Serum levels of the hepcidin-20 isoform in a large general population: The Val Borbera study

Journal of Proteomics

Volumn 76, Issue , 2012, Pages 28-35

  Campostrini, Natascia ^a   Traglia, Michela ^b   Martinelli, Nicola ^a   Corbella, Michela ^a   Cocca, Massimiliano ^b   Manna, Daniele ^a   Castagna, Annalisa ^a   Masciullo, Corrado ^b   Silvestri, Laura ^d   Olivieri, Oliviero ^a   Toniolo, Daniela ^b,c   Camaschella, Clara ^b,d   Girelli, Domenico ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c CNR   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Ferritin; Hepcidin; Iron metabolism; SELDI TOF MS

Indexed keywords

CREATININE; FERRITIN; HEPCIDIN 20; HEPCIDIN 24; HEPCIDIN 25; HORMONE; IRON; TRANSFERRIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BODY MASS; CREATININE BLOOD LEVEL; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IRON BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TRANSFERRIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ANTIMICROBIAL CATIONIC PEPTIDES; FEMALE; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTEIN ISOFORMS; PROTEOMICS; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 84869882814     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.08.006     Document Type: Article

References (27)

1. Ganz T. Hepcidin and iron regulation, 10years later. Blood 2011, 117:4425-4433.
2. Hentze M.W., Muckenthaler M.U., Galy B., Camaschella C. Two to tango: regulation of mammalian iron metabolism. Cell 2010, 142:24-38.
3. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
4. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003, 3:710-720.
5. Valore E.V., Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis 2008, 40:132-138.
6. Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001, 276:7806-7810.
7. Castagna A., Campostrini N., Zaninotto F., Girelli D. Hepcidin assay in serum by SELDI-TOF-MS and other approaches. J Proteomics 2010, 73:527-536.
8. Kemna E.H., Tjalsma H., Podust V.N., Swinkels D.W. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007, 53:620-628.
9. Nemeth E., Preza G.C., Jung C.L., Kaplan J., Waring A.J., Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 2006, 107:328-333.
10. Maisetta G., Petruzzelli R., Brancatisano F.L., Esin S., Vitali A., Campa M., et al. Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: effect of copper and acidic pH. Peptides 2010, 31:1995-2002.
11. Tavanti A., Maisetta G., Del Gaudio G., Petruzzelli R., Sanguinetti M., Batoni G., et al. Fungicidal activity of the human peptide hepcidin 20 alone or in combination with other antifungals against Candida glabrata isolates. Peptides 2011, 32:2484-2487.
12. Suzuki H., Toba K., Kato K., Ozawa T., Tomosugi N., Higuchi M., et al. Serum hepcidin-20 is elevated during the acute phase of myocardial infarction. Tohoku J Exp Med 2009, 218:93-98.
13. Tomosugi N., Kawabata H., Wakatabe R., Higuchi M., Yamaya H., Umehara H., et al. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system. Blood 2006, 108:1381-1387.
14. Tessitore N., Girelli D., Campostrini N., Bedogna V., Solero P.G., Castagna A., et al. Hepcidin is not useful as a biomarker for iron needs in haemodialysis patients on maintenance erythropoiesis-stimulating agents. Nephrol Dial Transplant 2010, 25:3996-4002.
15. Campostrini N., Castagna A., Zaninotto F., Bedogna V., Tessitore N., Poli A., et al. Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based on SELDI-TOF MS. J Biomed Biotechnol 2010, 2010:329646.
16. Peters H.P., Laarakkers C.M., Swinkels D.W., Wetzels J.F. Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate. Nephrol Dial Transplant 2010, 25:848-853.
17. Kroot J.J., Laarakkers C.M., Geurts-Moespot A.J., Grebenchtchikov N., Pickkers P., van Ede A.E., et al. Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders. Clin Chem 2010, 56:1570-1579.
18. Traglia M., Girelli D., Biino G., Campostrini N., Corbella M., Sala C., et al. Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations. J Med Genet 2011, 48:629-634.
19. Traglia M., Sala C., Masciullo C., Cverhova V., Lori F., Pistis G., et al. Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS One 2009, 4:e7554.
20. Swinkels D.W., Girelli D., Laarakkers C., Kroot J., Campostrini N., Kemna E.H., et al. Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry. PLoS One 2008, 3:e2706.
21. Kulaksiz H., Gehrke S.G., Janetzko A., Rost D., Bruckner T., Kallinowski B., et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2004, 53:735-743.
22. Hadley K.B., Johnson L.K., Hunt J.R. Iron absorption by healthy women is not associated with either serum or urinary prohepcidin. Am J Clin Nutr 2006, 84:150-155.
23. Looker A., Dallman P., Carroll M., Gunter E., Johnson C. Prevalence of iron deficiency in the United States. JAMA 1997, 277:973-976.
24. Galesloot T.E., Vermeulen S.H., Geurts-Moespot A.J., Klaver S.M., Kroot J.J., et al. Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood 2011, 117:e218-e225.
25. Kroot J.J., Kemna E.H., Bansal S.S., Busbridge M., Campostrini N., Girelli D., et al. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica 2009, 94:1748-1752.
26. Schranz M., Bakry R., Creus M., Bonn G., Vogel W., Zoller H. Activation and inactivation of the iron hormone hepcidin: biochemical characterization of prohepcidin cleavage and sequential degradation to N-terminally truncated hepcidin isoforms. Blood Cells Mol Dis 2009, 43:169-179.
27. Barrett A.J. Cellular proteolysis. An overview. Ann N Y Acad Sci 1992, 674:1-15.