Inhibitory effects of TAK-044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: A comparison with selective ET(A) and ET(B) receptor antagonists

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 516-522

  Awane Igata, Yumiko ^a   Ikeda, Shota ^a   Watanabe, Toshifumi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Canine arteries; Endothelin isopeptide; Endothelin receptor antagonist; ET(A) receptors; ET(B) receptors; Porcine coronary arteries; Sarafotoxin S6c; TAK 044

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SARAFOTOXIN S6C; TAK 044;

ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DOG; FEMORAL ARTERY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RENAL ARTERY; SWINE; VASOCONSTRICTION;

ANIMALS; ARTERIES; CORONARY VESSELS; DOGS; ENDOTHELIN-1; ENDOTHELIN-3; MALE; PEPTIDES, CYCLIC; RECEPTORS, ENDOTHELIN; SWINE; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 0031016216     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700925     Document Type: Article

References (33)

1. BAX, W.A. & SAXENA, P.R. (1994). The current endothelin receptor classification: time for reconsideration? Trends Pharmacol. Sci., 15, 379-386.
2. A sub-type. Br. J. Pharmacol., 114, 1110-1116.
3. EGUCHI, S., HIRATA, Y., IMAI, T., KANNO, K. & MARUMO, F. (1994). Phenotypic changes of endothelin receptor subtype in cultured rat vascular smooth muscle cells. Endocrinology, 134, 222-228.
4. FUKURODA, T., NISHIKIBE, M., OHTA, Y., IHARA, M., YANO, M., ISHIKAWA, K., FUKAMI, T. & IKEMOTO, F. (1992). Analysis of responses to endothelins in isolated porcine blood vessels by using a novel endothelin antagonist, BQ-153. Life Sci., 50, 107-112.
5. GODFRAIND, T. (1993). Evidence for heterogeneity of endothelin receptor distribution in human coronary artery. Br. J. Pharmacol., 110, 1201-1205.
6. GROVER, G.J., DZWONCZYK, S. & PARHAM, C.S. (1993). The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc. Res., 27, 1613-1618.
7. HARRISON, V.J., RANDRIANTSOA, A. & SCHOEFFTER, P. (1992). Heterogeneity of endothelin-sarafotoxin receptors mediating contraction of pig coronary artery. Br. J. Pharmacol., 105, 511-513.
8. B receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation, 92, 357-363.
9. B-mediated blood pressure responses in rats. J. Pharmacol. Exp. Ther., 270, 728-733.
10. B. Biochem. Biophys. Res. Commun., 200, 1708-1712.
11. KITAYOSHI, T., IKEDA, S., KUBO, K., AWANE-IGATA, Y., WATANABE, T. & FUJINO, M. (1996). Effects of a new endothelin receptor antagonist, TAK-044, on myocardial stunning in dogs. Eur. J. Pharmacol., 305, 137-143.
12. KOJIMA, M., KUBO, K., FUJIWARA, S., KANDORI, H., CHATANI, F. & WATANABE, T. (1995). Effects of TAK-044, an endothelin receptor antagonist, on reperfusion model of canine myocardial infarction. Jpn. J. Pharmacol., 67, 266p.
13. KUSUMOTO, K., AWANE, Y., FUJIWARA, S. & WATANABE, T. (1993). Role of endogenous endothelin in extension of rabbit myocardial infarction. J. Cardiovasc. Pharmacol., 22, S339-342.
14. KUSUMOTO, K., KUBO, K., KANDORI, H., KITAYOSHI, T., SATO, S., WAKIMASU, M., WATANABE, T. & FUJINO, M. (1994). Effects of a new endothelin antagonist, TAK-044, on post-ischemic acute renal failure in rats. Life Sci., 55, 301-310.
15. A receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. Br. J. Pharmacol., 115, 191-197.
16. MASAKI, T., YANAGISAWA, M. & GOTO, K. (1992). Physiology and pharmacology of endothelins. Med. Res. Rev., 12, 391-421.
17. MASAKI, T., VANE, J.R. & VANHOUTTE, P.M. (1994). V. International union of pharmacology nomenclature of endothelin receptors. Pharmacol. Rev., 46, 137-142.
18. B receptors. J. Pharmacol. Exp. Ther., (in press).
19. A receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischemia and reperfusion. Br. J. Pharmacol., 112, 75-80.
20. A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/ reperfusion in pigs. J. Pharmacol. Exp. Ther., 278, 42-49.
21. MILLER, V.M., KOMORI, K., BURNETT, J.C. JR & VANHOUTTE, P.M. (1989). Differential sensitivity to endothelin in canine arteries and veins. Am. J. Physiol., 257,H1127-H1131.
22. MIYAUCHI, T., TOMOBE, Y., ISHIKAWA, T., GOTO, K. & SUGISHITA, Y. (1996). Vasoconstriction by endothelin-1 in resistance and conduit portions of isolated human mesenteric arteries. Eur. J. Pharmacol., 303, 193-196.
23. NAMBI, P., PULLEN, M., JUGUS, M. & GELLAI, M. (1993). Rat kidney endothelin receptors in ischemia-induced acute renal failure. J. Pharmacol. Exp. Ther., 264, 345-348.
24. RIEZEBOS, J., WATTS, I.S. & VALLANCE, J.T. (1994). Endothelin receptors mediating functional responses in human small arteries and veins. Br. J. Pharmacol., 111, 609-615.
25. SARGENT, C.A., LIU, E.C.K., CHAO, C.-C., WEBB, M.L. & GROVER, G.J. (1994). Role of endothelin receptor subtype B (ET-B) in myocardial ischemia. Life Sci., 55, 1833-1844.
26. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation, 89, 1203-1208.
27. SHIBOUTA, Y., SUZUKI, N., SHINO, A., MATSUMOTO, H., TERASHITA, Z., KONDO, K. & NISHIKAWA, K. (1990). Pathophysiological role of endothelin in acute renal failure. Life Sci., 46, 1611-1618.
28. B receptors in canine coronary arteries. Circ. Res., 74, 105-114.
29. WARNER, T.D. (1994). Endothelin receptor antagonist. Cardiovasc. Drug Rev., 12, 105-122.
30. WATANABE, T., SUZUKI, N., SHIMAMOTO, N., FUJINO, M. & IMADA, A. (1991). Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Circ. Res., 69, 370-377.
31. B receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br. J. Pharmacol., 114, 949-954.
32. WATANABE, T. & FUJINO, M. (1996). TAK-044: an endothelin receptor antagonist. Cardiovasc. Drug Rev., 14, 36-46.
33. WILLETTE, R.N., ZHANG, H., MITCHELL, M.P., SAUERMELCH, C.F., OHLSTEIN, E.H., SULPIZIO, A.C. & KATUSIC, Z.S. (1994). Nonpeptide endothelin antagonist: cerebrovascular characterization and effects on delayed cerebral vasospasm. Stroke, 25, 2450-2456.