Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice

Experimental and Therapeutic Medicine

Volumn 5, Issue 1, 2013, Pages 17-22

  Maeda, Naoki ^a   Kokai, Yasuo ^b   Hada, Takahiko ^c   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Hada Giken Co Ltd   (Japan)

Author keywords

cyclodextrin; Anti proliferation; Antitumor; DNA polymerase; Monogalactosyl diacylglycerol

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CD31 ANTIGEN; CYCLINE; GAMMA CYCLODEXTRIN; GLYCEROL DERIVATIVE; MONOGALACTOSYL DIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER PREVENTION; CELL LABELING; COLON ADENOCARCINOMA; CONTROLLED STUDY; FEMALE; HEALTH PROMOTION; IMMUNOHISTOCHEMISTRY; LD 50; MITOSIS; MOUSE; NICK END LABELING; NONHUMAN; SPINACH;

EID: 84869458898     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.792     Document Type: Article

References (32)

1. Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L and Wolk A: Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 93: 525-533, 2001.
2. Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780, 2003.
3. Liu RH: Potential synergy of phytochemicals in cancer prevention: mechanism of a ction. J Nut r 134: 3479 S -3 4 85S, 2004.
4. Hubscher U, Maga G and Spadari S: Eukaryotic DNA poly-merases. Annu Rev Biochem 71: 133-163, 2002.
5. Bebenek K and Kunkel TA: DNA repair and replication. In: Advances in Protein Chemistry. Yang W (ed). Vol 69. Elsevier, San Diego, CA, pp137-165, 2004.
6. Takata K, Shimizu T, Iwai S and Wood RD: Human DNA poly-merase N (POLN) is a low fdelity enzyme capable of error-free bypass of 5S-thymine glycol. J Biol Chem 281: 23445-23455, 2006.
7. Murakami C, Kumagai T, Hada T, Kanekazu U, Nakazawa S, Kamisuki S, Maeda N, Xu X, Yoshida H, Sugawara F, Sakaguchi K and Mizushina Y: Effects of glycolipids from spinach on mammalian DNA polymerases. Biochem Pharmacol 65: 259-267, 2003.
8. Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S and Sakaguchi K: Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella. Chem Pharm Bull (Tokyo) 46: 684-686, 1998.
9. Hanashima S, Mizushina Y, Ohta K, Yamazaki T, Sugawara F and Sakaguchi K: Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoqui-novosylacylglycerols. Jpn J Cancer Res 91: 1073-1083, 2000.
10. Maeda N, Hada T, Yoshida H and Mizushina Y: Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach. Curr Med Chem 14: 955-967, 2007.
11. Roughan PG and Batt RD: The glycerolipid composition of leaves. Phytochemistry 8: 363-369, 1969.
12. Sugawara T and Miyazawa T: Separation and determination of glycolipids from edible plant sources by high-performance liquid chromatography and evaporative light-scattering detection. Lipids 34: 1231-1237, 1999.
13. Yunoki K, Sato M, Seki K, Ohkubo T, Tanaka Y and Ohnishi M: Simultaneous quantifcation of plant glyceroglycolipids including sulfoquinovosyldiacylglycerol by HPLC-ELSD with binary gradient elution. Lipids 44: 77-83, 2009.
14. Kuriyama I, Musumi K, Yonezawa Y, Takemura M, Maeda N, Iijima H, Hada T, Yoshida H and Mizushina Y: Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation. J Nutr Biochem 16: 594-601, 2005.
15. Maeda N, Hada T, Murakami-Nakai C, Kuriyama I, Ichikawa H, Fukumori Y, Hiratsuka J, Yoshida H, Sakaguchi K and Mizushina Y: Effects of DNA polymerase inhibitory and antitumor activities of lipase-hydrolyzed glycolipid fractions from spinach. J Nutr Biochem 16: 121-128, 2005.
16. Matsubara K, Matsumoto H, Mizushina Y, Mori M, Nakajima N, Fuchigami M, Yoshida H and Hada T: Inhibitory effect of glyco-lipids from spinach on in vitro and ex vivo angiogenesis. Oncol Rep 14: 157-160, 2005.
17. Maeda N, Matsubara K, Yoshida H and Mizushina Y: Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors based on the selective inhibition of DNA polymerase activity. Mini Rev Med Chem 11: 32-38, 2011.
18. Bruno A, Rossi C, Marcolongo G, Di Lena A, Venzo A, Berrie CP and Corda D: Selective in vivo anti-infammatory action of the galactolipid monogalactosyldiacylglycerol. Eur J Pharmacol 524: 159-168, 2005.
19. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
20. Fukuda K, Teramoto Y, Goto M, Sakamoto J, Mitsuiki S and Hayashida S: Specifc inhibition by cyclodextrins of raw starch digestion by fungal glucoamylase. Biosci Biotechnol Biochem 56: 556-559, 1992.
21. Sugawara T and Miyazawa T: Digestion of plant monogalactosyl-diacylglycerol and digalactosyldiacylglycerol in rat alimentary canal. J Nutr Biochem 11: 147-152, 2000.
22. Matsui Y, Hada T, Maeda N, Sato Y, Yamaguchi Y, Takeuchi T, Takemura M, Sugawara F, Sakaguchi K, Yoshida H and Mizushina Y: Structure and activity relationship of monoga-lactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth. Cancer Lett 283: 101-107, 2009.
23. Grammatikos SI, Subbaiah PV, Victor TA and Miller WM: n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines. Br J Cancer 70: 219-227, 1994.
24. Coakley M, Banni S, Johnson MC, Mills S, Devery R, Fitzgerald G, Paul Ross R and Stanton C: Inhibitory effect of conjugated α-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. Lipids 44: 249-256, 2009.
25. Kubben FJ, Peeters-Haesevoets A, Engels LG, Baeten CG, Schutte B, Arends JW, Stockbrugger RW and Blijham GH: Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation. Gut 35: 530-535, 1994.
26. Bromley M, Rew D, Becciolini A, Balzi M, Chadwick C, Hewitt D, Li YQ and Potten CS: A comparison of proliferation markers (BrdUrd, Ki-67, PCNA) determined at each cell position in the crypts of normal human colonic mucosa. Eur J Histochem 40: 89-100, 1996.
27. Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N and Mizushina Y: Anti-tumor effects of dehydroaltenusin, a specifc inhibitor of mammalian DNA polymerase α. Biochem Biophys Res Commun 352: 390-396, 2007.
28. Kuriyama I, Mizuno T, Fukudome K, Kuramochi K, Tsubaki K, Usui T, Imamoto N, Sakaguchi K, Sugawara F, Yoshida H and Mizushina Y: Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase α inhibitor, on DNA replication in cultured cells. Molecules 13: 2948-2961, 2008.
29. Berdis AJ: DNA polymerases as therapeutic targets. Biochemistry (Moscow) 47: 8253-8260, 2008.
30. Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
31. Folkman J: Tumor angiogenesis. Adv Cancer Res 43: 175-203, 1985.
32. Bossi P, Viale G, Lee AK, Alfano R, Coggi G and Bosari S: Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 55: 5049-5053, 1995.