we need to know? Am J Physiol. 2010;298:R254-R260.
4. Thakali K, Galligan JJ, Fink GD, et al. Pharmacological endothelin receptor interaction does not occur in veins from ET (B) receptor deficient rats. Vascul Pharmacol. 2008;49:6-13.
5. Bender SB, Klabunde RE. Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and a1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes. Am J Physiol. 2007;293:H2281-H2288. (Pubitemid 47605872)
6. Johnson RJ, Fink GD, Galligan JJ. Mechanisms of endothelin-induced venoconstriction in isolated guinea pig mesentery. J Pharmacol Exp Ther. 1999;289:762-767. (Pubitemid 29191229)
7. Lodge NJ, Zhang R, Halaka NN, et al. Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle. Eur J Pharmacol. 1995;287:279-285. (Pubitemid 26006340)
8. Benamou AE, Marlin DJ, Callingham BC, et al. Spasmogenic action of endothelin-1 on isolated equine pulmonary artery and bronchus. Equine Vet J. 2003;35:190-196. (Pubitemid 38698769)
9. Fukuroda T, Ozaki S, Ihara M, et al. Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin-1-induced contraction in human bronchi. Br J Pharmacol. 1996;117:995-999.
10. Hay DWP, Luttmann MA, Pullen MA, et al. Functional and binding characterization of endothelin receptors in human bronchus: evidence for a novel endothelin B receptor subtype? J Pharmacol Exp Ther. 1998;284:669-677. (Pubitemid 28086657)
11. Dechanet C, Fort A, Barbero-Camps E, et al. Endothelin-dependent vasoconstriction in human uterine artery: application to preeclampsia. PLoS One. 2011;6:e16540.
12. Pérez-Rivera AA, Fink GD, Galligan JJ. Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure. Vascul Pharmacol. 2005;43:1-10. (Pubitemid 40828827)
13. Schildroth J, Retting-Zimmerman J, Kalk P, et al. Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice. Nephrol Dial Transplant. 2011;26:779-789.
14. Henry PJ, Goldie RG. ETB but not ETA receptor-mediated contractions to endothelin-1 attenuated by respiratory tract viral infection in mouse airways. Br J Pharmacol. 1994;112:1188-1194.
15. Carr MJ, Goldie RG, Henry PJ. Time course of changes in ETB receptor density and function in tracheal airway smooth muscle during respiratory tract viral infection in mice. Br J Pharmacol. 1996;117:1222-1228.
16. Awane-Igata Y, Ikeda S, Watanabe T. Inhibitory effects of TAK-044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists. Br J Pharmacol. 1997;120:516-522. (Pubitemid 27052852)
17. Docherty CC, MacLean MR. EndothelinB receptors in rabbit pulmonary resistance arteries: effect of left ventricular dysfunction. J Pharmacol Exp Ther. 1998;284:895-903. (Pubitemid 28130815)
18. La Douceur DM, Flynn MA, Keiser JA, et al. ETA and ETB receptors coexist on rabbit pulmonary artery vascular smooth muscle mediating contraction. Bichem Biophys Res Commun. 1993;196:209-215. (Pubitemid 23309495)
19. Fukuroda T, Ozaki S, Ihara M, et al. Synergistic inhibition by BQ-123 and BQ-788 of endothelin-1-induced contractions of the rabbit pulmonary artery. Br J Pharmacol. 1994;113:336-338. (Pubitemid 24310722)
20. Fukuroda T, Nishikibe M. Enhancement of pulmonary artery contraction induced by endothelin-B receptor antagonism. J Cardiovasc Pharmacol. 1998;31(suppl 1):S169-S171. (Pubitemid 128709898)
21. O'Donnell SR, Kay CS. Effects of endothelin receptor selective antagonists, BQ-123 and BQ-788, on IRL 1620 and endothelin-1 responses of airway and vascular preparations from rats. Pulm Pharmacol. 1995;8:11-19.
22. Adner M, Shankley N, Edvinsson L. Evidence that ET-1, but not ET-3 and S6b, ET (A)-receptor mediated contractions in isolated rat mesenteric arteries are modulated by co-activation of ET (B) receptors. Br J Pharmacol. 2001;133:927-935. (Pubitemid 32751803)
23. Meens MJ, Compeer MG, Hackeng TM, et al. Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET (A)-receptor complexes. PLoS One. 2010;5:e10917.
24. McCulloch KM, Docherty C, MacLean MR. Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in the rat. Br J Pharmacol. 1998;123:1621-1630. (Pubitemid 28182045)
25. Sauvageau S, Thorin E, Caron A, et al. Evaluation of endothelin-1-induced pulmonary vasoconstriction following myocardial infarction. Exp Biol Med (Maywood). 2006;231:840-846. (Pubitemid 43845538)
26. Sauvageau S, Thorin E, Caron A, et al. Endothelin-1-induced pulmonary vasoreactivity is regulated by ET (A) and ET (B) receptor interactions. J Vasc Res. 2007;44:375-381. (Pubitemid 47312658)
27. Sato K, Oka M, Hasunuma K, et al. Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs. Am J Physiol. 1995;269:L668-L672.
28. Inscho EW, Imig JD, Cook AK, et al. ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin. Br J Pharmacol. 2005;146:1019-1026. (Pubitemid 41722175)
29. Just A, Olson AJ, Arendshorst WJ. Dual constrictor and dilator actions of ET (B) receptors in the rat renal microcirculation: interactions with ET (A) receptors. Am J Physiol. 2004;286:F660-F668. (Pubitemid 38365084)
30. Henry PJ. Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems. Br J Pharmacol. 1993;110:435-441. (Pubitemid 23257816)
31. Clozel M, Gray GA. Are there different ETB receptors mediating constriction and relaxation? J Cardiovasc Pharmacol. 1995;26(suppl 3):S262-S264.
32. Zuccarello M, Boccaletti R, Rapoport RM. Endothelin ET (B) receptormediated constriction in the rabbit basilar artery. Eur J Pharmacol. 1998;350:R7-R9. (Pubitemid 28288321)
33. Zuccarello M, Boccaletti R, Rapoport RM. Does blockade of endothelinB1-receptor activation increase endothelinB2/endothelin A receptor-mediated constriction in the rabbit basilar artery? J Cardiovasc Pharmacol. 1999;33:679-684. (Pubitemid 29196703)
34. Yoon SH, Zuccarello M, Rapoport RM. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:437-441.
35. Seo B, Oemar BS, Siebenmann R, et al. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Circulation. 1994;89:1203-1208.
36. Moreland S, McMullen D, Abboa-Offei B, et al. Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature. Br J Pharmacol. 1994;112:704-708. (Pubitemid 24172923)
37. McCulloch KM, MacLean MR. EndothelinB receptor-mediated contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on endothelin responses in the rat. J Cardiovasc Pharmacol. 1995;26(suppl 3):S169-S176.
38. McCulloch KM, Docherty CC, Morecroft I, et al. EndothelinB receptormediated contraction in human pulmonary resistance arteries. Br J Pharmacol. 1996;119:1125-1130. (Pubitemid 26385981)
39. Compeer MG, Suylen DP, Hackeng TM, et al. Endothelin-1 and -2: two amino acids matter. Life Sci. 2012;91:607-612.
40. Claing A, Shbaklo H, Plante M, et al. Comparison of the contractile and calcium-increasing properties of platelet-activating factor and endothelin-1 in the rat mesenteric artery and vein. Br J Pharmacol. 2002;135:433-443. (Pubitemid 34151176)
41. Liu JJ, Chen JR, Buxton BF. Unique response of human arteries to endothelin B receptor agonist and antagonist. Clin Sci (Lond). 1996;90:91-96. (Pubitemid 26034713)
42. Sand AE, Ostlund E, Andersson E, et al. Endothelin-induced contractions in placental arteries is mediated by both ETA-and ETB-receptors. Acta Physiol Scand. 1998;163:227-234.
43. Tosun M, Erac Y, Selli C, et al. Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibition prevents endothelin A receptor antagonism in rat aorta. Am J Physiol Heart Circ Physiol. 2007;292:H1961-H1966. (Pubitemid 46572422)
44. Marsault R, Feolde E, Frelin C. Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta. Am J Physiol. 1993;264:C687-C693. (Pubitemid 23103930)
45. Warner TD, Allcock GH, Vane JR. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994;112:207-213. (Pubitemid 24151728)
46. Nishizawa S, Chen D, Yokoyama T, et al. Endothelin-1 initiates the development of vasospasm after subarachnoid haemorrhage through protein kinase C activation, but does not contribute to prolonged vasospasm. Acta Neurochir (Wien). 2000;142:1409-1415. (Pubitemid 32204515)
47. Meens MJ, Mattheij NJ, Nelissen J, et al. Calcitonin gene-related peptide terminates long-lasting vasopressor responses to endothelin 1 in vivo. Hypertension. 2011;58:99-106.
48. Sauvageau S, Thorin E, Villeneuve L, et al. Change in pharmacological effect of endothelin receptor antagonists in rats with pulmonary hypertension: role of ETB-receptor expression levels. Pulm Pharmacol Ther. 2009;22:311-317.
49. Hilal-Dandan R, Villegas S, Gonzalez A, et al. The quasi-irreversible nature of endothelin binding and G protein-linked signaling in cardiac myocytes. J Pharmacol Exp Ther. 1997;281:267-273. (Pubitemid 27203077)
50. Compeer MG, Meens MJ, Hackeng TM, et al. Agonist-dependent modulation of arterial endothelinA-receptor function. Br J Pharmacol. 2012;166:1833-1845.
51. Bkaily G, Choufani S, Avedanian L, Ahmarani L, Nader M, Jacques D, D'Orléans-Juste P, Al Khoury J. Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Can J Physiol Pharmacol. 2008;86:546-555.
52. Thakili K, Fink GD, Watts SW. Arteries and veins desensitize differently to endothelin. J Cardiovasc Pharmacol. 2004;43:387-393. (Pubitemid 38270605)
53. Roux S, Löffler BM, Gray GA, et al. The role of endothelin in experimental cerebral vasospasm. Neurosurgery. 1995;37:78-85.
54. Mickley EJ, Swan PJH, Webb DJ, Gray GA. Comparison of two methods of myography for detection of constrictor endothelin ETB receptors in rat small mesenteric arteries. Br J Pharmacol. 1995;116:424P.
55. Takase H, Moreau P, Lüscher TF. Endothelin receptor subtypes in small arteries. Studies with FR139317 and bosentan. Hypertension. 1995;25:739-743.
56. Hempelmann RG, Pradel RH, Mehdorn HM, et al. Contractions induced by NO synthase inhibition in isolated rat basilar artery: role of the endothelium and endogenous vasoconstrictors. Neurol Res. 1998;20:63-72. (Pubitemid 28051660)
57. MacLean MR, McCulloch KM. Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: effect of chronic hypoxia. Br J Pharmacol. 1998;123:991-999. (Pubitemid 28085402)
58. Schmeck J, Gluth H, Mihaljevic N, et al. ET-1-induced pulmonary vasoconstriction shifts from ET (A) - to ET (B)-receptor-mediated reaction after preconstriction. J Appl Physiol. 1999;87:2284-2289.
59. Hansen-Schwartz J, Edvinsson L. Increased sensitivity to ET-1 in rat cerebral arteries following organ culture. Neuroreport. 2000;11:649-652. (Pubitemid 30120492)
60. Li J, Cao YX, Liu Y, et al. Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. Microvasc Res. 2012;83:178-184.
61. Vatter H, Konczalla J, Weidauer S, et al. Characterization of the endothelin-B receptor expression and vasomotor function during experimental cerebral vasospasm. Neurosurgery. 2007;60:1100-1108. (Pubitemid 46849859)
62. Dunn WR, Wellman GC, Bevan JA. Enhanced resistance artery sensitivity to agonists under isobaric compared with isometric conditions. Am J Physiol. 1994;266:H147-H155. (Pubitemid 24051503)
63. Tykocki NR, Gariepy CE, Watts SW. Endothelin ET (B) receptors in arteries and veins: multiple actions in the vein. J Pharmacol Exp Ther. 2009;329:875-881.
64. Rapoport RM, Williams SP. Role of prostaglandins in acetylcholineinduced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1996;28:64-75. (Pubitemid 26231092)
65. Kirkby NS, Hadoke PW, Bagnall AJ, et al. The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? Br J Pharmacol. 2008;153:1105-1119. (Pubitemid 351415492)
66. Alabadí JA, Miranda FJ, Lloréns S, et al. Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery. Eur J Pharmacol. 2004;486:289-296. (Pubitemid 38231059)
67. Aramori I, Nirei H, Shoubo M, et al. Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells. Mol Pharmacol. 1993;43:127-131. (Pubitemid 23055054)
68. Eguchi S, Hirata Y, Imai T, et al. Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature. Endocrinology. 1993;132:524-529. (Pubitemid 23056102)
69. Sokolovsky M. Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades. Cell Mol Neurobiol. 1995;15:561-571. (Pubitemid 26023383)
70. Mullaney I, Vaughan DM, MacLean MR. Regional modulation of cyclic nucleotides by endothelin-1 in rat pulmonary arteries: direct activation of G (i) 2-protein in the main pulmonary artery. Br J Pharmacol. 2000;129:1042-1048. (Pubitemid 30142920)
71. Sokolovsky M, Shraga-Levine Z, Galron R. Ligand-specific stimulation/inhibition of cAMP formation by a novel endothelin receptor subtype. Biochemistry. 1994;33:11417-11419. (Pubitemid 24330073)
72. Hay DWP, Luttmann MA, Beck G, et al. Comparison of endothelin B (ETB) receptors in rabbit isolated pulmonary artery and bronchus. Br J Pharmacol. 1996;116:1209-1217. (Pubitemid 26235620)
73. Nakahata N. Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther. 2008;118:18-35.
74. Osol G, Laher I, Kelley M. Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries. Am J Physiol. 1993;265:H415-H420. (Pubitemid 23224738)
75. Schubert R, Lehmann G, Serebryakov VN, et al. cAMP-dependent protein kinase is in an active state in rat small arteries possessing a myogenic tone. Am J Physiol. 1999;277:H1145-H1155. (Pubitemid 29459630)
76. Hill MA, Meininger GA, Davis MJ, et al. Therapeutic potential of pharmacologically targeting arteriolar myogenic tone. Trends Pharmacol Sci. 2009;30:363-374.
77. Ozaki S, Ohwaki K, Ihara M, et al. Coexpression studies with endothelin receptor subtypes indicate the existence of intracellular cross-talk between ET (A) and ET (B) receptors. J Biochem. 1997;121:440-447. (Pubitemid 27145897)
78. Trow TK, Taichman DB. Endothelin receptor blockade in the management of pulmonary arterial hypertension: selective and dual antagonism. Respir Med. 2009;103:951-962.
79. Thorin E, Clozel M. The cardiovascular physiology and pharmacology of endothelin-1. Adv Pharmacol. 2010;60:1-26.
80. Rapoport RM, Zuccarello M. Endothelin (A)-endothelin (B) receptor cross-talk and endothelin receptor binding. J Pharm Pharmacol. 2011;63:1373-1377.
81. Evans NJ, Walker JW. Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophys J. 2008;95:483-492.
82. Gregan B, Jürgensen J, Papsdorf G, et al. Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem. 2004;279:27679-27687. (Pubitemid 38812609)
83. Meens MJ, Mattheij NJ, van Loenen PB, et al. G protein bg-subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. Br J Pharmacol. 2012;166:297-308.
84. Mazzuca MQ, Khalil RA. Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease. Biochem Pharmacol. 2012;84:147-162.