-
1
-
-
84856581006
-
The perpetual challenge of infectious diseases
-
Fauci AS, Morens DM. The perpetual challenge of infectious diseases. N Engl J Med 2012;366:454-61
-
(2012)
N Engl J Med
, vol.366
, pp. 454-461
-
-
Fauci, A.S.1
Morens, D.M.2
-
4
-
-
84870829463
-
-
Avilable from http://www.bioparadigms.org/slc/menu.asp
-
-
-
-
5
-
-
29144523534
-
A human transporter protein that mediates the final excretion step for toxic organic cations
-
Otsuka M, Matsumoto T, Morimoto R, et al. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 2005;102:17923-8
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17923-17928
-
-
Otsuka, M.1
Matsumoto, T.2
Morimoto, R.3
-
6
-
-
33749988040
-
The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations
-
Omote H, Hiasa M, Matsumoto T, et al. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci 2006;27:587-93
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 587-593
-
-
Omote, H.1
Hiasa, M.2
Matsumoto, T.3
-
7
-
-
33746508758
-
Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1
-
Terada T, Masuda S, Asaka J, et al. Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res 2006;23:1696-701
-
(2006)
Pharm Res
, vol.23
, pp. 1696-1701
-
-
Terada, T.1
Masuda, S.2
Asaka, J.3
-
8
-
-
33751106714
-
Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney
-
Ohta KY, Inoue K, Hayashi Y, Yuasa H. Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Drug Metab Dispos 2006;34:1868-74
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1868-1874
-
-
Ohta, K.Y.1
Inoue, K.2
Hayashi, Y.3
Yuasa, H.4
-
9
-
-
34548048791
-
Molecular identification and functional characterization of rabbit MATE1 and MATE2-K
-
Zhang X, Cherrington NJ, Wright SH. Molecular identification and functional characterization of rabbit MATE1 and MATE2-K. Am J Physiol Renal Physiol 2007;293:F360-70
-
(2007)
Am J Physiol Renal Physiol
, vol.293
-
-
Zhang, X.1
Cherrington, N.J.2
Wright, S.H.3
-
10
-
-
34249943356
-
Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
-
Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007;24:1227-51
-
(2007)
Pharm Res
, vol.24
, pp. 1227-1251
-
-
Koepsell, H.1
Lips, K.2
Volk, C.3
-
11
-
-
48749128261
-
Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics
-
Moriyama Y, Hiasa M, Matsumoto T, Omote H. Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics. Xenobiotica 2008;38:1107-18
-
(2008)
Xenobiotica
, vol.38
, pp. 1107-1118
-
-
Moriyama, Y.1
Hiasa, M.2
Matsumoto, T.3
Omote, H.4
-
12
-
-
41949113401
-
Physiological and pharmacokinetic roles of H(+)/organic cation antiporters (MATE/SLC47A)
-
Terada T, Inui KI. Physiological and pharmacokinetic roles of H(+)/organic cation antiporters (MATE/SLC47A). Biochem Pharmacol 2008;75:1689-96
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1689-1696
-
-
Terada, T.1
Inui, K.I.2
-
13
-
-
79551489546
-
Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents
-
Yonezawa A, Inui K. Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents. Biochem Pharmacol 2011;81:563-8
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 563-568
-
-
Yonezawa, A.1
Inui, K.2
-
14
-
-
33746548445
-
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
-
Masuda S, Terada T, Yonezawa A, et al. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 2006;17:2127-35
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2127-2135
-
-
Masuda, S.1
Terada, T.2
Yonezawa, A.3
-
15
-
-
34250005960
-
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters
-
Tanihara Y, Masuda S, Sato T, et al. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol 2007;74:359-71
-
(2007)
Biochem Pharmacol
, vol.74
, pp. 359-371
-
-
Tanihara, Y.1
Masuda, S.2
Sato, T.3
-
16
-
-
34250015651
-
Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE)
-
Asaka J, Terada T, Tsuda M, et al. Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE). Mol Pharmacol 2007;71:1487-93
-
(2007)
Mol Pharmacol
, vol.71
, pp. 1487-1493
-
-
Asaka, J.1
Terada, T.2
Tsuda, M.3
-
17
-
-
79955919557
-
Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter
-
Komatsu T, Hiasa M, Miyaji T, et al. Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter. Int J Biochem Cell Biol 2011;43:913-18
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 913-918
-
-
Komatsu, T.1
Hiasa, M.2
Miyaji, T.3
-
18
-
-
80054935612
-
Mammalian MATE (SLC47A) Transport Proteins: Impact on Efflux of Endogenous Substrates and Xenobiotics
-
Damme K, Nies AT, Schaeffeler E, Schwab M. Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics. Drug Metab Rev 2011;43:499-523
-
(2011)
Drug Metab Rev
, vol.43
, pp. 499-523
-
-
Damme, K.1
Nies, A.T.2
Schaeffeler, E.3
Schwab, M.4
-
19
-
-
36048934236
-
Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter
-
Hiasa M, Matsumoto T, Komatsu T, et al. Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter. Am J Physiol Cell Physiol 2007;293:C1437-44
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Hiasa, M.1
Matsumoto, T.2
Komatsu, T.3
-
20
-
-
81355124801
-
Importance of the Multidrug and Toxin Extrusion MATE/SLC47A Family to Pharmacokinetics, Pharmacodynamics/Toxicodynamics and Pharmacogenomics
-
Yonezawa A, Inui KI. Importance of the Multidrug and Toxin Extrusion MATE/SLC47A Family to Pharmacokinetics, Pharmacodynamics/Toxicodynamics and Pharmacogenomics. Br J Pharmacol 2011;164:1817-25
-
(2011)
Br J Pharmacol
, vol.164
, pp. 1817-1825
-
-
Yonezawa, A.1
Inui, K.I.2
-
21
-
-
68049094117
-
MATE1 has an external COOH terminus, consistent with a 13-helix topology
-
Zhang X, Wright SH. MATE1 has an external COOH terminus, consistent with a 13-helix topology. Am J Physiol Renal Physiol 2009;297:F263-71
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Zhang, X.1
Wright, S.H.2
-
22
-
-
84864987301
-
Twelve transmembrane helices form the functional core of mammalian multidrug and toxin extruder 1 (MATE1)
-
Zhang X, He X, Baker J, et al. Twelve transmembrane helices form the functional core of mammalian multidrug and toxin extruder 1 (MATE1). J Biol Chem 2012;287(33):27971-82
-
(2012)
J Biol Chem
, vol.287
, Issue.33
, pp. 27971-27982
-
-
Zhang, X.1
He, X.2
Baker, J.3
-
23
-
-
77958596325
-
Structure of a cation-bound multidrug and toxic compound extrusion transporter
-
He X, Szewczyk P, Karyakin A, et al. Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature 2010;467:991-4
-
(2010)
Nature
, vol.467
, pp. 991-994
-
-
He, X.1
Szewczyk, P.2
Karyakin, A.3
-
24
-
-
80054970528
-
A common 5'-utr variant in mate2-k is associated with poor response to metformin
-
Choi JH, Yee SW, Ramirez AH, et al. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther 2011;90:674-84
-
(2011)
Clin Pharmacol Ther
, vol.90
, pp. 674-684
-
-
Choi, J.H.1
Yee, S.W.2
Ramirez, A.H.3
-
25
-
-
79955903884
-
Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: Determinants of uptake and transcellular translocation of organic cations
-
K€onig J, Zolk O, Singer K, et al. Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. Br J Pharmacol 2011;163:546-55
-
(2011)
Br J Pharmacol
, vol.163
, pp. 546-555
-
-
Konig, J.1
Zolk, O.2
Singer, K.3
-
26
-
-
33749327002
-
Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations
-
Hiasa M, Matsumoto T, Komatsu T, Moriyama Y. Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. Am J Physiol Cell Physiol 2006;291:C678-86
-
(2006)
Am J Physiol Cell Physiol
, vol.291
-
-
Hiasa, M.1
Matsumoto, T.2
Komatsu, T.3
Moriyama, Y.4
-
27
-
-
33846854920
-
Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1
-
Tsuda M, Terada T, Asaka J, et al. Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1. Am J Physiol Renal Physiol 2007;292:F593-8
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Tsuda, M.1
Terada, T.2
Asaka, J.3
-
28
-
-
37349059967
-
A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail
-
Kobara A, Hiasa M, Matsumoto T, et al. A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail. Arch Biochem Biophys 2008;469:195-9
-
(2008)
Arch Biochem Biophys
, vol.469
, pp. 195-199
-
-
Kobara, A.1
Hiasa, M.2
Matsumoto, T.3
-
29
-
-
0021255131
-
Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles
-
Takano M, Inui K, Okano T, et al. Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles. Biochim Biophys Acta 1984;773:113-24
-
(1984)
Biochim Biophys Acta
, vol.773
, pp. 113-124
-
-
Takano, M.1
Inui, K.2
Okano, T.3
-
30
-
-
0027133590
-
Mechanisms mediating renal secretion of organic anions and cations
-
Pritchard JB, Miller DS. Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 1993;73:765-96
-
(1993)
Physiol Rev
, vol.73
, pp. 765-796
-
-
Pritchard, J.B.1
Miller, D.S.2
-
31
-
-
0031893146
-
Organic cation transporters in intestine, kidney, liver, and brain
-
Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 1998;60:243-66
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 243-266
-
-
Koepsell, H.1
-
32
-
-
33751168746
-
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and MATE family)
-
Yonezawa A, Masuda S, Yokoo S, et al. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and MATE family). J Pharmacol Exp Ther 2006;319:879-86
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 879-886
-
-
Yonezawa, A.1
Masuda, S.2
Yokoo, S.3
-
33
-
-
59649105503
-
Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones
-
Ohta KY, Imamura Y, Okudaira N, et al. Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones. J Pharmacol Exp Ther 2009;328:628-34
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 628-634
-
-
Ohta, K.Y.1
Imamura, Y.2
Okudaira, N.3
-
34
-
-
79960155485
-
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2
-
Kido Y, Matsson P, Giacomini KM. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem 2011;54:4548-58
-
(2011)
J Med Chem
, vol.54
, pp. 4548-4558
-
-
Kido, Y.1
Matsson, P.2
Giacomini, K.M.3
-
35
-
-
77949675459
-
Potent and specific inhibition of mMate1-mediated efflux of type i organic cations in the liver and kidney by pyrimethamine
-
Ito S, Kusuhara H, Kuroiwa Y, et al. Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine. J Pharmacol Exp Ther 2010;333:341-50
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 341-350
-
-
Ito, S.1
Kusuhara, H.2
Kuroiwa, Y.3
-
36
-
-
77950852256
-
Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: Functional characterization, interaction with OCT2, and single nucleotide polymorphisms
-
Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, et al. Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2, and single nucleotide polymorphisms. Am J Physiol Renal Physiol 2010;298:F997-F1005
-
(2010)
Am J Physiol Renal Physiol
, vol.298
-
-
Meyerzu Schwabedissen, H.E.1
Verstuyft, C.2
Kroemer, H.K.3
-
37
-
-
79956333806
-
Effects of a mate protein inhibitor pyrimethamine on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
-
Kusuhara H, Ito S, Kumagai Y, et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther 2011;89:837-44
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 837-844
-
-
Kusuhara, H.1
Ito, S.2
Kumagai, Y.3
-
38
-
-
84861540616
-
Molecular Determinants of Ligand Selectivity for the Human Multidrug and Toxin Extrusion Proteins, MATE1 and MATE-2K
-
Astorga B, Ekins S, Morales M, Wright SH. Molecular Determinants of Ligand Selectivity for the Human Multidrug And Toxin Extrusion Proteins, MATE1 and MATE-2K. J Pharmacol Exp Ther 2012;341:743-55
-
(2012)
J Pharmacol Exp Ther
, vol.341
, pp. 743-755
-
-
Astorga, B.1
Ekins, S.2
Morales, M.3
Wright, S.H.4
-
39
-
-
77954905149
-
Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice
-
Watanabe S, Tsuda M, Terada T, et al. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther 2010;334:651-6
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 651-656
-
-
Watanabe, S.1
Tsuda, M.2
Terada, T.3
-
40
-
-
77950355259
-
Functional characteristics of two human MATE transporters: Kinetics of cimetidine transport and profiles of inhibition by various compounds
-
Ohta KY, Inoue K, Yasujima T, et al. Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. J Pharm Pharm Sci 2009;12:388-96
-
(2009)
J Pharm Pharm Sci
, vol.12
, pp. 388-396
-
-
Ohta, K.Y.1
Inoue, K.2
Yasujima, T.3
-
41
-
-
78649646556
-
Organic cation transporters (octs mates) in vitro and in vivo evidence for the importance in drug therapy
-
Nies AT, Koepsell H, Damme K, Schwab M. Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol 2011;1:105-67
-
(2011)
Handb Exp Pharmacol
, vol.1
, pp. 105-167
-
-
Nies, A.T.1
Koepsell, H.2
Damme, K.3
Schwab, M.4
-
42
-
-
84855995429
-
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
-
Ito S, Kusuhara H, Yokochi M, et al. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther 2012;340:393-403
-
(2012)
J Pharmacol Exp Ther
, vol.340
, pp. 393-403
-
-
Ito, S.1
Kusuhara, H.2
Yokochi, M.3
-
43
-
-
51249105551
-
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1
-
Sato T, Masuda S, Yonezawa A, et al. Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochem Pharmacol 2008;76:894-903
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 894-903
-
-
Sato, T.1
Masuda, S.2
Yonezawa, A.3
-
44
-
-
36048993190
-
Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1
-
Kajiwara M, Terada T, Asaka J, et al. Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1. Am J Physiol Renal Physiol 2007;293:F1564-70
-
(2007)
Am J Physiol Renal Physiol
, vol.293
-
-
Kajiwara, M.1
Terada, T.2
Asaka, J.3
-
45
-
-
70349742624
-
Identification and characterization of novel polymorphisms in the basal promoter of the human transporter. MATE1
-
Ha Choi J, Wah Yee S, Kim MJ, et al. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter. MATE1. Pharmacogenet Genomics 2009;19:770-80
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 770-780
-
-
Ha Choi, J.1
Wah Yee, S.2
Kim, M.J.3
-
46
-
-
78549256786
-
Alterations in hepatic mrna expression of phase ii enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha
-
Lu H, Gonzalez FJ, Klaassen C. Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci 2010;118:380-90
-
(2010)
Toxicol Sci
, vol.118
, pp. 380-390
-
-
Lu, H.1
Gonzalez, F.J.2
Klaassen, C.3
-
47
-
-
45249105082
-
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice
-
Lickteig AJ, Cheng X, Augustine LM, et al. Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sci 2008;83:59-64
-
(2008)
Life Sci
, vol.83
, pp. 59-64
-
-
Lickteig, A.J.1
Cheng, X.2
Augustine, L.M.3
-
48
-
-
79952991292
-
Use of transgenic and knockout mouse models to assess solute carrier transporter function
-
Degorter MK, Kim RB. Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function. Clin Pharmacol Ther 2011;89:612-16
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 612-616
-
-
Degorter, M.K.1
Kim, R.B.2
-
49
-
-
66849142125
-
Targeted disruption of the multidrug and toxin extrusion 1 (Mate1) gene in mice reduces renal secretion of metformin
-
Tsuda M, Terada T, Mizuno T, et al. Targeted disruption of the multidrug and toxin extrusion 1 (Mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol 2009;75:1280-6
-
(2009)
Mol Pharmacol
, vol.75
, pp. 1280-1286
-
-
Tsuda, M.1
Terada, T.2
Mizuno, T.3
-
50
-
-
82955240616
-
Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice
-
Li Q, Peng X, Yang H, et al. Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice. Mol Pharm 2011;8:2476-83
-
(2011)
Mol Pharm
, vol.8
, pp. 2476-2483
-
-
Li, Q.1
Peng, X.2
Yang, H.3
-
51
-
-
77957929019
-
Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity
-
Nakamura T, Yonezawa A, Hashimoto S, et al. Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity. Biochem Pharmacol 2010;80:1762-7
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1762-1767
-
-
Nakamura, T.1
Yonezawa, A.2
Hashimoto, S.3
-
52
-
-
84860865479
-
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis
-
Toyama K, Yonezawa A, Masuda S, et al. Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. Br J Pharmacol 2012;166:1183-91
-
(2012)
Br J Pharmacol
, vol.166
, pp. 1183-1191
-
-
Toyama, K.1
Yonezawa, A.2
Masuda, S.3
-
53
-
-
77956235037
-
Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1)
-
Lai Y, Sampson KE, Balogh LM, et al. Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther 2010;334:936-44
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 936-944
-
-
Lai, Y.1
Sampson, K.E.2
Balogh, L.M.3
-
54
-
-
0036175142
-
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
-
Takeda M, Khamdang S, Narikawa S, et al. Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 2002;300:918-24
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 918-924
-
-
Takeda, M.1
Khamdang, S.2
Narikawa, S.3
-
55
-
-
34250764918
-
Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity
-
Yokoo S, Yonezawa A, Masuda S, et al. Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol 2007;74:477-87
-
(2007)
Biochem Pharmacol
, vol.74
, pp. 477-487
-
-
Yokoo, S.1
Yonezawa, A.2
Masuda, S.3
-
56
-
-
71849088050
-
Pharmacogenetics of antimalarial drugs: Effect on metabolism and transport
-
Kerb R, Fux R, Morike K, et al. Pharmacogenetics of antimalarial drugs: effect on metabolism and transport. Lancet Infect Dis 2009;9:760-74
-
(2009)
Lancet Infect Dis
, vol.9
, pp. 760-774
-
-
Kerb, R.1
Fux, R.2
Morike, K.3
-
59
-
-
78650514267
-
Prediction of fluoroquinolone-induced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion
-
Imamura Y, Murayama N, Okudaira N, et al. Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther 2011;89:81-8
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 81-88
-
-
Imamura, Y.1
Murayama, N.2
Okudaira, N.3
-
60
-
-
0022631053
-
Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs
-
van CJ, Bochner F, Keal J, Somogyi A. Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs. J Pharmacol Exp Ther 1986;236:481-7
-
(1986)
J Pharmacol Exp Ther
, vol.236
, pp. 481-487
-
-
Van Cj Bochner, F.1
Keal, J.2
Somogyi, A.3
-
61
-
-
76649136531
-
Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration
-
Soyinka JO, Onyeji CO, Omoruyi SI, et al. Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration. Br J Clin Pharmacol 2010;69:262-70
-
(2010)
Br J Clin Pharmacol
, vol.69
, pp. 262-270
-
-
Soyinka, J.O.1
Onyeji, C.O.2
Omoruyi, S.I.3
-
62
-
-
63149121717
-
Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function
-
Chen Y, Teranishi K, Li S, et al. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J 2009;9:127-36
-
(2009)
Pharmacogenomics J
, vol.9
, pp. 127-136
-
-
Chen, Y.1
Teranishi, K.2
Li, S.3
-
63
-
-
58849154128
-
Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity
-
Kajiwara M, Terada T, Ogasawara K, et al. Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity. J Hum Genet 2009;54:40-6
-
(2009)
J Hum Genet
, vol.54
, pp. 40-46
-
-
Kajiwara, M.1
Terada, T.2
Ogasawara, K.3
-
64
-
-
75649118895
-
Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients
-
Toyama K, Yonezawa A, Tsuda M, et al. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. Pharmacogenet Genomics 2010;20:135-8
-
(2010)
Pharmacogenet Genomics
, vol.20
, pp. 135-138
-
-
Toyama, K.1
Yonezawa, A.2
Tsuda, M.3
-
65
-
-
70349091471
-
Genetic variation in the proximal promoter of ABC and SLC superfamilies: Liver and kidney specific expression and promoter activity predict variation
-
Hesselson SE, Matsson P, Shima JE, et al. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One 2009;4:e6942
-
(2009)
PLoS One
, vol.4
-
-
Hesselson, S.E.1
Matsson, P.2
Shima, J.E.3
-
66
-
-
84900657449
-
ADME pharmacogenetics and its impact on drug-drug interactions
-
Pang KS, Rodrigues AD, Peter RM, editors Springer; New York
-
Kerb R, Schwab M. ADME pharmacogenetics and its impact on drug-drug interactions. In: Pang KS, Rodrigues AD, Peter RM, editors. Enzyme-and transporter-based drug-drug interactions: progress and future challenges. Springer; New York:2010. p. 51-74
-
(2010)
Enzyme-and Transporter-based Drug-drug Interactions: Progress and Future Challenges
, pp. 51-74
-
-
Kerb, R.1
Schwab, M.2
-
67
-
-
77949265977
-
DNA methylation profiles of organic anion transporting polypeptide 1b3 in cancer cell lines
-
Ichihara S, Kikuchi R, Kusuhara H, et al. DNA methylation profiles of organic anion transporting polypeptide 1B3 in cancer cell lines. Pharm Res 2010;27:510-16
-
(2010)
Pharm Res
, vol.27
, pp. 510-516
-
-
Ichihara, S.1
Kikuchi, R.2
Kusuhara, H.3
-
68
-
-
84155173299
-
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
-
Schaeffeler E, Hellerbrand C, Nies AT, et al. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med 2011;3:82
-
(2011)
Genome Med
, vol.3
, pp. 82
-
-
Schaeffeler, E.1
Hellerbrand, C.2
Nies, A.T.3
-
69
-
-
63849121023
-
Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells
-
Tsuda M, Terada T, Ueba M, et al. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther 2009;329:185-91
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 185-191
-
-
Tsuda, M.1
Terada, T.2
Ueba, M.3
-
70
-
-
79959199435
-
Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine
-
Müller F, K€onig J, Glaeser H, et al. Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother 2011;55:3091-8
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 3091-3098
-
-
Müller, F.1
Konig, J.2
Glaeser, H.3
-
71
-
-
62749133967
-
Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study
-
Becker ML, Visser LE, van Schaik RH, et al. Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes 2009;58:745-9
-
(2009)
Diabetes
, vol.58
, pp. 745-749
-
-
Becker, M.L.1
Visser, L.E.2
Van Schaik, R.H.3
-
72
-
-
69449098951
-
The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
-
Tzvetkov MV, Vormfelde SV, Balen D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009;86:299-306
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 299-306
-
-
Tzvetkov, M.V.1
Vormfelde, S.V.2
Balen, D.3
-
73
-
-
84870802316
-
-
Avilable from http://www.ncbi.nlm.nih.gov/pccompound
-
-
-
|