Glycogen synthase kinase-3β inhibition improved survivability of mice infected with Burkholderia pseudomallei

Tropical Biomedicine

Volumn 29, Issue 4, 2012, Pages 551-567

  Tay, T F ^a   Maheran, M ^a   Too, S L ^a   Hasidah, M S ^a   Ismail, G ^a   Embi, N ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; IMMUNOLOGIC FACTOR; LITHIUM CHLORIDE;

ANIMAL; ARTICLE; BACTERIAL LOAD; BACTERIUM; BAGG ALBINO MOUSE; BLOOD; BLOOD ANALYSIS; BURKHOLDERIA PSEUDOMALLEI; CHEMISTRY; DISEASE MODEL; DRUG ANTAGONISM; ISOLATION AND PURIFICATION; LIVER; LUNG; MALE; MELIOIDOSIS; MICROBIOLOGY; MOUSE; PATHOGENICITY; SPLEEN; SURVIVAL; TREATMENT OUTCOME;

ANIMALS; BACTERIA; BACTERIAL LOAD; BLOOD CHEMICAL ANALYSIS; BURKHOLDERIA PSEUDOMALLEI; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; IMMUNOLOGIC FACTORS; LITHIUM CHLORIDE; LIVER; LUNG; MALE; MELIOIDOSIS; MICE; MICE, INBRED BALB C; SPLEEN; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84869801194     PISSN: 01275720     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Beurel, E., Michalek, S.M. & Jope, R.S. (2010). Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunology 31(1): 24-31.
2. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254.
3. Bundschuh, D.S., Barsig, J., Hartung, T., Randow, F., Docke, W.D., Volk, H.D. & Wendel, A. (1997). Granulocytemacrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. The Journal of Immunology 158(6): 2862-2871.
4. Cannon, J.G., Tompkind, R.G., Gelfand, J.A., Michie, H.R., Stanford, G.G., van der Meer, J.W., Endres, S., Lonnemann, G., Corsetti, J. & Chernow, B. (1990). Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. Journal of Infectious Diseases 161(1): 79-84.
5. Clarke, C.J.P., Hales, A., Hunt, A. & Foxwell, B.M.J. (1998). IL-10-mediated suppression of TNF-ssproduction is independent of its ability to inhibit NFNB activity. European Journal of Immunology 28(5): 1719-1726.
6. Cohen, J. (2002). The immunopathogenesis of sepsis. Nature 420(6917): 885-891.
7. Cortés-Vieyra, R., Bravo-Patiño, A., Valdez-Alarcón, J. J., Cajero Juárez, M., Finlay, B.B. and Baizabal-Aguirre, V.M. (2012). Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. Journal of Inflammation 9: 23. doi:10.1186/1476-9255-9-23.
8. Dinarello, C.A. (1996). Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
9. Dinarello, C.A. (2000). Proinflammatory cytokines. Chest 118(2): 503-508.
10. Duan, Y., Liao, A.P., Kuppireddi, S., Ye, Z., Ciancio, M.J. & Sun, J. (2007). C-catenin activity negatively regulates bacteriainduced inflammation. Laboratory Investigation 87: 613-624.
11. Doherty, G.M., Lange, J.R., Langstein, H.N., Alexander, H.R., Buresh, C.M. & Norton, J.A. (1992). Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha. Journal of Immunology 149(5): 1666-1670.
12. Dugo, L., Abdelrahman, M., Murch, O., Mazzon, E., Cuzzocrea, S. & Thiemermann, C. (2006). Glycogen Synthase Kinase-3(inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation. Shock 25(5): 485-491.
13. Embi, N., Rylatt, D.B. & Cohen, P. (1980). Glycogen Synthase Kinase-3 from rabbit skeletal muscle: separation from Cyclic-AMP-Dependent Protein Kinase and Phosphorylase Kinase. European Journal of Biochemistry 107(2): 519-527.
14. Fischer, E., Marano, M.A., Van Zee, K.J., Rock, C.S., Hawes, A.S., Thompson, W.A., DeForge, L., Kenney, J.S., Remick, D.G. & Bloedow, D.C. (1992). Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia. Journal of Clinical Investigation 89(5): 1551-1557.
15. Gary, S., Firetein, M.D., Ralph, C., Budd, M.D., Harris, E. D, Jr., Mclnnes, L.B., Ruddy, S. & Sergent, J.S. (2009). Kelley's Textbook of Rheumatology. Philadelphia. Expert Consult Premium Ed.
16. Ismail, G., Razak, N., Mohamed, R., Embi, N. & Omar, O. (1988). Resistance of Pseudomonas pseudomallei to normal human serum bactericidal action. Microbiology Immunology 32(7): 645-52.
17. Jope, R.S. & Johnson, G.V.W. (2004). The glamour and gloom of glycogen synthase kinase 3. Trends in Biochemical Sciences 29(2): 95-102.
18. Jope, R.S., Yuskaitis, C.J. & Beurel, E. (2007). Glycogen Synthase Kinase-3 (GSK3): inflammation, diseases and therapeutics. Neurochemical Research 32: 577-595.
19. Kawai, T. & Akira, S. (2007). TLR signaling. Seminar in Immunology 19: 24-32.
20. Kelvin, J., Tracey, M.D. & Cerami, A. (1994). Tumor necrosis factor: A pleiotropic cytokine and therapeutic target. Annual Review of Medicine 45: 491-503.
21. Ko, R., Jang, H.D. & Lee, S.Y. (2010). GSK3K inhibitor peptide protects mice from LPS-induced endotoxin shock. Immune Network 10(3): 99-103.
22. Kumar, H., Kawai, T. & Akira, S. (2009). Tolllike receptors and innate immunity. Biochemical and Biophysical Research Communications 388(4): 621-625.
23. Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227: 680-685.
24. Leakey, A.K., Ulett, G.C. & Hirst, R.G. (1998). BALB/c and C57Bl/6 mice infected with virulent Burkholderia pseudomallei provide contrasting animal models for the acute and chronic forms of human melioidosis. Microbiology Pathogen 24: 269-276.
25. Li, P., Allen, H., Baneriee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L. & Salfeld, J. (1995). Mice deficient in IL-1betacoverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80(3): 401-411.
26. Martin, M., Rehani, K., Jope, R.S. & Michalek, S.M. (2005). Toll like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nature Immunology 6: 777-784.
27. Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A. (1997). A human homologue of the Drosophila toll protein signals activation of adaptive immunity. Nature 388: 394-397.
28. Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C., Ghosh, S. & Janeway, C.A. (1998). MyD88 is an adaptor protein in the Toll/IL-1 receptor family signaling pathways. Molecular Cell 2(2): 253-258.
29. Mohamed, R., Nathan, S., Embi, N., Razak, N. & Ismail, G. (1989). Inhibition of macromolecular synthesis in cultured macrophages by Pseudomonas pseudomallei exotoxin. Microbiology and Immunology 33(10): 811-820.
30. Novem, V., Shui, G., Wang, D., Bendt, A.K., Sim, S.H., Liu, Y., Thong, T.W., Sivalingam, S.P., Ooi, E.E., Wenk, M.R. & Tan, G. (2009). Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis. Clinical and Vaccine Immunology 16(10): 1420-1428.
31. Opal, S.M. & DePalo, V.A. (2000). Antiinflammatory cytokines. Chest 117: 1162-1172.
32. Opal, S.M., Wherry, J.C. & Grint, P. (1998). Interleukin-10: potential benefits and possible risks in clinical infectious diseases. Clinical Infectious Disease 27: 1497-1507.
33. Phelan, H., Stahls, P., Hunt, J., Bagby, G.J. & Molina, P.E. (2002). Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shock. Journal Trauma-Injury Infection and Critical Care 52(4): 675-682.
34. Razak, N. & Ismail, G. (1982). Interaction of human polymorphonuclear leukocytes with Pseudomonas pseudomallei. Journal of General and Applied Microbiology 28(6): 509-518.
35. Redl, H. & Schlag, G. (1999). Cytokines in severe sepsis and septic shock. Switzerland, Birkhauser Berlag.
36. Ryves, W.J. & Harwood, A.J. (2001). Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochemical and Biophysical Research Communications 280(3): 720-725.
37. Sinha, D., Wang, Z., Ruchalski, K.L., Levine, J.S., Krishnan, S., Lieberthal, W., Schwartz, J.H. & Borkan, S.C. (2005). Lithium activates the Wnt and phosphatidylinositol 3 kinase Akt signaling pathways to promotes cell survival in the absence of soluble survival factors. American Journal of Physiology-Renal Physiology 288: F703-F713.
38. Thompson, A. & Lotze, M. (1999). The Cytokine Handbook. San Diego, CA: Academic Press, Inc.
39. Wang, H., Brown, J. & Martin, M. (2011). Glycogen synthase kinase 3: A point of convergence for the host inflammatory response. Cytokine 53(2): 130-140.
40. Wang, L.Z. & Zhu, X.Z. (2003). Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development. Acta Pharmacologica Sinica 24(10): 965-974.
41. West, T.E., Ernst, R.K., Jansson-Hutson, M.J. & Skerrett, S.J. (2008). Activation of Tolllike receptors by Burkholderia pseudomallei. BMC Immunology 9: 46.
42. White, N.J. (2003). Melioidosis. The Lancet 361(9370): 1715-1722.
43. Wiersinga, W.J., Wieland, C.W., Dessing, M.C., Chantratita, N., Cheng, A.C., Limmathurotsakul, D., Chierakul, W., Leendertse, M., Florquin, S., Vos, A.F., White, N., Dondorp, A.M., Day, M.P., Peacock, S.J. & Poll, T. (2007). Toll-like receptor 2 impairs host defense in gramnegative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med 4: e248.
44. Wong, W.R., Chen, Y.Y., Yang, S.M., Chen, Y.L. & Horng, J.T. (2005). Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71. Life Sciences 78(1): 82-90.
45. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. & Mathison, J.C. (1990). CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249(4975): 1431-1433.
46. Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Gorddard, A., Wood, W.I., Gurney, A.L. & Godowski, P.J. (1998). Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling. Nature 395: 284-2888.
47. Zhang, F., Phiel, C.J., Spece, L., Gurvich, N. & Klein, P.S. (2003). Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. The Journal of Biological Chemistry 278: 33067-33077.
48. Zhang, P., Katz, J. & Michalek, S.M. (2009). Glycogen synthase kinase-3 (GSK3) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. Molecular Immunology 46: 677-687.