The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies

Biochimie

Volumn 93, Issue 8, 2011, Pages 1318-1327

  Petraccone, Luigi ^a   Fotticchia, Iolanda ^a   Cummaro, Annunziata ^a   Pagano, Bruno ^b   Ginnari Satriani, Luca ^c   Haider, Shozeb ^d   Randazzo, Antonio ^a   Novellino, Ettore ^a   Neidle, Stephen ^e   Giancola, Concetta ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Circular dichroism; G quadruplex DNA; Isothermal titration calorimetry; Molecular crowding conditions; Molecular modeling; Quadruplex ligand interaction

Indexed keywords

AZATRUX; CARBAZOLE DERIVATIVE; DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; DNA STRUCTURE; DRUG DNA BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; MOLECULAR MODEL; THERMODYNAMICS;

BIOPHYSICS; CALORIMETRY; CARBAZOLES; CIRCULAR DICHROISM; DNA; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; PIPERIDINES; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; TELOMERE;

EID: 79960700586     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.05.017     Document Type: Article

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