Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation

Journal of Nutritional Biochemistry

Volumn 16, Issue 10, 2005, Pages 594-601

  Kuriyama, Isoko ^a   Musumi, Keiichi ^b   Yonezawa, Yuko ^a   Takemura, Masaharu ^c   Maeda, Naoki ^a   Iijima, Hiroshi ^a   Hada, Takahiko ^d   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Takii Plant Breeding and Experiment Station   (Japan)

^c MIE UNIVERSITY   (Japan)

^d Hada Giken Co Ltd   (Japan)

Author keywords

Anticancer agent; DNA polymerase ; Enzyme inhibitor; Glycolipids; Spinach; SQDG (sulfoquinovosyl diacylglycerol)

Indexed keywords

DIACYLGLYCEROL DERIVATIVE; DNA DIRECTED DNA POLYMERASE ALPHA; GALACTOSYLDIACYLGLYCEROL; GLYCOLIPID; SULFOQUINOVOSYL DIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CARROT; CELL PROLIFERATION; CHIVE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; GARLIC; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID ANALYSIS; MAMMAL; METASTASIS; ONION; PARSLEY; PURIFICATION; SPINACH; SWEET PEPPER; TEA; VEGETABLE;

ANIMALS; CATTLE; CELL DIVISION; CELL LINE, TUMOR; DNA POLYMERASE I; ENZYME INHIBITORS; GLYCOLIPIDS; HUMANS; NEOPLASMS; PLANT LEAVES; SPINACIA OLERACEA; STOMACH NEOPLASMS; VEGETABLES;

ALLIUM CEPA; ALLIUM SATIVUM; ALLIUM SCHOENOPRASUM; ANNA; CAPSICUM ANNUUM VAR. ANNUUM; DAUCUS CAROTA; MAMMALIA; PETROSELINUM CRISPUM; SPINACIA OLERACEA;

EID: 25144465053     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2005.02.007     Document Type: Article

References (38)

1. U. Hubscher, G. Maga, and S. Spadari Eukaryotic DNA polymerases Annu Rev Biochem 71 1999 133 163
2. A. Kornberg, and T.A. Baker 2nd ed. DNA replication 1992 WH Freeman New York 197 225
3. Y. Mizushina, N. Tanaka, H. Yagi, T. Kurosawa, M. Onoue, and H. Seto Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro Biochim Biophys Acta 1308 1996 256 262
4. Y. Mizushina, S. Yoshida, A. Matsukage, and K. Sakaguchi The inhibitory action of fatty acids on DNA polymerase β Biochim Biophys Acta 1336 1997 509 521
5. Y. Mizushina, T. Ohkubo, T. Date, T. Yamaguchi, M. Saneyoshi, and F. Sugawara Mode analysis of a fatty acid molecule binding to the N-terminal 8-kDa domain of DNA polymerase β J Biol Chem 274 1999 25599 25607
6. Y. Mizushina, M. Sagisaka, H. Sakai, M. Abe, and K. Sakaguchi Mode analysis of binding of fatty acids to mammalian DNA polymerases Biochim Biophys Acta 1486 2000 211 218
7. Y. Mizushina, C. Murakami, K. Ohta, H. Takikawa, K. Mori, and H. Yoshida Selective inhibition of the activities of both eukaryotic DNA polymerases and DNA topoisomerases by elenic acid Biochem Pharmacol 63 2000 399 407
8. Y. Mizushina, T. Ohkubo, F. Sugawara, and K. Sakaguchi Structure of lithocholic acid binding to the N-terminal 8-kDa domain of DNA polymerase β Biochemistry 39 2000 12606 12613
9. Y. Mizushina, N. Kasai, K. Miura, S. Hanashima, M. Takemura, and H. Yoshida Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase β Biochemistry 43 2004 10669 10677
10. Y. Mizushina, N. Tanaka, A. Kitamura, K. Tamai, M. Ikeda, and M. Takemura The inhibitory effect of novel triterpenoid compounds, fomitellic acids, on DNA polymerase β Biochem J 330 1998 1325 1332
11. N. Tanaka, A. Kitamura, Y. Mizushina, F. Sugawara, and K. Sakaguchi Fomitellc acid, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea J Nat Prod 61 1998 193 197
12. Y. Mizushina, N. Takahashi, L. Hanashima, H. Koshino, Y. Esumi, and J. Uzawa Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum Bioorg Med Chem 9 1999 2047 2052
13. Y. Mizushina, T. Ueno, Y. Goto, Y. Isobe, M. Sako, and T. Fujita Carboxyflavins, novel inhibitors of Taq DNA polymerase Int J Mol Med 2 1998 283 286
14. Y. Mizushina, T. Ueno, M. Oda, T. Yamaguchi, M. Saneyoshi, and K. Sakaguchi The biochemical mode of inhibition of DNA polymerase β by α-rubromycin Biochim Biophys Acta 1523 1998 172 181
15. Y. Mizushina, I. Watanabe, K. Ohta, M. Takemura, H. Sahara, and N. Takahashi Studies on inhibitors of mammalian DNA polymerase α and β: sulfolipids from a pteridophyte, Athyrum niponicum Biochem Pharmacol 55 1998 537 541
16. K. Ohta, Y. Mizushina, N. Hirata, M. Takemura, F. Sugawara, and A. Matsukage Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella Chem Pharm Bull 46 1998 684 686
17. K. Ohta, Y. Mizushina, N. Hirata, M. Takemura, F. Sugawara, and A. Matsukage Action of new mammalian DNA polymerase inhibitor, sulfoquinovosyldiacylglycerol Biol Pharm Bull 22 1999 111 116
18. S. Hanashima, Y. Mizushina, K. Ohta, T. Yamazaki, F. Sugawara, and K. Sakaguchi Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols Jpn J Cancer Res 91 2000 1073 1083
19. S. Hanashima, Y. Mizushina, T. Yamazaki, K. Ohta, S. Takahashi, and H. Koshino Structural determination of sulfoquinovosyldiacylglycerol by chiral syntheses Tetrahedron Lett 41 2000 4403 4407
20. K. Ohta, S. Hanashima, Y. Mizushina, T. Yamazaki, M. Saneyoshi, and F. Sugawara Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: inhibitory action on cell proliferation Mutat Res 467 2000 139 152
21. S. Hanashima, Y. Mizushina, T. Yamazaki, K. Ohta, S. Takahashi, and H. Sahara Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase α and β Bioorg Med Chem 9 2001 367 376
22. C. Murakami, T. Yamazaki, S. Hanashima, S. Takahashi, K. Ohta, and H. Yoshida Structure-activity relationship of synthetic sulfoquinovosylacylglycerols as a mammalian DNA polymerases inhibitor and apoptosis inducer Arch Biochem Biophys 403 2002 229 236
23. H. Sahara, S. Hanashima, T. Yamazaki, S. Takahashi, F. Sugawara, and S. Ohtani Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols Jpn J Cancer Res 93 2002 85 92
24. C. Murakami, M. Takemura, Y. Sugiyama, S. Kamisuki, H. Asahara, and M. Kawasaki Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases Biochim Biophys Acta 1574 2002 85 92
25. Y. Mizushina, X. Xu, K. Matsubara, C. Murakami, I. Kuriyama, and M. Oshige Pyridoxal 5′-phosphate is a selective inhibitor in vivo of DNA polymerase α and ε Biochem Biophys Res Commun 312 2003 1025 1032
26. Y. Mizushina, X. Xu, C. Murakami, T. Okano, M. Takemura, and H. Yoshida Selective inhibition of mammalian DNA polymerase α by vitamin D2 and D3 J Pharmacol Sci 92 2003 283 290
27. Y. Mizushina, A. Matsukage, and K. Sakaguchi The biochemical inhibition mode of bredinin-5′-monophosphate on DNA polymerase β Biochim Biophys Acta 1403 1998 5 11
28. Y. Mizushina, N. Takahashi, A. Ogawa, K. Tsurugaya, H. Koshino, and M. Takemura The cyanogenic glucoside, prunasin (d-mandelonitrile-β-d-glucose), is a novel inhibitor of DNA polymerase β J Biochem (Tokyo) 126 1999 430 436
29. I. Ishizuka, and T. Yamakiwa H. Wiegandt New comprehensive biochemistry vol. 10 1985 Elsevier Amsterdam 101
30. N. Maeda, T. Hada, C.M. Nakai, I. Kuriyama, H. Ichikawa, and Y. Fukumori Effects of DNA polymerase inhibitory and anti-tumor activities of lipase-hydrolyzed glycolipids fraction from spinach J Nutr Biochem 16 2005 121 128
31. K. Tamai, K. Kojima, T. Hanaichi, S. Masaki, M. Suzuki, and H. Umekawa Structural study of immunoaffinity-purified DNA polymerase α-DNA primase complex from calf thymus Biochim Biophys Acta 950 1998 263 273
32. T. Date, M. Yamaguchi, F. Hirose, Y. Nishimoto, K. Tanihara, and A. Matsukage Expression of active rat DNA polymerase β in Esherichia coli Biochemistry 27 1988 2983 2990
33. K. Sakaguchi, Y. Hotta, and H. Stern Chromatin-associated DNA polymerase activity in meiotic cells of lily and mouse Cell Struct Funct 5 1980 323 334
34. K.T. Koizumi, T. Murate, M. Suzuki, C.G. Simbulan, M. Nakagawa, and M. Takemura Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells Biochem Mol Biol Int 41 1997 1179 1189
35. C. Nakayama, and M. Saneyoshi Inhibitory effects of 9-β-d- xylofuranosyladenine 5′-triphosphate on DNA-dependent RNA polymerase I and II from cherry salmon (Oncorhynchus masou) J Biochem (Tokyo) 97 1985 1385 1389
36. D.A. Soltis, and O.C. Uhlenbeck Isolation and characterization of two mutant forms of T4 polynucleotide kinase J Biol Chem 257 1982 11332 11339
37. B.C. Lu, and K. Sakaguchi An endo-exonuclease from meiotic tissues of the basidiomycete Coprinus cinereus: its purification and characterization J Biol Chem 266 1991 21060 21066
38. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63