Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

Biotechnology and Bioengineering

Volumn 110, Issue 1, 2013, Pages 191-205

  Lu, Franklin ^a   Toh, Poh Choo ^b   Burnett, Iain ^a   Li, Feng ^a   Hudson, Terry ^a   Amanullah, Ashraf ^a   Li, Jincai ^a  

^a GENENTECH INC   (United States)

^b AGENCY FOR SCIENCE   (Singapore)

Author keywords

Automated sampling; Capacitance; CHO cell culture; Dynamic feeding; Fed batch; Nova Flex

Indexed keywords

ANIMAL CELL CULTURE; AUTOMATION; BATCH CELL CULTURE; BATCH DATA PROCESSING; CAPACITANCE; CAPACITANCE MEASUREMENT; CHEMICAL CONTAMINATION; FIXED PLATFORMS; GLUCOSE; GLUCOSE SENSORS; NUTRIENTS; OPTIMIZATION; PRODUCTIVITY;

AUTOMATED CELL; AUTOMATED SAMPLING; AUTOSAMPLERS; BIOPROFILE; CELL CULTURE PROCESS; CELL LINES; CULTURE CONDITIONS; DATA PROCESSING SYSTEMS; DELTA-V; FED BATCHES; FED-BATCH PROCESS; FEED-RATES; GLUCOSE LEVEL; GLUCOSE MEASUREMENTS; HIGH PRODUCTIVITY; INDUSTRY PRACTICES; MAMMALIAN CELL CULTURE; MEDIA OPTIMIZATION; NOVA FLEX; NUTRIENT CONSUMPTION; NUTRIENT DEMAND; PROCESS IMPROVEMENT; PRODUCT QUALITY; PRODUCTIVITY IMPROVEMENTS; RAPID PROCESS DEVELOPMENT; STOICHIOMETRIC RATIO; STRATEGY OPTIMIZATION;

FEEDING;

GLUCOSE;

ALGORITHM; ANIMAL CELL; ARTICLE; AUTOMATION; CELL CULTURE; CELL LINE; CULTURE MEDIUM; DATA PROCESSING; FED BATCH CULTURE; NONHUMAN; NUTRIENT; STOICHIOMETRY;

MAMMALIA;

EID: 84869875529     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24602     Document Type: Article

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